Fly Labs and References


  • Rongwen Xi National Institute of Biological Science, Beijing
    Shi, J., Jin, Z., Yu, Y., Zhang, Y., Yang, F., Huang, H., Cai, T. and Xi, R. (2020). A Progressive Somatic Cell Niche Regulates Germline Cyst Differentiation in the Drosophila Ovary. Curr Biol. PubMed ID: 33340458

    Jin, Z., Chen, J., Huang, H., Wang, J., Lv, J., Yu, M., Guo, X., Zhang, Y., Cai, T. and Xi, R. (2020). The Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level. Cell Rep 31(8): 107683. PubMed ID: 32460025

    Li, Z., Guo, X., Huang, H., Wang, C., Yang, F., Zhang, Y., Wang, J., Han, L., Jin, Z., Cai, T. and Xi, R. (2020). A Switch in Tissue Stem Cell Identity Causes Neuroendocrine Tumors in Drosophila Gut. Cell Rep 30(6): 1724-1734.e1724. PubMed ID: 32049006

    Guo, X., Yin, C., Yang, F., Zhang, Y., Huang, H., Wang, J., Deng, B., Cai, T., Rao, Y. and Xi, R. (2019). The cellular diversity and transcription factor code of Drosophila enteroendocrine cells. Cell Rep 29(12): 4172-4185.e4175. PubMed ID: 31851941

    Yang, F., Quan, Z., Huang, H., He, M., Liu, X., Cai, T. and Xi, R. (2019). Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing. Elife 8. PubMed ID: 30648969

    Yin, C. and Xi, R. (2018). A phyllopod-mediated feedback loop promotes intestinal stem cell enteroendocrine commitment in Drosophila. Stem Cell Reports 10(1): 43-57. PubMed ID: 29276156

    Chen, J., Xu, N., Wang, C., Huang, P., Huang, H., Jin, Z., Yu, Z., Cai, T., Jiao, R. and Xi, R. (2018). Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells. Nat Cell Biol 20(2): 152-161. PubMed ID: 29335529

    Li, Y., Pang, Z., Huang, H., Wang, C., Cai, T. and Xi, R. (2017). Transcription Factor Antagonism Controls Enteroendocrine Cell Specification from Intestinal Stem Cells. Sci Rep 7: 988. PubMed ID: 28428611

    Li, X., Yang, F., Chen, H., Deng, B., Li, X. and Xi, R. (2016). Control of germline stem cell differentiation by polycomb and trithorax group genes in the niche microenvironment. Development [Epub ahead of print]. PubMed ID: 27510973

    Chen, J., Xu, N., Huang, H., Cai, T. and Xi, R. (2016). A feedback amplification loop between stem cells and their progeny promotes tissue regeneration and tumorigenesis. Elife 5. PubMed ID: 27187149

    Wang, C., Guo, X., Dou, K., Chen, H. and Xi, R. (2015). Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages. Development [Epub ahead of print]. PubMed ID: 26293304

  • Yang Xiang Neurobiology, University of Massachusetts Medical School, Worcester
    Gu, P., Gong, J., Shang, Y., Wang, F., Ruppell, K. T., Ma, Z., Sheehan, A. E., Freeman, M. R. and Xiang, Y. (2019). Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1. Curr Biol. PubMed ID: 31735672

    Yan, Z., Zhang, W., He, Y., Gorczyca, D., Xiang, Y., Cheng, L.E., Meltzer, S., Jan, L.Y, Jan, Y.N. (2013). Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature 493(7431): 221-5. PubMed ID: 23222543

    Xiang, Y., Yuan, Q., Vogt, N., Looger, L. L., Jan, L. Y., Jan, Y. N. (2010). Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. 468(7326): 921-6. PubMed ID: 21068723

  • Ting Xie Stowers Institute for Medical Research, Kansas City
    Tu, R., Duan, B., Song, X., Chen, S., Scott, A., Hall, K., Blanck, J., DeGraffenreid, D., Li, H., Perera, A., Haug, J. and Xie, T. (2020). Multiple Niche Compartments Orchestrate Stepwise Germline Stem Cell Progeny Differentiation. Curr Biol. PubMed ID: 33357404

    Tu, R., Duan, B., Song, X. and Xie, T. (2020). Dlp-mediated Hh and Wnt signaling interdependence is critical in the niche for germline stem cell progeny differentiation. Sci Adv 6(20): eaaz0480. PubMed ID: 32426496

