Ackley, B. D., et al. (2005). The two isoforms of the Caenorhabditis elegans leukocyte-common antigen related receptor tyrosine phosphatase PTP-3 function independently in axon guidance and synapse formation. J. Neurosci. 25(33): 7517-28. 16107639

Aicher, B., et al. (1997). Cellular redistribution of protein tyrosine phosphatases LAR and PTPsigma by inducible proteolytic processing. J. Cell Biol. 138(3): 681-696. 9245795

Arora, K., Levine, M. S. and O'Connor, M. B. (1994). The screw gene encodes a ubiquitously expressed member of the TGF-beta family required for specification of dorsal cell fates in the Drosophila embryo. Genes Dev. 8: 2588-601. PubMed ID: 7958918

Autero, M., et al. (1994). Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase. Mol. Cell. Biol. 14(2): 1308-21. PubMed ID: 7507203

Bate, M., Rushton, E. and Currie, D. A. (1991). Cells with persistent twist expression are the embryonic precursors of adult muscles in Drosophila. Development 113: 79-89. PubMed ID: 1765010

Bateman, J., Shu, H. and Van Vactor, D. (2000). The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryo. Neuron 26: 93-106. PubMed ID: 10798395

Bateman, J., et al. (2001). The receptor tyrosine phosphatase Dlar and integrins organize actin filaments in the Drosophila follicular epithelium. Curr. Biol. 11: 1317-1327. 11553324

Bernabeu, R., et al. (2006). Downregulation of the LAR protein tyrosine phosphatase receptor is associated with increased dentate gyrus neurogenesis and an increased number of granule cell layer neurons. Mol. Cell. Neurosci. [Epub ahead of print]. 16488625

Bilwas, A. M., et al. (1996). Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization. Nature 382: 555-559. PubMed ID: 8700232

Bodden, K. and Bixby, J. L. (1996). CRYP-2: a receptor-type tyrosine phosphatase selectively expressed by developing vertebrate neurons. J. Neurobiol. 31(3): 309-24. PubMed ID: 8910789

Cameron, S., Chang, W. T., Chen, Y., Zhou, Y., Taran, S. and Rao, Y. (2013). Visual circuit assembly requires fine tuning of the novel Ig transmembrane protein Borderless. J Neurosci 33: 17413-17421. PubMed ID: 24174674

Chang, C., Yu, T. W., Bargmann, C. I. and Tessier-Lavigne, M. (2004). Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase. Science 305: 103-106. 15232111

Choe, K. M., Prakash, S., Bright, A. and Clandinin, T. R. (2006). Liprin-α is required for photoreceptor target selection in Drosophila. Proc. Natl. Acad. Sci. 103(31): 11601-6. 16864799

Chui, D., et al. (1994). Specific CD45 isoforms differentially regulate T cell receptor signaling. EMBO J. 13(4): 798-807. PubMed ID: 7509278

Cui, Y. and English, K. (1997). Phosphatidic acid-mediated regulation of neutrophil plasma membrane CD45-phosphotyrosine phosphatase. Cell Signal. 9(3-4): 257-63. PubMed ID: 9218125

Desai, C. J., et al. (1997). Competition and cooperation among receptor tyrosine phosphatases control motoneuron growth cone guidance in Drosophila. Development 124(10): 1941-52. PubMed Citation: 9169841

Desai, D. M., et al. (1994). The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation. EMBO J. 13(17): 4002-10

D'Oro, U. and Ashwell, J. D. (1999). The CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes. J. Immunol. 162(4): 1879-83

Debant, A., et al. (1996). The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc. Natl. Acad. Sci. 93(11): 5466-5471

Dunah, A. W., et al. (2005). LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses. Nat. Neurosci. 8(4): 458-67. 15750591

Elchebly, M., et al. (1999). Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase sigma. Nat. Genet. 21(3): 330-3

Felberg, J. and Johnson, P. (1998). Characterization of recombinant CD45 cytoplasmic domain proteins. Evidence for intramolecular and intermolecular interactions. J. Biol. Chem. 273(28): 17839-45

Fox, A. N. and Zinn, K. (2005). The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase. Curr. Biol. 15(19): 1701-11. 16213816

Frydman, H. M. and Spradling, A. C. (2001). The receptor-like tyrosine phosphatase Lar is required for epithelial planar polarity and for axis determination within Drosophila ovarian follicles. Development 128: 3209-3220. 11688569

