logo Alphabetical list of genes

Genes A - B - C - D - -- [Genes E-K -- Genes L-R -- Genes S-Z ]
A

abdominal-A
homeodomain transcription factor - Antp class - involved in subdivision of the visceral mesoderm

Abdominal-B
homeodomain transcription factor - bithorax complex - required to specify the posterior abdomen and the genitalia

Abelson Interacting Protein
regulates WASP-/WAVE mediated F-actin formation and modulates the activity of the Abelson tyrosine kinase -
recruits EGFR to the membrane to promote SOP development

Abl oncogene
non receptor tyrosine kinase with SH2 and SH3 domains - involved in axon extension

abnormal chemosensory jump 6 (common alternative name: Ipou)
transcription factor - homeodomain and POU domain - determines odorant response profile of subsets of olfactory neurons

abnormal spindle
microtubule binding protein - required for the integrity of microtubule organizing centers - may organize microtubules during cytokinesis

abrupt
transcription factor - zinc finger BTB domain - controls the specificity of neuromuscular connections

absent MD neurons and olfactory sensilla
proneural - required for the identity of a class of multidendritic neurons and for a class of olfactory sensilla

absent, small, or homeotic discs 1
histone methyl transferase that indirectly prevents gene silencing - provides a specific signal for establishment of active transcription

absent, small, or homeotic discs 2
trithorax family member - maintains active transcription by binding a producer of nuclear phosphoinositides
and downregulating histone H1 hyperphosphorylation

abstrakt
DEAD-box subfamily ATP-dependent helicase protein - involved in post-transcriptional regulation effecting synaptic function
and axon outgrowth and fasciculation

Accessory gland peptide 26aa (common alternative name: Ovulin)
male ejaculate accessory gland protein - increases ovulation through octopamine based neuronal signaling

Accessory gland peptide 70A (preferred name name: Sex Peptide)
male ejaculate accessory gland protein - decreases female receptivity and stimulates egg production in the first mating of virgin females

achaete
transcription factor - basic HLH - proneural - involved in the determination of the neural fate

achintya
homeodomain transcription factor (TGIF subclass) - required, along with homeodomain protein Vismay, for spermatogenesis

Actin-related protein 2/3 complex, subunit 1
A component of the Arp2/3 complex - involved in catalyzing actin filament nucleation - essential to cap expansion and pseudocleavage furrow during cellularization -
required for ring canal expansion during oogenesis

Activated Cdc42 kinase
an evolutionarily conserved non-receptor tyrosine kinases - anti-apoptotic - interacts with Drk (Grb2 homolog)
and Yorkie for pro-survival activity and promotion of tissue growth respectively - cooperates with Dpp to regulate myosin levels
during dorsal closure - targets the sorting nexin DSH3PX1 to regulate axonal guidance

Activating transcription factor-2 (alternative name: Atf-2)
transcription factor - basic leucine zipper protein - regulates fat metabolism and osmotic stress response

Activator of SUMO 1
E1 SUMO-activating complex comprising the Aos1/Uba2 heterodimeric pair - required for SUMOylation - tumor suppressor regulating cell cycle, imaginal disc development, hematopoesis, and CNS development

activin-β
TGFβ ligand of Baboon - required for tiling of photoreceptor R7 axon terminals

act up (preferred name: capulet)
cyclase-associate protein homolog - required to prevent actin filament polymerization in the eye disc

alpha-Adaptin (preferred name: Adaptor Protein complex 2, alpha subunit)
necessary for the formation of clathrin-coated pits and participates in the dynamin-dependent release of coated vesicles
from the membrane surface as a prelude to vesicle recycling - acts downstream of Numb in the determination of alternative cell fates in asymmetric cell division

Adar
double-stranded RNA adenosine deaminase - RNA editing enzyme that affects nervous system function, integrity, and behavior

Adenomatous polypopsis coli tumor suppressor homolog 2
signaling protein in Wingless pathway and affects cytoskeletal regulation

Adenosine deaminase-related growth factor A
a secreted enzyme that converts extracellular adenosine into inosine - regulates adenosine levels - opposes the effects
of Hedgehog signaling within the hematopoietic progenitor cells - regulates energy allocation during immune response

Adherens junction protein p120
Armadillo/beta-catenin-like repeat protein - a componenet of the adherens junction that plays a supporting role in cell adhesion -
protects epithelial integrity - involved in retinal patterning and dendritic morphogenesis

Adh transcription factor 1 (common alternative name: Nalyot)
transcription factor - Myb helix-turn-helix family involved in terminal stages of neuronal differentiation and function

Adipokinetic hormone-like
metabolic neuropeptide, made in the corpora cardiaca, that mediates mobilization of energy substrates from the fat body - regulates starvation-induced foraging behavior

Adipokinetic hormone receptor (preferred name: Gonadotropin-releasing hormone receptor)
GPCR - involved in storage-fat mobilization - essential to adjust normal body fat content
and ensure lifelong fat-storage homeostasis - functional analog of the mammalian glucagon receptor

adrift
novel protein involved in tracheal branching

ahuizotl (common alternative name: Azot)
calcium dependent protein that ensures the elimination of less fit cells, fitness-based cell culling is naturally used
to maintain tissue health, delay aging, and extend lifespan

A kinase anchor protein 200
Involved in Protein kinase A localization - PKA in turn regulates the function of specialized actin structures during oogenesis

Akt1
S/T kinase with Src homology 2 domain - promotes cell survival - component of insulin pathway

α actinin
actin filament crosslinking protein that regulates cell adhesion and motility

alan shepard
RNA-binding protein - regulates insulator activity - regulates neuronal remodeling during metamorphosis, regulates gravitaxis

α-Catenin
an essential physical linker, acting at the adherins junction, between the cadherin-β-catenin complex and the actin cytoskeleton

alicorn
regulatory subunit of AMP-activated protein kinase - regulation of cellular energy homeostasis - maintainance
of integrity of mature neurons under conditions of increased activity - regulation of developmental and stress-induced autophagy

Allatostatin A
neuropeptide secreted by the corpus cardiacum - a modulator of AKH and DILP signaling and feeding choices
between dietary carbohydrates and protein - conveys inhibitory input onto protocerebral dopamine neurons

altered disjunction (common alternative name: Mps1)
kinase - regulation of mitotic spindle checkpoint - required for cell cycle arrest in response to hypoxia - ensures the proper segregation of achiasmatic chromosomes
during meiosis - required for cell cycle arrest of the three haploid products of female meiosis that are not used as the female pronucleus

always early
regulator of chromatin structure - a 'meiotic arrest' gene required for transcription of key G2-M cell cycle control genes and of spermatid differentiation genes

amalgam
IG superfamily - ligand for Neurotactin - maintains proper cohesion between axons and contributes to the organization of fascicles

amnesiac
pacap-like neuropeptide that activates the cAMP pathway stimulating learning and memory

AMP-activated protein kinase
adenosine 5'monophosphate-activated kinase - cellular energy sensor - coordinates epithelial polarity and proliferation with cellular energy status

Amphiphysin
SH3 domain protein that functions in membrane morphogenesis - involved in cellularization and plays a role in establisment of proper localization of postsynaptic proteins

beta amyloid protein precursor-like
beta amyloid homolog - contributes to synapse formation, maintenance, and plasticity

anachronism
secreted glial glycoprotein that inhibits premature neuroblast proliferation

anakonda
transmembrane receptor protein - interacts extracellularly to mediate assembly of tricellular junctions - septate junctions - ectodermal and endodermal epithelia

Anaplastic lymphoma kinase
transmembrane protein - receptor tyrosine kinase - the ligand Jelly belly activates Alk
to specify a select group of visceral muscle precursors as muscle-patterning pioneers

anastral spindle 2
centrosomal protein, regulates spindle orientation during neuroblast asymmetical division, tumor suppressor

anillin (preferred name: scraps)
conserved component of the contractile ring that is essential for cytokinesis - physically interacts
with three conserved cleavage furrow proteins, F-actin, myosin II and septins - required for cellularization

Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein
adherins junction protein that acts as a positive regulator of C-terminal Src kinase - fine tunes cell-cell adhesion during development by directing Csk and Src activity

Ankyrin 2
a membrane-cytoskeleton linker - a target of G-protein signaling required for neuromuscular
junction formation - regulation of presynaptic microtubules and transsynaptic cell adhesion

Anktm1 (common alternative name: TrpA1)
heat-activated TRP family ion channel that is essential for thermotaxis

Antennapedia
homeodomain transcription factor - Antp class - initiator of a cascade of events that result in the development of an adult leg

anterior open (common alternative names: pokkuri or yan)
ets domain transcription factor - target of Ras pathway that serves to inhibit neural and other types of differentiation

anti-silencing factor 1
histone chaperone that assists in chromatin assembly and remodeling during replication, transcription activation,
and gene silencing - contributes to the repression of Notch target genes - directly interacts Hairless

AP-2
transcription factor that plays essential roles in leg and proboscis outgrowth -
involved in development of the adult brain central complex

Apaf-1-related-killer
CED-4 domain protein that links mitochondrial events to activation of caspases during programd cell death

APC-like
adenomatous polyposis coli homolog involved in the wingless pathway - functions in neural development

apontic
novel bZIP transcription factor and RNA-binding protein - multi-functional protein involved in translational regulation
and organ development

APP-like protein interacting protein 1
JNK scaffolding scaffolding protein that is part of motor-cargo linkage complexes for both kinesin-1 and dynein - acts downstream of the JNK pathway
to affect axonal transport - binds APP family proteins

approximated
DHHC family protein, responsible for the palmitoylation of selected cytoplasmic proteins - acts by controlling the normal subcellular localization
and activity of Dachs in the Fat signaling pathway

aproctous
transcription factor - brachyury homolog - mediates specification of caudal visceral mesoderm

apterous
transcription factor - homeodomain - lim domain - involved in boundary formation in the developing wing

araucan
transcription factor - homeodomain Pbx class - establishes a prepattern that determines the size, shape and number
of sensory organ mother cells in imaginal discs

arc
PDZ domain protein involved in structuring epithelia

archipelago
F box component of an SCF-ubiquitin ligase - negatively regulates the levels and activity of Drosophila Myc by linking Myc
to a protein degradation pathway - also negatively regulates Cyclin E and Notch

Argonaute 1
PAZ domain protein involved in post-transcriptional gene silencing - mutants exhibit defects in the embryonic nervous system

Argonaute 2
endonuclease - an essential component for siRNA-directed RNA interference (RNAi) response -
required for the unwinding of siRNA duplex and in consequence, assembly of siRNA into RISC

Argonaute 3
cleaves transposon derived piwi-interacting RNAs to form an adaptive system for transposon control

argos
ligand for Egf receptor - inhibitor of Egfr activation

aristaless
transcription factor - homeodomain - paired-like - involved in the ontogeny of specific head segments and
the initiation of appendage development

armadillo
plakoglobin and beta catenin homolog - functions in transducing signals from the Wingless/Wnt family of proteins
and works with cadherins to mediate cell adhesion

armitage
RNA helicase involved in posttranscriptional gene silencing - mutations disrupt mRNA translational silencing of oskar in the oocyte
and silencing of Stellate in male germ cells

armless (preferred name: GDI interacting protein 3)
ubiquitin-like protein that functions in protein degradation - required for Wingless target gene expression

arrest
ribonucleoprotein-type RNA-binding protein - regulates multiple mRNAs involved in female and male gametogenesis -
posterior group gene involved in assembly of the pole plasm

Arrestin 2
a protein that interacts stoichiometrically with activated rhodopsin, inhibiting its ability to interact with the G protein, transducin, thus terminating the visual response

arrow
LDL-receptor-related protein (LRP) family - Wingless pathway - binds Axins and consequently induces LEF-1 activation
by destabilizing Axin and stabilizing ß-catenin

Arrowhead
LIM domains and LIM homeodomain - requirement for proliferation of histoblast and imaginal ring tissue

Ars2
RNA-binding protein - key component of Drosophila antiviral immunity - interacts with Dcr-2 - required for siRNA-mediated silencing -
plays an essential role in miRNA-mediated silencing

asense
basic HLH transcription factor - detected in neural precursors and their progeny but is not expressed in proneural clusters -
participates in the allocation of the sensory mother cells that give rise to the bristles of the anterior wing margin

asterless
coiled-coil protein - component of pancentriole and basal body - involved in stabilization/maintenance of pericentriolar material at the centrosome

Ataxin-2
multi-functional protein that binds DEAD box helicases of the Me31B family that associated with Argonaute and microRNA function -
required for microRNA function and synapse-specific long-term olfactory habituation -
assembles with polyribosomes and poly(A)-binding protein, a key regulator of mRNA translation

Ataxin-2 binding protein 1 (common alternative name: Rbfox)
RNA-binding protein - homolog of an autism-susceptibility gene - targets pumilio mRNA for destabilization
and translational silencing, thereby promoting germ cell development, oogenesis

A3-3
ATF3 basic leucine-zipper transcription factor - partner of Jun in preventing extrusion and replacement
of epidermal cells with histoblasts during larval morphogenesis

atlastin
dynamin-family transmembrane GTPase that drives endoplasmic reticulum membrane fusion in a GTP-dependent fashion - self-associating protein
that is able to form trans-oligomeric complexes - required for normal growth of muscles and synapses at the neuromuscular junction

ATM (preferred name: telomere fusion)
Phosphatidylinositol 3- and 4-kinase - Serves as Drosophila's ATM (ataxia telangiectasia mutated) - plays a conserved and essential role in the maintenance of normal telomeres and chromosome stability

atonal
transcription factor - basic HLH -proneural gene that governs the development of chordotonal organs (stretch receptors in the body wall and joints) and as auditory organs in the antennae

ATP synthase, subunit d
mitochondrial ATP synthesis coupled proton transport - component of electron transport complex V - regulates aging and stress

ATP-utilizing chromatin assembly and remodeling factor
PHD finger motifs and chromodomain - involved in chromatin assembly

atypical protein kinase C
kinase regulating asymmetric cell division

aubergine
related to eukaryotic translation initiation factor 2C - involved in post-transcriptional gene silencing

aurora A
kinase required for centrosome separation - functions in asymmetric protein localization during mitosis

aurora B
signaling protein involved in chromatin condensation during mitosis

Autophagy-related 1
autophagy-specific protein kinase - induces a coordinated autophagic response that can lead to caspase induced cell death

Autophagy-related 9
a vesicular transmembrane protein that is a constituent of autophagic vesicles and is required for oxidative stress-induced JNK activation

auxilin
serine/threonine protein kinase - a J-domain-containing protein that cooperates with Hsc70 in the disassembly of clathrin coats from clathrin-coated vesicles
an integral component of the Notch signaling pathway, participating in the ubiquitin-dependent endocytosis of Delta in the signal receiving cell

Axin
scaffolding protein - wingless pathway component

Axud1
conserved phospho-acceptor site for acidophilic serine/threonine kinases domain protein -
cysteine- serine-rich nuclear protein - tumor suppressor that regulates proliferation of imaginal cells

B

baboon
transmembrane protein - Type 1 activin-A-receptor - essential for proper pupation and adult viability

bag of marbles
novel protein involved in oogenesis and spermatogenesis - functions as a translational repressor by interfering with translation initiation

bagpipe
transcription factor - homeodomain - NK-2 class - forms visceral mesoderm that differentiates into gut musculature

bantam
a 21 nucleotide microRNA that promotes tissue growth, stimulates cell proliferation and prevents apoptosis

BarH1 & BarH2
transcription factor - homeodomain - neural selector genes involved in the development of the external sensilli

barren (common alternative name: CAP-H)
CAP-H homologue, a condensin subunit exclusively associated with condensin I - promotes sister chromatid resolution
and maintains the structural integrity of centromeric heterochromatin during mitosis

