logo Drosophila genes listed by biochemical function
Miscellaneous transcription factors and chromatin proteins A - G ||H - O || P - Z

absent, small, or homeotic discs 1
histone methyl transferase that indirectly prevents gene silencing - provides
a specific signal for establishment of active transcription

absent, small, or homeotic discs 2
trithorax family member - maintains active transcription by binding a producer of nuclear phosphoinositides
and downregulating histone H1 hyperphosphorylation

Activating transcription factor-2 (alternative name: Atf-2)
transcription factor - basic leucine zipper protein - regulates fat metabolism and osmotic stress response

Activating transcription factor 3
basic leucine-zipper transcription factor - partner of Jun in preventing extrusion and replacement
of epidermal cells with histoblasts during larval morphogenesis

Adh transcription factor 1 (common alternative name: Nalyot)
transcription factor - Myb helix-turn-helix family

abnormal chemosensory jump 6 (common alternative name: Ipou)
transcription factor - homeodomain and POU domain

always early
regulator of chromatin structure - a 'meiotic arrest' gene required for transcription
of key G2-M cell cycle control genes and of spermatid differentiation genes

anterior open (common alternative name: pokkuri and yan)
ets domain

anti-silencing factor 1
histone chaperone that assists in chromatin assembly and remodeling during replication, transcription activation,
and gene silencing - contributes to the repression of Notch target genes - directly interacts Hairless

transcription factor that plays essential roles in leg and proboscis outgrowth -
involved in development of the adult brain central complex

novel bZIP transcription factor and RNA-binding protein

ATP-utilizing chromatin assembly and remodeling factor
PHD finger motifs and chromodomain - involved in chromatin assembly

barren (common alternative name: CAP-H)
CAP-H homologue, a condensin subunit exclusively associated with condensin I - promotes sister chromatid resolution
and maintains the structural integrity of centromeric heterochromatin during mitosis

proneural - basic amphipathic alpha-helix

Bicoid interacting protein 1 (common alternative name: Sap18)
part of the Sin3A/Rpd3 histone deacetylase complex - helps convert Bicoid from an activator
into a repressor by recruitment of a co-repressor to Bicoid-dependent promoters

fork head domain transcription factor essential for maintaining the distinction between splanchnic and somatic
mesoderm and for differentiation of the splanchnic mesoderm into midgut musculature

produces non-coding RNA that may mediate or counteract epigenetic silencing - bxd RNA mediates recruitment of Ash1
to stimulates gene expression

blistered (common alternative name: Serum response factor)
MADS-box motif

Boundary element-associated factor of 32kD (common alternative name: BEAF)
chromatin protein required for insulator function, and chromatin structure and dynamics - required for oogenesis and zygotic development

trithorax group - SWI2/SNF2 homolog - DNA dependent ATPase - helicase motif

Brahma associated protein 55kD
member of both the Brahma and the Tat interactive protein 60 kD (TIP60) ATP-dependent chromatin remodeling complexes -
functions through the TIP60 complex to regulate dendrite wiring specificity in olfactory projection neurons -
as a member of the Brahma complex it is needed for cell growth and survival in the wing imaginal disc

transcription factor TRF1 forms a complex with the TFIIB-related factor Brf that plays a major role in RNA pol III transcription

bric à brac
transcription factor bearing a BTB/POZ domain

novel transcription factor bearing weak homology to homeobox domains

bunched (common alternative name: shortsighted)
transcription factor - leucine zipper - dpp pathway

TAFII80, Trp-Asp repeat (WD-repeat) protein expressed only in spermatocytes, where it is required for
transcription of genes required for spermatid differentiation

transcription factor - HMG box protein

basic leucine zipper

caravaggio (common alternative names: HOAP, HP1/ORC-associated protein)
poorly conserved component of the telomere capping complex - prevents end fusion
by maintaining a chromatin state that is independent of the underlying DNA sequence

centromere protein required for normal attachment of kinetochores to the spindle

centromere identifier
a variant of histone H3 - chromatin component that plays a key role in assembling the kinetochore at meiosis and mitosis

Centrosomal protein 190kD
BTB/POZ domain and microtubule binding protein that alternatively serves as a chromatin insulator and as a component of centrioles -
involved in axial expansion, the spreading out along the anterior-to-posterior axis during syncytial development

transcription factor - enhancer facilitator

chromodomain protein that contributes to the maintenance of polytene chromosome morphology - a component of spindle matrix that contributes to microtubule spindle dynamics and proper chromosome segregation during mitosis

chromosome alignment defect 1
substochiometric centromeric linker protein involved in centromere propagation - regulator of centromeric deposition
of Cenp-A/Cid and Cenp-C during exit from mitosis

