logo Alphabetical list of genes

Genes E - F - G - H - I - J - K --[Genes A-D -- Genes L-R -- Genes S-Z ]

E

E2F transcription factor
positively regulates genes involved in the S (DNA synthesis) phase of the cell cycle

E2F transcription factor 2
negatively regulates genes involved in the S (DNA synthesis) phase of the cell cycle

eagle
nuclear receptor - zinc finger - involved in the determination the cell fate of serotonergic neurons

earmuff
zinc finger transcription factor - functions cell-autonomously to maintain the restricted developmental potential of the intermediate neural progenitors
generated by type II neuroblasts in Drosophila larval brains

easily shocked
ethanolamine kinase - catalyzes the first step of the synthesis of phosphatidylethanolamine, one of the three major membrane phospholipids - a behavioral mutant
that belongs to a family of bang-sensitive paralytic mutants - required in mushroom body neuroblasts to allow a rapid rate of cell division at metamorphosis

easter
required for establishment of embryonic polarity - serine protease, trypsin family - generates processed Späzle, which in turn acts as the Toll ligand

eater
EGF-like repeat transmembrane protein located on phagocytic cells - mediates resistence to bacteria

Eb1
microtubule end-binding protein - controls the plus end of growing microtubules - targets other microtubule-associated
proteins to the plus end and thereby regulates interactions of microtubules with the cell cortex, mitotic kinetochores,
and different cellular organelles

ebi
Trp-Asp (WD) repeats protein - regulates Egfr pathway & protein degradation

ebony
an β-alanyl-dopamine synthase regulating β-alanyl conjugation of dopamine and histamine, thus 'trapping' these biogenic amines
preventing their further function - regulates pigmentation, photoreceptor activity and behavioral rhythmicity

E-cadherin (preferred name: shotgun)
E-cadherin homolog - regulates cell aggregation preventing mixing of cells at tissue boundaries

Ecdysis triggering hormone
Regulates the process of preecdysis and ecdysis behaviors in the process shedding of the old cuticle

Ecdysone-induced protein 75B
nuclear receptor - ensures proper temporal progression of larval development

Ecdysone-inducible gene L2
a secreted protein that binds Drosophila insulin-like peptide 2 and inhibits growth non-autonomously

Ecdysone-induced protein 63E
cyclin dependent kinase that plays a role in cell differentiation rather than in cell division

Ecdysone-induced protein 74EF
ETS domain transcription factor that encodes two isoforms that control the timing of gene induction during molting

Ecdysone-induced protein 93F
Pipsqueak family transcription factor - programs a cell death response during larval development

ecdysoneless
conserved protein of unknown function - mutants disrupt production of the steroid hormone ecdysone causing developmental and reproductive defects

Ecdysone receptor
transcription factor - nuclear receptor - zinc finger - regulates molting cycles and oogenesis

Eclosion hormone
neuropeptide - acts directly on the CNS to release the stereotyped motor programs that trigger the shedding of the old cuticle at the end of each molt

echinoid & friend of echinoid
cell-adhesion molecules (CAMs) - Ig and fibronectin domains proteins - The genes are adjacent to one another and co-ordinately regulated - Echinoid acts to antagonize Egf receptor signaling - Friend of echinoid exhibits interaction with the Notch pathway

effete
E2 ubiquitin-conjugating enzyme - mediates anaphase-promoting complex degradation - controls germ-line stem cell maintenance
by targeting Cyclin A - regulates programmed cell death and neuronal process remodeling

egalitarian
RNA binding protein - participates along with BicaudalD in transport of mRNA during oogenesis - salivary gland morphogenesis

egghead
glycosyltransferase - required for glycosphingolipid sugar chain elongation - affects extracellular Gurken gradiant
by controlling Gurken planar transport in the extracellular space

eggless
SET domain hydroxymethyltransferase required for oogenesis - trimethylates histone H3 at its K9 residue - involved in gene silencing

eIF4E-Homologous Protein
Eukaryotic initiation factor 4E - a cap binding protein that inhibits hunchback, caudal and bicoid mRNA translation

eiger
TNF superfamily; type II membrane protein - ligand that induces cell death by activating the JNK pathway

18 wheeler
transmembrane - leucine-rich repeat motif (LRR) - a critical component of the humoral immune response

elbow B
zinc finger transcription factor - specifies distinct tracheal cell fates

ELL (preferred name: Su(Tpl))
occludin homology domain protein - a Pol II elongation factor capable of stimulating the rate of transcription

embryonic lethal abnormal vision (common alternative name: elav)
RNA binding protein - a pan-neural gene required for correct differentiation and maintenance of the nervous system

empty spiracles
transcription factor - homeodomain - required for head development and brain morphogenesis

enabled
VASP homolog and SH3 domain protein - cytoskeletal adaptor protein implicated in axonal outgrowth and fasciculation

encore
During oogenesis Encore physically interacts with the proteasome, protein degradation factor Cul1 and Cyclin E -
In encore mutant germaria Cyclin E degradation is compromised, thus impairing exit from cystoblast cell divison

Endostatin (preferred name: Multiplexin)
homolog of Collagen XV/XVIII, a matrix protein that can be proteolytically cleaved to release Endostatin, an antiangiogenesis signaling factor -
required for normal calcium channel abundance, presynaptic calcium influx, and neurotransmitter release - functions in motor axon pathfinding

engrailed
transcription factor - homeodomain - engrailed class - segment polarity gene - involved in compartment identity and boundary formation

Enhancer of bithorax
major subunit of nucleosome remodeling factor (nurf) - multiple domain protein with HMGI/Y and bromodomain motifs

Enhancer of Polycomb
novel Polycomb group protein and a suppressor of position effect variegation

Enhancer of split m7, helix-loop-helix
neurogenic bHLH transcription factor - Hairy/E(spl) class - an inhibitor of neural fate - Hairy/E(spl) class

Enhancer of split m8, helix-loop-helix
transcription factor - bHLH - Hairy/E(spl) class - neurogenic gene - target of Notch pathway

Enhancer of yellow 3 (common alternative name: SAYP)
Trithorax group protein, constituent PBAP chromatin remodeling complex, a coactivator supercomplex consisting of Brahma and TFIID;
participates in ecdysone-dependent transcriptional regulation

Enhancer of zeste
transcription factor - polycomb group with trithorax homology - chromatin associated

ensconsin
a conserved microtubule-associated protein - promotes productive recruitment of kinesin to microtubules

Eph receptor tyrosine kinase
receptor tyrosine kinase involved in axon pathfinding

Ephrin
functions as a ligand for Eph receptor - expressed on the surface of neuron cell bodies - acts to confine Eph receptor bearing axons to longitudinal tracts by repulsion

Epidermal growth factor receptor (common alternative name: Torpedo)
transmembrane receptor- tk - EGF-R homology - during oogenesis helps set up egg polarity, determines the identity of cells in the ectoderm; during larval stages participates in the development of the eye and wing.

