We seek a highly motivated fellow to explore the new frontier of non-neural bioelectricity in tissue development and regeneration. This is a newly funded multi-disciplinary project among Drs. Cheng Ming Chuong, Randall Widelitz, and Robert Chow.
With developing chicken skin as the model, we use next-gen sequencing, molecular expression, lentivirus-mediated gene mis-expression, 4D cell behavior movies, and electro-physiological analysis to study roles of ion channels and gap junctions in skin morphogenesis.
(1) Coupling bioelectric signaling with biochemical signaling. See Li et al. Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks. Nat. Commun. 9, 5377, 2018. Calcium channel activities passing through gap junctions work with Shh/Wnt to control collective cell movement in feather bud elongation.
(2) How periodic pigment patterns form across the body. See Inaba et al. Instructive role of melanocytes during pigment pattern formation of the avian skin. PNAS 116: 684, 2019. Melanocyte progenitors form periodic patterns of differentiated melanocytes autonomously in a gap junction-dependent manner.
Contact information: Please send a curriculum vitae, personal statement on research and 3 references to Dr. Randall Widelitz (email@example.com); Dr. Chuong (firstname.lastname@example.org).