Chromosome associated protein D3
condensin II subunit, chromosome assembly and segregation during mitosis and meiosis - regulation of anti-bacterial
immune determinants - restriction of retrotransposon mobilization

Chromosome associated protein H2
a condensin II subunit functioning during meiosis - promotes prophase I chromosome territory formation
preventing heterologous chromosomal associations - promotes disassembly of polytene chromosomal structure into chromosomal components

Chronologically inappropriate morphogenesis
BTB/POZ domain transcription factor - helps specify distinct birth order-dependent cell fates in an extended neuronal lineage -
regulates the time at which neuroblasts undergo Prospero-dependent cell-cycle exit or Reaper/Hid/Grim-dependent apoptosis

REB/ATF superfamily bZIP domain transcription factor - controls expression of diverse neuropeptides and peptide hormones involved in metamorphosis

potential transcription factor - light response protein - cryptochrome/photolyase

Chromodomain-helicase-DNA-binding protein
chromodomain protein in the SNF2-like family of ATPases - functions in assembly of active chromatin

Chromatin assembly factor 1 subunit
A histone chaperone protein

clockwork orange
a transcriptional repressor that synergizes with Per and inhibits Clk-mediated activation -
acts preferentially to help terminate Clk-Cyc-mediated transcription of direct target genes

Co-repressor of Pangolin
Myb/SANT-like transcription factor that antagonizes Wingless signaling binding to Pangolin

corepressor, component of L(3)mbt repressor complex, component of LSD1-CoREST demethylase, complex regulation of Notch signaling, ovarian follicular cells, wing, regulates DPP signaling, associates with Charlatan

Chromodomain protein - partners with CycG which regulates the activity of Corto at chromatin - acts alternatively as an enhancer of TrxG and an Enhancer of PcG

A novel Polycomb group protein

CrebB-17A (preferred name: Cyclic-AMP response element binding protein B; common alternative name: dCREB2)
cAMP response element binding protein

CREB-binding protein (preferred name: nejire)
CBP, a transcriptional co-activator

CREB-regulated transcription coactivator
transcription factor - transducer of regulated CREB activity - starvation triggers TORC activation -
TORC maintains energy balance through induction of CREB target genes in the brain

winged helix, forkhead family

potential transcription factor - light response protein - cryptochrome/photolyase

C-terminal binding protein
transcription factor-interacting protein

cut homeodomain

a protein related to a yeast transcription termination factor - involved in piwiRNA cluster expression, which is critical for oocyte development

transcription factor - bHLH, pas domain - photoperiod response

Cyclic-AMP response element binding protein A
basic leucine zipper - regulates secretory pathways

Cyclic-AMP response element binding protein B (common alternative names: dCREB2 and CrebB-17A)
cAMP response element binding protein

dCREB2 (preferred name: CrebB-17A)
basic leucine zipper - regulates learning and memory

retina aberrant in pattern
transcription factor - ARID domain protein

Deformed epidermal autoregulatory factor-1
SAND and zf-MYND domain transcription factor - involved in embryonic development, Deformed autoregulation and the immune response

Diabetes- and obesity regulated
coactivator of ecdysone receptor needed during metamorphosis - antagonized by insulin signaling via FOXO in the fat body -
part of a feed-forward mechanism whereby ecdysone potentiates its own signaling - regulates autophagosome formation and protein degradation

Dichaete (preferred name: Sox box protein 70D, common alternative name: fish-hook)
HMG-domain protein - SOX-domain protein

disc proliferation abnormal
Licensing factor component - Zn finger motif - cdc21 homolog - MCM4 homolog - Chromatin component

distal antenna & distal antenna-related
two closely linked genes coding for pipsqueak domain proteins - effector genes that act downstream
of homothorax and Distal-less to control differentiation of distal antennal structures

DJun (preferred name: Jun related antigen)
basic leucine zipper

DNA replication-related element factor
a transcription factor that activates genes involved in cell proliferation

transcription factor - NFkappaB/rel homolog - functions in establishment of dorsal/ventral polarity - Dorsal and DIF act downstream of the Toll pathway in the immune response

Dorsal interacting protein 3
MADF DNA-binding domain and BESS protein interaction domain protein - interacts with Rel domain proteins -
enhances Rel family transcription factor function in both dorsoventral patterning and the immune response

Dorsal related immune factor
NFkappaB/rel homolog - a regulator of the immune response - Dorsal and DIF act downstream of the Toll pathway in the immune response

forkhead/winged-helix class

DNA helicase/adenosine triphosphatase - component of the Tip60 chromatin-remodeling complex
that acetylates nucleosomal phospho-H2Av and exchanges it with an unmodified H2Av