erect wing
novel transcription factor - exhibits a neural defect due to expression in neurons and a muscle defect due to expression in myoblasts

escargot
transcription factor - zinc finger - regulates the cell cycle in histoblasts

E(spl) region transcript m4
Bearded family - required to positively transduce the Notch signal during neurogenesis, and presumably during bristle development as well

estrogen-related receptor
transcription factor - nuclear receptor - regulates a coordinate switch in gene expression that drives a metabolic program normally
associated with proliferating cells - supports growth during larval development

ETHR (common alternative name: Ecdysis triggering hormone receptor)
G-protein coupled receptor - scheduling successive behavioral steps in the ecdysis, regulation of pupal and adult ecdysis

Ets at 97D
Ets domain transcription factor - homolog of the alpha subunit of mammalian NRF-2/GABP - required for proper expression of most genes encoding mitochondrial proteins -
regulator of mitochondrial number and mass - required for proper follicle cell migration, chorion formation, and nurse cell chromosome decondensation

Eukaryotic initiation factor 4E
binds to the mRNA 5' cap thus controlling a crucial step in translation initiation - required for cell growth -
promotes dedifferentiation of neuroblasts back to a stem cell-like state thus functioning as an oncogene -
a target of Ago2 in translational repression - functions as a splice factor for msl-2 and Sxl pre-mRNAs

even-skipped
transcription factor - homeodomain - pair rule gene establishing epidermal cell fate

Excitatory amino acid transporter 1
transmembrane excitatory amino acid transporter expressed in glial cells - tightly regulates
extracellular glutamate levels to control neurotransmission functions in locomotor behavior

exo84
exocyst complex 84-kDa subunit Pleckstrin Homology (PH) domain protein - involved in apical polarity of epithelial tissue -
the exocyst complex functions in polarized exocytosis

expanded
Band 4.1 protein with three potential SH3-binding sites - localization to adherens junctions allows Expanded to exert effects on multiple processes
involved in disc development, including effects on cell proliferation, cell fate determination, and tissue polarity

extra-extra
a homeodomain transcription factor - regulates motorneuron cell fate by restricting expression of Even-skipped and Lim2

extra macrochaetae
transcription factor - HLH non basic - antagonist of proneural genes

extra sexcombs
Polycomb group - WD40 domain - in combination with Enhancer of zeste and histone deacetylases, promotes gene silencing

extradenticle
transcription factor - homeodomain - cooperatively interacts with homeotic proteins to increase the specificity of homeotic protein binding to DNA

exuperantia
a core component of a large protein complex involved in localizing mRNAs both within nurse cells and the developing oocyte

eyegone
transcription factor - homeodomain & pax domain - plays a role in the process of joining morphogenesis that is crucial to the formation of salivary gland ducts

eyeless
transcription factor - homeodomain & pax domain - plays a crucial role in eye and brain development

eyelid (preferred name: osa)
transcription factor - Bright family - associates with the Brahma chromatin remodeling complex - antagonizes Wingless signaling
during Drosophila development and affects patterning of the eye imaginal disc

eyes absent (preferred name: clift)
transcriptional co-activator and protein tyrosine phosphatase - cell survival factor - functions in eye development -
also plays a role in the embryonic determination of somatic gonadal precursor (SGP) cell fate

eyes closed
a fly homolog of p47, a protein co-factor of the p97 ATPase involved in membrane fusion - mutation results in a lethal failure of nuclear envelope assembly in early zygotic divisions and results in defective photoreceptor morphogenesis

eyes shut
a proteoglycan secreted into the ommatidial apical matrix - critical for the formation of epithelial lumina in the fly retina -
forms an extracellular shield that guards mechanosensory neurons from environmental insult

F

fab1
phosphatidylinositol phosphate kinase - controls vesicular trafficking but not silencing of endocytosed receptors, including Wingless and Notch -
functions in negative regulation of cell volume - regulates autophagy by being required for the maturation of autolysosomes

faint sausage
Ig superfamily - involved in neural cell migration and axon pathfinding

falafel
Protein Phosphatase 4 regulatory subunit - a key mediator specific for the localization of Miranda and associated cell fate determinants during both interphase and mitosis

Fasciclin I
lipid linked novel protein - homophilic cell adhesion molecule that acts in axon guidance

Fasciclin II
transmembrane - NCAM homolog - Ig superfamily - controls number and stability of neuromuscular synapses

Fasciclin III
transmembrane - cam - novel - aids in cell adhesion, axon pathfinding and fasciculation ensuring proper muscle innervation

fat
cadherin domain transmembrane receptor that negatively controls cell proliferation - also functions in planar polarity

fat facets
conserved Cys and His domains - ubiquitin-specific protease - plays multiple roles in eye and oocyte development

fat-like (common alternative names: kugelei, fat2)
a cadherin related to Fat - required for the planar polarity of actin filament orientation
at the basal side of ovarian follicle cells - acts non-autonomously in follicle cells in the transmission of polarity information
required for morphogenesis and maintenance of tubular structures of ectodermal origin

fear of intimacy
transmembrane domain protein - FICL family - zinc transporter - required in the mesoderm for gonad morphogenesis - required for tracheal branch fusion

female sterile (1) homeotic
double-bromodomain protein - trithorax group gene that cooperates with Zeste in Ultrabithorax activation

female sterile (3) homeless (preferred name: spindle E)
DE-H family of RNA-dependent ATPases - possible roles during oocyte development in RNA processing, transport, or stabilization

female sterile (1) Yb (common alternative name: Yb)
tudor domain RNA helicase, post-transcriptional gene regulation - regulates transposon silencing via the piRNA pathway -
component of the Yb body, a site for Piwi-associated RNA biogenesis, regulates Piwi transport to the nucleus

FER ortholog (H. sapiens) (common alternative name: Fps oncogene analog)
Fes/Fer non-receptor tyrosine kinases - regulates cell adhesion and cytoskeletal reorganisation through the modification
of adherens junctions - regulates dorsal closure

Ferritin 1 heavy chain homologue and Ferritin 2 light chain homologue
iron storage proteins; ferroxidase and iron core nucleation

fgf-receptor homolog 1 (preferred name: heartless - common alternative name: DFR1)
receptor tyrosine kinase - involved in the development of mesodermal and neuronal cells

fizzy
WD40 domain protein - homolog of Cdc20 - required for the activity of the anaphase promoting complex in mitosis -
functions to target the three mitotic cyclins A, B and B3 for destruction in the egg and drive anaphase progression during meiosis

fizzy related (preferred name: retina aberrant in pattern)
Trp-Asp repeat (WD-repeat) protein - negatively regulates the levels of cyclins A, B and B3 thus promoting mitosis

flamingo (preferred name: starry night)
Cadherin-related 7TM protein involved in tissue polarity

flapwing
Isoform of serine/threonine protein phosphatase 1 - regulates nonmuscle myosin by dephosphorylating the myosin II regulatory light chain (Spaghetti squash)

flower
Transmembrane protein - expressed in 'loser' cells to mediate win/lose decisions in cell competition by means of differentially expressed isoforms

