Post-doc position at the NIH: New mechanisms of WNT/R-spondin signaling in development and stem cells

Posted 6/10/2019

https://ccr.cancer.gov/Laboratory-of-Cellular-and-Molecular-Biology/andres-m-lebensohn

We seek highly motivated post-doctoral Fellows interested in cell signaling at the intersection of development, stem cells and cancer. Candidates will join the group of Dr. Andres Lebensohn, an Earl Stadtman Principal Investigator in the Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health. We combine functional genomics, CRISPR/Cas9-mediated genome editing, cell biology and biochemistry to study how signaling pathways are used, reused and repurposed to drive the myriad different cellular processes that give rise to tissues and organs during embryonic development, and maintain them in adult life. A major focus of the lab is on WNT/R-spondin signaling, a fundamental pathway that orchestrates embryonic patterning and morphogenesis, and promotes stem cell self-renewal and tissue regeneration. We recently discovered a new mode of signaling by R-spondins that does not require LGRs, thought to be the main R-spondin receptors (https://elifesciences.org/articles/33126). We seek a Fellow who will use mouse genetics to elucidate the physiological functions of LGR-independent signaling by R-spondins during embryonic development and in stem cells.

Please send a cover letter describing your specific interest in my lab, a CV and contact information for three references to Dr. Lebensohn at andres.lebensohn@nih.gov

Last Updated 06/10/2019