Postdoctoral Fellow

Cincinnati Children's Hospital Medical Center

Cincinnati, OH

Posted 10/13/2023

The Özbudak Lab is looking for a postdoctoral fellow interested in combining multidisciplinary approaches to discover mechanisms governing spatiotemporal pattern formation during embryonic development.
Embryos develop spatiotemporal patterns by encoding and interpreting biological signals in real time. A striking example of robust spatiotemporal patterning is the rhythmic segmentation of somites, which are precursors of the vertebral column. Segmentation of somites is controlled by: 1) oscillatory expression of Hes/Her gene family, known as the vertebrate segmentation clock, 2) short-distance Notch signaling, 3) long-distance Fgf and Wnt signaling gradients, and 4) a network of transcription factors integrating outputs of the segmentation clock and the signaling pathways. Errors in this regulatory cascade result in various birth defects, including congenital scoliosis. We combine single-cell microscopy measurements, time-resolved perturbation experiments and biophysical modeling to decipher the mechanism underlying robust spatiotemporal pattern formation and cell fate determination.
Relevant recent publications: Zinani et al., Nature, 2021 and Simsek et al., Nature, 2023,
Interested candidate must have a PhD and strong experience in:

  1. Microscopy and image analysis; OR
  2. Crispr/Cas0 gene editing; OR
  3. Biomechanics

We are looking for a colleague who is highly motivated and independent. Please send a cover letter detailing your past research accomplishments and future research goals, and your CV by email to:
Ertugrul M. Özbudak, Ph.D.
Professor of Pediatrics
Division of Developmental Biology
Laboratory of Systems Developmental Biology
Cincinnati Children's Hospital Medical Center
Email: [email protected]


Last Updated 10/13/2023