logo Alphabetical list of genes

Genes: Sa-m - Sn-z - T - U - V - W - XYZ -- [Genes A-D -- Genes E-K -- Genes L-R]
S

SAGA factor-like TAF6
histone fold domain protein - component of histone acetyltransferase (SAGA) complex - required for SAGA coactivator function

SAK (common alternative name: Plk4)
member of the polo-like kinase family - required for centriole duplication and for formation of basal bodies and flagella

salvador
restricts cell numbers in vivo by functioning as a dual regulator of cell proliferation and apoptosis - physically interacts with Warts

sanpodo
encodes a four-pass transmembrane protein that localizes to the cell membrane - specifies Notch-dependent fate - Notch and Numb physically associate with Sanpodo

sans fille (also known as U1AsnRNP)
splicing factor - a crucial component of the spliceosome - involved in Sex-lethal splicing and consequently in sex determination

Sap18 (FlyBase name: Bicoid interacting protein 1)
part of the Sin3A/Rpd3 histone deacetylase complex - helps convert Bicoid from an activator
into a repressor by recruitment of a co-repressor to Bicoid-dependent promoters

sarah
regulates female meiosis by controlling calcineurin activity in the germline

Sas-4
centriolar constituent - required for centriolar assembly, centriole replication, flagellum biogenesis, cilium biogenesis and locomotion -
regulates asymmetric cell division

saxophone
receptor s/t kinase - a Dpp receptor - necessary for the specification of the dorsalmost cell fate (amnioserosa) which requires the highest levels of Dpp activity

SAYP (preferred name: Enhancer of yellow 3)
Trithorax group protein, constituent PBAP chromatin remodeling complex, a coactivator supercomplex consisting of Brahma and TFIID;
participates in ecdysone-dependent transcriptional regulation

scab
alpha integrin - involved in dorsal closure, tracheal and salivary gland development and in the localization of pericardial cells

scabrous
secreted - fibrinogen family - regulates spacing of photoreceptors - a Notch pathway inhibitory signal secreted by photoreceptor precursors in response to Egfr signaling

scalloped
transcription factor - human TEF-1 homolog - a downstream effector molecule in the Wingless pathway of wing imaginal discs - partners vestigial

SCAR
promotes actin polymerization via Arp2/3 protein complex

scarface
belongs to a subgroup of serine protease homologues with an inactive catalytic site - functions extracellularly during dorsal closure
as an antagonist of the JNK pathway - regulates the polarized localization of laminin A during the development of epithelial polarity

schnurri
transcription factor - zinc finger - target of Dpp - the activity of the Mad/Schnurri complex is modulated in a promoter specific fashion to active or repress gene transcription

Scm-related gene containing four mbt domains
PcG protein - Pleiohomeotic interactor that binds mono- and di-methylated H3-K9 and H4-K20
and acts to maintain a Polycomb-repressed chromatin state

scotti
pseudosubstrate inhibitor of a Cullin-3-based E3 ubiquitin ligase complex required for caspase activation during Drosophila spermatid terminal differentiation

scraps
encodes anillin - conserved component of the contractile ring that is essential for cytokinesis - physically interacts
with three conserved cleavage furrow proteins, F-actin, myosin II and septins - required for cellularization

scratch            FlyExpress: scratch neuroblast expression
transcription factor - zinc finger - panneural repressor of non-neural cell fate

scrawny
protein deubiquitinase required in germline, epithelial, and intestinal stem cells - acts to repress differentiation genes - deubiquitylates histone H2B
and functions in gene silencing - participates in a conserved pathway of chromatin regulation linking H2B ubiquitylation with H3K4me3 methylation

screw
TGF-ß superfamily - functions along with its partner Dpp to produce the amnioserosa

scribbled
scaffolding protein: multiple PDZ and LLR regions - functions to localize junctional components in the determination of epithelial cell polarity

scribbler
novel protein with a single zinc finger - multifunctional protein that regulates foraging activity and shapes the activity gradient of Dpp through regulation of thickveins

scute
transcription factor - basic helix loop helix - proneural gene that also functions to regulate Sex-lethal

scylla and charybde
conserved proteins acting downstream of PKB and upstream of TSC to regulate growth - they are induced under hypoxic conditions,
thus establishing a potential cross-talk between growth and oxygen sensing

sec5
promotes vesicular trafficking involved in cell growth and membrane protein insertion -
required for membrane traffic and polarity in the oocyte

sec6
component of the exocyst which tethers secretory vesicles to specific plasma membrane sites - a Rab11 effector
that facilitates protein transport to the apical rhabdomere in Drosophila photoreceptor cells -
regulates E-Cadherin trafficking from recycling endosomes to the plasma membrane

sec15
functions in polarized exocytosis/secretion - involved in targeting photoreceptor axons that involves localization of specific cell adhesion and signaling molecules

semaphorin-1a
axon guidance transmembrane protein - motor axons requiring Sema-1a for choice-point defasciculation

semaphorin-2a
secreted - Ig superfamily - axon guidance - expressed by muscle 33 - functions by inhibiting the neuronal growth cone
from forming a synaptic arborization (branching) to alternative muscles

senseless (preferred name: Lyra)
zinc finger - target of proneural genes - expressed and required in sensory organ precursors for proper proneural gene expression

Sensory neuron membrane protein
CD36-related transmembrane protein - essential for the response of olfactory sensory neurons to cis-vaccenyl acetate,
a male-specific fatty-acid-derived pheromone that regulates sexual and social aggregation behaviours

Separase
endopeptidase required for sister chromatid separation during mitosis

sequoia
zinc finger - required for specification of a subset of neurons - functions in regulating dendrite and axon development

Serotonin receptor 1A and Serotonin receptor 1B (5-HT1A and 5-HT1B)
seven-pass transmembrane protein, 5-HT1A promotes baseline sleep

Serotonin receptor 2
seven-pass transmembrane protein - coordinates germband extension movements

serpent (common alternative name: dGATAb)            FlyExpress: srp expression in the head mesoderm anlage, posterior endoderm anlage and the fat body
transcription factor - zinc finger - GATA family - plays a pivotal role in promoting morphogenesis of the anterior and posterior midgut -
necessary for embryonic fat-cell differentiation

serpentine and vermiform
polysaccharide deacetylases - converts chitin to chitosan - required to assemble
cable-like extracellular matrix and restrict tracheal tube elongation

serpin-27A
protease inhibitor functioning in the immune response - regulates melanization cascade through specific inhibition of the terminal protease (prophenoloxidase-activating enzyme)

