Fly Labs and References


  • Gabriel Haddad Biomedical Sciences Graduate Program, University of California, San Diego
    Jha, A. R., Zhou, D., Brown, C. D., Kreitman, M., Haddad, G. G. and White, K. P. (2015). Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations. Mol Biol Evol [Epub ahead of print]. PubMed ID: 26576852

    Huang, H., Lu-Bo, Y. and Haddad, G. G. (2014). A Drosophila ABC Transporter Regulates Lifespan. PLoS Genet 10: e1004844. PubMed ID: 25474322

    Heinrichsen, E. T., Zhang, H., Robinson, J. E., Ngo, J., Diop, S., Bodmer, R., Joiner, W. J., Metallo, C. M. and Haddad, G. G. (2014). Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Mol Metab 3: 42-54. PubMed ID: 24567903

    Udpa, N., et al. (2014). Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes. Genome Biol 15: R36. PubMed ID: 24555826

    Yin, S., Xue, J., Sun, H., Wen, B., Wang, Q., Perkins, G., Zhao, H. W., Ellisman, M. H., Hsiao, Y. H., Yin, L., Xie, Y., Hou, G., Zi, J., Lin, L., Haddad, G. G., Zhou, D. and Liu, S. (2013). Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions. PLoS One 8: e74011. PubMed ID: 24069262

    Xie, L., Ng, C., Ali, T., Valencia, R., Ferreira, B. L., Xue, V., Tanweer, M., Zhou, D., Haddad, G. G., Bourne, P. E. and Xie, L. (2013). Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia. BMC Genomics 14 Suppl 3: S9. PubMed ID: 23819581

    Zhou, D. and Haddad, G. G. (2013). Genetic analysis of hypoxia tolerance and susceptibility in Drosophila and humans. Annu Rev Genomics Hum Genet 14: 25-43. PubMed ID: 23808366

  • Penelope Haddrill Institute of Evolutionary Biology, University of Edinburgh
    Keightley, P. D., Ness, R. W., Halligan, D. L. and Haddrill, P. R. (2013). Estimation of the Spontaneous Mutation Rate per Nucleotide Site in a Drosophila melanogaster Full-Sib Family. Genetics. PubMed ID: 24214343

    Campos, J. L., Zeng, K., Parker, D. J., Charlesworth, B. and Haddrill, P. R. (2013). Codon usage bias and effective population sizes on the X chromosome versus the autosomes in Drosophila melanogaster. Mol Biol Evol 30: 811-823. PubMed ID: 23204387

    Campos, J. L., Charlesworth, B. and Haddrill, P. R. (2012). Molecular evolution in nonrecombining regions of the Drosophila melanogaster genome. Genome Biol Evol 4: 278-288. PubMed ID: 22275518

  • Marc Haenlin Centre de Biologie du Développement, Université Toulouse
    Miller, M., Chen, A., Gobert, V., Auge, B., Beau, M., Burlet-Schiltz, O., Haenlin, M. and Waltzer, L. (2017). Control of RUNX-induced repression of Notch signaling by MLF and its partner DnaJ-1 during Drosophila hematopoiesis. PLoS Genet 13(7): e1006932. PubMed ID: 28742844

    Benmimoun, B., Polesello, C., Haenlin, M. and Waltzer L. (2015). The EBF transcription factor Collier directly promotes Drosophila blood cell progenitor maintenance independently of the niche. Proc Natl Acad Sci U S A [Epub ahead of print]. PubMed ID: 26150488

    Breig, O., Bras, S., Soria, N. M., Osman, D., Heidenreich, O., Haenlin, M. and Waltzer, L. (2013). Pontin is a critical regulator for AML1-ETO-induced leukemia. Leukemia. PubMed ID: 24342949

    Benmimoun, B., Polesello, C., Waltzer, L. and Haenlin, M. (2012). Dual role for Insulin/TOR signaling in the control of hematopoietic progenitor maintenance in Drosophila. Development 139: 1713-1717. PubMed ID: 22510984

    Hijazi, A., Haenlin, M., Waltzer, L. and Roch, F. (2011). The Ly6 protein coiled is required for septate junction and blood brain barrier organisation in Drosophila. PLoS One 6: e17763. PubMed ID: 21423573

    Polesello, C., Roch, F., Gobert, V., Haenlin, M. and Waltzer, L. (2011). Modeling cancers in Drosophila. Prog Mol Biol Transl Sci 100: 51-82. PubMed ID: 21377624

  • Ernst Hafen Institute of Molecular Systems Biology, Zurich
    Okada, H., Ebhardt, H. A., Vonesch, S. C., Aebersold, R. and Hafen, E. (2016). Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster. Nat Commun 7: 12649. PubMed ID: 27582081

    Lujan, E., Bornemann, D. J., Rottig, C., Bayless, B. A., Stocker, H., Hafen, E., Arora, K. and Warrior, R. (2016). Analysis of novel alleles of brother of tout-velu, the Drosophila ortholog of human EXTL3 using a newly developed FRT42D ovoD chromosome. Genesis [Epub ahead of print]. PubMed ID: 27636555

    Vonesch, S.C., Lamparter, D., Mackay, T.F., Bergmann, S. and Hafen, E. (2016). Genome-wide analysis reveals novel regulators of growth in Drosophila melanogaster. PLoS Genet 12: e1005616. PubMed ID: 26751788

    Jevtov, I., Zacharogianni, M., van Oorschot, M. M., van Zadelhoff, G., Aguilera-Gomez, A., Vuillez, I., Braakman, I., Hafen, E., Stocker, H. and Rabouille, C. (2015). TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules. J Cell Sci. PubMed ID: 26054799

    Okada, H., Schittenhelm, R. B., Straessle, A. and Hafen, E. (2015). Multi-Functional Regulation of 4E-BP Gene Expression by the Ccr4-Not Complex. PLoS One 10: e0113902. PubMed ID: 25793896

    Medici, V., Vonesch, S. C., Fry, S. N. and Hafen, E. (2015). The FlyCatwalk: A high throughput feature-based sorting system for artificial selection in Drosophila. G3 (Bethesda) [Epub ahead of print]. PubMed ID: 25556112

    Handke, B., Szabad, J., Lidsky, P. V., Hafen, E. and Lehner, C. F. (2014). Towards long term cultivation of Drosophila wing imaginal discs in vitro. PLoS One 9: e107333. PubMed ID: 25203426

    Nowak, K., Seisenbacher, G., Hafen, E. and Stocker, H. (2013). Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues. Elife 2: e00380. PubMed ID: 23853709

    Handke, B., Poernbacher, I., Goetze, S., Ahrens, C. H., Omasits, U., Marty, F., Simigdala, N., Meyer, I., Wollscheid, B., Brunner, E., Hafen, E. and Lehner, C. F. (2013). The hemolymph proteome of fed and starved Drosophila larvae. PLoS One 8: e67208. PubMed ID: 23840627

    Sarraf-Zadeh, L., Christen, S., Sauer, U., Cognigni, P., Miguel-Aliaga, I., Stocker, H., Kohler, K. and Hafen, E. (2013). Local requirement of the Drosophila insulin binding protein Imp-L2 in coordinating developmental progression with nutritional conditions. Dev Biol. PubMed ID: 23773803

  • Pejmun Haghighi Buck Institute for Research on Aging, Novato, CA
    Kauwe, G., Tsurudome, K., Penney, J., Mori, M., Gray, L., Calderon, M. R., Elazouzzi, F., Chicoine, N., Sonenberg, N. and Haghighi, A. P. (2016). Acute fasting regulates retrograde synaptic enhancement through a 4E-BP-dependent mechanism. Neuron [Epub ahead of print]. PubMed ID: 27916456

    Penney, J., Tsurudome, K., Liao, E. H., Kauwe, G., Gray, L., Yanagiya, A., M, R. C., Sonenberg, N. and Haghighi, A. P. (2016). LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction. Nat Commun 7: 12188. PubMed ID: 27432119

    Penney, J., Tsurudome, K., Liao, E. H., Elazzouzi, F., Livingstone, M., Gonzalez, M., Sonenberg, N. and Haghighi, A. P. (2012). TOR is required for the retrograde regulation of synaptic homeostasis at the Drosophila neuromuscular junction. Neuron 74(1): 166-178. PubMed ID: 22500638

    Sun, K., Westholm, J. O., Tsurudome, K., Hagen, J. W., Lu, Y., Kohwi, M., Betel, D., Gao, F. B., Haghighi, A. P., Doe, C. Q. and Lai, E. C. (2012). Neurophysiological defects and neuronal gene deregulation in Drosophila mir-124 mutants. PLoS Genet 8(2): e1002515. PubMed ID: 22347817

  • Kaisa Haglund Oslo University Hospital
    Eikenes, A. H., Malerod, L., Christensen, A. L., Steen, C. B., Mathieu, J., Nezis, I. P., Liestol, K., Huynh, J. R., Stenmark, H. and Haglund, K. (2015). ALIX and ESCRT-III coordinately control cytokinetic abscission during germline stem cell division in vivo. PLoS Genet 11: e1004904. PubMed ID: 25635693

    Eikenes, A. H., Brech, A., Stenmark, H., Haglund, K. (2013) Spatiotemporal control of Cindr at ring canals during incomplete cytokinesis in the Drosophila male germline. Dev Biol. PubMed ID: 23499247

    Oppelt, A., Lobert, V. H., Haglund, K., Mackey, A. M., Rameh, L. E., Liestol, K., Schink, K. O., Pedersen, N. M., Wenzel, E. M., Haugsten, E. M., Brech, A., Rusten, T. E., Stenmark, H. and Wesche, J. (2013). Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. EMBO Rep 14: 57-64. PubMed ID: 23154468

    Haglund, K., Nezis, I. P., Lemus, D., Grabbe, C., Wesche, J., Liestol, K., Dikic, I., Palmer, R. and Stenmark, H. (2010). Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster. Curr Biol 20: 944-950. PubMed ID: 20451383