Fmr1
KH domain RNA-binding protein - homolog of mammalian Fragile X mental retardation gene - represses Futsch translation - mutants have synaptic structural defects

FMRFamide-related
neuropeptide of unknown function in Drosophila expressed in sets of brain and ventral cord neurons

Focal adhesion kinase-like
involved in integrin signaling - targets multiple cytoskeletal and signal transduction proteins

folded gastrulation
secreted - novel protein - regulates gastrulation - necessary for coordination of cell shape changes throughout the invaginating primordia

Follicle cell protein 26Aa (preferred name: palisade)
multi-domain protein that acts during oogenesis to coordinate assembly of the vitelline membrane -
required for functional properties of the eggshell

follistatin (accepted FlyBase name: Fs)
modulates TGF-β ligand signaling - inhibits activin-β signaling but activates Dawdle

foraging
cGMP-dependent protein kinase - controls feeding behavior and locomotory behavior

fork head
transcription factor - forkhead domain - plays two roles for fkh in the formation of the embryonic salivary glands:
an early role in promoting survival of the secretory cells, and a later role in secretory cell invagination

Forkhead box P
forkhead domain transcription factor - a highly conserved transcription factor known for its importance in human speech and language production -
reduced expression in Drosophila leads to decreased levels of courtship behavior, altered pulse-song structure, and sex-specific motor impairments in walking and flight

forkhead domain 3F
required for the specialization of mechanosensory cilium of chordotonal neurons

Fos-related antigen (preferred name: kayak)
transcription factor - basic leucine zipper - regulates dorsal closure - also required downstream from Decapentaplegic signaling for the regulation of labial in the midgut

4E-BP (preferred name: Thor)
messenger RNA 5' cap binding protein - regulates translation during environmental stress

4EHP (preferred name: eIF4E-Homologous Protein)
Eukaryotic initiation factor 4E - a cap binding protein that inhibits hunchback, caudal and bicoid mRNA translation

four-jointed
transmembrane protein kinase that targets Fat and its transmembrane ligand Dachsous - conveys positional information in the leg and eye

14-3-3ε
regulates the activity of cellular proteins in a phosphorylation-dependent manner by binding as a dimer to phosphoserine/threonine-containing motifs -
acts as a cofactor for PAR-1 by binding to proteins that are phosphorylated by the PAR-1 kinase

14-3-3zeta (common alternative name name: leonardo)
a 14-3-3zeta isoform - a phosphoserine/threonine interacting protein - positively regulates
Ras-mediated signaling in the development of the compound eye - also involved in facilitating olfactory learning

foxo
forkhead domain transcription factor - a target of the insulin receptor signaling pathway - modulates growth and proliferation

Fps oncogene analog [Preferred name: FER ortholog (H. sapiens)]
Fes/Fer non-receptor tyrosine kinases - regulates cell adhesion and cytoskeletal reorganisation through the modification
of adherens junctions - regulates dorsal closure

frayed
serine/threonine kinase - PAK family - required for normal axonal ensheathment

frazzled
Ig superfamily - functions as a Netrin receptor in axon pathfinding

fringe
secreted glycosyltransferase involved boundary formation - Notch antagonist that functions by targeting extracellular domain of Notch

frizzled
transmembrane - 7 pass - frizzled family - receptor for Wingless - tissue polarity gene

frizzled2
transmembrane - 7 pass - frizzled family - receptor for Wingless - tissue polarity gene

frizzled3
transmembrane - 7 pass - frizzled family - antagonizes wingless signal

fruitless
zinc finger - sex determination - regulates mating behavior

Fs (common alternative name: Follistatin)
modulates TGF-β ligand signaling - inhibits activin-β signaling but activates Dawdle

ftz transcription factor 1
transcription factor - nuclear receptor - zinc finger - bridges early and late gene expression during the process of metamorphosis

FTZ-F2 (preferred name: tramtrack)
transcription factor - zinc finger - represses neural cell fate in the peripheral nervous system

furrowed
selectin (carbohydrate binding protein) - mutants have defects in eye patterning and in cell determination of the ommatidia and bristles

furry
conserved protein that is required for Tricornered activity in control of wing hair and bristle morphology -
controls dendritic branching and tiling in sensory neurons

fused
serine/threonine kinase - segment polarity gene - cytoplasmic component of Hedgehog signaling pathway

fushi tarazu
transcription factor - homeodomain - Antp class - pair rule gene

futsch
microtubule-associated protein regulating axon guidance

G

GABA-B-R1, GABA-B-R2 and GABA-B-R3
metabotropic GABA-B receptors - G-protein coupled receptor - expressed by pheromone-sensing olfactory receptor neurons which as a consequence exhibit
strong presynaptic inhibition - mediates inter-glomerular inhibition - responsible for decreased intracellular calcium of clock neurons blocking their calcium cycling

Gadd45
exhibits a genetic interaction with JNK pathway affecting egg asymmetry in the oocyte; induced by wounding in embryos

GAGA (preferred name: Trithorax like)
transcription factor - zinc finger - btb domain - a transcriptional activator that functions by influencing chromatin structure

gamma-tubulin ring protein 84
gamma-tubulin associated protein required for aspects of microtubule nucleation, dynamics and organization both in interphase and mitosis

gammy legs (preferred name: pygopus)
nuclear PHD-finger protein - a core component of the Wingless signaling pathway that acts downstream of or at the level of Pangolin

gastrulation-defective
a maternally supplied protease involved in establishment of dorsal/ventral polarity - targets Snake

gata-2 (preferred name: pannier)
transcription factor - zinc finger - GATA family - a local repressor of achaete and scute that is required for the normal pattern of sensory bristles

GATAe
GATA family zinc finger transcription factor - Required downstream of serpent for the expression of specific genes in the differentiated midgut

gawky
RNA-binding protein - glycine-tryptophan (GW) repeat protein required for P-body integrity -
promotes mRNA deadenylation, decapping and degradation

GCN2
protein kinase that promotes avoidance of the essential amino acid-deficient diet - blocks translation initiation
through eIF2a phosphorylation - required for infection-induced host translational blockage

Gcn5 ortholog
a major histone H3 acetylase in Drosophila that plays a key role in the control of specific morphogenetic cascades during developmental transitions

GDI interacting protein 3 (common alternative name: Armless)
ubiquitin-like protein that functions in protein degradation - required for Wingless target gene expression

Ge-1
a molecular scaffold that brings together decapping enzymes and activators that are involved in silencing of microRNA targets

geminin
limits DNA replication by preventing Mcm loading onto chromatin

genderblind
glutamate permease - regulates ambient extracellular glutamate to suppress glutamatergic synapse strength - controls mate choice

