We seek highly motivated post-docs interested in cell signaling at the intersection of development, stem cells and cancer to join the group of Dr. Andres Lebensohn, Earl Stadtman Investigator in the Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH. We combine functional genetic screens in human cells, cell biology and biochemistry to study how signaling pathways are used, reused and repurposed to drive the myriad cellular processes that give rise to tissues and organs during embryonic development, and maintain them in adults. Our major focus is on WNT/R-spondin signaling, a pathway that orchestrates embryonic patterning and morphogenesis, and promotes stem cell self-renewal and tissue regeneration. We discovered a new mode of signaling by R-spondins that does not require LGRs (considered the main R-spondin receptors) and is instead mediated by heparan sulfate proteoglycans (https://elifesciences.org/articles/33126). We seek a post-doc who will use mouse genetics to elucidate the physiological functions of this mode of signaling during embryonic development and in stem cells. See descriptions of this and other projects at https://ccr.cancer.gov/Laboratory-of-Cellular-and-Molecular-Biology/andres-m-lebensohn. To apply send a cover letter describing how your scientific background and interests fit our research, a CV, and contacts for three references to firstname.lastname@example.org.