The Interactive Fly

The Eye-Antenna Disc and Eye Morphogenesis
Genes involved in tissue and organ development
  • Genes expressed in eye morphogenesis
  • Genes expressed in antennal morphogenesis
  • Bolwig's Organ, the Hofbauer-Buchner Eyelet and Ocelli
  • Structure of the eye
  • Development of the eye
  • Image: Specification of the eye disc primordium and establishment of dorsal/ventral asymmetry

    Eye-antenna disc
  • Specification of the eye versus the antenna
  • 5D imaging via light sheet microscopy reveals cell dynamics during the eye-antenna disc primordium formation in Drosophila
  • Transformation of eye to antenna by misexpression of a single gene
  • Genes expressed in antennal differentiation
  • Notch-dependent epithelial fold determines boundary formation between developmental fields in the Drosophila antenna
  • Identification of genomic enhancers through spatial integration of single-cell transcriptomics and epigenomics
  • Avalanches during epithelial tissue growth; Uniform Growth and a Drosophila eye disc model

    Eye development
  • The Drosophila Adult Ommatidium
  • Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis
  • Mapping gene regulatory networks in Drosophila eye development by large-scale transcriptome perturbations and motif inference
  • Stochastic spineless expression creates the retinal mosaic for colour vision
  • Binary cell fate decisions and fate transformation in the Drosophila larval eye
  • The spatiotemporal order of signaling events unveils the logic of development signaling
  • Single-base pair differences in a shared motif determine differential Rhodopsin expression
  • Polycomb group genes are required to maintain a binary fate choice in the Drosophila eye
  • Wingless mediated apoptosis: How cone cells direct the death of peripheral ommatidia in the developing Drosophila eye
  • Proteasome, but not autophagy, disruption results in severe eye and wing dysmorphia: a subunit- and regulator-dependent process in Drosophila
  • A population of G2-arrested cells are selected as sensory organ precursors for the interommatidial bristles of the Drosophila eye
  • The mir-279/996 cluster represses receptor tyrosine kinase signaling to determine cell fates in the Drosophila eye
  • The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing Drosophila eye
  • Cellular homeostasis in the Drosophila retina requires the lipid phosphatase Sac1
  • Lipidome unsaturation affects the morphology and proteome of the Drosophila eye
  • Motif 1┬áBinding Protein suppresses wingless to promote eye fate in Drosophila
  • Buffered EGFR signaling regulated by spitz-to-argos expression ratio is a critical factor for patterning the Drosophila eye
  • Herzog is not required for mushroom body development or courtship learning & memory but is required for eye development in Drosophila melanogaster
  • Cell Cycle Regulation by NF-YC in Drosophila Eye Imaginal Disc: Implications for Synchronization in the Non-Proliferative Region
  • Peripodial adherens junctions regulate Ajuba-Yorkie signaling to preserve fly eye morphology
  • A deficiency screen of the 3rd chromosome for dominant modifiers of the Drosophila ER integral membrane protein, Jagunal
  • Medioapical contractile pulses coordinated between cells regulate Drosophila eye morphogenesis

  • The actomyosin machinery is required for Drosophila retinal lumen formation
  • Ire1 supports normal ER differentiation in developing Drosophila photoreceptors
  • Past1 modulates Drosophila eye development
  • Cell surface molecule, Klingon, mediates the refinement of synaptic specificity in the Drosophila visual system
  • Integrins are required for synchronous ommatidial rotation in the Drosophila eye linking planar cell polarity signalling to the extracellular matrix
  • Nonsynaptic Transmission Mediates Light Context-Dependent Odor Responses in Drosophila melanogaster
  • Exploring the molecular makeup of support cells in insect camera eyes
  • Drosophila Phosphatase of Regenerating Liver Is Critical for Photoreceptor Cell Polarity and Survival during Retinal Development
  • Blimp-1/PRDM1 and Hr3/RORβ specify the blue-sensitive photoreceptor subtype in Drosophila by repressing the hippo pathway
  • Orthogonal coupling of a 3D cytoskeletal scaffold coordinates cell morphogenesis and maintains tissue organization in the Drosophila pupal retina
  • Establishing the contribution of active histone methylation marks to the aging transcriptional landscape of Drosophila photoreceptors
  • Identification of genes regulating stimulus-dependent synaptic assembly in Drosophila using an automated synapse quantification system


    Exploring the molecular makeup of support cells in insect camera eyes

  • Contribution of photoreceptor subtypes to spectral wavelength preference in Drosophila
  • Color discrimination with broadband photoreceptors
  • Genetic dissection reveals two separate retinal substrates for polarization vision in Drosophila
  • Identifying functional connections of the inner photoreceptors in Drosophila using Tango-Trace
  • Loss of Na/K-ATPase in Drosophila photoreceptors leads to blindness and age-dependent neurodegeneration
  • Proteins involved in visual signal transduction
  • Anatomical reconstruction and functional imaging reveal an ordered array of skylight polarization detectors in Drosophila
  • Circuit mechanisms underlying chromatic encoding in Drosophila photoreceptors

  • progression of the morphogenetic furrow across the eye disc
    Progression of the morphogenetic furrow across the eye disc

    Genes involved in eye morphogenesis

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