Genghis Kahn
similar to myotonic dystrophy protein kinase - regulates cytoskeletal dynamics

germ cell-less
chromatin component - BTB/POZ domain protein- responsible for establishment transcriptional quiescence in germ cells

giant
transcription factor - basic leucine zipper - gap gene

gigas
Rap1 GAP domain protein - tuberous sclerosis-2 homolog - regulates growth rate - a modifies of the insulin pathway

gilgamesh
Casein kinase 1 γ homolog - interacts Arrow to modify Wingless signaling - mutants show a defect in spermatid individualization -
required to potentiate Wingless signaling in limb development - acts in the posterior region of the eye disc to prevent precocious glial cell migration

glass
transcription factor - zinc finger - required for normal development of photoreceptor cells in a larval photoreceptor known as Bolwig's organ,
in the adult compound eye and in adult simple eyes, known as ocelli

glass bottom boat (common alternative name: Transforming growth factor beta at 60A)
TGF-beta superfamily - BMP 7 homolog - potentiates dpp signaling

glial cells missing
transcription factor - novel - required for glial cell fate

Glial cell line-derived neurotrophic family receptor-like
a GPI-anchored membrane protein with four GDNF family receptor-like domains - regulates oogenesis and male fertility -
expressed in the central and peripheral nervous systems

Gliolectin
lectin (carbohydrate binding protein) - regulates cell adhesion in midline glia

Gliotactin
transmembrane - novel serine esterase homolog - functions in glia to ensure a secure blood-brain barrier.

gluon
condensin subunit SMC4 - involved in mitotic chromatin condensation

Glutamate receptor IIA and Glutamate receptor IIB
transmembrane Ca2+ channel protein - expressed on muscular synaptic boutons targeted by motor neurons

Golden goal
transmembrane receptor that is dynamically expressed in all photoreceptor neurons and localizes predominantly to growth cones - regulates axon-axon
and axon-target interactions in R8 photoreceptor axon - acts as a functional partner of Flamingo for R8 photoreceptor axon targeting in the medulla

Gonadotropin-releasing hormone receptor (common alternative name: Adipokinetic hormone receptor)
GPCR - involved in storage-fat mobilization - essential to adjust normal body fat content
and ensure lifelong fat-storage homeostasis - functional analog of the mammalian glucagon receptor

gooseberry-neuro (common alternative name: gsb-p)
transcription factor - homeodomain - paired domain - regulates neuroblast cell fate - functions redundently with gooseberry

gooseberry (common alternative name: gsb-d)
transcription factor - homeodomain - paired domain - regulates neuroblast cell fate

Goosecoid
transcription factor - homeodomain - paired-like - regulates cell fate in the brain and stomatogastric nervous system

G protein αi subunit 65A
G protein α subunit involved in regulating asymmetric cell division

G protein β-subunit 13F
β subunit of heterotrimeric G protein complex - maternal expression involved in oogenesis - zygotic expression involved in regulating the Wnt pathway,
asymmetric cell division, wing maturation and maintaining cardiac integrity

G protein-coupled receptor kinase 2
Serine/threonine protein kinase - involved in a receptor-mediated signaling pathway that utilizes cAMP as a second messenger -
involved in oogenesis and implicated in learning

G protein α o subunit
G protein alpha subunit - regulates mesenchymal-epithelial transition that takes place in cardial cells and precursor cells of the visceral musculature

G protein α s subunit
s-α subunit of heterotrimeric G protein - regulates cyclic AMP second messenger system - functions in learning

grapes
kinase - Chk1 homolog - cell cycle checkpoint protein

grain (common alternative name: dGATAc)
zinc finger - GATA family - required during development for shaping the adult legs and the larval posterior spiracles

grainy head
a maternally expressed bHLH transcription factor that regulates precise timing of gene expression early in development - a key regulator of epidermal
barrier formation and repair - a temporally expressed regulator of neural cell identity functioning during embryonic and larval development

Gram-negative bacteria binding protein 3
a pattern recognition receptor that is required for the detection of fungal cell wall components -
required for Toll pathway activation in response to fungal infections

grappa
a histone methyltransferase that modifies the lysine 79 residue of histone H3 - necessary for the maintenance phase
of Bithorax complex expression - has characteristics of both polycomb- and trithorax-group genes

Grasp65
signaling protein that exhibits a dynamic association to the membrane of the early exocytic pathway and is involved building the Golgi stack

greatwall
kinase that coordinates with Polo for mitotic progression - absence of Gwl during meiosis results in excessive and/or premature Polo activity
leading to premature loss of sister chromatid cohesion

grim
pro-apoptotic protein whose N-terminus functions by disrupting IAP binding to caspases -
an additional mitochondrial-dependent apoptotic function carried out by a centrally located GH3 domain

grindelwald
tumour necrosis factor receptor - JNK signalling - integrates apoptotic functions from Eiger
with signaling from apical polarity determinants to induce JNK-dependent cell death or tumour growth

Grip
Scaffolding and signaling protein - participates in the reception of an attractive signal that emanates from muscle epidermal attachment sites to direct the motility of developing muscles

groovin (preferred name: short stop)
cytoskeletal cross-linker protein - expressed in the tendons and is essential for muscle-dependent tendon cell differentiation -
required for sensory and motor axons to reach their targets in the Drosophila embryo

groucho
transcription factor - WD40 domain - E(spl) complex - partners transcriptional repressors by functioning as a co-repressor

Growth-blocking peptide
a secreted cytokine that mediates acute innate immune reactions through association with IMD - activates Phospholipase C
which promotes increases in the levels of inositol phosphates involved in intracellular signaling - regulates larval growth

Grunge
transcriptional cofactor for Even-skipped - positive regulator of teashirt - homolog of mammalian Atrophin

GTPase-activating protein 1
Ras GTPase-activating protein with PH domain and C2-domain - functions in cone cell precursors to down-regulate Ras1

Guanylyl cyclase at 76C
cGMP production - receptor-type protein possessing a single transmembrane domain - required for Semaphorin-1a-Plexin A directed repulsive axon guidance

guftagu (common alternative name: Cul-3)
Cullen-3 homolog acting in protein degradation - loss of function has pleiotropic effects during development, including defects in external sensory organ development, pattern formation and cell growth and survival - targets Cubitus interruptus

GUK-holder
Scaffolding protein involved in synaptic budding - interacts with the GUK domain of Discs large - required for the proper synaptic localization of Scribbled

gurken
TGFß homolog - EGF-R ligand - required for dorsoventral patterning in the egg and embryo

Gustatory receptor 5a (common alternative name:Trehalose-sensitivity)
G-protein coupled receptor - Taste receptor

Gustatory receptor 21a and Gustatory receptor 63a
GPCRs that confer CO2-chemosensation in Drosophila

Gustatory receptor 43a
nutrient sensor for hemolymph fructose - promotes feeding in hungry flies but suppresses feeding in satiated flies