    Story, B., Ma, X., Ishihara, K., Li, H., Hall, K., Peak, A., Anoja, P., Park, J., Haug, J., Blanchette, M. and Xie, T. (2019). Defining the expression of piRNA and transposable elements in Drosophila ovarian germline stem cells and somatic support cells. Life Sci Alliance 2(5): e201800211. PubMed ID: 31624801

    Mao, Y., Tu, R., Huang, Y., Mao, D., Yang, Z., Lau, P. K., Wang, J., Ni, J., Guo, Y. and Xie, T. (2019). The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking. Development. PubMed ID: 31142545

    Ma, X., Zhu, X., Han, Y., Story, B., Do, T., Song, X., Wang, S., Zhang, Y., Blanchette, M., Gogol, M., Hall, K., Peak, A., Anoja, P. and Xie, T. (2017). Aubergine controls germline stem cell self-renewal and progeny differentiation via distinct mechanisms. Dev Cell 41(2): 157-169.e155. PubMed ID: 28441530

    Ma, X., Han, Y., Song, X., Do, T., Yang, Z., Ni, J and Xie, T. (2016). DNA damage-induced CHK2 activation compromises germline stem cell self-renewal and lineage differentiation. Development [Epub ahead of print]. PubMed ID: 27729408

    Lu, T., Wang, S., Gao, Y., Mao, Y., Yang, Z., Liu, L., Song, X., Ni, J. and Xie, T. (2015). COP9-Hedgehog axis regulates the function of the germline stem cell progeny differentiation niche in the Drosophila ovary. Development 142: 4242-4252. PubMed ID: 26672093

    Wang, S., Gao, Y., Song, X., Ma, X., Zhu, X., Mao, Y., Yang, Z., Ni, J., Li, H., Malanowski, K.E., Anoja, P., Park, J., Haug, J. and Xie, T. (2015). Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche. Elife 4. PubMed ID: 26452202

    Wang, S., Gao, Y., Song, X., Ma, X., Zhu, X., Mao, Y., Yang, Z., Ni, J., Li, H., Malanowski, K. E., Anoja, P., Park, J., Haug, J. and Xie, T. (2015). Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche. Elife 4. PubMed ID: 26452202

    Pan, L., Wang, S., Lu, T., Weng, C., Song, X., Park, J. K., Sun, J., Yang, Z. H., Yu, J., Tang, H., McKearin, D. M., Chamovitz, D. A., Ni, J. and Xie, T. (2014). Protein competition switches the function of COP9 from self-renewal to differentiation. Nature. PubMed ID: 25119050

  • Wei Xie Key Laboratory of Developmental Genes and Human Disease, Institute of Life Science, Southeast University, Nanjing
    Ou, M., Wang, S., Sun, M., An, J., Lv, H., Zeng, X., Hou, S. X. and Xie, W. (2018). The PDZ-GEF Gef26 regulates synapse development and function via FasII and Rap1 at the Drosophila neuromuscular junction. Exp Cell Res. PubMed ID: 30553967

    Xing, G., Li, M., Sun, Y., Rui, M., Zhuang, Y., Lv, H., Han, J., Jia, Z. and Xie, W. (2018). Neurexin-Neuroligin 1 regulates synaptic morphology and function via the WAVE regulatory complex in Drosophila neuromuscular junction. Elife 7. PubMed ID: 29537369

    Wu, J., Tao, N., Tian, Y., Xing, G., Lv, H., Han, J., Lin, C. and Xie, W. (2017). Proteolytic maturation of Drosophila Neuroligin 3 by tumor necrosis factor alpha-converting enzyme in the nervous system. Biochim Biophys Acta 1862(3):440-450. PubMed ID: 29107812

    Rui, M., Qian, J., Liu, L., Cai, Y., Lv, H., Han, J., Jia, Z. and Xie, W. (2017). The Neuronal Protein Neurexin Directly Interacts with the Scribble-Pix Complex to Stimulate F-actin Assembly for Synaptic Vesicle Clustering. J Biol Chem. PubMed ID: 28710284

    Zhang, X., Rui, M., Gan, G., Huang, C., Yi, J., Lv, H. and Xie, W. (2017). Neuroligin 4 regulates synaptic growth via the Bone morphogenetic protein (BMP) signaling pathway at the Drosophila neuromuscular junction. J Biol Chem [Epub ahead of print]. PubMed ID: 28912273

    Tu, R., Qian, J., Rui, M., Tao, N., Sun, M., Zhuang, Y., Lv, H., Han, J., Li, M. and Xie, W. (2017). Proteolytic cleavage is required for functional Neuroligin 2 maturation and trafficking in Drosophila. J Mol Cell Biol. PubMed ID: 28498949