  • Matthew Hahn Department of Biology and School of Informatics and Computing, Indiana University, Bloomington
    Williams, C. M., McCue, M. D., Sunny, N. E., Szejner-Sigal, A., Morgan, T. J., Allison, D. B. and Hahn, D. A. (2016). Cold adaptation increases rates of nutrient flow and metabolic plasticity during cold exposure in Drosophila melanogaster. Proc Biol Sci 283. PubMed ID: 27605506

    Williams, C. M., Watanabe, M., Guarracino, M. R., Ferraro, M. B., Edison, A. S., Morgan, T. J., Boroujerdi, A. F. and Hahn, D. A. (2014). Cold adaptation shapes the robustness of metabolic networks in Drosophila melanogaster. Evolution. PubMed ID: 25308124

    Pease, J. B. and Hahn, M. W. (2013). More accurate phylogenies inferred from low-recombination regions in the presence of incomplete lineage sorting. Evolution 67: 2376-2384. PubMed ID: 23888858

    Schrider, D. R., Houle, D., Lynch, M. and Hahn, M. W. (2013). Rates and Genomic Consequences of Spontaneous Mutational Events in Drosophila melanogaster. Genetics. PubMed ID: 23733788

    Langley, C. H., Stevens, K., Cardeno, C., Lee, Y. C., Schrider, D. R., Pool, J. E., Langley, S. A., Suarez, C., Corbett-Detig, R. B., Kolaczkowski, B., Fang, S., Nista, P. M., Holloway, A. K., Kern, A. D., Dewey, C. N., Song, Y. S., Hahn, M. W. and Begun, D. J. (2012). Genomic variation in natural populations of Drosophila melanogaster. Genetics 192: 533-598. PubMed ID: 22673804

    Han, M. V. and Hahn, M. W. (2012). Inferring the history of interchromosomal gene transposition in Drosophila using n-dimensional parsimony. Genetics 190: 813-825. PubMed ID: 22095076

    Schrider, D. R., Stevens, K., Cardeno, C. M., Langley, C. H. and Hahn, M. W. (2011). Genome-wide analysis of retrogene polymorphisms in Drosophila melanogaster. Genome Res 21: 2087-2095. PubMed ID: 22135405

  • Georg Halder VIB, Flanders, Belgium
    Pascual, J., Jacobs, J., Sansores-Garcia, L., Natarajan, M., Zeitlinger, J., Aerts, S., Halder, G. and Hamaratoglu, F. (2017). Hippo Reprograms the Transcriptional Response to Ras Signaling. Dev Cell 42(6): 667-680.e664. PubMed ID: 28950103

    Atkins, M., Potier, D., Romanelli, L., Jacobs, J., Mach, J., Hamaratoglu, F., Aerts, S. and Halder, G. (2016). An ectopic network of transcription factors regulated by Hippo signaling drives growth and invasion of a malignant tumor model. Curr Biol [Epub ahead of print]. PubMed ID: 27476594

    Davie, K., Jacobs, J., Atkins, M., Potier, D., Christiaens, V., Halder, G. and Aerts, S. (2015). Discovery of transcription factors and regulatory regions driving in vivo tumor development by ATAC-seq and FAIRE-seq open chromatin profiling. PLoS Genet 11: e1004994. PubMed ID: 25679813

    Yang, C.C., Graves, H.K., Moya, I.M., Tao, C., Hamaratoglu, F., Gladden, A.B. and Halder, G. (2015). Differential regulation of the Hippo pathway by adherens junctions and apical-basal cell polarity modules. Proc Natl Acad Sci USA [Epub ahead of print]. PubMed ID: 25624491Atkins, M., Jiang, Y., Sansores-Garcia, L.,

    Jusiak, B., Halder, G. and Mardon, G. (2013). Dynamic rewiring of the Drosophila retinal determination network switches its function from selector to differentiation. PLoS Genet 9: e1003731. PubMed ID: 24009524

    Bossuyt, W., Chen, C. L., Chen, Q., Sudol, M., McNeill, H., Pan, D., Kopp, A., Halder, G. (2013) An evolutionary shift in the regulation of the Hippo pathway between mice and flies. Oncogene. PubMed ID: 23563179

    Sansores-Garcia, L., Atkins, M., Moya, I. M., Shahmoradgoli, M., Tao, C., Mills, G. B. and Halder, G. (2013). Mask Is Required for the Activity of the Hippo Pathway Effector Yki/YAP. Curr Biol. PubMed ID: 23333314

    Schroeder, M. C., Chen, C. L., Gajewski, K. and Halder, G. (2012). A non-cell-autonomous tumor suppressor role for Stat in eliminating oncogenic scribble cells. Oncogene. PubMed ID: 23108407

    Graves, H. K., Woodfield, S. E., Yang, C. C., Halder, G. and Bergmann, A. (2012). Notch signaling activates Yorkie non-cell autonomously in Drosophila. PLoS One 7: e37615. PubMed ID: 22679484

  • Mark Halfon Department of Biochemistry, State University of New York at Buffalo
    Suryamohan, K., Hanson, C., Andrews, E., Sinha, S., Scheel, M. D. and Halfon, M. S. (2016). Redeployment of a conserved gene regulatory network during Aedes aegypti development. Dev Biol [Epub ahead of print]. PubMed ID: 27341759

    Halfon, M. S., Zhu, Q., Brennan, E. R. and Zhou, Y. (2011). Erroneous attribution of relevant transcription factor binding sites despite successful prediction of cis-regulatory modules. BMC Genomics 12: 578. PubMed ID: 22115527

    Kazemian, M., Zhu, Q., Halfon, M. S. and Sinha, S. (2011). Improved accuracy of supervised CRM discovery with interpolated Markov models and cross-species comparison. Nucleic Acids Res 39: 9463-9472. PubMed ID: 21821659

    Gallo, S. M., Gerrard, D. T., Miner, D., Simich, M., Des Soye, B., Bergman, C. M. and Halfon, M. S. (2011). REDfly v3.0: toward a comprehensive database of transcriptional regulatory elements in Drosophila. Nucleic Acids Res 39: D118-123. PubMed ID: 20965965

  • Fumika Hamada University of Cincinnati Department of Pediatrics
    Tang, X., Roessingh, S., Hayley, S. E., Chu, M. L., Tanaka, N. K., Wolfgang, W., Song, S., Stanewsky, R. and Hamada, F. N. (2017). The role of PDF neurons in setting preferred temperature before dawn in Drosophila. Elife 6. PubMed ID: 28463109

    Goda, T., Tang, X., Umezaki, Y., Chu, M. L. and Hamada, F. N. (2016). Drosophila DH31 neuropeptide and PDF receptor regulate night-onset temperature preference. J Neurosci 36: 11739-11754. PubMed ID: 27852781

    Head, L.M., Tang, X., Hayley, S.E., Goda, T., Umezaki, Y., Chang, E.C., Leslie, J.R., Fujiwara, M., Garrity, P.A. and Hamada, F.N. (2015). The influence of light on temperature preference in Drosophila. Curr Biol [Epub ahead of print]. PubMed ID: 25866391

    Goda, T., Leslie, J. R. and Hamada, F. N. (2014). Design and analysis of temperature preference behavior and its circadian rhythm in Drosophila. J Vis Exp. PubMed ID: 24457268

    Tang, X., Platt, M. D., Lagnese, C. M., Leslie, J. R., Hamada, F. N. (2013) Temperature Integration at the AC Thermosensory Neurons in Drosophila. J Neurosci 33: 894-901. PubMed ID: 23325228

    Kaneko, H., Head, L. M., Ling, J., Tang, X., Liu, Y., Hardin, P. E., Emery, P. and Hamada, F. N. (2012). Circadian rhythm of temperature preference and its neural control in Drosophila. Curr Biol 22: 1851-1857. PubMed ID: 22981774

    aniue, K., Nishida, A., Hamada, F., Sugie, A., Oda, T., Ui-Tei, K., Tabata, T. and Akiyama, T. (2010). Sunspot, a link between Wingless signaling and endoreplication in Drosophila. Development 137: 1755-1764. PubMed ID: 20430750

  • Junhai Han Institute of Life Sciences, Southeast University, Nanjing, China
    Li, Q., Li, Y., Wang, X., Qi, J., Jin, X., Tong, H., Zhou, Z., Zhang, Z. C. and Han, J. (2017). Fbxl4 serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABAA receptor. Curr Biol [Epub ahead of print]. PubMed ID: 29174887

    Liu, L., Tian, Y., Zhang, X. Y., Zhang, X., Li, T., Xie, W. and Han, J. (2017). Neurexin restricts axonal branching in columns by promoting Ephrin clustering. Dev Cell 41(1): 94-106.e104. PubMed ID: 28366281

    Tong, H., Li, Q., Zhang, Z. C., Li, Y. and Han, J. (2016). Neurexin regulates nighttime sleep by modulating synaptic transmission. Sci Rep 6: 38246. PubMed ID: 27905548
    Wan, D., Zhang, Z. C., Zhang, X., Li, Q. and Han, J. (2015). X chromosome-linked intellectual disability protein PQBP1 associates with and regulates the translation of specific mRNAs. Hum Mol Genet. PubMed ID: 26002102

    Li, T., Tan, Y., Li, Q., Chen, H., Lv, H., Xie, W. and Han, J. (2015). The Neurexin-NSF interaction regulates short-term synaptic depression. J Biol Chem. PubMed ID: 25953899

    Tian, L., Chen, J., Chen, M., Gui, C., Zhong, C. Q., Hong, L., Xie, C., Wu, X., Yang, L., Ahmad, V. and Han, J. (2014). The p38 pathway Regulates Oxidative Stress Tolerance by Phosphorylation of Mitochondrial Protein IscU. J Biol Chem. PubMed ID: 25204651