Basigin
conserved transmembrane IgCAM required pre- and post-synaptically at neuromuscular junctions to restrict synaptic bouton size,
controls distribution of synaptic vesicles and organization of the presynaptic cortical actin cytoskeleton

basket
MAP kinase homolog - Jun amino terminal kinase - involved in a pathway that regulates cell shape changes during dorsal closure

bazooka
PAR-3 homolog, PDZ domain protein involved in cell polarity and asymmetric cell division

Beadex (common alternative name: Lim-only (LMO)
LIM-only protein - functions to regulate Apterous activity levels

Bearded
proneural - basic amphipathic alpha-helix - novel effector or modulator of Notch signaling

beaten path
secreted - Ig superfamily - required for subsets of motor axons to correctly defasciculate from other motor axons
at specific choice points

benign gonial cell neoplasm
cofactor of Bag of marbles that directly inhibits Pumilio repression of Nanos mRNA activity
to promote differentiation of germ line stem cells

bendless
ubiquitin-conjugating enzyme that functions as a developmental switch that permits the transition from axonal growth and incipient synapse
formation to synaptic growth and maturation - required in the IMD immune response signaling pathway for IKK activation leading to NFkappaB activation

bereft
potentially an untranslated RNA - mutants exhibit defects in the peripheral nervous system

bicoid
transcription factor - homeodomain - maternally transcribed gene involved in anterior patterning of the Drosophila embryo

Bicoid interacting protein 1 (common alternative name: Sap18)
part of the Sin3A/Rpd3 histone deacetylase complex - helps convert Bicoid from an activator
into a repressor by recruitment of a co-repressor to Bicoid-dependent promoters

Bicaudal C
RNA-binding protein that regulates expression of specific germline mRNAs by controlling their poly(A)-tail length

Bicaudal-D
alpha helical coiled coiled protein that interacts with the cytoskeleton - regulates developmental fate of the the oocyte

bifocal
codes for a novel protein that interacts with f-actin - functions downstream of misshapen to reorganize the actin cytoskeleton

bigmax
bHLH transcription factor - binding partner of Mondo a nutrient sensor that functions in the fat body - regulates fatty acid synthesis -
facilitates use of sugar-rich nutrient sources - regulates transcription factor Cabut, coordinating energy metabolism

BIR repeat containing ubiquitin-conjugating enzyme (common alternative name: Bruce)
a large protein that contains an N-terminal baculovirus IAP repeat (BIR) and a C-terminal ubiquitin conjugation domain -
participates in regulation of apoptosis and autophagy

bithoraxoid
produces non-coding RNA that may mediate or counteract epigenetic silencing - bxd RNA mediates recruitment of Ash1
to stimulates gene expression

big brain
aquaporin - MIP family signature - neurogenic gene that functions outside of the Notch pathway

biniou
fork head domain transcription factor essential for maintaining the distinction between splanchnic and somatic mesoderm
and for differentiation of the splanchnic mesoderm into midgut musculature

blistered (common alternative name: Serum response factor)
transcription factor - MADS-box motif - required for vein/intervein formation in the fly wing

blistery
tensin homolog - at focal adhesion sites participates in a protein complex that establishes transmembrane linkage between the extracellular matrix and cytoskeletal actin filaments

blown fuse
a cytoplasmic protein essential for somatic myoblast fusion - functions in stretching and outgrowth of circular visceral muscles

BM-40-SPARC [preferred name: Secreted protein, acidic, cysteine-rich (Sparc)]
basement membrane component required for basal lamina maturation and condensation of the ventral nerve cord

borderless
Ig superfamily transmembrane protein that coordinates neurite-neurite interactions in the developing optic lobe

Borealin-related
as a componenet of the chromosomal passenger complex, Borealin-related is a key regulator of mitosis -
functions to control assembly and stability of bipolar spindles and faithful chromosome segregation into daughter cells

borealis
conserved protein required for the activation of Aurora-A at the onset of mitosis -
activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate Aurora-A

Boss (symbol for bride of sevenless)
transmembrane ligand for sevenless - regulates determination of R7 photoreceptor fate

boudin
glycosylphosphatidylinositol anchored membrane protein - essential for tracheal morphogenesis -
contributes to the maintenance of the paracellular barrier and the organisation of the septate junctions -
required for septate junction organisation in chordotonal organ glial cells

boule
RRM motif protein involved in spermatogenesis

Boundary element-associated factor of 32kD (common alternative name: BEAF)
chromatin protein required for insulator function, and chromatin structure and dynamics - required for oogenesis and zygotic development

brachyenteron
transcription factor - brachyury homolog - required for specification of hindgut and anal pads

brahma
transcription factor - SWI2/SNF2 homolog - overcomes the repressive effect of chromatin to activate gene transcription

Brahma associated protein 55kD
member of both the Brahma and the Tat interactive protein 60 kD (TIP60) ATP-dependent chromatin remodeling complexes -
functions through the TIP60 complex to regulate dendrite wiring specificity in olfactory projection neurons -
as a member of the Brahma complex it is needed for cell growth and survival in the wing imaginal disc

brainiac
glycosyltransferase - directs glycosphingolipid biosynthesis - functions in oogenesis and EGF-R signaling - helps maintain epithelial structures

brain-specific homeobox
homeodomain transcription factor - confers neural identity in specific neurons of medulla and lamina of the optic lobe

brain tumor
involved in post-transcriptional regulation of Hunchback mRNA

brakeless (preferred name: scribbler)
novel protein with a single zinc finger - multifunctional protein that regulates foraging activity and
shapes the activity gradient of Dpp through regulation of thickveins

branchless
fibroblast growth factor homolog - ligand for Breathless

Breast cancer 2, early onset homolog (alternative name: Brca2)
Brca2 homolog - plays a dual role in the repair of meiotic double-stranded breaks and the efficient activation
of the meiotic recombination checkpoint

Bre1
E3 ubiquitin ligase required for the monoubiquitination of histone H2B and, indirectly, for H3K4 methylation -
directs histone modification that is critical for the transcription of Notch target genes

breathless
transmembrane receptor, FGF-receptor homolog - used in the development of the trachea,
and later plays a role in migration of specific midline glia and the resultant effect on axonogenesis

Brf
transcription factor TRF1 forms a complex with the TFIIB-related factor Brf that plays a major role in RNA pol III transcription

bric à brac
transcription factor bearing a BTB/POZ domain - required for pattern formation along the proximal-distal axis of the leg and antenna

Bride of sevenless (common alternative name: Boss)
transmembrane - ligand of sevenless - 7 TM segments - regulates determination of R7 photoreceptor fate

brinker
novel transcription factor bearing weak homology to homeobox domain proteins - negatively regulates decapentaplegic target genes

broad (common alternative name: Broad Complex)
transcription factor - zinc finger - BTD domain - a key regulator of gene activity at the onset of metamorphosis in Drosophila

brother of odd with entrails limited (common alternative name: bowel)
zinc finger transcription factor - required for the elaboration of pattern in the tarsus -
promotes morphological changes associated with joint formation during leg development

bruchpilot
cytoskeletal protein critical for intact presynaptic active zone structure and normal-evoked neurotransmitter release at chemical synapses -
establishes proximity between Ca2+ channels and vesicles to allow efficient transmitter release and patterned synaptic plasticity

brummer
lipid storage droplet-associated lypase - a key factor of energy homeostasis control - involved in storage-fat mobilization

bruno (preferred name: arrest)
ribonucleoprotein-type RNA-binding protein - regulates multiple mRNAs involved in female and male gametogenesis

Btk family kinase at 29A (common alternative name: Tec29)
protein-tyrosine kinase - necessary for maintaining the equilibrium between monomeric actin and filamentous actin during invagination of the salivary placodes -
functions during oogenesis as a key downstream effector of Src64 during ring canal growth

