New Insights into Congenital Kidney Disease Workshop

September 28, 2022 - September 29, 2022


The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) encourages interested investigators to register for the  upcoming New Insights into Congenital Kidney Disease workshop, which is being held using a virtual format on September 28-29, 2022, to ensure it is more accessible. The goal of the workshop is to discuss challenges in moving beyond the current research state to an understanding of the mechanisms associated with congenital renal anomalies and low nephron endowment.  The workshop seeks to engage leaders in the field to foster cross-disciplinary discussions between clinicians, computational geneticists, developmental biologists, perinatologists, environmental scientists, health disparities researchers, and investigators who work with a range of renal model systems including organoids, to identify common scientific intersections and natural collaborations between disciplines.

The goal of the workshop is to broaden the current research field and promote multi-disciplinary approaches between individuals with expertise in genetics, epigenetics, multi-omics, clinical phenotyping, the intrauterine environment, environmental exposures and health disparities.

The workshop seeks to address and identify key needs of the community including:   

  • To determine the utility of assembling a well-phenotyped patient cohort and trios, and using whole genome sequencing to identify mutations in genes, non-coding regions and regulatory enhancers.  To consider what bioinformatic tools would be needed to interpret the data.
  • To determine the contribution of sequence heterogeneity in the patient population and model mechanisms using appropriate systems. (Could insights from such a whole genome sequence database be tested in organoids to see their relevance?)
  • To determine how the intrauterine environment, preterm delivery and maternal nutrition impact renal development and nephron endowment.
  • To identify environmental exposures that could affect renal development and nephron endowment and determine if racial disparities in exposures associate with increased risk of kidney failure in childhood and adulthood.


Last Updated 09/01/2022