    Li, Y., Zhou, Z., Zhang, X., Tong, H., Li, P., Zhang, Z. C., Jia, Z., Xie, W. and Han, J. (2013). Drosophila Neuroligin 4 Regulates Sleep through Modulating GABA Transmission. J Neurosci 33: 15545-15554. PubMed ID: 24068821

    Cao, J., Li, Y., Xia, W., Reddig, K., Hu, W., Xie, W., Li, H. S. and Han, J. (2011). A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin. EMBO J 30: 3701-3713. PubMed ID: 21804530

    Sun, M., Xing, G., Yuan, L., Gan, G., Knight, D., With, S. I., He, C., Han, J., Zeng, X., Fang, M., Boulianne, G. L. and Xie, W. (2011). Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction. J Neurosci 31: 687-699. PubMed ID: 21228178

  • Kyung-An Han The University of Texas at El Paso
    Lim, J., Fernandez, A. I., Hinojos, S. J., Aranda, G. P., James, J., Seong, C. S. and Han, K. A. (2017). The mushroom body D1 dopamine receptor controls innate courtship drive. Genes Brain Behav [Epub ahead of print]. PubMed ID: 28902472

    Kim, Y. C., Lee, H. G., Lim, J., Han, K. A. (2013) Appetitive Learning Requires the Alpha1-Like Octopamine Receptor OAMB in the Drosophila Mushroom Body Neurons. J Neurosci 33: 1672-1677. PubMed ID: 23345239

    Zhou, C., Huang, H., Kim, S. M., Lin, H., Meng, X., Han, K. A., Chiang, A. S., Wang, J. W., Jiao, R. and Rao, Y. (2012). Molecular genetic analysis of sexual rejection: roles of octopamine and its receptor OAMB in Drosophila courtship conditioning. J Neurosci 32: 14281-14287. PubMed ID: 23055498

    Makos, M. A., Han, K. A., Heien, M. L. and Ewing, A. G. (2010). Using In Vivo Electrochemistry to Study the Physiological Effects of Cocaine and Other Stimulants on the Drosophila melanogaster Dopamine Transporter. ACS Chem Neurosci 1: 74-83. PubMed ID: 20352129

  • Zhe Han Division of Molecular Medicine & Genetics, University of Michigan Medical School
    Fu, Y., Zhu, J. Y., Zhang, F., Richman, A., Zhao, Z. and Han, Z. (2017). Comprehensive functional analysis of Rab GTPases in Drosophila nephrocytes. Cell Tissue Res [Epub ahead of print]. PubMed ID: 28180992

    Zhu, J.Y., Fu, Y., Nettleton, M., Richman, A. and Han, Z. (2017). High throughput in vivo functional validation of candidate congenital heart disease genes in Drosophila. Elife [Epub ahead of print]. PubMed ID: 28084990

    Patel, M.V., Zhu, J.Y., Jiang, Z., Richman, A., VanBerkum, M.F. and Han, Z. (2016). Gia/Mthl5 is an aorta specific GPCR required for Drosophila heart tube morphology and normal pericardial cell positioning. Dev Biol [Epub ahead of print]. PubMed ID: 26994946

    Zhang, F., Zhao, Y. and Han, Z. (2013). An In Vivo Functional Analysis System for Renal Gene Discovery in Drosophila Pericardial Nephrocytes. J Am Soc Nephrol. PubMed ID: 23291470

    Chen, Z., Liang, S., Zhao, Y. and Han, Z. (2012). miR-92b regulates Mef2 levels through a negative-feedback circuit during Drosophila muscle development. Development 139: 3543-3552. PubMed ID: 22899845

  • Alfred Handler Agricultural Research Service, USDA, Gainesville, Florida
    Schetelig, M. F. and Handler, A. M. (2013). Germline transformation of the spotted wing drosophilid, Drosophila suzukii, with a piggyBac transposon vector. Genetica. PubMed ID: 23564446

    Schetelig, M. F. and Handler, A. M. (2013). A Functional Comparison of the 3xP3 Promoter by Recombinase-Mediated Cassette Exchange in Drosophila and a Tephritid Fly, Anastrepha suspensa. G3 (Bethesda). PubMed ID: 23550127

  • Greg Hannon Cold Spring Harbor Labs
    Fagegaltier, D., Falciatori, I., Czech, B., Castel, S., Perrimon, N., Simcox, A. and Hannon, G. J. (2016). Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway. Genes Dev 30: 1623-1635. PubMed ID: 27474441

    Yu, Y., Gu, J., Jin, Y., Luo, Y., Preall, J. B., Ma, J., Czech, B. and Hannon, G. J. (2015). Panoramix enforces piRNA-dependent cotranscriptional silencing. Science 350: 339-342. PubMed ID: 26472911

    Dequéant, M.L., Fagegaltier, D., Hu, Y., Spirohn, K., Simcox, A., Hannon, G.J. and Perrimon, N. (2015). Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization. Proc Natl Acad Sci U S A [Epub ahead of print]. PubMed ID: 26438832

    Fagegaltier, D., Konig, A., Gordon, A., Lai, E. C., Gingeras, T. R., Hannon, G. J. and Shcherbata, H. R. (2014). A Genome-Wide Survey of Sexually Dimorphic Expression of Drosophila miRNAs Identifies the Steroid Hormone-Induced miRNA let-7 as a Regulator of Sexual Identity. Genetics. PubMed ID: 25081570

    Zhou, R., Mohr, S., Hannon, G. J. and Perrimon, N. (2014). Inducing RNAi in Drosophila Cells by Soaking with dsRNA. Cold Spring Harb Protoc 2014. PubMed ID: 24786505
    Chang, K., Marran, K., Valentine, A. and Hannon, G. J. (2014). Generation of Transgenic Drosophila Expressing shRNAs in the miR-1 Backbone. Cold Spring Harb Protoc 2014. PubMed ID: 24786506

    Guzzardo, P. M., Muerdter, F. and Hannon, G. J. (2013). The piRNA pathway in flies: highlights and future directions. Curr Opin Genet Dev 23: 44-52. PubMed ID: 23317515

    Rozhkov, N. V., Hammell, M. and Hannon, G. J. (2013). Multiple roles for Piwi in silencing Drosophila transposons. Genes Dev. PubMed ID: 23392609

    Muerdter, F., Guzzardo, P. M., Gillis, J., Luo, Y., Yu, Y., Chen, C., Fekete, R., Hannon, G. J. (2013) A Genome-wide RNAi Screen Draws a Genetic Framework for Transposon Control and Primary piRNA Biogenesis in Drosophila. Mol Cell. PubMed ID: 23665228

    Ipsaro, J. J., Haase, A. D., Knott, S. R., Joshua-Tor, L. and Hannon, G. J. (2012). The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature 491: 279-283. PubMed ID: 23064227

  • Bill Hansson Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena
    Strube-Bloss, M. F., Grabe, V., Hansson, B. S. and Sachse, S. (2017). Calcium imaging revealed no modulatory effect on odor-evoked responses of the Drosophila antennal lobe by two populations of inhibitory local interneurons. Sci Rep 7(1): 7854. PubMed ID: 28798324

    Keesey, I. W., Koerte, S., Khallaf, M. A., Retzke, T., Guillou, A., Grosse-Wilde, E., Buchon, N., Knaden, M. and Hansson, B. S. (2017). Pathogenic bacteria enhance dispersal through alteration of Drosophila social communication. Nat Commun 8(1): 265. PubMed ID: 28814724

    Seki, Y., Dweck, H. K. M., Rybak, J., Wicher, D., Sachse, S. and Hansson, B. S. (2017). Olfactory coding from the periphery to higher brain centers in the Drosophila brain. BMC Biol 15(1): 56. PubMed ID: 28666437

    Getahun, M. N., Thoma, M., Lavista-Llanos, S., Keesey, I., Fandino, R. A., Knaden, M., Wicher, D., Olsson, S. B. and Hansson, B. S. (2016). Intracellular regulation of the insect chemoreceptor complex impacts odor localization in flying insects. J Exp Biol [Epub ahead of print]. PubMed ID: 27591307

    Grabe, V., Baschwitz, A., Dweck, H. K., Lavista-Llanos, S., Hansson, B. S. and Sachse, S. (2016). Elucidating the neuronal architecture of olfactory glomeruli in the Drosophila antennal lobe. Cell Rep 16: 3401-3413. PubMed ID: 27653699

    Keesey, I. W., Koerte, S., Retzke, T., Haverkamp, A., Hansson, B. S. and Knaden, M. (2016). Adult frass provides a pheromone signature for Drosophila feeding and aggregation. J Chem Ecol [Epub ahead of print]. PubMed ID: 27539589

    Dweck, H. K., Ebrahim, S. A., Khallaf, M. A., Koenig, C., Farhan, A., Stieber, R., Weissflog, J., Svatos, A., Grosse-Wilde, E., Knaden, M. and Hansson, B. S. (2016). Olfactory channels associated with the maxillary palp mediate short- and long-range attraction. Elife 5. PubMed ID: 27213519

    Miazzi, F., Hansson, B. S. and Wicher, D. (2016). Odor induced cAMP production in Drosophila melanogaster olfactory sensory neurons. J Exp Biol. PubMed ID: 27045092

    Mukunda, L., Miazzi, F., Sargsyan, V., Hansson, B. S. and Wicher, D. (2016). Calmodulin affects sensitization of Drosophila melanogaster odorant receptors. Front Cell Neurosci 10: 28. PubMed ID: 26903813

    Rybak, J., Talarico, G., Ruiz, S., Arnold, C., Cantera, R. and Hansson, B. S. (2016). Synaptic circuitry of identified neurons in the antennal lobe of Drosophila melanogaster. J Comp Neurol. PubMed ID: 26780543

  • Susan Harbison Laboratory of Systems Genetics, NHLBI, NIH
    Lobell, A. S., Kaspari, R. R., Serrano Negron, Y. L. and Harbison, S. T. (2017). The Genetic architecture of ovariole number in Drosophila melanogaster: Genes with major, quantitative, and pleiotropic effects. G3 (Bethesda). PubMed ID: 28550012