Gershon, T., et al. (1998a). The leech receptor protein tyrosine phosphatase HmLAR2 is concentrated in growth cones and is involved in process outgrowth. Development 125(7): 1183-1190

Gershon, T. R., et al. (1998b). Two receptor tyrosine phosphatases of the LAR family are expressed in the developing leech by specific central neurons as well as select peripheral neurons, muscles, and other cells. J. Neurosci. 18(8): 2991-3002

Gervais, F. G. and Veillette, A. (1997). Reconstitution of interactions between protein-tyrosine phosphatase CD45 and tyrosine-protein kinase p56(lck) in nonlymphoid cells. J. Biol. Chem. 272(19): 12754-61

Harrington, R. J., et al. (2002). The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis. Development 129: 2141-2153. 11959824

Herold, C., et al. (1996). CD100 is associated with CD45 at the surface of human T lymphocytes. Role in T cell homotypic adhesion. J. Immunol. 157(12): 5262-8.

Hofmeyer, K., Maurel-Zaffran, C., Sink, H. and Treisman, J. E. (2006). Liprin-α has LAR-independent functions in R7 photoreceptor axon targeting. Proc. Natl. Acad. Sci. 103(31): 11595-11600. 16864797

Holbrook, S., Finley, J. K., Lyons, E. L. and Herman, T. G. (2012). Loss of syd-1 from R7 neurons disrupts two distinct phases of presynaptic development. J Neurosci 32: 18101-18111. PubMed ID: 23238725

Honkaniemi, J., et al. (1998). LAR tyrosine phosphatase receptor: proximal membrane alternative splicing is coordinated with regional expression and intraneuronal localization. Brain Res. Mol. Brain Res. 60(1): 1-12

Inaba, M., Yuan, H., Salzmann, V., Fuller, M. T. and Yamashita, Y. M. (2010). E-cadherin is required for centrosome and spindle orientation in Drosophila male germline stem cells. PLoS ONE 5: e12473. PubMed Citation: 20824213

Johnson, K. G., et al. (2006). The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert distinct effects on synaptic development. Neuron 49(4): 517-31. 16476662

Kashio, N., Matsumoto, W., Parker, S. and Rothstein, D.M. (1998). The second domain of the CD45 protein tyrosine phosphatase is critical for interleukin-2 secretion and substrate recruitment of TCR-zeta in vivo. J. Biol. Chem. 273: 33856-33863

Kaufmann, N., Wills, Z. C. and Vactor, D. V. (1998). Drosophila Rac1 controls motor axon guidance. Development 125(3): 453-461

Kaufmann, N., et al. (2002). Drosophila Liprin-alpha and the receptor phosphatase Dlar control synapse morphogenesis. Neuron 34: 27-38. 11931739

Kaur, H., Sharma, S. K., Mandal, S. and Mandal, L. (2019). Lar maintains the homeostasis of the hematopoietic organ in Drosophila by regulating insulin signaling in the niche. Development 146(24). PubMed ID: 31784462

Krueger, N. X., Van Vactor, D. V., Wang, H., Gelbart, H., Goodman, C. S. and Saito, H. (1996). The transmembrane tyrosine phosphatase DLAR controls motor axon guidance in Drosophila. Cell 84: 611-622. PubMed Citation: 8598047

Kurusu, M. and Zinn, K. (2008). Receptor tyrosine phosphatases regulate birth order-dependent axonal fasciculation and midline repulsion during development of the Drosophila mushroom body. Mol. Cell. Neurosci. 38(1): 53-65. PubMed Citation: 18356078

Kuzin, A., Brody, T., Moore, A. W. and Odenwald, W. F. (2005). Nerfin-1 is required for early axon guidance decisions in the developing Drosophila CNS. Dev. Biol. 277: 347-365. 15617679

Kypta, R. M., Su, H. and Reichardt, L. F. (1996). Association between a transmembrane protein tyrosine phospatase and the Cadherin-Catenin complex. J. Cell Biol. 134: 1519-29

Lin, D. M., Auld, V. J. and Goodman, C. S. (1995). Targeted neuronal cell ablation in the Drosophila embryo: pathfinding by follower growth cones in the absence of pioneers. Neuron 14: 707-715

Maurel-Zaffran, C., et al. (2001). Cell-autonomous and -nonautonomous functions of LAR in R7 photoreceptor axon targeting. Neuron 32: 225-235. 11683993

Muller, T., et al. (1999). Phosphorylation and free pool of beta-catenin are regulated by tyrosine kinases and tyrosine phosphatases during epithelial cell migration. J. Biol. Chem. 274(15): 10173-83

Mustelin, T., et al. (1995). Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase. Eur. J. Immunol. 25(4): 942-6.