Serpin77Ba
inhibits a protease cascade, involving the MP1 and MP2 proteases, that activates phenol oxidase, a key enzyme in melanin biosynthesis -
Serpin77Ba inactivation and consequent tracheal melanization induces systemic expression of the antifungal peptide gene Drosomycin

Serrate
transmembrane - EGF homolog - ligand for Notch - involved in the induction, through Notch, of the wing margin at the dorsal-ventral interface of the wing imaginal disc

Serum response factor (preferred name: blistered)
transcription factor - MADS-box motif - required for vein/intervein formation in the fly wing

Sestrin
conserved proteins that accumulate in cells exposed to stress, potentiate adenosine monophosphate-activated
protein kinase (AMPK), and inhibit activation of TOR - prevents pathologies caused by chronic TOR activation

Set2
Histone 3 methyltransferase involved in dosage compensation, puparium formation and adult development

Seven in absentia
targets proteins to degradation - C3HC4 RING zinc-finger motif

seven up
transcription factor - orphan nuclear receptor - zinc finger - required for development of four of the eight photoreceptors
that develop in each ommatidium of the eye, the R3/R4 pair and the R1/R6 pair

sevenless
transmembrane - receptor TK - required for the development of the R7 photoreceptor

Sex combs extra (common alternative name: Ring)
Polycomb group - protein ubiquitination - a member of a protein complex, termed PRC1 (Polycomb repressive complex 1)

Sex combs on midleg
Polycomb group - a member of a protein complex, termed PRC1 (Polycomb repressive complex 1) - Preincubation of nucleosomal arrays
with PRC1 blocks the ability of these arrays to be remodeled by SWI/SNF.

Sex combs reduced            FlyExpress: Scr labial and prothoracic segment expression
transcription factor - homeodomain - Antp class - required for labial and first thoracic segment development

Sex lethal
RNA binding and splicing - the master regulation of sex determination in Drosophila

sex-peptide (preferred name: Accessory gland peptide 70A)
male ejaculate accessory gland protein - decreases female receptivity and stimulates egg production in the first mating of virgin females

sex peptide receptor
G-protein coupled receptor - required in Fruitless plus neurons for post-mating switch in female reproductive behaviour

s59 (preferred name: slouch; common alternative name nk-1)
transcription factor - homeodomain - NK-1 class - maintenance of slouch is directly involved in the control
of late aspects of muscle development, such as muscle differentiation and morphogenesis, and possibly also innervation

shaggy (common alternative name: zeste white 3)
glycogen synthase kinase - segment polarity - functions in the Wingless signaling pathway

Shaker cognate b
slow delayed rectifier K+ channel - upregulated by light stimulation - functions in light adaptation

shaven (common alternative name: sparkling)
paired domain and homeodomain (partial) - Pax2, 5 and 8 homolog - Denticle formation requires transcription of sparkling,
which is under positive regulation by the Egfr pathway and negative regulation by the Wingless pathway

SHC-adaptor protein
phosphotyrosine-binding domain protein - interacts with and regulates Torso and Egfr signaling conferring specificity to receptor function

shibire
GTPase involved in scission of clathrin-coated vesicles at the synapse and other sites of vesicle invagination

shifted
ortholog of the human Wnt inhibitory factor - required for Hh stability and for lipid-modified Hh diffusion -
colocalizes with Hh in the extracellular matrix and interacts with the heparan sulfate proteoglycans

short gastrulation            FlyExpress: sog lateral expression
chordin homolog - a Dpp antagonist involved in the determination of dorsal/ventral polarity - leads to the subdivision of the dorsal region of the fly into amnioserosa and dorsal ectoderm

short neuropeptide F precursor
neuropeptide that engenders ERK-mediated insulin expression and thus systemically modulates growth, metabolism and lifespan

shortsighted (preferred name: bunched)
transcription factor - leucine zipper - Dpp pathway - mutation leads to a delay in differentiation and to a loss of photoreceptors -
required for a morphogenetic movement in the brain - functions in wing margin development - required for both male and female fertility

short stop
cytoskeletal cross-linker protein - expressed in the tendons and is essential for muscle-dependent tendon cell differentiation -
required for sensory and motor axons to reach their targets in the Drosophila embryo

shotgun
cadherin - regulates cell aggregation preventing mixing of cells at tissue boundaries

shutdown
immunophilin - FK506-binding protein domain and a tetratricopeptide repeat - essential for the normal function of the germline stem cells

shuttle craft
zinc finger, C4HC3 type (PHD finger), and RD-domain protein - maternal mutants exhibit defects in segmentation, while zygotic mutants show defects in axon guidance

sickle
novel apoptosis activator - contains an N-terminal inhibitor of apoptosis motif

sidestep
Ig domain cell adhesion molecule - ligand for Beaten path Ia - axon guidance

sightless (preferred name: rasp)
acetyltransferase acting to acylate Hedgehog or to promote other modifications or trafficking events necessary for Hedgehog function

similar
bHLH-PAS domain transcription factor - a key regulator of responses to hypoxia

singed
fascin homolog - crosslinks actin filaments - the gnarled, kinky bristle phenotype is due to the lack of Actin filament bundles in both large and small bristles

sine oculis           FlyExpress: so expression in procephalic ectoderm and sensory nervous system
transcription factor - homeodomain - Sine oculis and Eyes absent form a complex that regulates multiple steps in eye development

single-minded            FlyExpress: sim expression in ventral midline
transcription factor - bHLH - pas homology - required for the developmental specification of the ventral midline

Sin3A
transcriptional corepressor; component of histone deacetylase complex that affects cell cycle progression

sinuous
claudin - localizes to septate junctions and is required for junction organization and paracellular barrier function -
required fo maintenance of cardiac integrity

Sir2
histone deacetylase required for euchromatic and heterochromatic silencing - interacts genetically and physically
with members of the Hairy/Deadpan/E(Spl) family of bHLH euchromatic repressors