NFkappaB/rel homolog

Dorsal related immune factor
NFkappaB/rel homolog

novel - sex determination

DP transcription factor
transcription factor - obligate dimerization partner of E2f1 and E2f2 - required for normal cell proliferation,
optimal DNA synthesis, and efficient G2/M progression

transcription factor - along with Structure specific recognition protein (Ssrp) forms a protein complex, FACT,
that facilates GAGA factor directed chromatin remodeling

E2F transcription factor
positively regulates genes involved in the S (DNA synthesis) phase of the cell cycle

E2F transcription factor 2
negatively regulates genes involved in the S (DNA synthesis) phase of the cell cycle

Ecdysone-induced protein 74EF (also known as E74A and E74B)
alternatively spliced ets domain transcription factor that controls the timing of gene activation during molting

Ecdysone-induced protein 93F
Pipsqueak family transcription factor - programs a cell death response during larval development

SET domain hydroxymethyltransferase required for oogenesis - trimethylates histone H3 at its K9 residue - involved in gene silencing

Enhancer of bithorax
nucleosome remodeling factor - NURF301

Enhancer of Polycomb
novel Polycomb group protein and a suppressor of position effect variegation

Enhancer of yellow 3 (common alternative name: SAYP)
Trithorax group protein, constituent PBAP chromatin remodeling complex, a coactivator supercomplex consisting of Brahma and TFIID;
participates in ecdysone-dependent transcriptional regulation

erect wing
novel transcription factor

Ets at 21C
stress-induced transcription factor - controls intestinal stem cell proliferation & enterocyte apoptosis through distinct sets of target genes - loss of function prevents
epithelial aging - ectopic expression increases tumor size - expression is regulated by the JNK pathway - Capicua represses cell proliferation via direct targets including Ets21C

Ets at 65A
Ets domain transcription factor - regulation of cholinergic cell fate - acts combinatorially to control T1 neuron morphogenesis in the optic lobe, brain and CNS

Ets at 97D
Ets domain transcription factor - homolog of the alpha subunit of mammalian NRF-2/GABP - required for proper expression of most genes encoding mitochondrial proteins -
regulator of mitochondrial number and mass - required for proper follicle cell migration, chorion formation, and nurse cell chromosome decondensation

extra macrochaetae
HLH non basic

eyelid (preferred name: osa)
Bright family

eyes absent (preferred name: clift)
transcriptional co-activator and protein tyrosine phosphatase - cell survival factor - functions in eye development -
also plays a role in the embryonic determination of somatic gonadal precursor (SGP) cell fate

female sterile (1) homeotic
double-bromodomain protein - trithorax group gene that cooperates with Zeste in Ultrabithorax activation

fork head
forkhead domain transcription factor - formation of the embryonic salivary glands

Forkhead box P
forkhead domain transcription factor - a highly conserved transcription factor known for its importance in human speech and language production -
reduced expression in Drosophila leads to decreased levels of courtship behavior, altered pulse-song structure, and sex-specific motor impairments in walking and flight

forkhead domain 3F
required for the specialization of mechanosensory cilium of chordotonal neurons

Fos-related antigen (preferred name: kayak)
transcription factor - basic leucine zipper

forkhead domain transcription factor - a target of the insulin receptor signaling pathway -
modulates growth and proliferation

transcriptional corepressor - inhibits Dpp signaling acting by inhibiting Smad4 - acts within
a chromatin modifying complex in the differentiation of bitter gustatory neurons - acts within an Rpd3 dependent
chromatin modifying complex - ortholog of the human functional smad suppressing element 15 (fussel-15), also
known as SKOR1, Corl1 or LBXcor1 within a chromatin modifying complex - protooncogene that
retains the ability of Ski/Sno proteins to inhibit the antiproliferative effects of TGF-β signalling

limits DNA replication by preventing Mcm loading onto chromatin

germ cell-less
chromatin component - BTB/POZ domain protein- responsible for establishment transcriptional quiescence in germ cells

basic leucine zipper - gap gene

glial cells missing

condensin subunit SMC4 - involved in mitotic chromatin condensation

WD40 domain - E(spl) comples

transcriptional cofactor for Even-skipped - homolog of mammalian Atrophin

novel basic protein - interacts with Suppressor of Hairless

Heat shock factor
master regulator of heat shock response - leucine zipper transcription factor

heterochromatin protein 1 (preferred name: Suppressor of variegation 205)
chromodomain - Polycomb group - chromatin binding protein

Heterochromatin Protein 1c
chromodomain protein - chromatin interactor and organizer - transcriptional co-regulator -
transcriptional activator - a components of a multiprotein complex involved in nervous system development - regulator of telomere function