Ledig, M. M., et al. (1999). Expression of receptor tyrosine phosphatases during development of the retinotectal projection of the chick. J. Neurobiol. 39(1): 81-96

Machide, M., Hashigasako, A., Matsumoto, K. and Nakamura, T. (2006). Contact inhibition of hepatocyte growth regulated by functional association of the c-Met/HGF receptor and LAR protein tyrosine phosphatase. J. Biol. Chem. [Epub ahead of print]. 16415345

Mehta, S. Q., et al. (2005). Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components. Neuron 46(2): 219-32. 15848801

Nam, H. J., et al. (1999). Crystal structure of the tandem phosphatase domains of RPTP LAR. Cell 97(4): 449-57

O'Grady, P., Thai, T. C. and Saito, H. (1998). The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR. J. Cell Biol. 141(7): 1675-84

Onodera, H., et al. (1996). Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase. J. Biol. Chem. 271(36): 22225-30

Ozel, M. N., Kulkarni, A., Hasan, A., Brummer, J., Moldenhauer, M., Daumann, I. M., Wolfenberg, H., Dercksen, V. J., Kiral, F. R., Weiser, M., Prohaska, S., von Kleist, M. and Hiesinger, P. R. (2019). Serial synapse formation through filopodial competition for synaptic seeding factors. Dev Cell 50(4):447-461. PubMed ID: 31353313

Prakash, S., McLendon, H. M., Dubreuil, C. I., Ghose, A., Hwa, J., Dennehy, K. A., Tomalty, K. M., Clark, K. L., Van Vactor, D. and Clandinin, T. R. (2009). Complex interactions amongst N-cadherin, DLAR, and Liprin-alpha regulate Drosophila photoreceptor axon targeting. Dev Biol 336(1): 10-19. PubMed ID: 19766621

Ryglewski, S., Vonhoff, F., Scheckel, K. and Duch, C. (2017). Intra-neuronal competition for synaptic partners conserves the amount of dendritic building material. Neuron 93(3): 632-645. PubMed ID: 28132832

Ruhe, J. E., Streit, S., Hart, S. and Ullrich, A. (2006). EGFR signaling leads to downregulation of PTP-LAR via TACE-mediated proteolytic processing. Cell Signal. [Epub ahead of print]. 16478662

Sajnani, G., et al. (2005). PTPsigma promotes retinal neurite outgrowth non-cell-autonomously. J. Neurobiol. 65(1): 59-71. 16003721

Schaapveld, R. Q. J., et al. (1997). Impaired mammary gland development and function in mice lacking LAR receptor-like tyrosine phosphatase activity. Dev. Biol. 188(1): 134-146

Schindelholz, B., et al. (2001). Regulation of CNS and motor axon guidance in Drosophila by the receptor tyrosine phosphatase DPTP52F. Development 128: 4371-4382. 11684671

Serra-Pages, C., Kedersha, N. L., Fazikas, L., Medley, Q., Debant, A. and Streuli, M. (1995). The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions. EMBO J. 14: 2827-2838. PubMed Citation: 7796809

Serra-Pages, C., et al. (1998). Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. J. Biol. Chem. 273(25): 15611-20. 9624153

Serra-Pages, C., Streuli, M., Medley Q. G. (2005). Liprin phosphorylation regulates binding to LAR: evidence for liprin autophosphorylation. Biochemistry 44(48): 15715-24. 16313174

Spinner, M. A., Walla, D. A. and Herman, T. G. (2018). Drosophila Syd-1 has RhoGAP activity that is required for presynaptic clustering of Bruchpilot/ELKS but not Neurexin-1. Genetics 208(2): 705-716. PubMed ID: 29217522

Srinivasan, S., Mahowald, A. P. and Fuller, M. T. (2012). The receptor tyrosine phosphatase Lar regulates adhesion between Drosophila male germline stem cells and the niche. Development 139(8): 1381-90. PubMed Citation: 22378638