Gustatory receptor 64a
taste receptor - response to sugar

Gustatory receptor 66a
7 transmembrane protein - taste receptor - mediates aversion to bitter taste in the labellum, pharynx, legs, wings, and abdomen
- mediates suppression of feeding behavior by the insect repellent DEET - mediates aversion to caffeine

Gustatory receptor 68a
an essential component of pheromone-driven courtship behavior

gutfeeling (preferred name: Ornithine decarboxylase antizyme)
modifies the activity of Ornithine decarboxylase - regulates the nuclear entry and overall levels of Sex-lethal in early germ cells

H

H15 and midline
T-box transcription factors that participate in cardiac fate specificity

Hairless
novel basic protein - a major antagonist of the Notch signaling-pathway - associates with Suppressor of Hairless, thereby inhibiting trans-activation of Notch target genes

hairy
transcription factor - bHLH - Hairy/E(spl) class - during embryogenesis it participates as a primary pair-rule gene in the establishment of segments -
in the larval stage it functions negatively in determining the pattern of sensory bristles on the adult fly.

Hairy/E(spl)-related with YRPW motif
bHLH-Orange protein family - expressed in a subset of newly born neurons that receive Notch signalling -
promotes one of two alternative fates adopted by sibling neurons

half pint (preferred name: poly-U-binding splicing factor)
RNA recognition motif protein - functions in both constitutive and alternative splicing - required during oogenesis

hamlet
zinc finger - regulates cell identity in the peripheral nervous system - a binary genetic switch that acts to repress a multiple dendritic arbor
and promote single-dendrite morphology

Hand
Member of a conserved family of bHLH transcription factors that performs a conserved function in cardiogenesis - also required for hematopoiesis

happyhour
a MAP4K3 that regulates TOR activity detected by phosphorylation of S6K and 4EBP - required for amino acids to stimulate TOR complex activity -
binds physically to the Rag GTPases - promotes caspase-dependent apoptosis

HDAC6
a microtubule-associated deacetylase - interacts with polyubiquitinated proteins to stimulate autophagy as a compensatory degradation system
when the ubiquitin-proteasome system is impaired

headcase
novel basic protein - expression prefigures the mitotic activation of imaginal tissue proliferation - regulates tracheal branching

head involution defective (common alternative name: Wrinkled)
death domain protein - programmed cell death - cell death function required for the movement of the dorsal fold
across the procephalon and clypeolabrum, a process that forms the frontal sac

heartbroken (preferred name: stumps)
novel signal transduction protein functioning downstream of two FGF receptors -
mutations are associated with defects in the migration and later specification of mesodermal and tracheal cells

heartless (commonly known as Fibroblast growth factor receptor 1 or DFR-1)
receptor tyrosine kinase - involved in the development of mesodermal and neuronal cells

HEAT repeat containing 2
Dynein assembly factor involved in assembly of motile cilia - component of intracellular pre-assembly and transport network -
necessary to deliver functional dynein machinery to the ciliary compartment - spermatogenesis

Heat shock factor
leucine zipper - transcription factor - functions to activate transcription of heat shock genes during heat stress

Heat-shock-protein-70
a family of proteins that functions as molecular chaperones - thermotolerance - required for border cell migration

Heat shock protein 83 (common alternative name: Heat shock protein 90)
a molecular chaperones that promotes the maturation of several important proteins - maintains and optimizes RNA polymerase II pausing
via stabilization of the negative elongation factor complex - promotes anaphase-promoting complex/cyclosome function during cell cycle exit -
acts to generate neuroblast cortical polarity - acts to prevent phenotypic variation

hedgehog
Hedgehog N-terminal signaling domain and C-terminal autoprocessing domain - helps establish embryonic segmentation - a segment polarity intercellular signaling protein

held out wings
KH motif - putative RNA-binding protein - functions in the migration and attachment of somatic muscle cells

Helicase at 25E (common alternative name: UAP56)
DExH/D RNA helicase required in the nucleus for mRNA export - required in the cytoplasm for remodeling
the transacting factors that dictate mRNA cytoplasmic destination

Helix loop helix protein 106 (common alternative name: Sterol regulatory element-binding protein, SREBP)
bHLH-leucine zipper transcription factor - membrane bound HLH106 is released by phosphatidylethanolamine, exerting feedback control
on the synthesis of fatty acids and phospholipids - cleavage by Drice releases an SREBP fragment to travel to the nucleus
where it mediates the increased transcription of target genes needed for lipid synthesis and uptake

hemiperous
a kinase (MapKK/JunKK) involved is dorsal closure - required for the correct differentiation of epithelia

HEM-protein (common alternative name: kette)
alternatively a membrane associated and a cytosolic protein that transduces information to the neuronal cytoskeleton affecting axon guidance

Hen1
RNA methyltransferase - carries out methylation of small interfering RNAs, the final step in assembly of RISC occurring
after the Argonaute-bound siRNA duplex is converted to single-stranded RNA

Hepatocyte growth factor regulated tyrosine kinase substrate (common alternative name: Hrs)
endosomal sorting of ubiquitinated receptors - targeting of EGFR, PVR, Notch, Hedgehog and Dpp receptors for degradation

Hepatocyte nuclear factor 4
zinc finger transcription factor - mutants show defects in midgut, Malpighian tubule and salivary gland development

hephaestus
polypyrimidine tract binding protein - controls alternative splicing - required to attenuate Notch activity after ligand-dependent activation during wing development

hermaphrodite
C2H2 zinc finger transcription factor - plays a permissive role in sex determination and differentiation - required for female sexual differentiation

heterochromatin protein 1 (preferred name: Suppressor of variegation 205)
chromodomain - Polycomb group - chromatin associated protein -
required both for activation of heterochromatic genes and silencing of euchromatic genes

Heterochromatin Protein 1c
chromodomain protein - chromatin interactor and organizer - transcriptional co-regulator -
transcriptional activator - a components of a multiprotein complex involved in nervous system development - regulator of telomere function

Heterochromatin Protein 1e
testis-specific HP1 protein that acts during spermiogenesis by exerting post-fertilization control
to ensure faithful chromosome segregation in the embryo

Hexamethylene bisacetamide inducible
negative regulator of transcription from RNA polymerase II promoters - ensures the integrity of Hedgehog signaling
in the wing disc - component of a macromolecular complex that keeps TEFb in a catalytically inactive state

HGTX
homeobox, NK decapeptide domain transcription factor - acts within a subclass of early born neurons to link
neuronal subtype identity to neuronal morphology and connectivity

hibris
Ig repeat transmembrane protein with fibronectin type III domain - a receptor involved in muscle cell fusion

HIF prolyl hydroxylase (alternative name: fatiga)
oxygen sensor - a specific prolyl-4-hydroxylases required for hydroxylation of key prolyl residues in the HIFα sequence -
Fe (II) and 2-oxoglutarate dependent dioxygenase superfamily protein that uses O2 as a co-substrate for catalysis -
involved in tracheal development, oogenesis and drives cell growth downstream of Cyclin D