Bub1-related kinase
protein serine/threonine kinase - mitotic checkpoint control protein - inhibits ubiquitin ligase activity of anaphase promoting complex (APC) preventing mitosis
until all chromosomes are correctly attached to the mitotic spindle

Bub3
mitotic checkpoint protein that serves as an essential protein required during normal mitotic progression to prevent premature sister chromatid separation,
missegreation and aneuploidy

Buffy
pro-survival homolog of the apoptosis regulator Bcl-2 - also regulates cell cycle

bunched (common alternative name: shortsighted)
transcription factor - leucine zipper - regulates Dpp signaling pathway

Bursicon
neuropeptide hormone that controls cuticle sclerotization and wing expansion behavior

buttonhead
transcription factor - zinc finger - transcriptonal activator that regulates the segmentation of the head

buttonless
transcription factor - homeodomain - regulates the identity of the dorsal median cells that are arranged
as a single pair within each segment along the dorsal midline just above the central nervous system

C

cabeza
conserved neurally expressed nuclear RNA binding protein whose mutants exhibit reduced climbing abilities of adult flies and
anatomical defects in presynaptic terminals of motoneurons in third instar larvae - negatively regulates the EGFR signaling pathway
required for determination of cone cell fate in the eye

cabut
zinc finger transcription factor, dorsal closure, wing disc, regulator of growth, transcriptional partner of Yorkie,
promotes cell cycling, essential for dietary sugar tolerance, modulates Dpp signalling and the JAK/STAT pathway

cacophony
voltage sensitive calcium channel that stimulates neurotransmetter release at the presynaptic terminus at the neuromuscular junction

cactus
signaling protein - IkappaB homolog - regulates the nuclear transport of Dorsal

Cadherin-E (preferred name: Shotgun)
cadherin - regulates cell aggregation preventing mixing of cells at tissue boundaries

Cadherin-N
cadherin - cell aggregation - regulates axon pathfinding

Cadherin 99C
receptor - cadherin superfamily - expressed in follicle cells - regulator of microvillus length

Ca2+-channel protein α1 subunit T
voltage-gated calcium channel underlying the amiloride-sensitive transient current, projection neurons located in the antennal lobe,
negative modulation of sleep, voltage-activated calcium currents in Drosophila motoneurons

Calcineurin (preferred name: Protein phosphatase 2B at 14D)
Calcium-dependent protein serine/threonine phosphatase - negatively regulates Egf receptor signaling

Calcium/calmodulin-dependent protein kinase (preferred name: CASK ortholog)
kinase that acts synaptically as a gain controller on the transition to calcium-independence -
affects activity-dependent autophosphorylation of CaMKII

Calcium-independent receptor for α-latrotoxin (common alternative name: Latrotoxin receptor)
G-protein coupled receptor - involved in the perception of tactile, proprioceptive, and auditory stimuli through chordotonal neurons of the PNS -
sensitizes these neurons for the detection of mechanical stimulation by amplifying their input-output function

Calcium/calmodulin-dependent protein kinase II
CaM kinase II - ATP binding motif - coordinates cellular responses to neurotransmitters and hormones -
effects behavior and learning

Calmodulin
calcium ion binding signaling protein - regulation of cellular processes dependent on Ca2+

Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein
signaling protein that organizes epithelial architecture by regulating the polarized secretion of basement membrane proteins

Calnexin 99A
binds Ca2+ - a chaperone that functions in the transition of proteins from the ER to the outer cellular membrane -
glycoprotein folding and quality control in the ER - molecular chaperone for Rh1 biosynthesis -
regulates cytosolic Ca2+ levels following activation of the light-sensitive TRP channels

cAMP-dependent protein kinase 1 (preferred name: Protein kinase, cAMP-dependent, catalytic subunit 1)
catalytic subunit of PKA - involved in Hedgehog signaling pathway and functions in learning in the adult

cannonball
TAFII80, Trp-Asp repeat (WD-repeat) protein expressed only in spermatocytes, where it is required for transcription of genes
required for spermatid differentiation

canoe
glgf/dhr motif scaffolding protein - interacts with genes in both the Notch and the Ras pathways

CAP
Drosophila's Cbl-associated protein - interacts with Vinculin (which functions in actin-mediated organization of cellular morphology) -
regulates assembly and function of tension-sensing structures - involved in muscle and sensory organ development and function -
binds to Axin and Arrow through SH3 domains leading to a potential role in insulin-mediated glucose transport

Cap-G
Armadillo-like helical HEAT domain protein - non-SMC subunit of the condensin complex -
responsible for ensuring that replicated chromosomes are condensed prior to metaphase

capicua
transcription factor - HMG box protein - acts as a repressor of tailless and huckebein
in both the anterior and posterior domains of the early Drosophila embryo

cap'n'collar
transcription factor - basic leucine zipper - involved in the segmentation of the head -
effects both labral and mandibular structures

capping protein alpha & capping protein beta
regulates nonbundle actin filament assembly during bristle development - acts upstream of the Hippo pathway and functions as a tumor suppressor,
antagonized by Enabled, maintains epithelial integrity and prevents JNK-mediated apoptosis, functions in oocyte determination

cappuccino
Formin domain protein that interacts with Spire to facilitate actin filament capping and nucleation

capricious
leucine-rich repeat transmembrane protein involved in selective synapse formation;
contributes to formation of the affinity boundary between dorsal and ventral compartments of the wing

capsuléen
protein arginine methyltransferase - together with its partner Valois Capsuléen is involved in protein localization in germ cells -
required for the localization of specific components of the nuage and pole plasm, and in particular of Tudor

capulet (common alternative name: act up)
cyclase-associate protein homolog - sequesters monomeric actin - required to prevent
actin filament polymerization in the eye disc

caravaggio (common alternative names: HOAP, HP1/ORC-associated protein)
poorly conserved component of the telomere capping complex - prevents end fusion
by maintaining a chromatin state that is independent of the underlying DNA sequence

CAS/CSE1 segregation protein
signaling protein - functions in axonal fasciculation and pathfinding - functions with integrins to specify axon guidance -
functions in nuclear transport in the Notch pathway

CASK ortholog
kinase that acts synaptically as a gain controller on the transition to calcium-independence -
affects activity-dependent autophosphorylation of CaMKII

caskin
a neuronal adaptor protein required for axon growth and guidance -
interacts physically and genetically with Lar receptor protein tyrosine phosphatase

Casein kinase II alpha subunit and beta subunit
CkII catalytic and regulatory subunits - modulates Antennapedia's properties, restricting its activity to an appropriate level

Caspase 1 (preferred name: Death caspase-1)
ICE/CED-3 protease - regulates developmental apoptosis or programmed cell death

castor
transcription factor - zinc finger - regulates the development of late CNS sublineages

caudal
transcription factor - homeodomain - plays a role in establishing the posterior domains of the embryo, which give rise to the posterior gut

caupolican
transcription factor - homeodomain Pbx class - a prepattern gene that determines the size, shape and
number of sensory organ mother cells in imaginal discs

Cbl proto-oncogene ortholog
ubiquitin ligase - positively regulates receptor tyrosine ubiquitination accelerating degradation of ligand-receptor complexes

cdc2
a cdc2 kinase - heterdimerizes with cyclin A and cyclin B - responsible for the execution of the mitotic (M) phase of the cell cycle

cdc6
AAA-superfamily ATP helicase involved in initiation of DNA replication - involved in the formation of the prereplicative complex -
checkpoint protein involved in controlling the G2/M transition

CCHamide-2
a larval fat body and gut produced nutrient-dependent hormone regulator of Drosophila insulin-like peptide -
targets brain insulin-producing cells

cdc42
a Ras type GTPase - involved in epithelial cell elongation - facilitates nucleation of actin filaments