Six4
homeodomain transcription factor - confers ventral mesodermal cell fate - regulates somatic cell function during gonadogenesis

skittles
1- phosphatidylinositol-4 phosphate kinase - alteration of Skittles levels results in structural defects in sensory bristles,
providing genetic evidence for the involvement of PIP5KIs in cytoskeletal regulation

skpA
component of protein degradation complex - regulates centrosome duplication, chromatin condensation, cell cycle progression and endoreduplication

slimfast
Amino acid transporter - downregulation within the fat body causes a global growth defect involving TSC/TOR signaling
in the fat body and a remote inhibition of organismal growth

slingshot
phosphatase - plays a pivotal role in actin dynamic by reactivating the actin depolymerizing factor cofilin

slipper
mixed lineage kinase - signal transduction protein conveying information about changes in cytoskeleton to the nucleus

slit
extracellular - egf like - ligand of Roundabout - regulates axon guidance

sloppy paired 1 and 2            FlyExpress: Slp1 gap and segmental expression
transcription factor - forkhead domain - has combined characteristics of a gap, pair rule and segment polarity gene

slouch (common alternative names: S59 and NK-1)
transcription factor - homeodomain - NK-1 class - maintenance of slouch is directly involved in the control of late aspects of muscle development,
such as muscle differentiation and morphogenesis, and possibly also innervation

slow as molasses
novel protein that is essential for polarized growth of the plasma membrane during cellularization

slow border cells            FlyExpress: slbo expression in posterior spiracle
basic leucine zipper - CCAAT/enhancer-binding protein homolog - slbo targets breathless and is essential
for terminal differentiation and migration of the anterior follicle cells known as border cells

slowpoke
Ca-activated, voltage-activated potassium channel that functions to modulate ion flow in presynaptic nerve terminals, including those of the neuromuscular synapse

Smad on X
Dpp signaling pathway - Smad2 and Smad3 homolog - a target of Baboon

smallminded
AAA-protein family - ATPase - Mutants are defective in larval mitoses - expression of Smallminded in cells that undergo late embryonic
or larval mitosis suggests a general role in promoting mitosis

small wing
phosphatidylinositol-specific phospholipase C gamma, Src homology 2 and 3 domain protein - a negative regulator in the pathways leading to R7 development -
mutation results in additional cells being recruited to an R7 cell fate

smaug
RNA binding protein - repressor of Nanos translation

smoothened
seven-pass transmembrane protein - transmits Hedgehog signal - Hedgehog causes phosphorylation, stabilization, and accumulation
of Smoothened at the cell surface - Patched may act indirectly to regulate Smoothened activity

Smrter
SMRT-related ecdysone receptor-interacting protein - a corepressor that mediates transcriptional silencing of the Ecdysone receptor:Ultraspiracle heterodimer

smt3 (common alternative nam: Sumo)
a low molecular weight protein modifier that is vital for multicellular development - over 140 SUMO conjugates have been identified in the early embryo including Dorsal, Tramtrack, Vestigial, SoxNeuro, Medea, Mod(mdg4) and CP190 and the bi-functional tRNA charging enzyme glutamylprolyl-tRNA synthetase

Smurf1
ubiquitin-protein ligase that regulates Decapentaplegic pathway signaling by targeting Mothers against Dpp for degradation

snail            FlyExpress: sna expression in mesodermal anlage and neuroblasts
transcription factor - zinc finger - DV polarity - a transcriptional repressor - acts to restrict neuroectoderm and neural fate
in the invaginating mesoderm - mutants display a massive derepression of mesectoderm

sneaky
transmembrane acrosomal protein involved in sperm plasma membrane breakdown; required for sperm activation in the egg cytoplasm

SNF1A/AMP-activated protein kinase
adenosine 5'monophosphate-activated kinase - cellular energy sensor - coordinates epithelial polarity and proliferation with cellular energy status

snf5-related 1 (common alternative name: snr1)
a component of the Swi/Snf complex (Brahma complex) in Drosophila - suppresses mutations in Polycomb complex genes

snoN
mediator of Baboon signaling - antagonizes Dpp signaling -
physically interacts with Medea - inhibits growth when overexpressed

Son of sevenless
a dual specificity GEF that regulates both Ras and Rho family GTPases - integrates signals that affect gene expression and cytoskeletal reorganization

Sox box protein 15
HMG-domain protein - SOX-domain protein - under the control of the canonical wingless pathway such that
wg and Sox15 regulate each other's transcription through a feedback loop that results in proliferation of wing hinge cells

Sox box protein 70D ( common alternative name: Dichaete or fish-hook)
HMG-domain protein - SOX-domain protein - implicated in the regulation of pair-rule genes
and later functions in wing morphogenesis

SoxNeuro
HMG1/2 (high mobility group) box transcription factor - essential for the formation of neural progenitor cells in the central nervous system

spaghetti squash
EF-hand, calcium binding motif protein that serves as the regulatory light chain of nonmuscle myosin II

spalt
transcription factor - zinc finger - PRDII-BF1 homolog - a target of Dpp signaling - Spalt and Spalt-related regulate
the vein-specific expression of knirps and and the iroquois gene complex,
delimiting their domains of expression in the wing pouch

Spargel
transcriptional coactivator - required for the expression of multiple genes encoding mitochondrial proteins - mediates mitochondrial activity,
cell growth and transcription of target genes in response to insulin signalling

sparkling (preferred name: shaven)
paired domain and homeodomain (partial) - Pax2, 5 and 8 homolog - Denticle formation requires transcription of sparkling,
which is under positive regulation by the Egfr pathway and negative regulation by the Wingless pathway

spastin
AAA (ATPase Associated with diverse cellular Activities) family member - regulates microtubule stability - mutants show defects in synaptic growth and neurotransmission

spätzle
secreted - ligand for Toll - the Easter protease is likely to be the direct proteolytic activator of Spätzle

Spd-2
centriole duplication - required for recruitment of pericentriolar material to sperm centrioles after fertilization

alpha Spectrin
cytoskeletal protein - structural and docking protein - a principle component of the fusome, a protein complex involved
in asymmetric cell division and cell fate determination in oogenesis

betaHeavy Spectrin (preferred name: karst)
cytoskeletal protein - structural and docking protein - a junctional protein involved in cell adhesion

spichthyin
ortholog of proteins that are defective in hereditary spastic paraplegia and ichthyin - transmembrane protein found on early endosomes -
antagonizes BMP signaling by interacting with BMP receptors and promoting their internalization from the plasma membrane

spindle assembly abnormal 6
centriolar constituent - required for the assembly of the centriolar microtubules - a cartwheel protein
that establishes the 9-fold symmetry of the centriole

spindle E
DE-H family of RNA-dependent ATPases - a dorsal appendage phenotype suggests that spn-E plays a role in dorsalization of the oocyte -
mislocalization phenotypes suggest that spn-E is also involved earlier in establishment egg polarity