Heterochromatin Protein 1e
testis-specific HP1 protein that acts during spermiogenesis by exerting post-fertilization control
to ensure faithful chromosome segregation in the embryo

Hexamethylene bisacetamide inducible
negative regulator of transcription from RNA polymerase II promoters - ensures the integrity of Hedgehog signaling
in the wing disc - component of a macromolecular complex that keeps TEFb in a catalytically inactive state

High mobility group protein - d
HMG domain protein

Hira (alternative name Sesame)
histone chaperone - required for nucleosome assembly during sperm nucleus decondensation - GAGA factor and
FACT-dependent replacement of methylated histone H3 by H3.3 occurs through association with Hira

Histone deacetylase 3
chromatin component - deacetylates histone H4 - counteracts the overgrowth induced by InR, PI3K or S6K over-expression -
a target of the PI3K pathway - helps retain chromatin compaction and gene silencing in nuclear lamina-interacting multigenic chromatin domains

Histone gene-specific Epigenetic Repressor in late S phase
chromatin component - a molecular switch linking epigenetic gene silencing to cell cycle-dependent histone production

Histone H1
Chromatin component - linker histone

Histone H1 variant BigH1
germline linker histone that enhances transcriptional silencing - replaced by somatic dH1 in somatic cells - oogenesis and
spermatogenesis - along with the translational regulator Bam forms a repressor loop essential for male germ stem cell differentiation

Histone H2A
Chromatin component - a core histone that can be modified by ubiquitination - a target of polycomb gene silencing -
involved in trans-histone regulation through histone H3

Histone H2A variant
replacement histone participates in an ordered cascade of events leading to the
establishment of heterochromatin

Histone H2B
Nucleosome core histone component, chromatin assembly, target of ubiquitination by the dosage compensation and SWI/SNF complexes,
regulates of neuronal connectivity in the visual system, regulates Notch target genes and repression of key differentiation genes

Histone H3
Nucleosome component - core histone

Histone H3.3A
H3 histone subtype - deposition is coupled to transcription and continues while a gene is active -
histone replacement suggests a mechanism to maintain both the structure of chromatin and access to DNA at active genes

Histone H4
Nucleosome component - core histone

Holes in muscle
WRPW motif protein that binds Groucho to inhibit both muscle differentiation and Mef2 activity during development

HP1 family member - mchromatin interactor and organizer - physically interacts with DNA-binding zinc-finger transcription factors
Without children and Relative-of-WOC to act as a transcriptional activator

Hybrid male rescue
transcription factor and chromatin factor - boundary element protein - along with Lethal hybrid rescue interacts with HP1 to repress transcripts
from satellite DNAs and many families of transposable elements - gain-of-function phenotype causing lethality in F1 male hybrids between D. melanogaster and D. simulans

the Cdc73 component of the Polymerase-Associated Factor 1 (PAF1) complex - required for nuclear transduction of the Wnt/Wg signal -
manifests its effects on transcription through modulating chromatin structure

Imitation SWI (common alternative name: ISWI)
ATPase domain - chromatin remodeler

a nuclear factor that physically interacts with Suppressor of Hairless and inhibits Notch signalling during peripheral nervous system development

Inverse regulator a (common alternative name: Pre-mRNA cleavage complex 2 protein Pcf11)
forms a bridge between the RNA polymerase C-terminal domain and RNA- dismantles elongation
complexes by a C-terminal domain-dependent but nucleotide-independent mechanism

Inverted repeat binding protein 18 kDa
bZIP transcription factor - Minute cell competition, arising from mutation of ribosomal proteins, requires the transcription factors
Irbp18 and Xrp1 - Xrp1 forms heterodimers with Irbp18, and removal of Irbp18 also strongly suppresses the competitive
elimination of Rp/+ cells in mosaic tissues - IRBP18/Xrp1 heterodimer binds sequence-specifically to its dsDNA-binding site
within P-element terminal inverted repeats - both proteins are critical for repair of DNA breaks following transposase cleavage in vivo

jing-interacting gene regulatory 1
a putative DNA-binding protein containing a MADF domain - hosts miR-92a in the intron and miR-92b
in the 3'UTR - miRNA limits expression in neuroblasts and is essential for maintenance of a neuroblast pool

Jumonji, AT rich interactive domain 2 (alternative name: Jarid2)
component of Polycomb repressive complex 2, which is involved in methylation of histone 3 at K27, required for transcriptional repression

