Development and Regulation of the GnRH System


Bethesda, MD

Posted 8/7/2023

Funded postbaccalaureate and postdoctoral fellow positions for Intramural Training Awards . Postdocs must be newly granted Ph.Ds. Lab focuses on mechanisms directing development and regulation of GnRH cells which arise in olfactory regions and migrate into the brain, where they control reproductive function.

Research addresses Cell lineage, Neuronal Migration, Axonal Targeting, Craniofacial develop-ment and understanding mutations identified in patients with Kallmann Syndrome. Experience in mouse development, molecular and imaging techniques preferred. Primary GnRH neurons are also used to study the molecular and cellular properties of neuronal activity and correlate activity with secretion. Experience in calcium imaging or electrophysiology, molecular biology and mouse anatomy preferred.

Applicants should email updated C.V., cover letter and reference names to [email protected].  

Recent publications:

  • Shan, Y. Farmer, SM, Wray, S. Drebrin Regulates Cytoskeleton Dynamics in Migrating Neurons through Interaction with CXCR4. PNAS, 2021.
  • Dairaghi L, Constantin S, Oh A, Shostak D, Wray, S. The Dopamine D4 receptor regulates gonadotropin-releasing hormone neuron excitability in male mice. eNeuro, 2022.
  • Welch B, Cho H-J, Ucakturk SA, Farmer, SM, Cetinkaya S, Abaci A, Akkus G, Simsek E, Kotan LD, Turan I, Yuksel B, Wray S, Topaloglu AK. PLXNB1 Mutations in the Etiology of Idiopathic Hypogonadotropic Hypogonadism. J. of Neuroendocrinology, 2022.
  • Shostak D, Constantin S, Flannery J, Wray S. Acetylcholine regulation of GnRH neuronal activity: A circuit in the medial septum, Frontiers in Endocrinology, 2023.
  • Cho-H-J, Gurbuz F, Stamou M, Kotan LD, Farmer SM, Can S, Tompkins MF, Mamadova J, Altincik SA, Gokce C, Catli G, Bugrul F, Bartlett K, Turan I, Balasubramanian R, Yuksel B, Seminara SB, Wray S, Topaloglu AK. POU6F2 mutation in humans with pubertal failure alters GnRH transcript expression. Frontiers in Endocrinology, 2023.

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Last Updated 08/07/2023