Cdc42-interacting protein 4 & Nostrin
F-BAR proteins involved in regulation of membrane curvature and dynamics - regulation of dynamin-dependent endocytosis of E-cadherin
during oogenesis - Cip4 acts downstream of Cdc42 to activate the WASP-WAVE-Arp2/3 pathway in the notum and the wing epithelium -
Nostrin makes contact with microtubules through the kinesin Khc-73 for trafficking of recycling endosomes

Cdc27 (common alternative name makos)
subunit of anaphase-promoting complex (APC) - involved in regulating cell cycle

Ced-12
ELMO/CED-12 family protein that functions together with Myoblast city as a bipartite GEF to optimally activate Rac to mediate the engulfment of apoptotic cells
and cell migration - functions in myoblast fusion and border cell migration

Centrobin
a constituent of the daughter centriole - a key determinant of the orientation of cell division

centromere identifier
a variant of histone H3 - localizes exclusively to centromeres - chromatin component that plays a key role in assembling the kinetochore at meiosis and mitosis

Centromeric protein-C
centromere protein required for normal attachment of kinetochores to the spindle

Centrosomal protein 190kD
BTB/POZ domain and microtubule binding protein that alternatively serves as a chromatin insulator and as a component of centrioles -
involved in axial expansion, the spreading out along the anterior-to-posterior axis during syncytial development

centrosomin
cytoskeletal protein - important for assembly of mitotic spindles and spindle poles - Aurora-A regulates centrosome assembly by
controlling the CNN's ability to target and/or anchor γ-tubulin to the centrosome and organizing microtubule-nucleating sites

centrosomin's beautiful sister
a trans-Golgi protein that links Golgi inheritance to the cell cycle

Cep135
scaffolding protein - assembly of microtubule based structures, centriole and flagella biogenesis

Ceramidase
enzyme that hydrolyzes ceramide to sphingosine, a critical structural components of cell membranes that act as second messengers
in diverse signal transduction cascades - maintains photoreceptor homeostasis - regulates synaptic vesicle exocytosis and trafficking

C15 (common alternative name Clawless)
member of the 93E cluster of homeodomain proteins - regulates spatial patterning of the tarsus, a distal portion of the leg -
homolog of vertebrate oncogene Hox11

chameau
histone acetyltransferase - acts as antagonistic cofactor to the histone deacetylase Rpd3 to modulate JNK-dependent
transcription during pupal thorax metamorphosis and JNK-induced apoptosis - recruited by DJun and DFos

charlatan
zinc finger transcription factor - facilitates accumulation of proneural proteins Achaete and Scute by forming a transcriptional stimulatory loop

charybde and scylla
conserved proteins acting downstream of PKB and upstream of TSC to regulate growth - they are induced under hypoxic conditions,
thus establishing a potential cross-talk between growth and oxygen sensing

cheerio
a dimeric F-actin crosslinking protein - organizes the F-actin cytoskeleton in ovarian germline ring canals - functions in migrating somatic cells,
neuronal growth cones and larval neuromuscular junction - mechanosensor - a target of JNK signaling that links cytoskeleton dynamics to tumor progression

chickadee
profilin homolog - regulates polymerization of the actin cytoskeleton

chico
insulin receptor substrate family - the major cytoplasmic substrate of the insulin receptor

chiffon
Dbf4 homolog - regulatory subunit of Cdc7-Dbf4 dimer - interacts with unknown regulators and
activates the kinase function of its dimerization partner, thus triggering the initiation of cellular DNA replication

Chip
transcription factor - enhancer facilitator - functions at enhancers to bring together diverse transcriptional factors and
form higher order activation complexes; or, in some cases, it may block formation of such complexes

chk2 (preferred name: loki)
homolog of mammalian Chk2 - a serine/threonine kinase required required for DNA damage-mediated cell cycle arrest and apoptosis

Cholecystokinin-like receptor at 17D1 (also known as cholecystokinin-like receptor)
G-protein coupled receptor - along with drosulfakinin, its predicted ligand, a strong positive growth regulator of the larval neuromuscular junction

Chorion factor 2
zinc finger transcription factor - along with Mef2, Cf2 functions as critical regulator of the myogenic program - a mediator of EGF-R-activated dorsoventral patterning in oogenesis

Chromatin assembly factor 1 subunit
A histone chaperone protein - mediates nucleosome assembly on both the leading and lagging strands
immediately after passage of the DNA replication fork

Chromator
chromodomain protein that contributes to the maintenance of polytene chromosome morphology - a component of spindle matrix that contributes to microtubule spindle dynamics and proper chromosome segregation during mitosis

Chromodomain-helicase-DNA-binding protein
chromodomain protein in the SNF2-like family of ATPases - functions in assembly of active chromatin

chromosome alignment defect 1
substochiometric centromeric linker protein involved in centromere propagation - regulator of centromeric deposition
of Cenp-A/Cid and Cenp-C during exit from mitosis

Chromosome associated protein D3
condensin II subunit, chromosome assembly and segregation during mitosis and meiosis - regulation of anti-bacterial
immune determinants - restriction of retrotransposon mobilization

Chromosome associated protein H2
a condensin II subunit functioning during meiosis - promotes prophase I chromosome territory formation
preventing heterologous chromosomal associations - promotes disassembly of polytene chromosomal structure into chromosomal components

chromosome bows (common alternative names: Orbit and Mast)
microtubule-associated protein that plays an essential role facilitating the kinetochore-microtubule interaction -
maternially it facilitates multiple interactions of the fusome with mitotic spindles and ring canals -
zygotically it mediates the action of Slit and its receptors acting as a partner of the Abelson tyrosine kinase

Chronologically inappropriate morphogenesis
BTB/POZ domain transcription factor - helps specify distinct birth order-dependent cell fates in an extended neuronal lineage -
regulates the time at which neuroblasts undergo Prospero-dependent cell-cycle exit or Reaper/Hid/Grim-dependent apoptosis

Chx1 and Chx2 (preferred names: Visual system homeobox 1 ortholog and Visual system homeobox 2 ortholog)
homeodomain transcription factors - markers for the brain central neuroendocrine system termed the pars intercerebralis
that expresses the hormones Drosophila insulin-like peptide (Dilp), FMRF, and myomodulin

CIN85 and CD2AP orthologue (common alternative name cindr)
adaptor protein that links cell surface junctions and adhesion proteins with multiple components of the actin cytoskeleton -
regulates cytoskeletal dynamics and eye patterning - cooperates with anillin to promote intercellular bridge stability
during cytokinesis - promotes endocytosis

citron (preferred name: sticky)
Rho effector kinase functioning downstream of pebble - required for cytokinesis

Clathrin heavy chain
A basic component of the vesicle coat that is involved in many cellular processes including intracellular transport
of proteins and lipids, endocytosis of signaling proteins and released neurotransmitters. and exocytosis of secreted proteins -
Clathrin molecules assemble themselves into closed cages that capture the molecules to be transported,
then quickly disassemble once the contents are delivered

clift (common alternative name: eyes absent)
novel protein - eyes absent family - cell survival factor - functions in eye development
and in the embryonic determination of the somatic gonadal precursor cell fate

Clock
transcription factor - bHLH and PAS domains - regulates circadian rhythms

clockwork orange
a transcriptional repressor that synergizes with Per and inhibits Clk-mediated activation -
acts preferentially to help terminate Clk-Cyc-mediated transcription of direct target genes

clueless
novel protein required for normal mitochondrial function - negative regulator of the PINK1-Park pathway - associates with mitochondrial
outer membrane proteins, including Translocase of outer membrane 20 - works to promote damaged mitochondrial clearance

Collagen type IV
the main component of basement membranes - synthesized by the fat body, secreted to the hemolymph,
and incorporated into the BM - determines organ shape - regulates BMP signaling

collier (preferred name: knot)
EBF/Olf-1 homolog, HLH protein - required for the formation of the hypopharyngeal lobe,
the proper development of the larval head skeleton, and suppresses vein formation between veins 3 and 4,

comatose
N-ethylmaleimide-sensitive fusion (NSF) gene - required in disassembly or rearrangement of the SNARE complex at the plasma membrane after vesicle fusion

combgap
zinc finger transcription factor - involved in pattern formation and the regulation of cell fate

commissureless
novel transmembrane protein - involved in axon pathfinding and neuromuscular synaptogenesis

complexin
SNARE-complex-binding proteins that regulate synaptic vesicle release and consequently neurotransmitter release

concertina
Gα12/13 G-protein - necessary to trigger acto-myosin contractility during gastrulation - required for RhoGEF2
and consequent MyosinII apical recruitment