Stepanek, L., et al. (2005). Receptor tyrosine phosphatases guide vertebrate motor axons during development. J. Neurosci. 25(15): 3813-3823. 15829633

Stoker, A.W., Gehrig, B., Haj, F. and Bay, B.H. (1995a). Axonal localisation of the CAM-like tyrosine phosphatase CRYPalpha: a signaling molecule of embryonic growth cones. Development 121: 1833-1844

Stoker, A. W., et al. (1995b). Comparative localisation of CRYP alpha, a CAM-like tyrosine phosphatase, and NgCAM in the developing chick visual system. Brain Res. Dev. Brain Res. 90(1-2): 129-40

Streuli, M., et al. (1989). A family of receptor-linkd protein tyrosine phosphatases in humans and Drosophila. Proc. Natl. Acad. Sci. 86:8698-8702

Sun, Q., et al. (2001). Complex genetic interactions among four receptor tyrosine phosphatases regulate axon guidance in Drosophila. Mol. Cell. Neurosci. 17(2): 274-91. 11178866

Symons, J. R., LeVea, C. M., Mooney, R. A. (2002). Expression of the leucocyte common antigen-related (LAR) tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes. Biochem. J. 365(Pt 2): 513-9. 12095414

Tian, S.-S., Tsoulfas, P. and Zinn, K. (1991). Three receptor-linked protein-tyrosine phosphatases are selectively expresssed on central nervous system axons in the Drosophila embryo. Cell 67: 675-685

Uetani, N., et al. (2000). Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice. EMBO J. 19(12): 2775-85. 10856223

Uetani, N., Chagnon, M. J., Kennedy, T. E., Iwakura, Y. and Tremblay, M. L. (2006). Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and delta. J. Neurosci. 26(22): 5872-80. 16738228

Wallace, M. J., Fladd, C., Batt, J. and Rotin, D. (1998). The second catalytic domain of protein tyrosine phosphatase delta (PTPdelta) binds to and inhibits the first catalytic domain of PTPsigma. Mol. Cell. Biol. 18: 2608-2616

Wang, X., Weng, L. P., Yu, Q. (2000). Specific inhibition of FGF-induced MAPK activation by the receptor-like protein tyrosine phosphatase LAR. Oncogene 19(19): 2346-53. 10822386

Weng, L. P., Yuan, J. and Yu, Q. (1998). Overexpression of the transmembrane tyrosine phosphatase LAR activates the caspase pathway and induces apoptosis. Curr. Biol. 8(5): 247-256

Weng, L. P., Wang, X. and Yu, Q. (1999). Transmembrane tyrosine phosphatase LAR induces apoptosis by dephosphorylating and destabilizing p130Cas. Genes Cells 4(3): 185-96

Weng, Y. L., Liu, N., Diantonio, A. and Broihier, H. T. (2011). The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance. J. Neurosci. 31(12): 4421-33. PubMed Citation: 21430143

Wills, Z., et al. (1999). The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance. Neuron 22(2): 301-12. PubMed Citation: 10069336

Wyszynski, M., et al. (2002). Interaction between GRIP and liprin-/SYD2 is required for AMPA receptor targeting. Neuron 34: 39-52. 11931740

Xie, Y., et al. (2001). The leukocyte common antigen-related protein tyrosine phosphatase receptor regulates regenerative neurite outgrowth in vivo. J. Neurosci. 21(14): 5130-5138. 11438588

Yang, T., Yin, W., Derevyanny, V. D., Moore, L. A. and Longo, F. M. (2005). Identification of an ectodomain within the LAR protein tyrosine phosphatase receptor that binds homophilically and activates signalling pathways promoting neurite outgrowth. Eur. J. Neurosci. 22(9): 2159-70. 16262654

Zhang, J. S., et al. (1998). LAR tyrosine phosphatase receptor: A developmental isoform is present in neurites and growth cones and its expression is regional- and cell-specific. Mol. Cell. Neurosci. 10: 271-286. 9604206

Zhen M. and Jin Y. (1999) The liprin protein syd-2 regulates the differentiation of presynaptic termini in C. elegans. Nature 401: 371-375. 10517634

Leukocyte-antigen-related-like/Dlar: Biological Overview | Evolutionary Homologs | Regulation | Developmental Biology | Effects of Mutation

date revised: 20 April 2020

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