Spindly
conserved mitotic checkpoint protein - regulator of mitotic dynein - functions to target dynein to kinetochores

spineless (also known as spineless-aristapedia)
bHLH PAS domain protein - plays a central role in defining the distal regions of both the antenna and leg - Spineless is a homolog of the mammalian dioxin receptor

spinster
conserved transmembrane protein expressed in glia - mutants exhibit increased neural survival and altered sexual behavior

spire
Wiscott-Aldrich syndrome protein (WASP) homology domain 2 (WH2) family - a maternal effect locus that affects both the dorsal-ventral
and anterior-posterior axes of the Drosophila egg and embryo - required for localization of determinants within the developing oocyte

spitz
ligand for Epidermal growth factor receptor - Egf/Tgf alpha homolog - required for the differentiation of all ommatidial cell types, with the exception of R8 -
Spi is found on retinal axons that project into the lamina; this transported Spitz is required for lamina cartridge neuron differentiation

split ends
codes for RRM motif RNA-binding protein - mutants have defects in Notch and Egf receptor signaling resulting defects in cell-fate and in axon guidance

spotted dick (preferred name: pita)
zinc finger transcription factor that serves as an activator of expression of a set of genes required for initiation of DNA replication

sprouty
membrane associated or secreted antagonist of FGF signaling - functions during tracheal development - mutant follicle-cell clones
demonstrates an essential role for Sprouty in restricting Egfr activation throughout oogenesis

Spt6
transcription elongation factor implicated in RNA processing and degradation of improperly processed pre-mRNA

squeeze
zinc finger transcription factor - regulates neuropeptidergic cellular identity and FMRFamide expression

squid
RNA-binding protein, hnRNP D homolog - Gurken mRNA localization and translation are coupled by an interaction between Sqd and
the translational repressor protein Bruno - Squid promotes apical cytoplasmic transport and localization of Fushi tarazu transcripts

Src homology 2, ankyrin repeat, tyrosine kinase
Known as Shark kinase this signaling protein is required for dorsal closure upstream of Dpp - also required during oogenesis for dorsal-appendage morphogenesis

Src oncogene at 42A
Src homolog - a protein tyrosine kinase with SH3 and SH2 domains - essential for cell-cell matching during dorsal closure -
involved in adherins junction stabilization

Src oncogene at 64B
Src homolog: a protein tyrosine kinase with SH3 and SH2 domains - plays a role in ring canal morphogenesis during oogenesis

S6K (preferred name: RPS6-p70-protein kinase)
signaling - regulates growth response - targets ribosomal protein S6 - a target of the TOR pathway

Star
transmembrane protein - Rhomboid and Star facilitate Egfr signaling by processing membrane-bound Spitz to an active, soluble form

stardust
codes for a regulatory component of the subapical complex of cellular junctions - crucial in the control of epithelial cell polarity

starry night (common alternative name: flamingo)
Cadherin-related 7TM protein involved in tissue polarity

STAT (common alternative name: marelle)
transcription factor - cytoplasmic signal transducing protein - regulates the even-skipped stripe 3 promoter and the pair rule gene runt -
central to the establishment of planar polarity during Drosophila eye development

staufen
Double stranded RNA binding protein - required for the localization of multiple mRNA species during oogenesis and zygotic development -
direct binding of Staufen to Bicoid and Prospero mRNAs is a requirement for their subcellular distribution -
as a posterior group protein Staufen required for the localization of Oskar mRNA to the posterior pole of the oocyte

steamer-duck
LIM-only protein that is required for integrin-dependent cell adhesion - physically interacts with Integrin-linked kinase

Stellate
ß subunit of Casein kinase II - a normally inactive gene which, when active, leads to male sterility - a target of post-transcriptional gene regulation

stem cell tumor (also known as rhomboid-2)
Rhomboid-related transmembrane protein - serine-type protease - activates the oocyte-specific Gurken ligand and
thereby participate in defining posterior cell fates in the early follicular epithelium

Sterol regulatory element-binding protein
bHLH-leucine zipper transcription factor - membrane bound HLH106 is released by phosphatidylethanolamine, exerting feedback control
on the synthesis of fatty acids and phospholipids - cleavage by Drice releases an SREBP fragment to travel to the nucleus
where it mediates the increased transcription of target genes needed for lipid synthesis and uptake

sticks and stones
transmembrane protein expressed on the surface of fusion competent myoblasts - essential for fusion of embryonic myoblasts

sticky (alternative name: citron)
Rho effector kinase functioning downstream of pebble - required for cytokinesis

stoned A and stoned B
a dicistronic locus encoding two proteins involved in synaptic vesicle recycling

strabismus (preferred name: Van Gogh)
novel transmembrane protein - a tissue polarity gene - mutants show a disrupted orientation of ommatidia

Strawberry notch
nuclear protein in the Notch pathway

string
protein tyrosine phosphatase - activates cyclin dependent kinase causing mitotic entry

stripe
transcription factor - zinc finger - involved muscle development

Structure specific recognition protein
transcription factor - along with Dre4 forms a protein complex, FACT,
that facilates GAGA factor directed chromatin remodeling

stumps (common alternative name: heartbroken)
novel signal transduction protein functioning downstream of two FGF receptors

subito
a kinesinlike protein required for spindle formation and cytokinesis - involved in both meiosis and mitosis

Sumo (preferred name: smt3)
a low molecular weight protein modifier that is vital for multicellular development - over 140 SUMO conjugates have been identified in the early embryo including Dorsal, Tramtrack, Vestigial, SoxNeuro, Medea, Mod(mdg4) and CP190 and the bi-functional tRNA charging enzyme glutamylprolyl-tRNA synthetase

sunspot
zinc finger transcription factor that interacts with Armadillo - acts downstream of wingless to positively regulate the proliferation
of imaginal disc cells and the endoreplication of salivary gland cells - activates E2F-1 and PCNA expression

supernumerary limbs
beta-transducin family Trp-Asp repeats family - subunit of a multi-protein complex that targets proteins for degradation by
the ubiquitin-proteasome pathway - an important regulator of Wingless, Hedgehog and Dorsal pathways

Suppressor of fused
novel protein with PEST sequence - inhibits Hedgehog signaling pathway

Suppressor of Hairless
transcription factor - integrase domain - Notch pathway - Notch intracellular domain associates with Su(H) and Mastermind, a transcriptional coactivator

suppressor of Hairy wing
transcription factor - zinc finger - blocks enhancer-promoter interactions

Suppressor of bithorax
major subunit of nucleosome remodeling factor (nurf) - multiple domain protein with HMGI/Y and bromodomain motifs

Suppressor of profilin 2
A component of the Arp2/3 complex - involved in catalyzing actin filament nucleation - essential to cap expansion and pseudocleavage furrow during cellularization -
required for ring canal expansion during oogenesis

Suppressor of variegation 3-3
homolog of the human LSD1 amine oxidase - demethylates H3K4me2 and H3K4me1 and facilitates subsequent H3K9 methylation by SU(VAR)3-9 -
dictates the distinction between euchromatic and heterochromatic domains during early embryogenesis