Connectin
Leucine rich repeat homophilic cell adhesion protein expressed in a subset of muscles and the motoneurons that innervate them

Contactin
required for organization of septate junctions and for function of the paracellular barrier -
Forms a tripartite complex with Neuroglian and Neurexin

convoluted
fly ortholog of the vertebrate insulin-like growth factor-binding protein acid-labile subunit (ALS) -
antagonizes Dilp function to control animal growth and carbohydrate and fat metabolism

COP9 complex homolog subunit 5
Component of COP9 signalsome - regulates ubiquitin-dependent protein degradation - Jab1/MPN domain metalloenzyme motif

coracle
protein 4.1 homolog - links transmembrane proteins to cytoskeleton

Co-repressor of Pangolin
Myb/SANT-like transcription factor that antagonizes Wingless signaling binding to Pangolin

CoRest
corepressor, component of L(3)mbt repressor complex, component of LSD1-CoREST demethylase, complex regulation of Notch signaling, ovarian follicular cells, wing,
regulates DPP signaling, associates with Charlatan

corkscrew
protein tyrosine phosphatase - SH2 domains - downregulates receptor tyrosine kinase signaling

cornichon
cargo receptor required for transport of the TGFalpha growth factor Gurken to the oocyte surface

Cortactin
cytoskeletal component that acts as a link, via Src, between surface receptors and actin - interacts with F-actin and can stimulate actin polymerization by direct interaction with the Arp2/3 complex

cortex
a meiosis-specific anaphase-promoting complex/cyclosome activator - functions together Fizzy to target mitotic cyclins for destruction in the egg

corto
Chromodomain protein - partners with CycG which regulates the activity of Corto at chromatin - acts alternatively as an enhancer of TrxG and an Enhancer of PcG

costa (common alternative name: costal2)
kinesin like protein - hedgehog signaling - a cytoplasmic anchor for Cubitus interruptus

courtless
ubiquitin conjugation enzyme - plays a role in protein degradation - mutation disrupts early steps of courtship behavior in Drosophila males and the development of their sperm

cousin of atonal
bHLH transcription factor required for sensory neuron morphology

Cp110
a conserved centriolar protein - controls centriole length & suppresses centriole overduplication

cp309 (common alternative name: pericentrin-like protein)
PACT domain protein - associated with both the centrioles and pericentriolar material -
essential for the formation of functional cilia and flagella

cramped
a novel Polycomb group protein - physically interacts with Proliferating cell nuclear antigen,
a protein involved in DNA replication and repair

CrebB (preferred name: Cyclic-AMP response element binding protein B)
transcription factor - cAMP response element binding protein - acts downstream of Protein kinase A - regulates genes involved
in learning and memory

CREB-binding protein (preferred name: nejire)
CBP, a transcriptional co-activator that interacts with
a large number of developmentally important transcription factors

CREB-regulated transcription coactivator
transcription factor - transducer of regulated CREB activity - starvation triggers TORC activation -
TORC maintains energy balance through induction of CREB target genes in the brain

crimpy
cysteine-rich transmembrane BMP regulator - physically interacts with and inhibits BMP ligand glass bottom boat in motoneurons
thus permitting the muscle-derived Gbb pool to predominate at the NMJ and establishing the retrograde directionality of the pro-growth BMP pathway

crinkled
bidirectional molecular motor that acts in concert with Wg targets to orchestrate the proper shaping of denticles
in the embryonic epidermis - necessary for auditory organ development

crocodile
winged helix, forkhead family - establishing the domains of expression for wingless and engrailed in the clypeolabrum,
the anterior most segment of the fly's head

crooked legs
multiple zinc finger transcription factor - mutants exhibit both a morphological defect in leg morphogenesis
and altered gene expression during morphogenesis

crooked neck
mRNA splicing factor that participates in the assembly and control of the splicing machinery

crossveinless
twisted gastrulation family member - along with Short gastrulation, Crossveinless promotes BMP signaling
by transporting a Dpp/Gbb heterodimer from the longitudinal veins into the crossvein regions

crossveinless 2
chordin-like cysteine rich domain protein: modifies BMP signaling

crossveinless c (common alternative name: RhoGAP88C)
required in tissues actively undergoing morphogenesis -- regulates GTPase function of Rho
to promote the coordinated organisation of the actin cytoskeleton

crumbs
transmembrane - egf repeats - laminin A homolog - involved in epithelial polarity

Crustacean cardioactive peptide (common alternative name: Cardioacceleratory peptide)
a neuropeptide - controls behavior during molting

cryptocephal
REB/ATF superfamily bZIP domain transcription factor - controls expression of diverse neuropeptides and peptide hormones involved in metamorphosis

cryptochrome
potential transcription factor - light response protein - cryptochrome/photolyase

CTCF
CCCTC-binding factor is a zinc finger transcription factor that confers enhancer blocking in all known chromatin insulators

C-terminal binding protein
transcription factor-interacting protein - a transcriptional co-repressor

C-terminal Src kinase
tyrosine kinase acts as a tumor suppressor through Src pathway regulation -
loss of Csk activity leads to increased organ size, organismal lethality, and increased cell proliferation

cubitus interruptus
transcription factor - zinc finger - mediates Hedgehog signaling

Cullin1 (preferred name: lin-19-like)
a major component of a series of multimeric ubiquitin ligases that control the degradation of a broad range of proteins

Cullin-3
Cullen acting in protein degradation - loss of function has pleiotropic effects during development,
including defects in external sensory organ development, pattern formation and cell growth and survival - targets Cubitus interruptus

Cullin-4
cullin family protein that regulates cell cycle by controlling degradation of Dacapo and Cyclin E

cup
translational repressor - represses oskar translation - physically interacts with Bruno

cut
transcription factor - homeodomain - cut domain - mediates choice between chordotonal sense organ
and external sensory organ fate - also involved in wing and follicle cell morphogenesis

cutoff
a protein related to a yeast transcription termination factor - involved in piwiRNA cluster expression, which is critical for oocyte development

cycle
transcription factor - bHLH, pas domain - photoperiod response

Cyclic-AMP response element binding protein A
basic leucine zipper transcription factor - regulates secretory pathways

Cyclic-AMP response element binding protein B
transcription factor - basic leucine zipper - acts downstream of Protein kinase A -
regulates genes involved in learning and memory

Cyclin A
a a G2-M phase cyclin - cell cycle regulator - dimerization partner of cdc2 kinase

Cyclin B
a G2-M phase cyclin - cell cycle regulator - dimerization partner of cdc2 kinase

Cyclin C
regulatory partner of CDK8 - mediator complex component - cofactor for EcR-dependent transcription - links nutrient intake to developmental transitions and fat metabolism -
negative regulator of the lipogenic pathway - regulation of Serpent-dependent transcription and innate immunity - involved in small nuclear RNA (snRNA) 3' end processing -
recruited to phosphorylate the Notch ICD and coordinate activation with turnover

Cyclin D
cell cycle regulator - a G1-S phase cyclin

Cyclin-dependent kinase 2
G1 cyclin dependent kinase - heterodimerizes with Cyclin D, Cyclin E and Cyclin J - regulates somatic cell proliferation,
germline stem cell proliferation maintenance, follicle stem cells and endocycle - target of the cyclin-dependent kinase inhibitor Dacapo -
regulates Double-parked and Retinoblastoma protein

Cyclin-dependent kinase 4/6
a Cdk involved in control of growth of cells - partners cyclin D - governs progression through the G1 phase of the cell cycle