    Huang, W., Lyman, R. F., Lyman, R. A., Carbone, M. A., Harbison, S. T., Magwire, M. M. and Mackay, T. F. (2016). Spontaneous mutations and the origin and maintenance of quantitative genetic variation. Elife 5. PubMed ID: 27213517

    Jumbo-Lucioni, P., Bu, S., Harbison, S. T., Slaughter, J. C., Mackay, T. F., Moellering, D. R. and De Luca, M. (2012). Nuclear genomic control of naturally occurring variation in mitochondrial function in Drosophila melanogaster. BMC Genomics 13: 659. PubMed ID: 23171078

    Swarup, S., Harbison, S. T., Hahn, L. E., Morozova, T. V., Yamamoto, A., Mackay, T. F. and Anholt, R. R. (2012). Extensive epistasis for olfactory behaviour, sleep and waking activity in Drosophila melanogaster. Genet Res (Camb) 94: 9-20. PubMed ID: 22353245

    De Luca, M., Klimentidis, Y. C., Casazza, K., Chambers, M. M., Cho, R., Harbison, S. T., Jumbo-Lucioni, P., Zhang, S., Leips, J. and Fernandez, J. R. (2010). A conserved role for syndecan family members in the regulation of whole-body energy metabolism. PLoS One 5: e11286. PubMed ID: 20585652

  • Roger Hardie Department of Physiology, Development and Neuroscience, University of Cambridge
    Cao, J., Bollepalli, M. K., Hu, Y., Zhang, J., Li, Q., Li, H., Chang, H., Xiao, F., Hardie, R. C., Rong, Y. S. and Hu, W. (2017). A single residue mutation in the Galphaq subunit of the G protein complex causes blindness in Drosophila. G3 (Bethesda). PubMed ID: 29158337

    Bollepalli, M. K., Kuipers, M. E., Liu, C. H., Asteriti, S. and Hardie, R. C. (2017). Phototransduction in Drosophila is compromised by Gal4 expression but not by InsP3 receptor knockdown or mutation. eNeuro 4(3). PubMed ID: 28660247

    Asteriti, S., Liu, C. H. and Hardie, R. C. (2017). Calcium signalling in Drosophila photoreceptors measured with GCaMP6f. Cell Calcium. PubMed ID: 28238353

    Friederich, U., Billings, S. A., Hardie, R. C., Juusola, M. and Coca, D. (2016). Fly photoreceptors encode phase congruency. PLoS One 11: e0157993. PubMed ID: 27336733

    Dau, A., Friederich, U., Dongre, S., Li, X., Bollepalli, M. K., Hardie, R. C. and Juusola, M. (2016). Evidence for Dynamic Network Regulation of Drosophila Photoreceptor Function from Mutants Lacking the Neurotransmitter Histamine. Front Neural Circuits 10: 19. PubMed ID: 27047343

    Hardie, R. C., Liu, C. H., Randall, A. S. and Sengupta, S. (2015). In vivo tracking of phosphoinositides in Drosophila photoreceptors. J Cell Sci [Epub ahead of print]. PubMed ID: 26483384

    Randall, A. S., Liu, C. H., Chu, B., Zhang, Q., Dongre, S. A., Juusola, M., Franze, K., Wakelam, M. J. and Hardie, R. C. (2015). Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids. J Neurosci 35: 2731-2746. PubMed ID: 25673862

    Hardie, R. C. and Juusola, M. (2015). Phototransduction in Drosophila. Curr Opin Neurobiol 34C: 37-45. PubMed ID: 25638280

    Randall, A.S., Liu, C.H., Chu, B., Zhang, Q., Dongre, S.A., Juusola, M., Franze, K., Wakelam, M.J. and Hardie, R.C. (2015). Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids> J Neurosci 35: 2731-2746. PubMed ID: 25673862

    Pantazis, A., Segaran, A., Liu, C. H., Nikolaev, A., Rister, J., Thum, A. S., Roeder, T., Semenov, E., Juusola, M. and Hardie, R. C. (2008). Distinct roles for two histamine receptors (hclA and hclB) at the Drosophila photoreceptor synapse. J Neurosci 28: 7250-7259. PubMed ID: 18632929

  • Nicholas Harden Simon Fraser University, Vancouver
    Reed, B. and Harden, N. (2017). Studying nonproliferative roles for Egfr signaling in tissue morphogenesis using Dorsal closure of the Drosophila embryo. Methods Mol Biol 1652: 229-256. PubMed ID: 28791646

    Wang, S., Yoo, S., Kim, H. Y., Wang, M., Zheng, C., Parkhouse, W., Krieger, C. and Harden, N. (2015). Detection of in situ protein-protein complexes at the Drosophila larval neuromuscular junction using proximity ligation assay. J Vis Exp. PubMed ID: 25650626

    Vlachos, S., Jangam, S., Conder, R., Chou, M., Nystul, T. and Harden, N. (2015). A Pak-regulated cell intercalation event leading to a novel radial cell polarity is involved in positioning of the follicle stem cell niche in the Drosophila ovary. Development 142: 82-91. PubMed ID: 25516970

    Wang, S. J., Tsai, A., Wang, M., Yoo, S., Kim, H. Y., Yoo, B., Chui, V., Kisiel, M., Stewart, B., Parkhouse, W., Harden, N. and Krieger, C. (2014). Phospho-regulated Drosophila adducin is a determinant of synaptic plasticity in a complex with Dlg and PIP2 at the larval neuromuscular junction. Biol Open. PubMed ID: 25416060

    Shen, W., Chen, X., Cormier, O., Cheng, D. C., Reed, B., Harden, N. (2013) Modulation of Morphogenesis by Egfr during Dorsal Closure in Drosophila. PLoS One 8: e60180. PubMed ID: 23579691

    Wang, S., Yang, J., Tsai, A., Kuca, T., Sanny, J., Lee, J., Dong, K., Harden, N. and Krieger, C. (2011). Drosophila adducin regulates Dlg phosphorylation and targeting of Dlg to the synapse and epithelial membrane. Dev Biol 357: 392-403. PubMed ID: 21791202

    Vlachos, S. and Harden, N. (2011). Genetic evidence for antagonism between Pak protein kinase and Rho1 small GTPase signaling in regulation of the actin cytoskeleton during Drosophila oogenesis. Genetics 187: 501-512. PubMed ID: 21098722

  • Paul Hardin Department of Biology, Texas A&M, College Station
    Liu, T., Mahesh, G., Yu, W. and Hardin, P. E. (2017). CLOCK stabilizes CYCLE to initiate clock function in Drosophila. Proc Natl Acad Sci U S A 114(41): 10972-10977. PubMed ID: 28973907

    Gunawardhana, K. L. and Hardin, P. E. (2017). VRILLE vontrols PDF neuropeptide accumulation and arborization rhythms in small ventrolateral neurons to drive rhythmic behavior in Drosophila. Curr Biol 27(22): 3442-3453.e3444. PubMed ID: 29103936

    Agrawal, P., Houl, J. H., Gunawardhana, K. L., Liu, T., Zhou, J., Zoran, M. J. and Hardin, P. E. (2017). Drosophila CRY entrains clocks in body tissues to light and maintains passive membrane properties in a non-clock body tissue independent of light. Curr Biol [Epub ahead of print]. PubMed ID: 28781048

    Zhou, J., Yu, W. and Hardin, P. E. (2016). CLOCKWORK ORANGE enhances PERIOD mediated rhythms in transcriptional repression by antagonizing E-box binding by CLOCK-CYCLE. PLoS Genet 12: e1006430. PubMed ID: 27814361

    Agrawal, P. and Hardin, P. E. (2016). The Drosophila receptor protein tyrosine phosphatase LAR is required for development of circadian pacemaker neuron processes that support rhythmic activity in constant darkness but not during light/dark cycles. J Neurosci 36: 3860-3870. PubMed ID: 27030770

    Liu, T., Mahesh, G., Houl, J. H. and Hardin, P. E. (2015). Circadian activators are expressed days before they initiate clock function in late pacemaker neurons from drosophila. J Neurosci 35: 8662-8671. PubMed ID: 26041931

    Zhou, J., Yu, W. and Hardin, P. E. (2015). ChIPping Away at the Drosophila Clock. Methods Enzymol 551: 323-347. PubMed ID: 25662463

    Glossop, N. R., Gummadova, J. O., Ghangrekar, I., Hardin, P. E. and Coutts, G. A. (2014). Effects of TWIN-OF-EYELESS on Clock Gene Expression and Central-Pacemaker Neuron Development in Drosophila. J Biol Rhythms 29: 151-166. PubMed ID: 24916389

    Mahesh, G., Jeong, E., Ng, F. S., Liu, Y., Gunawardhana, K., Houl, J. H., Yildirim, E., Amunugama, R., Jones, R., Allen, D. L., Edery, I., Kim, E. Y. and Hardin, P. E. (2014). Phosphorylation of the Transcription Activator CLOCK Regulates Progression Through a ~24h Feedback Loop to Influence Circadian Period in Drosophila. J Biol Chem. PubMed ID: 24872414

    Kaneko, H., Head, L. M., Ling, J., Tang, X., Liu, Y., Hardin, P. E., Emery, P. and Hamada, F. N. (2012). Circadian rhythm of temperature preference and its neural control in Drosophila. Curr Biol 22: 1851-1857. PubMed ID: 22981774

  • Iswar Hariharan Molecular and Cell Biology, U. C. Berkeley
    Yoo, S. K., Pascoe, H. G., Pereira, T., Kondo, S., Jacinto, A., Zhang, X. and Hariharan, I. K. (2016). Plexins function in epithelial repair in both Drosophila and zebrafish. Nat Commun 7: 12282. PubMed ID: 27452696

    Bosch, J.A., Sumabat, T.M. and Hariharan, I.K. (2016). Persistence of RNAi-mediated knockdown in Drosophila complicates mosaic analysis yet enables highly sensitive lineage tracing. Genetics [Epub ahead of print]. PubMed ID: 26984059

