The Interactive Fly

progression of furrow across discProgression of the morphogenetic furrow
across the eye disc

diagram © 1999: Jessica Treisman, Skirball Institute

See specification of the eye disc primordium and establishment of dorsal/ventral asymmetry.

Progression of the morphogenetic furrow (blue vertical line) from posterior to anterior (here, right to left) across the eye disc is driven by hedgehog (hh) expressed in the developing photoreceptors (red dots).

hh activates the expression of decapentaplegic (dpp) and the proneural gene atonal (ato) in the furrow. ato expression is refined to the future R8 photoreceptor and is required for the development of this cell.

Photoreceptors further away from the morphogenetic furrow (on the right) are further along in their development. Other photoreceptors and accessory cells are recruited to each ommatidial cluster (composed of developing photoreceptors) by waves of expression of the ligand spitz (spi) for the EGF receptor.

back to Eye morphogenesis

Home page: The Interactive Fly © 1995, 1996 Thomas B. Brody, Ph.D.

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