Suppressor of variegation 3-7
chromatin constituent - C2H2 zinc finger protein - required for X-restricted dosage compensation complex targeting

Suppressor of variegation 3-9
involved in gene silencing - a modifier of position effect variegation - methylates histone H3 thus providing a mark for the association of HP1 to heterochromatin

Suppressor of variegation 205 (common alternative name: heterochromatin protein 1 or HP1)
chromodomain - Polycomb group - chromatin associated protein -
required both for activation of heterochromatic genes and silencing of euchromatic genes

Suppressor two of zeste
transcription factor - zinc finger - ring motif - chromatin associated protein - Su(Z)2 and Psc proteins co-localize to and silence
many of the same chromosomal loci acted upon by other Pc-G proteins, suggesting that Pc-G proteins function in a multi-protein complex to maintain gene silencing

survival motor neuron
RNA binding protein involved, along with Gemins, in the assembly of the small nuclear ribonucleoproteins that constitute the spliceosome -
neuromuscular junction protein required in both neurons and muscle for normal junctional morphology

Su(Tpl) (common alternative name: ELL)
occludin homology domain protein - a Pol II elongation factor capable of stimulating the rate of transcription

Su(z)12
Polycomb group -histone methyltransferase activity - constituent of polycomb PRC2 complex - functions in
nucleosome binding of Drosophila PRC2 - essential for tri-methylation of the lysine 27 residue of histone H3

synaptotagmin
calcium sensor in synaptic vesicle fusion - functions during exocytosis

Syndecan
a heparan sulfate proteoglycan - a necessary component of Slit/Robo signaling required in Slit target cells

Syntaxin 1A
vesicular docking protein - a t-SNARE - involved in docking and fusion of neurotransmitter-filled vesicles with the presynaptic membrane to release neurotransmitter into the synaptic cleft

Syntaxin 5
a Golgi-localized SNARE protein - required for ER-Golgi traffic and Golgi reassembly following cell division - required for steps leading to formation of mature sperm

T

tailless
transcription factor - nuclear receptor - zinc finger

tailup (common alternative name: islet)
transcription factor - homeodomain and LIM domain - required in combination with other transcription factors for serotonergic and dopaminergic neuron identity

taiman
steroid hormone receptor coactivator - required for border cell migration during oogenesis

takeout
secreted ligand-binding protein - A takeout mutant has aberrant locomotor activity and dies rapidly in response to starvation,
indicating a link between locomotor activity, survival, and food status

Talin
(preferred name: Rhea) essential for integrin function - crosslinks extracellular matrix-linked integrins to the cytoskeleton

tango
Myc-type, helix loop helix and PAS family protein - Tango heterodimerizes with two transcription factors, Trachealess and Single minded,
to regulate transcription in the trachea and central midline, respectively

target of Pox-n
bHLH transcription factor - Neurogenin/NeuroD homolog - a neural differentiation gene,
acting later in the hierarchy of gene activation than the proneural genes

Target of rapamycin
Phosphatidylinositol 3-kinase - involved in perception of nutrient status -
pivotal member of the TOR pathway involved in regulation of growth and cell proliferation

tarsal-less
codes for short encoded peptides that convert Shavenbaby from a transcriptional repressor to an activator
via the truncation of its N-terminal region, polycistronic message, epidermal differentiation, spatial pattern of trichomes, legs, trachea

tartan
Leucine-rich repeat transmembrane protein - along with Capricious, contributes to the adhesive properties of the cells
in the morphogenetic furrow, thus regulating control of spacing ommatidial clusters - regulates boundary formation in the leg and wing -
regulates tracheal branching

TATA binding protein
general transcription factor - component of TFIID - activates TATA-dependent transcription and represses DPE-dependent transcription

TATA box binding protein-related factor 2
differentially recognizes and regulates a subset of TATA-less promoters

TBP-associated factor 1
general transcription factor - kinase and histone transacetylase activities

Tbp-related factor
general transcription factor - cell type specific TATA-binding protein

teashirt            FlyExpress: tsh thoracic expression
transcription factor - zinc finger - required globally for segmental identity throughout the entire trunk - required for identity of the anterior prothorax -
required for the subdivision of midgut mesoderm acting in partnership with the homeotics.

Tec29 (preferred name name: Btk family kinase at 29A)
protein-tyrosine kinase - necessary for maintaining the equilibrium between monomeric actin and filamentous actin during invagination of the salivary placodes -
functions during oogenesis as a key downstream effector of Src64 during ring canal growth

telomere fusion (common alternative name: ATM)
Phosphatidylinositol 3- and 4-kinase - Serves as Drosophila's ATM (ataxia telangiectasia mutated) - plays a conserved and essential role
in the maintenance of normal telomeres and chromosome stability

Tenascin major
transmembrane - tenasin homolog - EGF and Fibronectin repeats - pair-rule gene product

terribly reduced optic lobes
extracellular matrix component - homolog of perlecan - regulates larval neuroblast division by modulating both FGF and Hedgehog signaling

TGF-ß activated kinase 1
serine/threonine kinase required for morphogenetic changes that take place during the fusion of the epithelial wing disc cell layers (thoracic closure),
acting in the context of JNK signaling - required for Relish cleavage and antibacterial immunity

thick veins           FlyExpress: tkv mesodermal expression
transmembrane - receptor serine/threonine kinase for Dpp

thisbe and pyramus
FGFs involved in mesodermal development - ligands for Heartless

Thor (common alternative name: d4E-BP)
messenger RNA 5' cap binding protein - regulates translation during environmental stress

thread (common alternative name: Diap1)
ubiquitin ligase that functions as an inhibitor of apoptosis - Thread inhibition of caspase function is counteracted by proapoptotic proteins Hid, Grim and Reaper

Thrombospondin
extracellular matrix ligand produced by tendon cells - essential for the formation of the integrin-mediated myotendinous junction

Tiggrin
secreted - extracellular matrix - required for muscle attachment

timeless
transcription factor - novel with pas domain - photoperiod response - partners the transcription factor Period

tinman (common alternative name: NK-4 and msh2)            FlyExpress: tin expression in primordia for the visceral musculature and the heart
transcription factor - homeodomain - NK-2 class - mesodermal - involved in the formation of the heart and dorsal vascular musculature

TNF-receptor-associated factor 1
Traf domain protein - involved in signal transduction in the JNK and pathway

tolkin (common alternative name: tolloid-related-1)
BMP-1 homolog - metalloprotease that functions to activate Dpp