    Harris, R.E., Setiawan, L., Saul, J. and Hariharan, I.K. (2016). Localized epigenetic silencing of a damage-activated WNT enhancer limits regeneration in mature Drosophila imaginal discs. Elife [Epub ahead of print]. PubMed ID: 26840050

    Hariharan, I. K. (2015). Organ size control: Lessons from Drosophila. Dev Cell 34: 255-265. PubMed ID: 26267393

    Bosch, J. A., Tran, N. H. and Hariharan, I. K. (2015). CoinFLP: a system for efficient mosaic screening and for visualizing clonal boundaries in Drosophila. Development 142: 597-606. PubMed ID: 25605786

    Bosch, J. A., Sumabat, T. M., Hafezi, Y., Pellock, B. J., Gandhi, K. D. and Hariharan, I. (2014). The Drosophila F-box protein Fbxl7 binds to the protocadherin Fat and regulates Dachs localization and Hippo signaling. Elife: e03383. PubMed ID: 25107277

    Worley, M. I., Setiawan, L. and Hariharan, I. K. (2013). TIE-DYE: a combinatorial marking system to visualize and genetically manipulate clones during development in Drosophila melanogaster. Development. PubMed ID: 23785055

    Kanda, H., Nguyen, A., Chen, L., Okano, H. and Hariharan, I. K. (2013). The Drosophila ortholog of MLL 3/MLL 4, trithorax related, functions as a negative regulator of tissue growth. Mol Cell Biol. PubMed ID: 23459941

    Worley, M. I., Setiawan, L. and Hariharan, I. K. (2012). Regeneration and transdetermination in Drosophila imaginal discs. Annu Rev Genet 46: 289-310. PubMed ID: 22934642

    Hafezi, Y., Bosch, J. A. and Hariharan, I. K. (2012). Differences in levels of the transmembrane protein Crumbs can influence cell survival at clonal boundaries. Dev Biol 368: 358-369. PubMed ID: 22683826

  • Greg Harris San Diego State University
    Ratliff, E. P., Mauntz, R. E., Kotzebue, R. W., Gonzalez, A., Achal, M., Barekat, A., Finley, K. A., Sparhawk, J. M., Robinson, J. E., Herr, D. R., Harris, G. L., Joiner, W. J. and Finley, K. D. (2015). Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila Behaviors. PLoS One 10: e0132768. PubMed ID: 26182057

    Walls, S. M., Attle, S. J., Brulte, G. B., Walls, M. L., Finley, K. D., Chatfield, D. A., Herr, D. R. and Harris, G. L. (2013). Identification of Sphingolipid Metabolites That Induce Obesity via Misregulation of Appetite, Caloric Intake and Fat Storage in Drosophila. PLoS Genet 9: e1003970. PubMed ID: 24339790

    Fyrst, H., Zhang, X., Herr, D. R., Byun, H. S., Bittman, R., Phan, V. H., Harris, G. L. and Saba, J. D. (2008). Identification and characterization by electrospray mass spectrometry of endogenous Drosophila sphingadienes. J Lipid Res 49: 597-606. PubMed ID: 18156591

  • Tony Harris Department of Cell & Systems Biology, University of Toronto
    Rodrigues, F. F., Shao, W. and Harris, T. J. (2016). The Arf GAP Asap promotes Arf1 function at the Golgi for cleavage furrow biosynthesis in Drosophila. Mol Biol Cell [Epub ahead of print]. PubMed ID: 27535433

    Lee, D. M., Rodrigues, F. F., Yu, C. G., Swan, M. and Harris, T. J. (2015). PH Domain-Arf G Protein Interactions Localize the Arf-GEF Steppke for Cleavage Furrow Regulation in Drosophila. PLoS One 10: e0142562. PubMed ID: 26556630

    Jiang, T., McKinley, R. F., McGill, M. A., Angers, S. and Harris, T. J. (2015). A Par-1-Par-3-centrosome cell polarity pathway and its tuning for isotropic cell adhesion. Curr Biol 25: 2701-2708. PubMed ID: 26455305

    Hunter, M.V., Lee, D.M., Harris, T.J. and Fernandez-Gonzalez, R. (2015). Polarized E-cadherin endocytosis directs actomyosin remodeling during embryonic wound repair. J Cell Biol [Epub ahead of print]. PubMed ID: 26304727

    Lee, D. M., Wilk, R., Hu, J., Krause, H. M. and Harris, T. J. (2015). Germ Cell Segregation from the Drosophila Soma Is Controlled by an Inhibitory Threshold Set by the Arf-GEF Steppke. Genetics. PubMed ID: 25971667

    Liu, J., Lee, D. M., Yu, C. G., Angers, S. and Harris, T. J. (2014). Stepping stone: a cytohesin adaptor for membrane cytoskeleton restraint in the syncytial Drosophila embryo. Mol Biol Cell. PubMed ID: 25540427

    Lee, D. M. and Harris, T. J. (2014). Coordinating the cytoskeleton and endocytosis for regulated plasma membrane growth in the early Drosophila embryo. Bioarchitecture 4. PubMed ID: 24874871

    Yu, C. G., Tonikian, R., Felsensteiner, C., Jhingree, J. R., Desveaux, D., Sidhu, S. S. and Harris, T. J. (2014). Peptide binding properties of the three PDZ domains of bazooka (Drosophila par-3). PLoS One 9: e86412. PubMed ID: 24466078

    Goldenberg, G. and Harris, T. J. (2013). Adherens Junction Distribution Mechanisms during Cell-Cell Contact Elongation in Drosophila. PLoS One 8: e79613. PubMed ID: 24223978

  • Doug Harrison Department of Biology, University of Kentucky
    Wang, L., Sexton, T. R., Venard, C., Giedt, M., Guo, Q., Chen, Q. and Harrison, D. A. (2014). Pleiotropy of the Drosophila JAK pathway cytokine Unpaired 3 in development and aging. Dev Biol. PubMed ID: 25245869

    Hayashi, Y., Sexton, T. R., Dejima, K., Perry, D. W., Takemura, M., Kobayashi, S., Nakato, H. and Harrison, D. A. (2012). Glypicans regulate JAK/STAT signaling and distribution of the Unpaired morphogen. Development 139: 4162-4171. PubMed ID: 23093424

    Cai, W., Rudolph, J. L., Harrison, S. M., Jin, L., Frantz, A. L., Harrison, D. A. and Andres, D. A. (2011). An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance. Mol Biol Cell 22: 3231-3241. PubMed ID: 21737674

    Zhu, F., Parthasarathy, R., Bai, H., Woithe, K., Kaussmann, M., Nauen, R., Harrison, D. A. and Palli, S. R. (2010). A brain-specific cytochrome P450 responsible for the majority of deltamethrin resistance in the QTC279 strain of Tribolium castaneum. Proc Natl Acad Sci U S A 107: 8557-8562. PubMed ID: 20410462

  • Jon Harrison School of Life Sciences, Arizona State University, Tempe
    Callier, V., Hand, S. C., Campbell, J. B., Biddulph, T. and Harrison, J. F. (2015). Developmental changes in hypoxic exposure and responses to anoxia in Drosophila melanogaster. J Exp Biol. PubMed ID: 26206351

    Farzin, M., Albert, T., Pierce, N., VandenBrooks, J. M., Dodge, T. and Harrison, J. F. (2014). Acute and chronic effects of atmospheric oxygen on the feeding behavior of Drosophila melanogaster larvae. J Insect Physiol. PubMed ID: 25008193

    Callier, V., Shingleton, A. W., Brent, C. S., Ghosh, S. M., Kim, J. and Harrison, J. F. (2013). The role of reduced oxygen in the developmental physiology of growth and metamorphosis initiation in Drosophila melanogaster. J Exp Biol 216: 4334-4340. PubMed ID: 24259256

    Schilman, P. E., Waters, J. S., Harrison, J. F. and Lighton, J. R. (2011). Effects of temperature on responses to anoxia and oxygen reperfusion in Drosophila melanogaster. J Exp Biol 214: 1271-1275. PubMed ID: 21430203

    Heinrich, E. C., Farzin, M., Klok, C. J. and Harrison, J. F. (2011). The effect of developmental stage on the sensitivity of cell and body size to hypoxia in Drosophila melanogaster. J Exp Biol 214: 1419-1427. PubMed ID: 21490250

  • Melissa Harrison Biomolecular Chemistory, University of Wisconsin, Madison
    Janssens, D. H., Hamm, D. C., Anhezini, L., Xiao, Q., Siller, K. H., Siegrist, S. E., Harrison, M. M. and Lee, C. Y. (2017). An Hdac1/Rpd3-poised circuit balances continual self-renewal and rapid restriction of developmental potential during asymmetric stem cell division. Dev Cell 40(4): 367-380.e367. PubMed ID: 28245922

    Nevil, M., Bondra, E. R., Schulz, K. N., Kaplan, T. and Harrison, M. M. (2016). Stable binding of the conserved transcription factor Grainy head to Its target genes throughout Drosophila melanogaster development. Genetics [Epub ahead of print]. PubMed ID: 28007888

    Schulz, K.N., Bondra, E.R., Moshe, A., Villalta, J.E., Lieb, J.D., Kaplan, T., McKay, D.J. and Harrison, M.M. (2015). Zelda is differentially required for chromatin accessibility, transcription-factor binding and gene expression in the early Drosophila embryo. Genome Res [Epub ahead of print]. PubMed ID: 26335634

    Hamm, D. C., Bondra, E. R. and Harrison, M. M. (2014). Transcriptional activation is a conserved feature of the early embryonic factor Zelda that requires a cluster of four zinc fingers for DNA binding and a low-complexity activation domain. J Biol Chem [Epub ahead of print]. PubMed ID: 25538246

    Gratz, S. J., Cummings, A. M., Nguyen, J. N., Hamm, D. C., Donohue, L. K., Harrison, M. M., Wildonger, J. and O'Connor-Giles, K. M. (2013). Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease. Genetics 194: 1029-1035. PubMed ID: 23709638