Jun related antigen (common alternative name:: DJun)
basic leucine zipper transcription factor - activated through RAS/MAPK-mediated phosphorylation - interacts with Fos - serves to activate genes
involved in neural function and the immune response - cooperates with the ETS domain protein Pointed to induce R7 fate in the developing eye

kayak (common alternative name: Fos-related antigen)
transcription factor - basic leucine zipper

member of the SWI2/SNF2 family of ATP-dependent chromatin-remodeling factors -
facilitates an early step in transcriptional elongation by Pol II

EBF/Olf-1 homolog, HLH protein

an intermediate filament protein - chromatin associated protein

Lethal hybrid rescue
chromatin factor - contains BESS motif found in boundary element proteins - along with Hybrid male rescue interacts with HP1 to repress transcripts from satellite
DNAs and many families of transposable elements - gain-of-function phenotype causing lethality in F1 male hybrids between D. melanogaster and D. simulans

lethal (3) malignant brain tumor
a chromatin compactor - tumor suppressor - targets Salvador-Warts-Hippo pathway - inactivator of germline genes - mutation result in the formation of brain tumors

transcription factor - Fragile X mental retardation 2 (Fmr2) family

phosphatidate phosphatase activity - transcriptional co-activator - downstream effector mediating effects of insulin and TORC1 signaling on lipid metabolism -
influences fat body development and function - affects cellular growth

little imaginal discs
trimethyl H3K4 demethylase - physically interacts with Myc to regulator Myc-induced cell growth

lola like
BTB/POZ domain protein - partner of Trithorax-like in maintaining gene repression

Lost PHDs of trr (alternative name: Cara mitad)
PHD zinc finger protein - cofactor for Trithorax-related - associates with EcR-USP receptor
and is required for hormone-dependent transcription - required for proper global trimethylation of H3K4

AML-1 homolog

DEAH-box subfamily ATP-dependent helicase

male-specific lethal-1
chromatin component - dosage compensation - basic motif, leucine zipper-like motif, glycine-rich motif protein that directly binds DNA

male-specific lethal-2
chromatin component - dosage compensation - ring finger - metallothionein motif

male-specific lethal 3
chromatin component - dosage compensation - MRG family, chromo-barrel domain

males absent on the first
histone acetyltransferase involved in dosage compensation

marelle (preferred name: STAT)
stat homolog

novel - neurogenic

maternal gene required for meiosis (common alternative name: Mamo)
BTB transcription factor - essential for the temporally defined, terminal identity of alpha'/beta' mushroom body neurons
and identity maintenance - required for the production of functional oocytes - necessary for vasa expression

methyl-DNA binding protein involved in methylation dependent transcriptional repression

Smad family member

Mediator complex subunit 1
a specific cofactor for GATA TFs - coactivator for the GATA factor Pannier during thoracic development - required
for cell proliferation and hematopoietic differentiation dependent on the GATA TF Serpent development

Mediator complex subunit 19
a subunit of the Mediator complex - directly binds Hox homeodomains, modulating Hox-directed developmental outcomes

Menin 1
conserved chromatin factor that modulates Jun activity in a manner dependent on the cellular context - tumor suppressor that functions
in maintenance of genomic integrity - controls stress responses

ATP dependent DNA helicase - Zinc finger, C4HC3 type (PHD finger)

a conserved regulator of cell cycle, co-ordination of centrosome and nuclear division cycles, and maintenance of chromosome condensation

modifier of mdg4
GAGA-like, BTB domain - interacts with suppressor of Hairy wing on gypsy insulator element

RRM-containing domain - modifier of PEV promoting chromatin compaction and inactivation - controls cellular growth rate downstream of dMYC

Trithorax-complex protein - SWI3 homolog - chromatin remodeling protein

Mothers against dpp
presumptive novel transcription factor - downstream of DPP

Motif 1 Binding Protein
a transcriptional activator that associates with a core promoter element known as Motif 1 - a member of the Enhancers of trithorax
and polycomb (ETP) family - boundary element binding protein - participates in co-regulation of ribosomal protein genes

multi sex combs
chromatin factor involved in assembly of histone locus body, an essential histone mRNA processing factor,
hemocyte proliferation and differentiation

mushroom body miniature
PHD finger superfamily protein - a nucleolar protein required for small ribosomal subunit biogenesis - transcriptionally
regulated by Myc which relays information from nutrient dependent signaling pathways to ribosomal gene expression -
part of the Myc and CK2 regulatory networks for coordination of neuroblast growth and proliferation