Toll
IL1 homolog - a crucial protein for embryonic dorsal/ventral polarity - receptor for spätzle

Tollo
Toll-like receptor - leucine rich repeat transmembrane protein - expressed in ectoderm
and required for neural-specific expression of the glycan HRP epitope

tolloid
secreted BMP-1 homolog - metalloprotease that cleaves Short gastrulation thus functioning to activate Dpp

tolloid-related-1 (preferred name: tolkin)
secreted BMP-1 homolog - metalloprotease that like Tolloid functions to activate Dpp

TORC
transcription factor - transducer of regulated CREB activity - starvation triggers TORC activation -
TORC maintains energy balance through induction of CREB target genes in the brain

torpedo (preferred name: EGF-R, common alternative name: Ellipse or EGR)
transmembrane receptor- tk - EGF-R homology - during oogenesis helps set up egg polarity, determines the identity of cells in the ectoderm;
during larval stages participates in the development of the eye and wing.

torso
transmembrane - receptor tyrosine kinase - membrane receptor for Trunk - crucial for establishment of anterior and posterior cell identity of the embryo

torso-like
torso pathway - localized determinant of terminal pattern formation

tout-velu
acetylglucosaminyltransferase - involved in heparan sulfate proteoglycan biosynthesis - affects diffusion of Wingless, Hedgehog and Decapentaplegic

trachealess            FlyExpress: trh expression in salivary gland and tracheal pits
transcription factor - basic HLH - PAS domains - mutants exhibit a defect in the ability of the tracheal precursors to organize tubes, the same defect seen in salivary glands

trailer hitch
conserved protein involved in mRNA localization that interfaces with the secretory pathway to promote efficient protein trafficking in the cell

tramtrack (common alternative name: FTZ-F2)
transcription factor - zinc finger - btd domain - Ttk is responsible for the effects of numb, repressing neural cell fate in support cells

Translationally controlled tumor protein
guanine nucleotide exchange for Rheb - functions in the TSC pathway to control growth

transforming acidic coiled-coil protein (common name: tacc)
centrosomal protein that stabilizes microtubules during mitosis by recruiting the microtubule plus end binding protein Minispindles

transient receptor potential
visual phototransduction, calcium channel, adaptation to light

Transient receptor potential A1
heat-activated TRP family ion channel that is essential for thermotaxis

Transportin-Serine/Arginine rich
an importin-ß family member responsible for transporting SR protein splice factors into the nucleus

transformer
RNA splice factor - Sex determination - productively spliced in the presence of Sex lethal

transformer 2
RNA splice factor - functions with Transformer to bring about the sex specific splicing of Doublesex

Transforming growth factor beta at 60A (preferred name: glass bottom boat)
TGF-beta superfamily - BMP 7 homolog - mutants lack the first constriction of the embryonic midgut and Antennapedia expression in parasegment 6

Transportin-Serine/Arginine rich
an importin-ß family member responsible for transporting SR protein splice factors into the nucleus

trapped in endoderm-1
G-protein coupled receptor - links cell polarity, modulation of cell adhesion, and invasion during germ cell migration

tre-1, tre-2 and tre-3
noncoding RNAs that mediate transcriptional activation by recruiting the epigenetic regulator Ash1 to template trithorax response elements

Trehalose-sensitivity
G-protein coupled receptor - Taste receptor

T-related gene - (preferred name: brachyenteron)            FlyExpress: trg expression in hindgut primordium
transcription factor - brachyury homolog - essential for the development of hindgut, anal pads and Malpighian tubules

tribbles
serine/threonine kinase-like domain protein - regulates cell cycle

tricornered
Ndr serine/threonine kinase - required for the normal morphogenesis of epidermal hairs, bristles, laterals, and dendrites

trio
Rac guanyl-nucleotide exchange factor - Loss-of-function trio mutations result in the misdirection or stall of axons in embryos and also cause malformation of the mushroom body.

trithorax
transcription factor - zinc finger - trithorax group - maintains activity of homeotic genes

Trithorax-like (common alternative name: GAGA)
transcription factor - GAGA - Zinc finger - BTD domain - a chromatin modifying protein

Troponin I (preferred name: wings up A)
cytoskeletal protein - along with Tropomyosin regulates muscle contraction - required to maintain nuclear integrity and
apico-basal polarity during early embryogenesis - required for myofibrillogenesis and sarcomere formation in Drosophila flight muscle

Trpa1 (common alternative name: Anktm1)
heat-activated TRP family ion channel that is essential for thermotaxis

trunk
secreted - ligand for torso - crucial for establishment of anterior and posterior cell identity of the embryo

Tsc1
acts in conjunction with TSC2 to suppress cell growth by inhibiting Tor, a central controller of cell growth - TSC1/TSC2 has GAP activity
toward the Rheb small GTPase which acts upstream of and stimulates TOR - TSC2 is the catalytic GAP subunit,
while TSC1 enhances TSC2 function by stabilizing TSC2

tube
cofactor with pelle to activate Dorsal - involved in dorsal/ventral polarity during early development

ß1 Tubulin
ß Tubulin56D - ubiquitious component of cytoskeleton

ß2 Tubulin
ß Tubulin85D - sperm tubulin - ß1 tubulin is found in mitotically active germ cells and all somatic parts of the testis -
starting with early spermatocytes, the ß1 isotype is switched off and all microtubular arrays contain ß2 tubulin.

ß-Tubulin at 60D            FlyExpress: ßTub60D mesodermal expression
beta Tubulin60D - microtubular cytoskeleton - transiently expressed in the embryo - higher pupal levels in the developing musculature -
Adult expression confined to specific somatic cells in the gonads

gamma Tubulin
gamma Tubulin at 23C - microtubule nucleating factor - critical component of microtubule organizing centers

gamma-Tubulin at 37C
microtubule nucleating factor - eggs produced by mutant mothers show an arrest of nuclear divisions during early embryogenesis
and a disruption in the anterior-posterior axis - required for bicoid mRNA localization

tubulin-specific chaperone E
multidomain protein - required for development and function of neuromuscular synapses - promotes microtubule formation

tudor
tudor domain protein - serves as 'docking platform' for polar granule assembly

tumor suppressor protein 101 (common alternative name: erupted)
binds monoubiquitinated substrates predicted to be ubiquitinated cytoplasmic tails of membrane bound proteins;
this interaction delivers cargos to the lysosome via multivesicular bodies

turtle
Ig superfamily - ligand or co-receptor - required to restrain dendrite branch formation in neurons with simple arbors,
and to promote dendrite self-avoidance in neurons with complex arbors - regulates the tiling pattern of R7 photoreceptor terminals

twin
degrades mRNA poly(A) tails - CCR4 componenet of an enzyme complex catalyzing mRNA deadenylation

twins
Protein phosphatase 2A - B subunit - mutation causes a peripheral nervous system defect similar to those of numb and musashi - mutation also causes a pattern duplication in imaginal discs

twinstar
Drosophila cofilin - actin-depolymerizing and actin-severing protein - essential for neuronal axon growth

twine
cdc25 phosphatase - dephosphorylation of cdc2 by Twine controls entry into meiosis in both males and females
twist            FlyExpress: twist mesodermal anlage and mesodermal expression
transcription factor - bHLH - DV pathway - a switch in the development of muscle - High levels required for somatic myogenesis -
this blocks formation of other mesodermal derivatives such as visceral mesoderm and heart

twisted gastrulation
secreted growth factor - Tsg dislodges latent BMPs bound to Short gastrulation thus activating BMP signaling