    Harrison, M. M., Li, X. Y., Kaplan, T., Botchan, M. R. and Eisen, M. B. (2011). Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition. PLoS Genet 7: e1002266. PubMed ID: 22028662

    Cline, T. W., Dorsett, M., Sun, S., Harrison, M. M., Dines, J., Sefton, L. and Megna, L. (2010). Evolution of the Drosophila feminizing switch gene Sex-lethal. Genetics 186: 1321-1336. PubMed ID: 20837995

    Harrison, M. M., Botchan, M. R. and Cline, T. W. (2010). Grainyhead and Zelda compete for binding to the promoters of the earliest-expressed Drosophila genes. Dev Biol 345: 248-255. PubMed ID: 20599892

  • Craig Hart Department of Biological Sciences, Louisana State University, Baton Rouge
    Avva, S. V. and Hart, C. M. (2016). Characterization of the Drosophila BEAF-32A and BEAF-32B insulator proteins. PLoS One 11: e0162906. PubMed ID: 27622635

    Hart, C. M. (2013). Do the BEAF insulator proteins regulate genes involved in cell polarity and neoplastic growth? Dev Biol. PubMed ID: 24211761

    Soshnev, A. A., He, B., Baxley, R. M., Jiang, N., Hart, C. M., Tan, K. and Geyer, P. K. (2012). Genome-wide studies of the multi-zinc finger Drosophila Suppressor of Hairy-wing protein in the ovary. Nucleic Acids Res 40: 5415-5431. PubMed ID: 22406832

    Roy, S., Jiang, N. and Hart, C. M. (2011). Lack of the Drosophila BEAF insulator proteins alters regulation of genes in the Antennapedia complex. Mol Genet Genomics 285: 113-123. PubMed ID: 21132442

  • Peter Harte Department of Genetics, School of Medicine, Case Western Reserve University
    Du, J., Zhang, J., He, T., Li, Y., Su, Y., Tie, F., Liu, M., Harte, P. J. and Zhu, A. J. (2016). Stuxnet facilitates the degradation of Polycomb protein during development. Dev Cell 37: 507-519. PubMed ID: 27326929

    Tie, F., Banerjee, R., Fu, C., Stratton, C.A., Fang, M. and Harte, P.J. (2016). Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain. Proc Natl Acad Sci U S A [Epub ahead of print]. PubMed ID: 26802126

    Tie, F., Banerjee, R., Saiakhova, A. R., Howard, B., Monteith, K. E., Scacheri, P. C., Cosgrove, M. S. and Harte, P. J. (2014). Trithorax monomethylates histone H3K4 and interacts directly with CBP to promote H3K27 acetylation and antagonize Polycomb silencing. Development 141: 1129-1139. PubMed ID: 24550119

    Mason-Suares, H., Tie, F., Yan, C., Harte, P. J. (2013) Polycomb silencing of the Drosophila 4E-BP gene regulates imaginal disc cell growth. Dev Biol. PubMed ID: 23523430

    Siebold, A. P., Banerjee, R., Tie, F., Kiss, D. L., Moskowitz, J. and Harte, P. J. (2010). Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance. Proc Natl Acad Sci U S A 107: 169-174. PubMed ID: 20018689

    Tie, F., Banerjee, R., Stratton, C. A., Prasad-Sinha, J., Stepanik, V., Zlobin, A., Diaz, M. O., Scacheri, P. C. and Harte, P. J. (2009). CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing. Development 136: 3131-3141. PubMed ID: 19700617

  • Volker Hartenstein Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles
    Lovick, J. K., Omoto, J. J., Ngo, K. T. and Hartenstein, V. (2017). Development of the anterior visual input pathway to the Drosophila central complex. J Comp Neurol. PubMed ID: 28675433

    Boyan, G., Liu, Y., Khalsa, S. K. and Hartenstein, V. (2017). A conserved plan for wiring up the fan-shaped body in the grasshopper and Drosophila. Dev Genes Evol 227(4): 253-269. PubMed ID: 28752327

    Kendroud, S., Bohra, A. A., Kuert, P. A., Nguyen, B., Guillermin, O., Sprecher, S. G., Reichert, H., VijayRaghavan, K. and Hartenstein, V. (2017). Structure and development of the subesophageal zone of the Drosophila brain. II. Sensory compartments. J Comp Neurol. PubMed ID: 28875566

    Hartenstein, V., Takashima, S., Hartenstein, P., Asanad, S. and Asanad, K. (2017). bHLH proneural genes as cell fate determinants of entero-endocrine cells, an evolutionarily conserved lineage sharing a common root with sensory neurons. Dev Biol [Epub ahead of print]. PubMed ID: 28751238

    Hartenstein, V., Omoto, J. J., Ngo, K. T., Wong, D., Kuert, P. A., Reichert, H., Lovick, J. K. and Younossi-Hartenstein, A. (2017). Structure and development of the subesophageal zone of the Drosophila brain. I. Segmental architecture, compartmentalization, and lineage anatomy. J Comp Neurol. PubMed ID: 28730682

    Boyan, G., Liu, Y., Khalsa, S. K. and Hartenstein, V. (2017). A conserved plan for wiring up the fan-shaped body in the grasshopper and Drosophila. Dev Genes Evol 227(4): 253-269. PubMed ID: 28752327

    Lovick, J. K., Omoto, J. J., Ngo, K. T. and Hartenstein, V. (2017). Development of the anterior visual input pathway to the Drosophila central complex. J Comp Neurol. PubMed ID: 28675433

    Ngo, K. T., Andrade, I. and Hartenstein, V. (2017). Spatio-temporal pattern of neuronal differentiation in the Drosophila visual system: A user's guide to the dynamic morphology of the developing optic lobe. Dev Biol [Epub ahead of print]. PubMed ID: 28533086

    Omoto, J. J., Keles, M. F., Nguyen, B. M., Bolanos, C., Lovick, J. K., Frye, M. A. and Hartenstein, V. (2017). Visual Input to the Drosophila Central Complex by Developmentally and Functionally Distinct Neuronal Populations. Curr Biol 27(8): 1098-1110. PubMed ID: 28366740

    Aghajanian, P., Takashima, S., Paul, M., Younossi-Hartenstein, A. and Hartenstein, V. (2016). Metamorphosis of the Drosophila visceral musculature and its role in intestinal morphogenesis and stem cell formation. Dev Biol. PubMed ID: 27765651

    Takashima, S., Aghajanian, P., Younossi-Hartenstein, A. and Hartenstein, V. (2016). Origin and dynamic lineage characteristics of the developing Drosophila midgut stem cells. Dev Biol [Epub ahead of print]. PubMed ID: 27321560

    Gresser, A. L., Gutzwiller, L. M., Gauck, M. K., Hartenstein, V., Cook, T. A. and Gebelein, B. (2015). Rhomboid enhancer activity defines a subset of Drosophila neural precursors required for proper feeding, growth and viability. PLoS One 10: e0134915. PubMed ID: 26252385

    Lovick, J. K., Kong, A., Omoto, J. J., Ngo, K. T., Younossi-Hartenstein, A. and Hartenstein, V. (2015). Patterns of growth and tract formation during the early development of secondary lineages in the Drosophila larval brain. Dev Neurobiol. PubMed ID: 26178322

    Hartenstein, V., Younossi-Hartenstein, A., Lovick, J., Kong, A., Omoto, J., Ngo, K. and Viktorin, G. (2015). Lineage-associated tracts defining the anatomy of the drosophila first instar larval brain. Dev Biol. PubMed ID: 26141956

  • Daniel Hartl Department of Organismic and Evolutionary Biology, Harvard University
    Lienard, M. A., Araripe, L. O. and Hartl, D. L. (2016). Neighboring genes for DNA-binding proteins rescue male sterility in Drosophila hybrids. Proc Natl Acad Sci U S A [Epub ahead of print]. PubMed ID: 27357670

    Ayroles, J. F., Buchanan, S. M., O'Leary, C., Skutt-Kakaria, K., Grenier, J. K., Clark, A. G., Hartl, D. L. and de Bivort, B. L. (2015). Behavioral idiosyncrasy reveals genetic control of phenotypic variability. Proc Natl Acad Sci U S A. PubMed ID: 25953335

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  • Fu-De Huang Shanghai Institutes for Biological Sciences
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    Han, M., Huang, J. K., Liu, H. Y., Wang, W. A., Sun, X. J. and Huang, F. D. (2015). Neither insufficiency nor overexpression of sac1 affects the accumulation of Abeta42 in Drosophila expressing Ab42. Eur Rev Med Pharmacol Sci 19(9): 1700-1705. PubMed ID: 26004612

  • Xun Huang Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing
    Fan, W., Lam, S. M., Xin, J., Yang, X., Liu, Z., Liu, Y., Wang, Y., Shui, G. and Huang, X. (2017). Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition. PLoS Genet 13(3): e1006664. PubMed ID: 28273089

    Bi, J., Xiang, Y., Chen, H., Liu, Z., Gronke, S., Kuhnlein, R. P. and Huang, X. (2012). Opposite and redundant roles of the two Drosophila perilipins in lipid mobilization. J Cell Sci 125: 3568-3577. PubMed ID: 22505614

    Wang, C., Liu, Z. and Huang, X. (2012). Rab32 is important for autophagy and lipid storage in Drosophila. PLoS One 7: e32086. PubMed ID: 22348149

    Ma, Z., Liu, Z. and Huang, X. (2012). Membrane phospholipid asymmetry counters the adverse effects of sterol overloading in the Golgi membrane of Drosophila. Genetics 190: 1299-1308. PubMed ID: 22234859

    Tian, Y., Bi, J., Shui, G., Liu, Z., Xiang, Y., Liu, Y., Wenk, M. R., Yang, H. and Huang, X. (2011). Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation. PLoS Genet 7: e1001364. PubMed ID: 21533227