Hig-anchoring scaffold protein
component of synaptic cleft of brain cholinergic synapses, regulates levels of Discs large and nAChR subunits
at postsynaptic terminals, required for trapping Hikaru genki at the synapse

High mobility group protein D
transcription factor - HMG domain protein - responsible for transcriptional silencing during early development

highwire
synaptic protein - B-box zinc finger superfamily - a negative regular of synaptic growth

hiiragi (also known as poly(A) polymerase)
involved in both nuclear and cytoplasmic polyadenylation of mRNA

hikaru genki
synaptic protein - IG superfamily - required at during pupariation for the formation of normal neural circuitry

hindsight (preferred name: pebbled)
multiple zinc finger transcription factor - regulates some aspect of amnioserosal signalling to surrounding ectoderm promoting germ band retraction

hippo
a serine/threonine kinase - acts in conjunction with Salvador and Warts to restrict cell growth - promotes cell death by decreasing the level of Thread, an inhibitor of apoptosis

Hira (alternative name Sesame)
histone chaperone - required for nucleosome assembly during sperm nucleus decondensation - GAGA factor and
FACT-dependent replacement of methylated histone H3 by H3.3 occurs through association with Hira

Histone deacetylase 3
chromatin component - deacetylates histone H4 - counteracts the overgrowth induced by InR, PI3K or S6K over-expression -
a target of the PI3K pathway - helps retain chromatin compaction and gene silencing in nuclear lamina-interacting multigenic chromatin domains

Histone gene-specific Epigenetic Repressor in late S phase
chromatin component - a molecular switch linking epigenetic gene silencing to cell cycle-dependent histone production

Histone H1
Chromatin component - linker histone - stabilize a higher order 30 nm diameter chromatin fiber that is fundamental to the structural organization of chromosomes

Histone H2A
Chromatin component - a core histone that can be modified by ubiquitination - a target of polycomb gene silencing -
involved in trans-histone regulation through histone H3

Histone H2B
Nucleosome core histone component, chromatin assembly, target of ubiquitination by the dosage compensation and SWI/SNF complexes,
regulates of neuronal connectivity in the visual system, regulates Notch target genes and repression of key differentiation genes

Histone H2A variant
replacement histone participates in an ordered cascade of events leading to the establishment of heterochromatin

Histone H3
Nucleosome component - core histone

Histone H3.3A
H3 histone subtype - deposition is coupled to transcription and continues while a gene is active -
histone replacement suggests a mechanism to maintain both the structure of chromatin and access to DNA at active genes

Histone H4
Nucleosome component - core histone - acetylation of Histone H4 plays a positive role in promoting access of transcription factors to nucleosomal DNA

HLH54F
bHLH transcription factor - earliest specific regulator of caudal visceral mesoderm development

HMG Coenzyme A reductase (common alternative name: columbus)
catalyzes the biosynthesis of a mevalonate precursor for isoprenoids - functions in the hedgehog signaling pathway,
implicated in the production of a signal by the somatic gonadal precursor cells that attracts migrating germ cells

Hnf4
zinc finger transcription factor - mutants show defects in midgut, Malpighian tubule and salivary gland development - activated by fatty acids
released from triglycerides, inducing enzymes that drive fatty acid oxidation for energy production

Holes in muscle
WRPW motif protein that binds Groucho to inhibit both muscle differentiation and Mef2 activity during development

homeodomain interacting protein kinase
serine/threonine kinase - homolog of mammalian Homeodomain interacting protein kinase - acts as a positive regulator of Wingless pathway
by stabilizing Armadillo - promotes Notch signal transduction in the eye by inhibition of the co-repressor Groucho

homer
scaffolding protein required for the function of neural networks controlling locomotor activity and behavioral plasticity

homeless (preferred name: spindle E)
homeless DE-H family of RNA-dependent ATPases - the failure to transport Bicoid and Oskar mRNAs is the earliest defect in RNA transport observed in spn-E mutants

homothorax
homeodomain transcription factor - HM domain protein - required for Extradenticle nuclear localization -
a partner of Hox genes - required for segmentation and proper head involution

hopscotch (common alternative name: jak kinase and janus kinase)
janus family tyrosine kinase - regulates even-skipped during segmentation -
mutation creates an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation.

Hormone receptor-like in 38
nuclear receptor superfamily - participates in a second ecdysteroid signaling pathway that responds to a distinct class of ecdysteroids
in a manner that is independent of EcR

Hormone receptor-like in 39
nuclear receptor superfamily - master regulator of a program for the production of female reproductive glands and other secretory tissues

Hormone receptor-like in 46 (common alternative name: DHR3)
transcription factor - nuclear receptor superfamily - a second tier regulator involved in Drosophila molting -
acts negatively on Ecdysone receptor and postively on genes expressed subsequently in the molting hierarchy

Hormone receptor 51 (common alternative name: Unfulfilled)
nuclear receptor superfamily - a thiolate heme-binding protein - necessary for mushroom body axon extension and branching
mutants modulate wing expansion and fertility through underlying neurological defects

Hormone-receptor-like in 78
nuclear receptor superfamily - mutants are blocked in their ability to trigger the mid-third instar regulatory hierarchy

Hormone receptor-like in 96
nuclear receptor superfamily - regulation of cholesterol and triacylglycerol homeostasis, genetic control of xenobiotic stress responses

HP1c
HP1 family member - mchromatin interactor and organizer - physically interacts with DNA-binding zinc-finger transcription factors
Without children and Relative-of-WOC to act as a transcriptional activator

Hr4
steroid hormone receptor - coordinates growth and maturation in Drosophila by mediating endocrine responses
to achieve critical weight during larval development

huckebein
tf - zinc finger - terminal gap gene - limits the extent of mesodermal development - required for proper endoderm formation

Hugin
controls growth and metabolism - encodes at least two distinct neuropeptides; one, hug-γ, has homology
to an ecdysone triggering hormone and a second, Drm-PK-2, is a pyrokinin with myostimulatory activity

hu-li tai shao
homolog of mammalian adducin - necessary for actin localization to ring canals during oogenesis

hunchback
transcription factor - zinc finger - a gap gene later expressed in neuroblasts - required for proper temporal generation of cellular sublineages during neurogenesis

huntingtin
cytoskeletal scaffolding protein required for axonal transport

Hus1-like
forms a clamp-like 9-1-1 complex with Rad9 and Rad1 - plays a central role in the DNA-damage-induced checkpoint response - required for S-phase and meiotic checkpoints