Myocardin-related transcription factor
conserved cofactor for serum response factor - required for border cell migration during oogenesis -
activation induced by cell stretching - regulates tracheal branching

multiprotein bridging factor 1
Helix-turn-helix transcription factor - coactivator that translocates from the cytoplasm into the nucleus to induce stress-response genes - protects
Enhancer of zeste mRNA from Pacman activity thereby ensuring Polycomb silencing - AP-1-dependent epithelial closure becomes sensitive to H2O2 in
flies lacking MBF1 - co-activator for Tracheae Defective contributing to the formation of tracheal and nervous systems

myocyte enhancer factor 2
mads box

Myb oncogene-like
Myb DNA-binding domain

Myelodysplasia/myeloid leukemia factor
interacts with various factors involved in transcriptional regulation, regulates cell proliferation during eye morphogenesis,
Lozenge activity during hematopoetic development and assembly of the COP9 signalosome complex

transcriptional cofactor - co-activator of Squeeze in CNS neurons - co-repressor of Rotund in wing

Negative elongation factor E
RNA-binding protein - along with other factors, NELF causes polymerase to pause in the promoter proximal region of heat shock genes

CREB-binding protein, a transcriptional co-activator

probable transcriptional co-repressor- described as an AKAP binding protein, zinc finger protein expressed in the CNS and involved in axon guidance

Homologue of the yeast Tra1 and human TRRAP proteins - a key component of both the SAGA and Tip60 (NuA4) chromatin-modifying complexes -
required for Mastermind function during wing development

a DNA-binding transcription factor regulates gene expression by controlling cohesin dynamics - regulates of sister chromatid cohesion

Nucleoporin 98-96kD
transcriptional regulator - viral-induced primary response gene - lymph gland hematopoietic development

Nucleosome assembly protein
Histone chaperone - chromatin assembly

NURF301 (preferred name: Enhancer of bithorax
Major subunit of Nucleosome remodeling factor

orientation disrupter
rapidly evolving gene - involved in meiotic cohesion, chromosome core maintenance and homologous recombination

Origin recognition complex 2
A subunit of the Origin recognition complex, involved in initiation of DNA replication

Origin recognition complex subunit 6
A DNA-binding protein that functions as subunit of the Origin recognition complex - involved in initiation of DNA replication -
facilitates GTPase activity and filament formation of the septin complex

osa (common alternative name: eyelid)
Bright family

DNA repair pathway and apoptosis transcription factor

Paired box neuro
paired domain - no homeodomain is present

Part of a protein complex that directs the histone methyltransferase activity and links active transcription and modifications of chromatin structure.

transcription factor - HMG domain - segment polarity

PAR-domain protein 1
PAR-domain bZIP transcription factor

PAX transcription activation domain interacting protein
BRCT (BRCA1 carboxy terminal) domain protein that can bind to phosphorylated serine residues - chromatin-binding protein implicated in epigenetic control
of development and differentiation - potential trithorax gene cofactor - potential interactor with transcription factors that also serves as a modifier of histones

Pcaf (common alternative name: Gcn5)
a major histone H3 acetylase in Drosophila that plays a key role in the control of specific morphogenetic cascades during developmental transitions

P-element somatic inhibitor
splice factor that regulates the thermosensitive alternative splicing of timeless (tim) - AGO1 interacts with Psi to repress Myc
transcription and inhibit developmental cell and tissue growth - Psi interacts with the mediator complex to modulate MYC transcription - Psi interaction
with the U1 small nuclear ribonucleoprotein complex (snRNP) controls male courtship behavior by regulation splicing
for fruitless - regulates splicing of the P-element transposase pre-mRNA by binding a pseudo-splice site upstream of the authentic splice site

transcription factor - pas domain - photoperiod response

PHD finger protein 7 ortholog
chromatin component - conserved epigenetic 'reader' that activates the male germline sexual program -
binds histone H3 N-terminal tails with a preference for dimethyl lysine 4

BTB domain & Psq motif transcription factor that targets a Polycomb group protein complex to Polycomb response elements

ets family

pokkuri (preferred name: anterior open, common alternative name: yan)
ets domain

transcription factor - chromo domain - Polycomb group - chromatin binding

a member of a distinct chromatin complex - functions downstream of Pleiohomeotic in the assembly of a repressive complex
that generates high levels of H3-K27 trimethylation in Polycomb target genes

Pox meso
Pax family transcription factor - demarcates the 'Poxm competence domain', a domain of competence for ventral and lateral muscle development
and for the determination of at least some adult muscle precursor cells

Pre-mRNA cleavage complex 2 protein Pcf11 (preferred name: Inverse regulator a)
forms a bridge between the RNA polymerase C-terminal domain and RNA- dismantles elongation
complexes by a C-terminal domain-dependent but nucleotide-independent mechanism