    Qian, J., Tu, R., Yuan, L. and Xie, W. (2016). Intronic miR-932 targets the coding region of its host gene, Drosophila neuroligin2. Exp Cell Res [Epub ahead of print]. PubMed ID: 26844630

    Sun, M., Zeng, X. and Xie, W. (2015). Temporal and spatial expression of Drosophila Neurexin during the life cycle visualized using a DNRX-Gal4/UAS-reporter. Sci China Life Sci. PubMed ID: 26501376

    Xing, G., Gan, G., Chen, D., Sun, M., Yi, J., Lv, H., Han, J. and Xie, W. (2014). Drosophila Neuroligin3 regulates neuromuscular junction development and synaptic differentiation. J Biol Chem. [Epub ahead of print]. PubMed ID: 25228693

    Gan, G., Lv, H. and Xie, W. (2014). Morphological identification and development of neurite in Drosophila ventral nerve cord neuropil. PLoS One 9: e105497. PubMed ID: 25166897

  • Hong Xu Laboratory of Molecular Genetics, NHLBI, NIH, Bethesda
    Zhang, F., Pirooznia, M. and Xu, H. (2020). Mitochondria regulate intestinal stem cell proliferation and epithelial homeostasis through FOXO. Mol Biol Cell: mbcE19100560. PubMed ID: 32374658

    Chen, Z., Wang, Z. H., Zhang, G., Bleck, C. K. E., Chung, D. J., Madison, G. P., Lindberg, E., Combs, C., Balaban, R. S. and Xu, H. (2020). Mitochondrial DNA segregation and replication restrict the transmission of detrimental mutation. J Cell Biol 219(7). PubMed ID: 32375181

    Wang, Z. H., Liu, Y., Chaitankar, V., Pirooznia, M. and Xu, H. (2019). Electron transport chain biogenesis activated by a JNK-insulin-Myc relay primes mitochondrial inheritance in Drosophila. Elife 8. PubMed ID: 31612862

    Qi, Y., Liu, H., Daniels, M. P., Zhang, G. and Xu, H. (2015). Loss of Drosophila i-AAA protease, dYME1L, causes abnormal mitochondria and apoptotic degeneration. Cell Death Differ. PubMed ID: 26160069

    Zhang, F., Qi, Y., Zhou, K., Zhang, G., Linask, K. and Xu, H. (2015). The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM. EMBO Rep. PubMed ID: 25648146

    Chen, Z., Qi, Y., French, S., Zhang, G., Garcia, R. C., Balaban, R. and Xu, H. (2014). Genetic mosaic analysis of a deleterious mitochondrial DNA mutation in Drosophila reveals novel aspects of mitochondrial regulation and function. Mol Biol Cell [Epub ahead of print]. PubMed ID: 25501370

    Hill, J. H., Chen, Z. and Xu, H. (2014). Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant. Nat Genet. PubMed ID: 24614072

    Ma, H., Xu, H. and O'Farrell, P. H. (2014). Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster. Nat Genet. PubMed ID: 24614071

  • Tian Xu Biological & Biomedical Sciences, Yale University
    Mishra-Gorur, K., Li, D., Ma, X., Yarman, Y., Xue, L. and Xu, T. (2019). Spz/Toll-6 signal guides organotropic metastasis in Drosophila. Dis Model Mech. PubMed ID: 31477571

    Dunn, B. S., Rush, L., Lu, J. Y. and Xu, T. (2018). Mutations in the Drosophila tricellular junction protein M6 synergize with Ras(V12) to induce apical cell delamination and invasion. Proc Natl Acad Sci U S A 115(33): 8358-8363. PubMed ID: 30061406

    Ma, X., Lu, J. Y., Dong, Y., Li, D., Malagon, J. N. and Xu, T. (2017). PP6 Disruption Synergizes with Oncogenic Ras to Promote JNK-Dependent Tumor Growth and Invasion. Cell Rep 19(13): 2657-2664. PubMed ID: 28658615

    Chabu, C., Li, D. M. and Xu, T. (2017). EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth. Nat Commun 8: 14688. PubMed ID: 28281543

    Chabu, C. and Xu, T. (2014). Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth. Development. PubMed ID: 25411211

    Olds, W. H. and Xu, T. (2014). Regulation of food intake by mechanosensory ion channels in enteric neurons. Elife 3. PubMed ID: 25285450