Cyclin-dependent kinase 5
a Cdk involved in control of cell differentiation and morphology

Cyclin-dependent kinase 7
a Cdk-activating kinase and general transcription factor - required for the activation of both Cdc2/Cyclin A and
Cdc2/Cyclin B complexes, and for cell division

Cyclin-dependent kinase 8
functions together with its partner CycC as a component of the mediator complex to regulate gene expression in the leg, eye and notum -
phosphorylates C-terminal domain of PolII

Cyclin-dependent kinase 9
subunit of P-TEFb, targets RNA polymerase II

Cyclin-dependent kinase subunit 30A
Cyclin-dependent kinase regulatory subunit required for progression through female meiosis and the mitotic divisions of the early embryo
through an interaction with Cdk1 (Cdc2)

Cyclin E
a G1-S phase cyclin - dimerization partner of cdc2c kinase

Cyclin G
a transcriptional regulator that interacts with the chromatin factor Corto and controls expression of the homeotic gene Abdominal B -
controls developmental stability by ensuring compensatory processes between cell growth and cell proliferation

Cyclin J
regulates S phase early in embryonic development, partners Cdk2

Cyclin Y
cyclin that interacts with the cyclin dependent kinase Eip63E - has essential functions during embryogenesis, larval development, and metamorphosis - regulates wnt signaling

cylindromatosis ortholog (H. sapiens)
deubiquitinating enzyme that deubiquitinates dTRAF2 and prevents dTRAF2 from ubiquitin-mediated
proteolytic degradation - involved in stress response - required for Eiger-triggered JNK activation and cell death

Cytochrome c proximal and Cytochrome c distal
electron transport - caspase activation during apoptosis

D

dacapo
cyclin dependent kinase inhibitor - inhibits cell cycle progression

dachs
unconventional myosin motor domain protein - downstream component of a Fat signaling pathway that influences growth,
cell affinity and developmental gene expression

dachsous
cadherin superfamily - controls imaginal disc morphogenesis

dachshund
transcriptional co-repressor - required for elongation of leg discs

dally-like
membrane bound glypican related proteoglycan - required for Hedgehog signalling in the embryonic epidermis of Drosophila

dappled (preferred name: wech)
LIN-41 subclade multiple domain protein of unknown function - let-7 micro RNA regulated

daughterless
transcription factor - basic HLH - proneural gene that is also involved in sex determination

daughter of sevenless
an adaptor protein that facilitates signal transduction as a downstream component of the receptor tyrosine kinases Sevenless, Egf receptor and Torso

Daughters against dpp
Smad family - inhibits Dpp signal transduction

dawdle
TGF-ß superfamily ligand - Activin-like protein - By activating Dawdle, Tolloid-related provides a permissive signal for axon guidance

DC0
Protein kinase A catalytic subunit - a signal transduction protein involved in learning and memory and in the Hedgehog pathway

dCREB2 (preferred name: Cyclic-AMP response element binding protein B)
transcription factor - basic leucine zipper - acts downstream of Protein kinase A -
regulates genes involved in learning and memory

Dbx
homeobox gene - contributes to the development of subsets of interneurons via cross-repressive, lineage-specific interactions
with the motoneuron-promoting factors eve and exex

deadpan
transcription factor - bHLH - hairy/E(spl) class - a pan-neural repressor

dead ringer (preferred name: retina aberrant in pattern)
transcription factor - ARID domain protein - required for proper patterning of the abdomen

Death caspase-1
ICE/CED-3 protease involved in apoptosis - an effector caspase

death executioner Bcl-2 homologue
Bcl-2/CED-9 family protein involved in regulating apoptosis

Death-associated inhibitor of apoptosis 1 (common alternative name: Thread)
ubiquitin ligase that functions as an inhibitor of apoptosis - the inhibition of caspase function is counteracted by proapoptotic proteins Hid, Grim and Reaper

Death-associated protein kinase related
regulation of myosin II dynamics - promotes proper morphogenesis of epithelial tissues during development - maintenance of
furrow canal structure and lateral plasma membrane integrity during cellularization - morphogenesis of retina,
functions during Myosin II-dependent cell constriction, subsequent multicellular alignment and adherens junction remodelling

Death regulator Nedd2-like caspase (Common alternate name: Dronc)
cysteine protease - an initiator caspase - functional homolog of CED-3/caspase-9 - involved in programed cell death

Death related ced-3/Nedd2-like protein
ICE/CED-3 protease involved in apoptosis - an initator caspase

debra
involved in the Hedgehog signaling pathway as a mediator of protein degradation by the lysosome -
required in a physiological, nondevelopmental aspect of long-term memory

DE-cadherin (preferred name: shotgun)
transmembrane - E-cadherin homolog - cell adhesion - sets up boundaries between epithelial compartments preventing cell mixing

decapentaplegic
ligand - tgf-beta homolog - early on dpp establishes embryonic dorsal/ventral --
later defines boundaries between appendage compartments

defective proventriculus
homeodomain transcription factor - involved in the establishment of two gut structures:
the proventriculus (a foregut structure) and the central midgut

Deformed
transcription factor - homeodomain - Antp class - required to form a normal head -
involved in establishing the form of the maxillary and mandibular segments

Deformed epidermal autoregulatory factor-1
SAND and zf-MYND domain transcription factor - involved in embryonic development, Deformed autoregulation and the immune response

degringolade
SUMO-targeted ubiquitin ligase that acts as a negative regulator of the repressor Hairy and its corepressor Groucho
during embryonic segmentation and neurogenesis - acts as a regulator in sex determination by interfering
with the repressive activities of Deadpan and Groucho

Delta
transmembrane - EGF family - Notch ligand - important in establishing neural cell fates

deltex
E3-ubiquitin ligase - Deltex mediated accumulation of Notch in the late-endosome compartment is required for the Dx-mediated Su(H)-independent Notch signaling

dendritic arbor reduction 1
zinc finger transcription factor that promotes dendrite growth in part by suppressing the expression
of the microtubule-severing protein Spastin

DER (Preferred name: EGF-R) (common alternative name: Torpedo)
transmembrane receptor- tk - EGF-R homology - during oogenesis helps set up egg polarity, determines the identity of cells in the ectoderm;
during larval stages participates in the development of the eye and wing.
ventral ectoderm; during larval stages participates in the development of the eye and wing.

derailed
receptor tyrosine kinase - functions in axon during central nervous system and brain development

Deterin (common alternative name: Survivin)
component of the chromosomal passenger complex that regulates chromosome condensation,
interaction between kinetochores and microtubules, spindle organization, cytokinesis, and apoptosis

DFR-1 (preferred name: Heartless - also commonly known as Fibroblast growth factor receptor 1)
receptor tyrosine kinase - involved in the development of mesodermal and neuronal cells

DHR3 (preferred name: Hormone receptor-like/Hr46)
transcription factor - nuclear receptor superfamily - a second tier regulator involved in Drosophila molting --
acts negatively on Ecdysone receptor and postively on genes expressed subsequently in the molting hierarchy

Diabetes- and obesity regulated
coactivator of ecdysone receptor needed during metamorphosis - antagonized by insulin signaling via FOXO in the fat body -
part of a feed-forward mechanism whereby ecdysone potentiates its own signaling - regulates autophagosome formation and protein degradation

diaphanous
Formin homology domain protein required for cytokinesis

Dicer-1
ribonuclease III family, double-stranded RNA domain binding domain, DEAD/DEAH box helicase, PAZ domain -
an enzyme involved in degrading RNA - involved in double-stranded RNA interference (RNAi) and post-transcriptional gene regulation (PTGS)

Dicer-2
DEAD/DEAH box helicase - mutants are defective in processing small interfering RNAs

