• A PhD in Molecular or Cellular Biology, Biochemistry, Physiology or other relevant discipline.
• Experience with primary cell culture, epithelial cells or organoids, with isolation and culture of mouse cholangiocytes a major prioritization.
• Experience with mouse models of metabolic disease or hepatobiliary disease.
• Experience with cell signaling and developmental biology, with membrane biology and bile acid signaling major prioritizations.
• Experience with standard RNA and Protein analytics (imaging and immunoblotting).
• Independence, scientific rigor and critical thinking.
Additional Position Details:
This research arc of the Karpen lab focuses upon wet bench validations of etiologic gene discoveries and therapeutic target identification for rare childhood liver diseases. Recent explorations have focused upon discovering etiologic causes of the # 1 reason to transplant a liver during childhood—biliary atresia. The successful candidate will develop and apply research methods to develop cholangiocyte cell cultures and organoids from various mouse and cell culture models to better understand the pathogenesis of biliary atresia as a developmental cholangiopathy. Interested applicants should submit a cover letter detailing previous research and interest in this lab, CV, and names and contact information for three academic references. Apply through the website above.