Hyperkinetic
cytoplasmic protein that acts as the β subunit and redox sensor of Shaker voltage-dependent K+ channels -
functional in neural pathway in arousal and circadian rhythms - interacts with Ether go-go channels

hyperplastic discs
a HECT domain E3 ubiquitin ligase that is likely to act by targeting Cubitus interruptus and an unknown activator of hedgehog expression for proteolysis

hyrax
the Cdc73 component of the Polymerase-Associated Factor 1 (PAF1) complex - required for nuclear transduction of the Wnt/Wg signal -
manifests its effects on transcription through modulating chromatin structure

I

iab-4 (common alternative name: infraabdominal)
directly inhibits Ubx activity in vivo - ectopic expression induces a classical homeotic mutant phenotype,
the transformation of halteres into wings

Ice
a effector caspase - activated during spermatogenesis and necessary
for the removal of cytoplasm and the generation of functional sperm

IGF-II mRNA-binding protein
zipcode-binding protein - regulator of RNA transport in oocytes and neurons - regulates aging of the Drosophila testis stem-cell niche -
contributes to the localized expression of gurken mRNA in the oocyte - counteracts endogenous small interfering RNAs to stabilize mRNAs

ik2 (common alternative name: DmIKKε)
IKK-related kinase - a regulator of caspase activation in a nonapoptotic context - promotes degradation of DIAP1 (Thread)
through direct phosphorylation - required for proper sensory organ precursor development -
acts on the cytoskeleton to regulate egg DV and AP polarity

imaginal discs arrested
homolog of APC5, a subunit of the anaphase-promoting complex (APC/cyclosome) - required for proliferation of imaginal disc cells -
required for the localisation of Miranda and its associated cargo proteins to the neuroblast basal cortex

Imitation SWI
transcription factor - ATPase domain - bromodomain - gene activator - a component of a nucleosome remodeling protein complex

immune deficiency
a death domain protein involved in signal transduction during antibacterial immune response

immune response deficient 5 and kenny (common alternative names: IKKβ and IKKγ)
IkappaB kinase, respectively IKK catalytic and regulatory subunits - induction of antimicrobial peptide genes

I'm not dead yet
plasma membrane transporter of Krebs cycle intermediates - midgut - regulation of lifespan - regulation of mitochondrial function

importin alpha1
one of a family of proteins that mediates nuclear transport by linking nuclear localization signal (NLS)-containing proteins to importin beta1

inactivation no afterpotential D
scaffolding protein - PDZ domain protein - involved in visual signal transduction

inactivation no afterpotential E
diacylglycerol lipase involved in visual signal transduction and lipid metabolism

inactive
transient receptor potential vanilloid channel - expressed in chordotonal neurons where it is involved in temperature preference -
expressed in antenna were it is involved in hearing

inebriated
neurotransmitter:sodium symporter - mutations appear to cause increased excitability of the motor neuron by causing defective reuptake of a substrate neurotransmitter

infraabdominal (preferred name: nuclear untranslated RNA gene iab-4)
directly inhibits Ubx activity in vivo - ectopic expression induces a classical homeotic mutant phenotype,
the transformation of halteres into wings

Inhibitor of apoptosis 2
N-terminal baculovirus IAP repeat domain and C-terminal RING ubiquitin ligase domain protein - required for immune response to bacteria -
promotes cytoplasmic cleavage and nuclear translocation of the NF-kappaB homolog Relish - controls the level of caspase activity by forming
a covalent adduct with the catalytic machinery of drICE

Inner centromere protein
a component of the chromosome passenger complex - regulates activity of Aurora B kinase through a positive-feedback
loop - as a microtubule-binding protein Incenp has a well-defined centromere-targeting domain at its
N-terminus, suggesting a role in targeting the kinase to particular locations within the mitotic cell

Innexin 2
gap junction protein; blood-brain barrier glia - mediates the influence of metabolic changes on stem cell behavior;
response of glia nutritional signals - functions in oogenesis, visual transmission in lamina glia,
and proventriculus development; crucial for epithelial organization and polarity of the embryonic epidermis

Inositol 1,4,5,-tris-phosphate receptor
calcium channel - required for embryonic and larval development - involved in muscle development and is implicated in chemosensory functions

Inositol-requiring enzyme-1
protein kinase, endonuclease, a regulator of the unfolded protein response, leading to the activation
of the transcription factor Xbp1 - regulated Ire1-dependent decay - regulation of RNA splicing - photoreceptor differentiation and rhabdomere morphogenesis

inscuteable
novel protein - SH3 binding domain, ankyrin repeats and cytoskeletal attachment domain - involved in establishment apical/basal polarity

insensitive
a nuclear factor that physically interacts with Suppressor of Hairless and inhibits Notch signalling during peripheral nervous system development

Insulin-like peptide 6
an insulin-like peptide that is produced by the fat body - induced by metabolic stress -
promotes growth in conditions of nutritional deprivation or following developmentally induced cessation of feeding

Insulin-like peptide 8
ensures developmental stability and robustness - delays metamorphosis by inhibiting ecdysone biosynthesis thus slowing growth
in the imaginal discs - coordinates tgrowth status of tissues with developmental timing

Insulin-like receptor
receptor tyrosine kinase - a key component of an evolutionarily conserved signaling pathway that plays an essential role in controlling body, organ, and cell size

Insulin-related peptide
Insulin-like growth factor that functions as a growth stimulator - regulates of trehalose metabolism

integrin - ß PS (preferred name myospheroid)
transmembrane - integrin - ß subunit - a major component of the cell's machinery
for adherence to substrate, based on a calcium dependent process that produces a focal adhesion plaque

Integrin linked kinase
s/t kinase with ankyrin repeats - required for integrin-mediated adhesion - links the cytoskeleton via integrins to the plasma membrane

interference Hedgehog
IGcam membrane protein - binds Hedgehog and mediates Hedgehog response

intermediate neuroblasts defective
homeodomain protein - determines the identity of the ventral most column of neuroblasts

invected
transcription factor - homeodomain - engrailed class - cooperates with engrailed in establishing posterior compartment identity

Inverse regulator a (preferred name: Protein 1 of cleavage and polyadenylation factor 1)
RNA binding motif protein - dismantles elongation complexes by a RNA Polymerase II C-terminal domain (CTD) dependent mechanism
- forms a bridge between the CTD and RNA

Ionotropic receptor 8a
a member of a novel family of chemosensory receptor ion channels - variant ionotropic glutamate receptor-like protein - expressed on antennal neurons

Ionotropic receptor 25a
Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors part of an input pathway to the circadian clock that detects small
temperature differences - required for humidity preference - co-receptor subunit in chemosensation and thermosensation

Ionotropic receptor 64a
chemosensory receptor ion channel - detection of acid

Ionotropic receptor 84a
chemosensory ionotropic glutamate receptor family protein, regulation of male courtship behavior, response to aromatic odors

IplI-aurora-like kinase (preferred name: Aurora B)
signaling protein involved in chromatin condensation during mitosis

Ipou (preferred name: Abnormal chemosensory jump 6)
transcription factor - homeodomain and POU domain - determines odorant response profile of subsets of olfactory neurons

islet (preferred name: tailup)
transcription factor - homeodomain and LIM domain - required in combination with other transcription factors for serotonergic and dopaminergic neuron identity