Tyramine β hydroxylase
an enzyme that converts tyramine to octopamine, a neurotransmitter that is the insect equivalent of norepinephrine -
octopamine modulates several physiological functions and behaviors including sleep, aggression and ovulation

Tyrosine decarboxylase 1 and Tyrosine decarboxylase 2
catalyze directly the biosynthesis of the neuromodulator tyramine and indirectly the biosynthesis of octopamine -
Tdc1 acts to synthesize tyramine, a potent diuretic factor in the Malpighian tubule - Tdc2 is required neurally for egg deposition

U

U1snRNP (preferred name: sans fille)
splicing factor - a crucial component of the spliceosome - involved in Sex-lethal splicing and consequently in sex determination

U2 small nuclear riboprotein auxiliary factor 50
splicing factor required for the ATP-dependent association of U2 snRNP with pre-mRNA branchpoints - forms a heterodimer
with the small splice factor U2af38 - U2af50 interacts with the intronic 3' polypyrimidine tract -
the small subunit functions in recognition of the 3' AG dinucleotide

Ultrabithorax            FlyExpress: Ubx abdominal and CNS expression
transcription factor - homeodomain - Antp class - Mutations of Ubx result in transformation of the dorsal and ventral appendages of the
third thoracic segment (the haltere and third leg) into their counterparts on the second thoracic segment (wing and second leg).

ultraspiracle
transcription factor - RXR homolog - nuclear receptor - cofactor for Ecdysone receptor

unc-5
multiple domain protein that functions as a repulsive netrin receptor

unc-13
a scaffold protein with a C1 lipid-binding motif and two C2 calcium-binding motifs - mediates signals to control synaptic vesicle exocytosis

unc-104 (common alternative name, immaculate connections or imac)
a Kinesin-3 family member that is essential for transporting synaptic vesicle precursors

unconventional myosin 10A
cytoskeletal motor protein required during dorsal closure for the correct alignment of cells on opposing sides
of the fusing epithelial sheets and for adhesion of the cells during the final zippering/fusion phase

uncoordinated
coiled-coil protein expressed in sensory neurons and the male germline - localizes to centrioles and basal bodies - required for ciliogenesis

unpaired (preferred name: outstretched)
a novel ligand - potential activator of JAK/STAT signaling pathway - mutation results in the stripe-specific loss of expression of even-skipped, fushi tarazu, and runt

unplugged
homeodomain protein - involved in tracheal branching morphogenesis by regulating cell migration or extension;
in the absence of such function, the tracheal founder cells either die or adopt other branch patterns

Upstream of N-ras
RNA-binding protein that interacts with Rox RNAs to repress dosage compensation complex formation in female
and promote its assembly on the male X chromosome

u-shaped           FlyExpress: ush expression in dorsal ectoderm anlage and amnioserosa
multiple zinc finger protein - antagonizes Pnr by physically interacting with the Pnr DNA-binding domain.

Utx
H3K27me3 demethylase - Notch antagonist - suppressor of Rbf-dependent tumors

V

Vacuolar H+ ATPase subunit 68-2
acidification of the endosomal compartment - required in signal-receiving cells for Notch signaling downstream of ligand activation - promotes degradation of Notch

valois
scaffolding protein - required for accumulation of high levels of Oskar protein, for posterior localization of Oskar in later stages of oogenesis
and for posterior localization of the Vasa protein during pole plasm assembly

Van Gogh (common alternative name: strabismus)
novel transmembrane protein - a tissue polarity gene - mutants show a disrupted orientation of ommatidia

Vap-33-1
cleaved secreted ligand for Eph receptors - plays a conserved role in synaptic homeostasis

varicose
Essential septate junction gene encoding a membrane associated guanylate kinase (MAGUK) - required for accumulation of the tracheal
size-control proteins Vermiform and Serpentine in the tracheal lumen

vasa
maternal - RNA helicase - overcomes the repressive effect of Nanos translational control element - activates Gurken translation in wild-type oocytes

vav
a signal transducing protein that participates in EGF receptor pathways and functions as a GEF for Rac

vein
EGF domain and Ig domain - an intrinsically weaker ligand for EGF-receptor than Spitz - Vein is the major ligand for activating EGF-R in intervein regions -
Spitz functions as the major ligand for activating EGF-R in vein territories

veinlet (preferred name: rhomboid)
receptor - transmembrane protein involved with Egfr - an activator of Spitz - spatially restricted Rho expression is responsible for spatially restricted activation of Egfr

veli (common alternative name: Lin-7)
scaffolding protein that acts downstream of DlgS97, in conjunction with its binding partner Metro, to control neuromuscular
junction expansion and proper establishment of synaptic boutons

ventral veins lacking (common alternative name: drifter)
transcription factor - homeodomain - pou domain - mutants display severe tracheal defects and defects in ventral midline glia migration

ventral nervous system defective (vnd) (common alternative name: NK2)
transcription factor - homeodomain - NK2 class - required for the formation of a subset of segmental neuroblasts, and possibly as
a neuroectodermal committment gene - upstream of proneural achaete-scute complex.

vermiform and serpentine
polysaccharide deacetylases - converts chitin to chitosan - required to assemble
cable-like extracellular matrix and restrict tracheal tube elongation