    Ren, J., Zhu, H., Chi, C., Mehrmohamadi, M., Deng, K., Wu, X. and Xu, T. (2014). Beadex affects gastric emptying in Drosophila. Cell Res. PubMed ID: 24566770

    Pastor-Pareja, J. C. and Xu, T. (2013). Dissecting Social Cell Biology and Tumors Using Drosophila Genetics. Annu Rev Genet. PubMed ID: 23988119

    Pastor-Pareja, J. C. and Xu, T. (2011). Shaping cells and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and perlecan. Dev Cell 21: 245-256. PubMed ID: 21839919

    Ohsawa, S., Sugimura, K., Takino, K., Xu, T., Miyawaki, A. and Igaki, T. (2011). Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila. Dev Cell 20: 315-328. PubMed ID: 21397843

  • Lei Xue School of Life Science Tongji University, Shanghai, China
    Wu, C., Ding, X., Li, Z., Huang, Y., Xu, Q., Zou, R., Zhao, M., Chang, H., Jiang, C., La, X., Lin, G., Li, W. and Xue, L. (2021). CtBP modulates Snail-mediated tumor invasion in Drosophila. Cell Death Discov 7(1): 202. PubMed ID: 34349099

    Li, Z., Wu, C., Ding, X., Li, W. and Xue, L. (2020). Toll signaling promotes JNK-dependent apoptosis in Drosophila. Cell Div 15: 7. PubMed ID: 32174999

    Sun, Y., Zhang, D., Li, C., Huang, J., Li, W., Qiu, Y., Mao, A., Zhou, M. and Xue, L. (2019). Lic regulates JNK-mediated cell death in Drosophila. Cell Prolif: e12593. PubMed ID: 30847993

    Zhang, S., Guo, X., Wu, H., Sun, Y., Ma, X., Li, J., Xu, Q., Wu, C., Li, Q., Jiang, C., Li, W., Ho, M. S., Lv, Z. and Xue, L. (2019). Wingless modulates activator protein-1-mediated tumor invasion. Oncogene. PubMed ID: 30683884

    Sun, Y., Zhang, D., Guo, X., Li, W., Li, C., Luo, J., Zhou, M. and Xue, L. (2019). MKK3 modulates JNK-dependent cell migration and invasion. Cell Death Dis 10(3): 149. PubMed ID: 30770795

    Wang, X., Huang, X., Wu, C. and Xue, L. (2018). Pontin/Tip49 negatively regulates JNK-mediated cell death in Drosophila. Cell Death Discov 5: 8. PubMed ID: 30062057

    Wang, X., Guo, X., Ma, Y., Wu, C., Li, W. and Xue, L. (2018). APLP2 Modulates JNK-Dependent Cell Migration in Drosophila. Biomed Res Int 2018: 7469714. PubMed ID: 30155482

    Ma, X., Guo, X., Richardson, H. E., Xu, T. and Xue, L. (2018). POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation. Proc Natl Acad Sci U S A 115(9): 2150-2155. PubMed ID: 29440430

    Ren, P., Li, W. and Xue, L. (2017). GLYAT regulates JNK-mediated cell death in Drosophila. Sci Rep 7(1): 5183. PubMed ID: 28701716

    Wang, X., Sun, Y., Han, S., Wu, C., Ma, Y., Zhao, Y., Shao, Y., Chen, Y., Kong, L., Li, W., Zhang, F. and Xue, L. (2017). Amyloid precursor like protein-1 promotes JNK-mediated cell migration in Drosophila. Oncotarget [Epub ahead of print]. PubMed ID: 28537903

    Ma, X., Wang, H., Ji, J., Xu, W., Sun, Y., Li, W., Zhang, X., Chen, J. and Xue, L. (2017). Hippo signaling promotes JNK-dependent cell migration. Proc Natl Acad Sci U S A [Epub ahead of print]. PubMed ID: 28174264

    Ma, X., Huang, J., Tian, Y., Chen, Y., Yang, Y., Zhang, X., Zhang, F. and Xue, L. (2017). Myc suppresses tumor invasion and cell migration by inhibiting JNK signaling. Oncogene [Epub ahead of print]. PubMed ID: 28068320

    Zhuang, L., Sun, Y., Hu, M., Wu, C., La, X., Chen, X., Feng, Y., Wang, X., Hu, Y. and Xue, L. (2016). Or47b plays a role in Drosophila males' preference for younger mates. Open Biol 6. PubMed ID: 27278650

    Zhang, S., Guo, X., Chen, C., Chen, Y., Li, J., Sun, Y., Wu, C., Yang, Y., Jiang, C.,

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