PR/SET domain containing protein 7
Set domain protein - methyltransferase that targets Histone H4 - helps maintain silent chromatin by a histone modification
that precludes neighboring acetylation of the H4 tail

multifunctional signaling protein involved in neurotransmitter release, a mitochondrial protein and a chromatin protein
functioning as a protamine chaperone in nucleosome assembly during sperm chromatin remodeling

nuclear PHD-finger protein - a core component of the Wingless signaling pathway that acts downstream of or at the level of Pangolin

Ankyrin-repeat and NFkappaB domain protein - a key factor in the induction of the humoral immune response in
Drosophila, including antibacterial as well as antifungal factors - Relish acts in the IMD pathway
Repressed by TOR (common alternative name: REPTOR)
Basic leucine zipper (bZIP) domain transcription factor - together with its binding partner encoded by REPTOR-BP, mediates much of the transcriptional response
observed upon Tor complex 1 inhibition - plays critical roles in maintaining energy homeostasis and promoting animal survival upon nutrient restriction

retina aberrant in pattern (common alternative names: retained and dead ringer)
transcription factor - ARID domain protein

Retinoblastoma-family protein
cell cycle regulator

Retinoblastoma-family protein 2
cell cycle and developmental regulator - functions in concert with E2F2 to repress the expression of differentiation markers
in ovaries and embryos where RBF2 is highly expressed

transcription factor - RFX DNA-binding domain - essential regulator of ciliated sensory neuron differentiation

HP1 homolog - required for nuage organization, transposon silencing, and ping-pong amplification of Piwi-interacting RNAs

BTB/POZ domain transcription factor - a regulator of epithelial morphogenesis that promotes cell migration

RNA on the X-1
X chomosome associated RNA

RNA polymerase II 215kD subunit
large subunit of the enzyme that catalyzes the synthesis of a complementary strand of RNA from a DNA template

histone deacetylase

functions as part of a protein complex in the monoubiquitination of histone H2B and the consequent methylation of histone H3 - functions in Notch signaling

Runt domain protein - pair rule gene

SAGA factor-like TAF6
histone fold domain protein - component of histone acetyltransferase (SAGA) complex - required for SAGA coactivator function

SAYP (Preferred name: Enhancer of yellow 3)
constituent PBAP chromatin remodeling complex, a coactivator supercomplex consisting of Brahma and TFIID; participates in ecdysone-dependent transcriptional regulation

SMRT-related ecdysone receptor-interacting protein

human TEF-1 homolog

Scm-related gene containing four mbt domains
PcG protein - Pleiohomeotic interactor that binds mono- and di-methylated H3-K9 and H4-K20
and acts to maintain a Polycomb-repressed chromatin state

Serum response factor (preferred name: blistered)
MADS-box motif

Histone 3 methyltransferase involved in dosage compensation, puparium formation and adult development

Sex combs extra (common alternative name: Ring)
Polycomb group - protein ubiquitination - a member of a protein complex, termed PRC1 (Polycomb repressive complex 1)

Sex combs on midleg
Polycomb group

shortsighted (preferred name: bunched)
transcription factor - leucine zipper - dpp pathway

shuttle craft
zinc finger, C4HC3 type (PHD finger), and RD-domain protein

transcriptional corepressor; component of histone deacetylase complex that affects cell cycle progression

histone deacetylase required for euchromatic and heterochromatic silencing - interacts genetically and physically with members of the Hairy/Deadpan/E(Spl) family of bHLH euchromatic repressors

sloppy paired 1 and 2
forkhead domain

slow border cells
basic leucine zipper - CCAAT/enhancer-binding protein homolog

snf5-related (common alternative name: snr1)
SWI/SNF family

Sox box protein 15
HMG-domain protein - SOX-domain protein - under the control of the canonical wingless pathway such that
wg and Sox15 regulate each other's transcription through a feedback loop that results in proliferation of wing hinge cells

Sox box protein 70D (common alternative name: Dichaete or fish-hook)
HMG-domain protein - SOX-domain protein

essential for enterocyte differentiation from enteroblast in the midgut - involved in feedback amplification loop that leads to rapid production from
intestinal stem cells of differentiation-defective enteroblasts and subsequent tumorigenesis - Sox100B directly regulates Sox21a to
promote differentiation - Sox21a and GATAe form a functional relay to orchestrate EB differentiation - genetic interaction
between peroxisomes and the JAK and STAT signaling restores the expression defect of Sox21a in peroxisome defective cells

a critical regulator of adult intestinal stem cell differentiation - required for differentiation of enteroblast progenitors into absorptive enterocytes - depletion inhibits
ISC proliferation via cell cycle arrest, while overexpression inhibits ISC proliferation by directly suppressing EGFR expression - testes differentiation