ISWI (preferred name: Imitation SWI)
transcription factor - ATPase domain - bromodomain - gene activator - a component of a nucleosome remodeling protein complex

J

jaguar
Drosophila myosin VI, a pointed end directed molecular motor - involved in asymmetric cell division -
regulates actin dynamics during sperm individualization

jak kinase (preferred name: hopscotch, common alternative name: janus kinase)
janus family tyrosine kinase - regulates even-skipped during segmentation -
mutation creates an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation.

jelly belly
a secreted ligand that contains an LDL receptor repeat - required for visceral mesoderm development

jetlag
an F-box protein with leucine-rich repeats (LRRs), a putative component of a SCF E3 ubiquitin ligase complex -
essential for resetting the clock by transmitting light signals from Cryptochrome to Timeless resulting in the degredation of Timeless

JIL-1
protein serine/threonine kinase involved in dosage compensation

jing
zinc finger transcription factor - a downstream target of slbo required for border cell migration -
also plays an essential role in controlling CNS midline and tracheal cell differentiation

jing-interacting gene regulatory 1
a putative DNA-binding protein containing a MADF domain - hosts miR-92a in the intron and miR-92b
in the 3'UTR - miRNA limits expression in neuroblasts and is essential for maintenance of a neuroblast pool

Jumeaux (preferred name: Domina)
forkhead/winged-helix class - a suppressor of position effect variegation that affects and regulates eye and bristle development

Jumonji, AT rich interactive domain 2 (alternative name: Jarid2)
component of Polycomb repressive complex 2, which is involved in methylation of histone 3 at K27, required for transcriptional repression

Jun amino terminal kinase (JNK) (preferred name: basket)
MAP kinase homolog - regulates cell shape change and epidermal layer movement during dorsal closure

Jun related antigen (common alternative name: DJun)
transcription factor - basic leucine zipper - cooperates with the ETS domain protein Pointed to induce R7 fate in the developing eye

K

kakapo - preferred name: short stop
cytoskeletal cross-linker protein - expressed in the tendons and is essential for muscle-dependent tendon cell differentiation -
required for sensory and motor axons to reach their targets in the Drosophila embryo

karst (common alternative name: betaHeavy Spectrin)
cytoskeletal protein - structural and docking protein - a junctional protein involved in cell adhesion

karyopherin α1 (common alternative name: importin alpha1)
one of a family of proteins that mediates nuclear transport by linking nuclear localization signal (NLS)-containing proteins to importin beta1

Katanin-60
AAA+ family enzyme that suppresses polymerization of microtubule plus-ends - regulates cell migration -
acts in mitosis to stimulates microtubule plus-end depolymerization and Pacman-based chromatid motility

kayak (common alternative name: Fos-related antigen)
transcription factor - basic leucine zipper - regulates dorsal closure - also required downstream from Decapentaplegic signaling for the regulation of labial in the midgut

kekkon-1
Ig domain protein, Leucine-rich repeat protein - plays a role in axonal outgrowth in the central nervous system -
acts in a negative feedback loop to modulate the activity of the Egfr tyrosine kinase during oogenesis

kelch
cytoskeletal protein - actin cross-linker - during oogenesis, phosphorylation of Kelch is critical for the proper morphogenesis of actin during ring canal growth

ken and barbie
BTB-POZ domain transcription factor with C-terminal zinc finger - recruits NURF by physical
interaction to engender transcriptional repression - involved in genital disc development

kenny and immune response deficient 5 (common alternative names: IKKγ and IKKβ)
IkappaB kinase, respectively IKK regulatory and catalytic subunits - induction of antimicrobial peptide genes

Keren
ligand for Epidermal growth factor receptor - homolog of Spitz with partially independent functional activity -
provides an autocrine mitogenic stimulus in midgut progenitor cells

ketel (preferred name: Female sterile (2) Ketel)
Importin-β - an essential component of nuclear protein import, spindle formation and nuclear envelope assembly

kette (preferred name: HEM-protein)
alternatively a membrane associated and a cytosolic protein that transduces information to the neuronal cytoskeleton affecting axon guidance

kibra
signaling protein that functions together with Merlin and Expanded in a protein complex that regulates the Hippo kinase cascade
via direct binding to Hippo and Salvador

kinase suppressor of ras
Ras pathway scaffolding protein - Ksr associates independently with Raf and Mek, and these interactions facilitate formation of a RAF/MEK complex
thus promoting signaling through the Ras pathway

Kinesin associated protein 3
the non-motor accessory subunit of Kinesin II - involved in intraflagellar transport - required for the axoneme growth and maintenance of the cilia
in Drosophila type I sensory neurons - expressed in Johnston's organ and required for hearing

Kinesin heavy chain
plus end directed vesicular transport motor protein

Kinesin-like protein at 10A
mitotic kinesin required to depolymerize microtubules at their pole-associated minus ends thereby moving chromatids by means of poleward flux

Kinesin-like protein at 61F
motor protein - crosslinking and sliding activities during mitosis facilitate accumulation within antiparallel interpolar MTs
at the equator, where the motor generates force to drive spindle poleward flux and pole-pole separation

kin of irre (common alternative name: dumbfounded)
IG superfamily - required for myoblast aggregation and fusion

kismet
member of the SWI2/SNF2 family of ATP-dependent chromatin-remodeling factors - facilitates an early step in transcriptional elongation by Pol II

klarsicht
controls bidirectional transport of lipid droplets, nuclear migration and transport of secretory vesicles

klumpfuss
transcription factor - zinc finger - early growth response family - involved in determination of the identities of secondary precursor cells within neuroblast lineages in the central nervous system.

knirps
transcription factor - steroid receptor - zinc finger - a gap gene that later organizes the development of the second wing vein

knot (common alternative name: collier)
EBF/Olf-1 homolog, HLH protein - required for the formation of the hypopharyngeal lobe

Krüppel
transcription factor - zinc finger transcriptional repressor - gap gene required later for proper generation of neural sublineages

Kruppel homolog 1
zinc finger transcription factor - mediates some of the juvenile hormone signaling in the adult abdominal epidermis
and is upstream of broad in this pathway

kugelei (common alternative names: fat-like, fat2)
a cadherin related to Fat - required for the planar polarity of actin filament orientation
at the basal side of ovarian follicle cells - acts non-autonomously in follicle cells in the transmission of polarity information
required for morphogenesis and maintenance of tubular structures of ectodermal origin

kurtz
non-visual β-arrestin that functions in GPCR desensitization - regulates the Hedgehog pathway, the Notch pathway,
MAPK signaling and Toll signaling - modifies exploratory activity and olfactory sensitivity

kuzbanian
disintegrin and metalloprotease motifs - neurogenic gene

Genes A-D-- Genes L-R -- Genes S-Z

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