  • Armin Huber Zentrum für Neurosensorik -, Institut für Physiologie, Tübingen University
    Katz, B., Voolstra, O., Tzadok, H., Yasin, B., Rhodes-Modrov, E., Bartels, J. P., Strauch, L., Huber, A. and Minke, B. (2017). The latency of the light response is modulated by the phosphorylation state of Drosophila TRP at a specific site. Channels (Austin): [Epub ahead of print]. PubMed ID: 28762890

    Voolstra, O., Rhodes-Mordov, E., Katz, B., Bartels, J. P., Oberegelsbacher, C., Schotthofer, S. K., Yasin, B., Tzadok, H., Huber, A. and Minke, B. (2017). The phosphorylation state of the Drosophila TRP channel modulates the frequency response to oscillating light in vivo. J Neurosci 37(15): 4213-4224. PubMed ID: 28314815

    Schopf, K. and Huber, A. (2016). Membrane protein trafficking in Drosophila photoreceptor cells. Eur J Cell Biol. PubMed ID: 27964885

    Paulsen, R., Bahner, M. and Huber, A. (2000). The PDZ assembled "transducisome" of microvillar photoreceptors: the TRP/TRPL problem. Pflugers Arch 439: R181-R183. PubMed ID: 27757613

    Cerny, A. C., Altendorfer, A., Schopf, K., Baltner, K., Maag, N., Sehn, E., Wolfrum, U. and Huber, A. (2015). The GTP- and Phospholipid-Binding Protein TTD14 Regulates Trafficking of the TRPL Ion Channel in Drosophila Photoreceptor Cells. PLoS Genet 11: e1005578. PubMed ID: 26509977

    Voolstra, O., Spat, P., Oberegelsbacher, C., Claussen, B., Pfannstiel, J. and Huber, A. (2015). Light-dependent phosphorylation of the Drosophila Inactivation No Afterpotential D (INAD) scaffolding protein at Thr170 and Ser174 by eye-specific Protein kinase C. PLoS One 10: e0122039. PubMed ID: 25799587

    Katz, B., Oberacker, T., Richter, D., Tzadok, H., Peters, M., Minke, B., Huber, A. (2013) The Drosophila TRP and TRPL are assembled as homomultimeric channels in vivo. J Cell Sci. PubMed ID: 23687378

    Cerny, A. C., Oberacker, T., Pfannstiel, J., Weigold, S., Will, C., Huber, A. (2013) Mutation of light-dependent phosphorylation sites of the Drosophila transient receptor potential-like (TRPL) ion channel affects its subcellular localization and stability. J Biol Chem. PubMed ID: 23592784

    Richter, D., Katz, B., Oberacker, T., Tzarfaty, V., Belusic, G., Minke, B. and Huber, A. (2011). Translocation of the Drosophila transient receptor potential-like (TRPL) channel requires both the N- and C-terminal regions together with sustained Ca2+ entry. J Biol Chem 286: 34234-34243. PubMed ID: 21816824

    Oberegelsbacher, C., Schneidler, C., Voolstra, O., Cerny, A. and Huber, A. (2011). The Drosophila TRPL ion channel shares a Rab-dependent translocation pathway with rhodopsin. Eur J Cell Biol 90: 620-630. PubMed ID: 21507505

  • Dan Hultmark Department of Molecular Biology, Umea University
    Schmid, M. R., Anderl, I., Vo, H. T., Valanne, S., Yang, H., Kronhamn, J., Ramet, M., Rusten, T. E. and Hultmark, D. (2016). Genetic screen in Drosophila larvae links ird1 function to Toll signaling in the fat body and hemocyte motility. PLoS One 11: e0159473. PubMed ID: 27467079

    Anderl, I., Vesala, L., Ihalainen, T.O., Vanha-Aho, L.M., Andó, I., Rämet, M. and Hultmark, D. (2016). Transdifferentiation and proliferation in two distinct hemocyte lineages in Drosophila melanogaster larvae after wasp infection. PLoS Pathog 12: e1005746. PubMed ID: 27414410

    Ekstrom, J. O. and Hultmark, D. (2016). A novel strategy for live detection of viral infection in Drosophila melanogaster. Sci Rep 6: 26250. PubMed ID: 27189868

    Yang, H. and Hultmark, D. (2016). Tissue communication in a systemic immune response of Drosophila. Fly (Austin): [Epub ahead of print] PubMed ID: 27116253

    Yang, H., Kronhamn, J., Ekström, J.O., Korkut, G.G. and Hultmark, D. (2015). JAK/STAT signaling in Drosophila muscles controls the cellular immune response against parasitoid infection. EMBO Rep [Epub ahead of print]. PubMed ID: 26412855

    Vanha-Aho, L.M., Anderl, I., Vesala, L., Hultmark, D., Valanne, S and Rämet, M. (2015). Edin expression in the fat body is required in the defense against parasitic wasps in Drosophila melanogaster PLoS Pathog 11: e1004895. PubMed ID: 25965263

    Schmid, M. R., Anderl, I., Vesala, L., Vanha-Aho, L. M., Deng, X. J., Ramet, M. and Hultmark, D. (2014). Control of Drosophila Blood Cell Activation via Toll Signaling in the Fat Body. PLoS One 9: e102568. PubMed ID: 25102059

    Ramet, M. and Hultmark, D. (2014). Drosophila immunity--glorious past, dynamic present and exciting future. Dev Comp Immunol 42: 1-2. PubMed ID: 23891875

    van Mierlo, J. T., Bronkhorst, A. W., Overheul, G. J., Sadanandan, S. A., Ekstrom, J. O., Heestermans, M., Hultmark, D., Antoniewski, C. and van Rij, R. P. (2012). Convergent evolution of argonaute-2 slicer antagonism in two distinct insect RNA viruses. PLoS Pathog 8: e1002872. PubMed ID: 22916019

  • Thomas Hummel Department for Neurobiology, Universität Wien
    Kulkarni, A., Ertekin, D., Lee, C. H. and Hummel, T. (2016). Birth order dependent growth cone segregation determines synaptic layer identity in the visual system. Elife 5. PubMed ID: 26987017

    Jafari, S., Alkhori, L., Schleiffer, A., Brochtrup, A., Hummel, T. and Alenius, M. (2012). Combinatorial activation and repression by seven transcription factors specify Drosophila odorant receptor expression. PLoS Biol 10: e1001280. PubMed ID: 22427741

    Brochtrup, A. and Hummel, T. (2011). Olfactory map formation in the Drosophila brain: genetic specificity and neuronal variability. Curr Opin Neurobiol 21: 85-92. PubMed ID: 21112768

  • Deb Hursh FDA, Bethesda
    Thomas, J.T., Eric Dollins, D., Andrykovich, K.R., Chu, T., Stultz, B.G., Hursh, D.A. and Moos, M. (2017). SMOC can act as both an antagonist and an expander of BMP signaling. Elife 6. PubMed ID: 28323621

    Hursh, D. A., Stultz, B. G. and Park, S. Y. (2016). Jun N-terminal Kinase signaling makes a face. Fly (Austin): [Epub ahead of print]. PubMed ID: 27384866

    Park, S. Y., Stultz, B. G. and Hursh, D. A. (2015). Dual role of Jun N-terminal kinase activity in bone morphogenetic protein-mediated Drosophila ventral head development. Genetics [Epub ahead of print]. PubMed ID: 26500262

    Stultz, B. G., Park, S. Y., Mortin, M. A., Kennison, J. A. and Hursh, D. A. (2012). Hox proteins coordinate peripodial decapentaplegic expression to direct adult head morphogenesis in Drosophila. Dev Biol 369: 362-376. PubMed ID: 22824425

    Sen, A., Stultz, B. G., Lee, H. and Hursh, D. A. (2010). Odd paired transcriptional activation of decapentaplegic in the Drosophila eye/antennal disc is cell autonomous but indirect. Dev Biol 343: 167-177. PubMed ID: 20403347

  • Stephan Hutter Evolutionary Biology, Ludwig Maxmillians-Universität München
    Croze, M., Wollstein, A., Bozicevic, V., Zivkovic, D., Stephan, W. and Hutter, S. (2017). A genome-wide scan for genes under balancing selection in Drosophila melanogaster. BMC Evol Biol 17(1): 15. PubMed ID: 28086750

    von Heckel, K., Stephan, W. and Hutter, S. (2016). Canalization of gene expression is a major signature of regulatory cold adaptation in temperate Drosophila melanogaster. BMC Genomics 17: 574. PubMed ID: 27502401

    Croze, M., Zivkovic, D., Stephan, W. and Hutter, S. (2016). Balancing selection on immunity genes: review of the current literature and new analysis in Drosophila melanogaster. Zoology (Jena). PubMed ID: 27106015

    Bozicevic, V., Hutter, S., Stephan, W. and Wollstein, A. (2016). Population genetic evidence for cold adaptation in European Drosophila melanogaster populations. Mol Ecol 25: 1175-1191. PubMed ID: 26558479

    Paparazzo, F., Tellier, A., Stephan, W. and Hutter, S. (2015). Survival Rate and Transcriptional Response upon Infection with the Generalist Parasite Beauveria bassiana in a World-Wide Sample of Drosophila melanogaster. PLoS One 10: e0132129. PubMed ID: 26154519

  • Jean-René Huynh Genetique et biologie du developpement, Institut Curie
    Christophorou, N., Rubin, T., Bonnet, I., Piolot, T., Arnaud, M. and Huynh, J. R. (2015). Microtubule-driven nuclear rotations promote meiotic chromosome dynamics. Nat Cell Biol 17: 1388-1400. PubMed ID: 26458247

    Molla-Herman, A., Vallés, A.M., Ganem-Elbaz, C., Antoniewski, C. and Huynh, J.R. (2015). tRNA processing defects induce replication stress and Chk2-dependent disruption of piRNA transcription. EMBO J [Epub ahead of print]. PubMed ID: 26471728