(common alternative name: SoxD) HMG-domain protein - SOX-domain transcription factor - optic lobe - olfactory perception - neuromuscular
junction - axon guidance, adult courtship behavior - wing - heart

HMG1/2 (high mobility group) box transcription factor - essential for the formation of neural
progenitor cells in the central nervous system

transcriptional coactivator - required for the expression of multiple genes encoding mitochondrial proteins - mediates mitochondrial activity,
cell growth and transcription of target genes in response to insulin signalling

transcription elongation factor implicated in RNA processing and degradation of improperly processed pre-mRNA

STAT (common alternative name: marelle)
STAT homolog

Structure specific recognition protein
transcription factor - along with Dre4 forms a protein complex, FACT,
that facilates GAGA factor directed chromatin remodeling

Suppressor of hairless
integrase domain - Notch pathway

suppressor of Hairy wing
zinc fingers and leucine zipper - binds gypsy insulator element

Suppressor of Under-Replication
SNF2-domain protein - inhibits replication fork progression to promote DNA underreplication< - binds to H1
which is required for SuUR binding to chromatin in vivo - interacts with Rif1 which has a direct role in copy number control

Suppressor of variegation 3-3
homolog of the human LSD1 amine oxidase - demethylates H3K4me2 and H3K4me1 and facilitates subsequent H3K9 methylation by SU(VAR)3-9 -
dictates the distinction between euchromatic and heterochromatic domains during early embryogenesis

Suppressor of variegation 3-7
chromatin constituent - C2H2 zinc finger protein - required for X-restricted dosage compensation complex targeting

Suppressor of variegation 3-9
involved in gene silencing - a modifier of position effect variegation - methylates histone H3 thus providing a mark for the association of HP1 to heterochromatin

Suppressor of variegation 205 (common alternative name: heterochromatin protein 1)
chromodomain - Polycomb group - chromatin binding protein

Polycomb group - histone methyltransferase activity- constituent of polycomb PRC2 complex - functions in
nucleosome binding of Drosophila PRC2 - essential for tri-methylation of the lysine 27 residue of histone H3

steroid hormone receptor coactivator

a novel trithorax group member potentially linked to the cell cycle regulatory apparatus, required for normal sleep patterns, protects regenerating tissue
from fate changes induced by the wound response, determinant of larval type I lineage-specific neural progenitor proliferation patterns, apparatus

TATA binding protein
general transcription factor - component of TFIID - activates TATA-dependent transcription and represses DPE-dependent transcription

TATA box binding protein-related factor 2
differentially recognizes and regulates a subset of TATA-less promoters

TBP-associated factor 1
general transcription factor - kinase and histone transacetylase activities

Tbp-related factor
general transcription factor - cell type specific TATA-binding protein

TfIIS (RNA polymerase II elongation factor)
critical for efficient release of stalled RNA Pol II from intrinsic stop sites in promoter regions -
promotes transcriptional elongation and decreases pausing

novel with pas domain - photoperiod

PHD zinc finger and bromodomain chromatin component - acts positively to activate proneural gene expression
in the PNS - associates with Iswi, Pnr and Chip - required during Pnr-driven neural development

traffic jam
orthologue of a large Maf transcription factor in mammals - gonad development - somatic gonadal cells - follicle cells - germline-soma
interactions - a transcriptional target of Hh signaling controlling cell-cell adhesion by negative regulation of E-cadherin expression

trithorax related
constituent of the Trr H3K4 methyltransferase, nuclear receptor co-activator complex, acts as a coactivator of Ecdysone receptor
by altering the chromatin structure at ecdysone-responsive promoters

presumptive transcription factor - novel

basic leucine zipper transcription factor

X-box-binding protein 1
basic leucine zipper - unfolded protein response (UPR) - enhances the expression of genes encoding ER chaperones, enzymes, and the ER protein degradation machinery

DEAD-like helicases superfamily - complements HIRA in recognizing exposed DNA and serving as a binding platform
for the efficient recruitment of H3.3 predeposition complexes to chromatin gaps

bZip-domain transcription factor - transcriptionally upregulated by an autoregulatory loop - triggers apoptosis in competitively looser cells - regulates translation and growth, delays development and is responsible for gene expression changes in mutant ribosomal proteins - induced by p53 following X-irradiation - partner of Inverted Repeat Binding Protein 18 - critical for repair of DNA breaks following transposase cleavage of DNA

yan (preferred name: anterior open)
ets domain - antagonist of ras

ortholog of the mammalian transcriptional coactivator yes-associated protein
- transcriptional coactivator that negatively regulates cell-cycle and cell-death regulators

transcription factor - hlh domain and leucine zipper domain - trithorax group

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Drosophila genes listed by biochemical function

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