The Craft lab is looking for an outstanding, highly motivated postdoctoral fellow to join our developmental biology and pluripotent stem cell-based team in the Dept of Orthopaedics at Boston Children’s Hospital, affiliated with the Harvard Stem Cell Institute and Harvard Medical School.
We are using our recently established model of articular cartilage differentiation from human pluripotent stem cells to identify unique molecular signatures associated with lineage commitment. The fellow will design mechanistic studies of validated targets using pathway modulation and GOF/LOF approaches in vitro and in vivo. This project spans other ongoing developmental studies such as characterizing progenitors that give rise to cartilage and other tissues in the joint, as well as translational experiments of cartilage repair in large animals and modeling congenital cartilage disease in vitro.
The successful candidate will have received a PhD or MD/PhD within the past 2 years, a minimum of 3 years laboratory experience including tissue culture, at least one first author publication, and excellent communication skills in English. Individuals with experience in one or more of the following are encouraged to apply: limb/joint/cartilage or early embryonic development, ESC/iPSCs, single cell RNAseq.
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