Dichaete (preferred name: Sox box protein 70D, common alternative name: fish-hook)
HMG-domain protein - SOX-domain protein - implicated in the regulation of pair-rule genes
and later functions in wing morphogenesis

diego
ankyrin repeat protein involved in tissue polarity - helps promote polarized clustering of Flamingo

dilute class unconventional myosin (common alternative names: Didum and MyosinV)
a motor protein that mediates sensory neuron morphogenesisin - forms a complex with Rab11 and Rab11 interacting protein
that trafficks rhodopsin in the developing rhabdomere

diminutive (Preferred name: Myc)
bHLH - leucine zipper - controls cell cycle progression

dimmed (common alternative name: Mist 1-related)
Atonal family bHLH transcription factor - component of a mechanism by which diverse neuroendocrine lineages
differentiate and maintain a pro-secretory state

Disabled
novel signaling protein - interacts with Abl to regulate axon guidance

disconnected and disco-related
zinc finger transcription factors - required for head segment identity during Drosophila embryogenesis -
required for optic lobe development and ventral appendage development

disc proliferation abnormal
Licensing factor - Zn finger motif - cdc21 homolog - MCM4 homolog - implicated in the initiation of DNA replication
and in the discrimination between replicated and unreplicated chromatin

discs large 1
Links septate junctions to cytoskeleton - Guanylate kinase signature and Src homology 3 domain

Discs large 5
MAGUK family scaffold protein - required for the maintenance of apical polarity of follicle epithelium during oogenesis

discs lost
conserved protein of unknown function - required for cell survival and cell cycle progression - implicated in modification of olfactory behavior

discs overgrown (common alternative name: double-time)
casein kinase Iepsilon - contributes to circadian rhythmicity

dishevelled
novel cytoplasmic protein - a component in the wingless pathway and regulates epithelial polarity

Dishevelled Associated Activator of Morphogenesis
Formin homology domain protein regulated by RhoA - functions upstream or parallel to Src42A
and Tec29 to organize the actin cytoskeleton and to determine the cuticle pattern of the respiratory system

dispatched
patched family protein regulating Hedgehog release

dissatisfaction
nuclear receptor superfamily - essential for many aspects of sexual behavior and neural development in both males and females

distal antenna & distal antenna-related
two closely linked genes coding for pipsqueak domain proteins - effector genes that act downstream of homothorax and Distal-less
to control differentiation of distal antennal structures

Distal-less
transcription factor - homeodomain - defines the termini of appendages and regulates appendage growth

Diuretic hormone 44
hormone produced by brain neurosecretory cells - sensor of nutritive sugar - directs the detection and consumption of nutritive sugar -
controls sperm retention and storage by females - a circadian output hormone that is required for normal rest:activity rhythms

division abnormally delayed
membrane bound glypican related proteoglycan - effects cell division of lamina precursor cells of the optic lobe

DJun (Preferred name: Jun-related antigen)
transcription factor - basic leucine zipper - cooperates with the ETS domain protein Pointed to induce R7 fate in the developing eye

Dlar (preferred name: Leukocyte-antigen-related-like)
transmembrane - receptor tyrosine kinase functioning to regulate axon guidance

dmyc (preferred name: diminutive)
bHLH - leucine zipper - controls cell cycle progression

DNA replication-related element factor
a transcription factor that activates genes involved in cell proliferation

dodo
peptidylprolyl isomerase - facilitates the degradation of the transcription factor CF2, which regulates expression of the rhomboid gene in follicle cells

domeless
a divergent member of the cytokine class I receptor family - required for segmentation and functions in trachea specification

Domina
forkhead/winged-helix class - a suppressor of position effect variegation that also affects and regulates eye and bristle development

domino
DNA helicase/adenosine triphosphatase - component of the Tip60 chromatin-remodeling complex
that acetylates nucleosomal phospho-H2Av and exchanges it with an unmodified H2Av

Dopamine/Ecdysteroid receptor
G-protein coupled receptor - activated by dopamine to increase cAMP levels - mediates the non-canonical actions of 20E
and rapidly modulates adult conditioned behavior through cAMP signaling - courtship memory - modulates appetite control of sugar sensing

Dopamine receptor
GPCR - mediates aversive and appetitive learning in pavlovian olfactory conditioning

Dopamine 1-like receptor 2
G-protein coupled receptor - Dopamine receptor - locomotor activity - presynaptic autoreceptor - appetitive and aversive learning

Dopamine transporter
mediates uptake of dopamine in dopamine positive neurons - functions in regulating sleep and arousal

dorsal
transcription factor - NFkappaB/rel homolog - functions in establishment of dorsal/ventral polarity

Dorsal interacting protein 3
MADF DNA-binding domain and BESS protein interaction domain protein - interacts with Rel domain proteins -
enhances Rel family transcription factor function in both dorsoventral patterning and the immune response

Dorsal related immune factor
NFkappaB/rel homolog - a regulator of the immune response

Dorsocross
three closely linked T-box domain transcription factors that are crucial for completion of differentiation,
cell proliferation arrest, and survival of amnioserosa cells

double parked
conserved protein required for DNA replication

doublesex
novel zinc finger transcription factor - regulates sexual differentiation of both sexes

double-time (preferred name: discs overgrown)
casein kinase Iepsilon - contributes to circadian rhythmicity

DP transcription factor
transcription factor - obligate dimerization partner of E2f1 and E2f2 - required for normal cell proliferation,
optimal DNA synthesis, and efficient G2/M progression

draper
encoding an EGF-repeat single-pass transmembrane domain receptor - required during metamorphosis for recognition and engulfment of degenerating axon branches by glia

dreadlocks
SH2 and SH3 domain signal transduction protein - required for photoreceptor cell growth cone guidance and targeting

dre4
transcription factor - along with Structure specific recognition protein (Ssrp) forms a protein complex, FACT,
that facilates GAGA factor directed chromatin remodeling

drifter (preferred name: ventral veins lacking)
transcription factor - homeodomain - pou domain - mutants display severe tracheal defects and defects in ventral midline glia migration

Drop (common alternative name: muscle segment homeobox-1)
transcription factor - homeodomain - confers cell fate on the dorsal (lateral-most) column of neuroblasts during ventral cord development

Dror (preferred name: Ror)
ROR proteins are a class of Wnt-binding receptor tyrosine kinases - expressed during neural differentiation

drosha
ribonuclease - acts on primary microRNA transcripts by cleaving it to excise the pre-microRNA polymer - physically interacts with Pasha,
a double-stranded RNA binding protein

Drosomycin
inducible antifungal peptide

drumstick
zinc finger transcription factor - regulates epidermal cell differentiation and patterning in the epithelia
of the foregut, hindgut, and imaginal discs

Dscam (preferred name: Downs syndrome cell adhesion molecule 1)
multiple Ig domain protein - acts with other proteins to direct pathfinding of Bolwig's nerve

Dscam2 (preferred name: Down syndrome cell adhesion molecule 2)
immunoglobulin superfamily - Dscam2 homophilic interactions mediate repulsion between neurites of L1 laminar cells in neighbouring columns of the optic lobe

dtfr (preferred name: thickveins)
receptor of Decapentaplegic

dumbfounded (preferred name: kin of irre)
IG superfamily - required for myoblast aggregation and fusion

dunce
cyclic AMP phosphodiesterase - involved in memory and learning

Dynamin related protein 1
a Dynamin GTPase - regulates mitochondrial fission in normal cells including primary spermatocytes -
mediates mitochondrial fragmentation during programmed cell death

Dynein heavy chain 64C
a molecular motor that functions in axon transport

dysbindin
coiled-coil domain protein required presynaptically for the retrograde, homeostatic modulation of neurotransmission

dysfusion
bHLH-PAS protein expressed in tracheal fusion cells and required for tracheal fusion

Dystroglycan
transmembrane receptor for extracellular matrix molecules - required for cellular polarity in epithelial cells and the oocyte

dystrophin
the postsynaptically localized scaffolding protein required for appropriate control of neuromuscular synaptic homeostasis


Genes E-K -- Genes L-R -- Genes S-Z

Home page: The Interactive Fly© 1995, 1996 Thomas B. Brody, Ph.D.


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