    Christophorou, N., Rubin, T., Bonnet, I., Piolot, T., Arnaud, M. and Huynh, J.R. (2015). Microtubule-driven nuclear rotations promote meiotic chromosome dynamics. Nat Cell Biol [Epub ahead of print]. PubMed ID: 26458247

    Christophorou, N., Rubin, T. and Huynh, J. R. (2013). Synaptonemal Complex Components Promote Centromere Pairing in Pre-meiotic Germ Cells. PLoS Genet 9: e1004012. PubMed ID: 24367278

    Mathieu, J., Cauvin, C., Moch, C., Radford, S. J., Sampaio, P., Perdigoto, C. N., Schweisguth, F., Bardin, A. J., Sunkel, C. E., McKim, K., Echard, A. and Huynh, J. R. (2013). Aurora B and cyclin B have opposite effects on the timing of cytokinesis abscission in Drosophila germ cells and in vertebrate somatic cells. Dev Cell 26: 250-265. PubMed ID: 23948252

    Jagut, M., Mihaila-Bodart, L., Molla-Herman, A., Alin, M. F., Lepesant, J. A., Huynh, J. R. (2013) A mosaic genetic screen for genes involved in the early steps of Drosophila oogenesis. G3 (Bethesda) 3: 409-425. Pubmed ID: 23450845

    Fichelson, P., Jagut, M., Lepanse, S., Lepesant, J. A. and Huynh, J. R. (2010). lethal giant larvae is required with the par genes for the early polarization of the Drosophila oocyte. Development 137: 815-824. PubMed ID: 20147382

  • Seogang Hyun School of Biological Sciences, Chung-Ang University, Seoul

    Jang, Y. H., Chae, H. S. and Kim, Y. J. (2017). Female-specific myoinhibitory peptide neurons regulate mating receptivity in Drosophila melanogaster. Nat Commun 8(1): 1630. PubMed ID: 29158481

    Upon mating, fruit fly females become refractory to further mating for several days. An ejaculate protein called sex peptide (SP) acts on uterine neurons to trigger this behavioural change, but it is still unclear how the SP signal modifies the mating decision. Here we describe two groups of female-specific local interneurons that are important for this process-the ventral abdominal lateral (vAL) and ventral abdominal medial (vAM) interneurons. Both vAL and vAM express myoinhibitory peptide (Mip)-GAL4. vAL is positive for Mip neuropeptides and the sex-determining transcriptional factor doublesex. Silencing the Mip neurons in females induces active rejection of male courtship attempts, whereas activation of the Mip neurons makes even mated females receptive to re-mating. vAL and vAM are located in the abdominal ganglion (AG) where they relay the SP signal to other AG neurons that project to the brain. Mip neuropeptides appear to promote mating receptivity both in virgins and mated females, although it is dispensable for normal mating in virgin females.

    Kadas, D., Klein, A., Krick, N., Worrell, J. W., Ryglewski, S. and Duch, C. (2017). Dendritic and axonal L-type calcium channels cooperate to enhance motoneuron firing output during Drosophila larval locomotion. J Neurosci 37(45): 10971-10982. PubMed ID: 28986465

    Behaviorally adequate neuronal firing patterns are critically dependent on the specific types of ion channel expressed and on their subcellular localization. This study combines in situ electrophysiology with genetic and pharmacological intervention in larval Drosophila melanogaster of both sexes to address localization and function of L-type like calcium channels in motoneurons. We demonstrate that Dmca1D (Cav1 homolog) L-type like calcium channels localize to both the somatodendritic and the axonal compartment of larval crawling motoneurons. In situ patch-clamp recordings in genetic mosaics reveal that Dmca1D channels increase burst duration and maximum intraburst firing frequencies during crawling-like motor patterns in semi-intact animals. Genetic and acute pharmacological manipulations suggest that prolonged burst durations are caused by dendritically localized Dmca1D channels, which activate upon cholinergic synaptic input and amplify EPSPs, thus indicating a conserved function of dendritic L-type channels from Drosophila to vertebrates. By contrast, maximum intraburst firing rates require axonal calcium influx through Dmca1D channels, likely to enhance sodium channel de-inactivation via a fast afterhyperpolarization through BK channel activation. Therefore, in unmyelinated Drosophila motoneurons different functions of axonal and dendritic L-type like calcium channels likely operate synergistically to maximize firing output during locomotion.

    Kistenpfennig, C., Nakayama, M., Nihara, R., Tomioka, K., Helfrich-Forster, C. and Yoshii, T. (2017). A Tug-of-War between Cryptochrome and the visual system allows the adaptation of evening activity to long photoperiods in Drosophila melanogaster. J Biol Rhythms: 748730417738612. PubMed ID: 29179610

    In many animals, the circadian clock plays a role in adapting to the coming season by measuring day length. The mechanism for measuring day length and its neuronal circuits remains elusive, however. Under laboratory conditions, the fruit fly, Drosophila melanogaster, displays 2 activity peaks: one in the morning and one in the evening. These peaks appear to be regulated by 2 separate circadian oscillators (the morning and evening oscillators) that reside in different subsets of pacemaker clock neurons in the brain. The morning and evening activity peaks can flexibly change their phases to adapt to different photoperiods by tracking dawn and dusk, respectively. In this study, we found that cryptochrome (CRY) in the evening oscillators (the fifth small ventral lateral neuron [5th s-LNv] and the dorsal lateral neurons [LNds]) limits the ability of the evening peak to track dusk during long days. In contrast, light signaling from the external photoreceptors (compound eyes, ocelli, and Hofbauer-Buchner eyelets) increases the ability of the evening peak to track dusk. At the molecular level, CRY signaling dampens the amplitude of PAR-domain protein 1 (PDP1) oscillations in most clock neurons during long days, whereas signaling from the visual system increases these amplitudes. Thus, our results suggest that light inputs from the two major circadian photoreceptors, CRY and the visual system, have opposite effects on day length adaptation. Their tug-of-war appears to determine the precise phase adjustment of evening activity.

    Klein, M., Krivov, S. V., Ferrer, A. J., Luo, L., Samuel, A. D. and Karplus, M. (2017). Exploratory search during directed navigation in C. elegans and Drosophila larva. Elife 6. PubMed ID: 29083306

    Many organisms-from bacteria to nematodes to insect larvae-navigate their environments by biasing random movements. In these organisms, navigation in isotropic environments can be characterized as an essentially diffusive and undirected process. In stimulus gradients, movement decisions are biased to drive directed navigation toward favorable environments. How does directed navigation in a gradient modulate random exploration either parallel or orthogonal to the gradient? Here, we introduce methods originally used for analyzing protein folding trajectories to study the trajectories of the nematode Caenorhabditis elegans and the Drosophila larva in isotropic environments, as well as in thermal and chemical gradients. We find that the statistics of random exploration in any direction are little affected by directed movement along a stimulus gradient. A key constraint on the behavioral strategies of these organisms appears to be the preservation of their capacity to continuously explore their environments in all directions even while moving toward favorable conditions.

    Koppik, M. and Fricke, C. (2017). Gene expression changes in male accessory glands during ageing are accompanied by reproductive decline in Drosophila melanogaster. Mol Ecol. PubMed ID: 29055154

    Senescence is accompanied by loss of reproductive functions. Here, we studied reproductive ageing in Drosophila melanogaster males and asked whether the expected decline in male reproductive success is due to diminished functionality of the male accessory gland (AG). The male AG produces the majority of seminal fluid proteins (SFPs) transferred to the female at mating. SFPs induce female postmating changes and are key to male reproductive success. We measured age-dependent gene expression changes for five representative SFP genes in males from four different age groups ranging from 1 to 6 weeks after eclosion. Simultaneously, we also measured male reproductive success in postmating traits mediated by transfer of these five SFPs. We found a decreased in male SFP gene expression with advancing age and an accompanying decline in male postmating success. Hence, male reproductive senescence is associated with a decline in functionality of the male AG. While overall individual SFP genes decreased in expression, our results point towards the idea that the composition of an ejaculate might change with male age as the rate of change was variable for those five genes.

    Lebreton, S., Borrero-Echeverry, F., Gonzalez, F., Solum, M., Wallin, E. A., Hedenstrom, E., Hansson, B. S., Gustavsson, A. L., Bengtsson, M., Birgersson, G., Walker, W. B., Dweck, H. K. M., Becher, P. G. and Witzgall, P. (2017). A Drosophila female pheromone elicits species-specific long-range attraction via an olfactory channel with dual specificity for sex and food. BMC Biol 15(1): 88. PubMed ID: 28962619

    Han, G., Lee, H. J., Jeong, S. E., Jeon, C. O. and Hyun, S. (2017). Comparative analysis of Drosophila melanogaster gut microbiota with respect to host strain, sex, and age. Microb Ecol [Epub ahead of print]. PubMed ID: 28054304

    Lee, G. J., Jun, J. W. and Hyun, S. (2014). MicroRNA miR-8 regulates multiple growth factor hormones produced from Drosophila fat cells. Insect Mol Biol. PubMed ID: 25492518

    Lee, G. J. and Hyun, S. (2014). Multiple targets of the microRNA miR-8 contribute to immune homeostasis in Drosophila. Dev Comp Immunol. PubMed ID: 24694685

    Jin, H., Kim, V. N. and Hyun, S. (2012). Conserved microRNA miR-8 controls body size in response to steroid signaling in Drosophila. Genes Dev 26: 1427-1432. PubMed ID: 22751499

    Choi, I. K. and Hyun, S. (2012). Conserved microRNA miR-8 in fat body regulates innate immune homeostasis in Drosophila. Dev Comp Immunol 37: 50-54. PubMed ID: 22210547

    Bang, S., Hyun, S., Hong, S. T., Kang, J., Jeong, K., Park, J. J., Choe, J. and Chung, J. (2011). Dopamine signalling in mushroom bodies regulates temperature-preference behaviour in Drosophila. PLoS Genet 7: e1001346. PubMed ID: 21455291

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