Verprolin 1
facilitator of myoblast fusion - homolog of the conserved Verprolin/WASp Interacting Protein family of WASp-binding proteins -
recruits the actin-polymerization machinery to sites of myoblast attachment and fusion

verthandi (common alternative name: Rad21)
constituent of the cohesin complex, functions in chromosome cohesion, spindle morphology, dynamics of a chromosome passenger protein,
and stability of the cohesin complex

vestigial
presumptive transcription factor - novel - the activation of several genes in the wing field requires Vg/Sd function,
for example activation of Serum response factor intervein promoter

vihar
E2 ubiquitin-conjugating enzyme - contributes to the spatiotemporal control of Cyclin B degradation that occurs first during mitosis at the spindle poles

virilizer
transmembrane protein involved in Sex lethal splicing

vismay
homeodomain transcription factor (TGIF subclass) - required, along with homeodomain protein Achintya, for spermatogenesis

vielfaltig (common alternaltive name: zelda)
zinc finger transcription factor - functions in the cellular blastoderm to activate many genes essential for
cellularization, sex determination and pattern formation

von Hippel-Lindau
E3 ubiquitin ligase - functions in follicular epithelial morphogenesis to stabilize microtubule bundles and aPKC -
in trachea controls the HIF-1 α/sima hypoxia response pathway

vps25
a component of the ESCRT machinery that regulates endocytic sorting of signaling receptors

vrille
basic leucine zipper transcription factor - an enhancer of ddp during the development of dorsal/ventral polarity in the early embryo -
a clock gene: suppression of the normal cycle of vri expression generates long-period rhythms or arrhythmicity

W

wallenda
MapKKK member of the JNK pathway - influences axonal transport by functioning as a kinesin-cargo dissociation factor -
suppresses autophagy-induced neuromuscular junction overgrowth - required for normal axon degeneration

warts
kinase - regulates cell cycle - loss of gene function leads to the cell-autonomous formation of epithelial tumors in the adult integumentary structures derived from imaginal discs.

washout
cytoskeletal protein - acts upstream of Arp2/3 which in turn mediates actin nucleation activity - functions downstream of Rho1
and the formin Cappuccino to control actin and microtubule dynamics during oogenesis - bundles and crosslinks F-actin and microtubules

WASp
Wiskott-Aldrich syndrome protein: regulates actin polymerization

wee
protein tyrosine kinase that targets Cdc2 thus preventing premature activation of the mitotic program

wengen
tumor necrosis factor receptor superfamily - forced expression triggers cell death

white
ABC transporter of amines that partners with Brown in determination of eye pigmentation - Behavioral abnormalities in white, brown and scarlet mutants
could arise from reduced amine levels in neurons

wilderborst
protein phosphatase PP2A-B' regulatory subunit - regulates insulin/insulin-like growth factor signalling through interaction with Akt

wingless
ligand - wnt family - segment polarity gene - two distinct roles for wingless in wing morphogenesis have been identified:
a primary role in specifying the wing primordium, and a subsequent role mediating the patterning activities of the dorso-ventral compartment boundary

wings up A (common alternative name: Troponin I)
cytoskeletal protein - along with Tropomyosin regulates muscle contraction - required to maintain nuclear integrity and
apico-basal polarity during early embryogenesis - required for myofibrillogenesis and sarcomere formation in Drosophila flight muscle

wishful thinking
type II TGFß receptor - functions presynaptically to regulate synaptic size at the neuromuscular junction

wispy
poly(A) polymerase acting on specific mRNA targets during late oogenesis and early embryogenesis - required at the final stage
of oogenesis for metaphase during meiosis I arrest - interacts with Orb genetically and physically in an ovarian complex.

wnt inhibitor of Dorsal (common alternative name: Wnt8)
Wnt family ligand - involved in establishment dorsal/ventral patterning and the immune response

wntless
novel conserved transmembrane protein that acts in the Wnt-sending cells to promote the secretion of Wnt proteins

Wnt oncogene analog 2
ligand - Wnt homolog - required for the development of the sheath of the male reproductive tract and testis morphogenesis

Wnt oncogene analog 4
ligand - TGF-B homolog - mesodermal - a Wingless antagonist

Wnt oncogene analog 5
Wnt superfamily ligand involved in axon guidance and salivary gland morphogenesis

wrapper
Immunoglobulin domain ligand - present in midline glia - required, along with neuronally-expressed
Neurexin IV, for ensheathment of commissural axons

Wrinkled (common alternative name: head involution defective)
induces programd cell death

wunen and wunen-2
lipid phosphate phosphohydrolases - somatic Wun and Wun2 provide a repulsive environment for germ cell migration
by depleting an extracellular, attractive substrate - in germ cells Wun2 competes with somatic Wun and Wun2
for a common lipid phosphate substrate, which is required by germ cells to produce a survival signal

X Y Z

yan (preferred name: anterior open)
ets domain transcription factor - target of Ras pathway that serves to inhibit neural and other types of differentiation
- antagonist of ras signaling

yorkie
ortholog of the mammalian transcriptional coactivator yes-associated protein - transcriptional coactivator that negatively regulates cell-cycle and cell-death regulators

ypsilon schachtel
cold-shock domain protein involved in post-transcriptional regulation of Oskar mRNA

yurt
ERM junctional protein involved in regulating apical-basal polarity - tracheal development

zerknüllt            FlyExpress: zen dorsal expression
transcription factor - homeodomain - Antp class - HoxA3, HoxB3 and HoxD3 homolog - DV polarity - The absence of the amnioserosa in zen
mutants might cause the germ band to be twisted and thrown into folds during an abortive elongation process

zero population growth
germline-specific gap junction protein - Innexin 4 - required for survival of differentiating early germ cells during gametogenesis in both sexes

zeste
transcription factor - hlh domain and leucine zipper domain - trithorax group - Zeste specifically interacts with the p400 Brahma complex component

zeste white 3 (preferred name: shaggy)
cytoplasmic - segment polarity - targets Armadillo and APC postively transducing the Wingless signal

Zinc finger protein RP-8
zinc finger domain transcription factor - essential for hematopoiesis - regulates cell proliferation through
modifiying the function of the centrosome - regulates the level and localization of cell-cycle components

Zn finger homeodomain 1
transcription factor - zinc finger domain and homeodomain - mutation results in various degrees of local errors in mesodermal cell fate or positioning

Zn finger homeodomain 2
transcription factor - zinc finger domain and homeodomain - required for correct proximal wing development

zipper
Myosin II or non-muscle myosin - crucial functions in motility, cytokinesis, dorsal closure, cytoplasmic transport

zucchini
nuclease that functions in germline RNAi processes, required in dorso-ventral patterning pathway - required early during oogenesis
for the translational silencing of osk mRNA and at later stages for proper expression of the Grk protein
- regulates telomere-specific transposable elements




Genes A-D -- Genes E-K -- Genes L-R

Home page: The Interactive Fly © 1995, 1996 Thomas B. Brody, Ph.D.


The Interactive Fly resides on the
Society for Developmental Biology's Web server.