Interactive Fly, Drosophila

DEVELOPMENTAL BIOLOGY

Afzal, A. R., et al. (2000). Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. Nat. Genet. 25(4): 419-22. 10932186

Al-Shawi, R., et al. (2001). Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development. Dev. Genes Evol. 211: 161-171. 11455430

Atwall, J. K., et al. (2000). The TrkB-Shc site signals neuronal survival and local axon growth via MEK and PI3-kinase. Neuron 27: 265-277. 10985347

Billiard, J., Way, D. S., Seestaller-Wehr, L. M., Moran, R. A., Mangine, A. and Bodine, P. V. (2005). The orphan receptor tyrosine kinase Ror2 modulates canonical Wnt signaling in osteoblastic cells. Mol. Endocrinol. 19: 90-101. PubMed citation: 18215320

Canossa, M., Rovelli, G. and Shooter, E. M. (1996). Transphosphorylation of the neurotrophin Trk receptors. J. Biol. Chem. 271: 5812-5818. 8621450

Carter, D. B., et al. (1996). Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75. Science 272: 542-545

Coudreuse, D. Y., Roel, G., Betist, M. C., Destree, O. and Korswagen, H. C. (2006). Wnt gradient formation requires retromer function in Wnt-producing cells. Science 312: 921-924. PubMed citation: 16645052

DeChiara, T. M., et al. (2000). Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development. Nat. Genet. 24(3): 271-4. 10700181

Dobrowsky, R. T., Jenkins, G. M. and Hannun, Y. A. (1995). Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors. J. Biol. Chem. 270: 22135-22142

Forrester, W. C., et al. (1999). A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division. Nature 400(6747): 881-5

Forrester, W. C., Kim, C. and Garriga, G. (2004). The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in cell migration. Genetics 168(4): 1951-62. 15371357

Francis, M. M., et al. (2005). The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. elegans neuromuscular junction. Neuron 46(4): 581-94. 15944127

Gaiddon, C., Loeffler, J. P., and Larmet, Y. (1996). Brain-derived neurotrophic factor stimulates AP-1 and cyclic AMP-responsive element dependent transcriptional activity in central nervous system neurons. J. Neurochem. 66: 2279-2286

Green, J. L., Inoue, T. and Sternberg, P. W. (2007). The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway. Development 134(22): 4053-62. PubMed citation: 17942487

Hallberg, B., et al. (1998). Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase. Oncogene 17(6): 691-7

Hikasa, H., et al. (2005). The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling. Development 129(22): 5227-39. 12399314

Kani, S., Oishi, I., Yamamoto, H., Yoda, A., Suzuki, H., Nomachi, A., Iozumi, K., Nishita, M., Kikuchi, A., Takumi, T. et al. (2004). The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon. J. Biol. Chem. 279: 50102-50109. PubMed citation: 15375164

Kim, C., and Forrester, W. C. (2003). Functional analysis of the domains of the C. elegans Ror receptor tyrosine kinase CAM-1. Dev. Biol. 264: 376-390. PubMed citation: 14651925

Koga, M., et al. (1999). Control of DAF-7 TGF-beta expression and neuronal process development by a receptor tyrosine kinase KIN-8 in Caenorhabditis elegans. Development 126: 5387-5398. 10556063

Mikels, A. J. and Nusse, R. (2006a). Purified Wnt5a protein activates or inhibits beta-Catenin-TCF signaling depending on receptor context. PLoS Biol. 4: e115. PubMed citation: 16602827

Mikels, A. J. and Nusse, R. (2006b). Wnts as ligands: processing, secretion and reception. Oncogene 25: 7461-7468. PubMed citation: 17143290

Kuruvilla, R., Ye, H. and Ginty, D. D. (2000). Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons. Neuron 27: 499-512.

Lefcort, F., et al. (1996). Inhibition of the NT-3 receptor TrkC, early in chick embryogenesis, results in severe reductions in multiple neuronal subpopulations in the dorsal root ganglia. J. Neurosci. 16: 3704-3713

Li, C., et al. (2008). Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. BMC Mol. Biol. 9: 11. PubMed citation: 18215320

Masiakowski, P. and Carroll, R. D. (1992). A novel family of cell surface receptors with tyrosine kinase-like domain. J. Biol. Chem. 267: 26181-90

Matsuda, T., et al. (2001). Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development. Mech. Dev. 105: 153-156. 11429290

McCarty, J. H. and Feinstein, S. C. (1999). The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL. J. Recept. Signal Transduct. Res. 19: 953-74.

Meakin, S. O., et al. (1999). The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation. J. Biol. Chem. 274(14): 9861-70

Minichiello, L., et al. (1995). Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons. Development 121: 4067-4075

Minichiello, L., et al. (1998). Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses. Neuron 21(2): 335-45

Nomi, M., et al. (2001). Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases. Mol. Cell. Biol. 21(24): 8329-35. 11713269

Oishi, I., et al. (1997). A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system. J. Biol. Chem. 272: 11916-25

Oishi, I., et al. (1999). Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells 4(1): 41-56

Oishi, I., et al. (2001). Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes to Cells 4: 41-56. 10231392

Oishi, I., et al. (2003). The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells 8: 645-654. PubMed citation: 12839624

Oldridge, M., et al. (2000). Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B. Nat. Genet. 24(3): 275-8. 10700182

Paganoni, S. and Ferreira, A. (2005). Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2. J. Cell Sci. 118: 433-46. 15654020

Patel, T. D., et al. (2000). Development of sensory neurons in the absence of NGF/TrkA signaling in vivo. Neuron 25(2): 345-57.

Perez, P., et al. (1995). NGF binding to the trk tyrosine kinase receptor requires the extracellular immunoglobulin-like domains. Mol Cell Neurosci 6: 97-105

Pulido, D., Campuzano, S., Koda, T., Modolell, J. and Barbacid, M. (1992). Dtrk, a Drosophila gene related to the trk family of neurotrophin receptors, encodes a novel class of neural cell adhesion molecule. EMBO J. 11: 391-404

Qian, X., et al. (1998). Identification and characterization of novel substrates of Trk receptors in developing neurons. Neuron 21(5): 1017-29

Riccio, A., et al. (1997). An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons. Science 277(5329): 1097-1100

Riccio, A., et al. (1999). Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science 286: 2358-2361.

Roszmusz, E., et al. (2001). Localization of disulfide bonds in the frizzled module of Ror1 receptor tyrosine kinase. J. Biol. Chem. 276(21): 18485-90. 11279007

Schwabe, G. C., et al. (2004). Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome. Dev. Dyn. 229(2): 400-10. 14745966

Takeuchi, S., et al. (2000). Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes Cells 5(1): 71-8.

van Bokhoven, H., et al. (2000). Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome. Nat. Genet. 25(4): 423-6. 10932187

van Kesteren, R. E., et al. (1998). Early evolutionary origin of the neurotrophin receptor family. Embo J. 17(9): 2534-2542. 9564036

von Bartheld, C. S., et al. (1996). Retrograde transport of neurotrophins from the eye to the brain in chick embryos: roles of the p75NTR and trkB receptors. J. Neurosci. 16: 2995-3008

Wang, T., Xie, K. and Lu, B. (1995). Neurotrophins promote maturation of developing neuromuscular synapses. J Neurosci 15: 4796-4805

Wilson, C., Goberdhan, D. C. I., and Steller, H. (1993). Dror, a potential neurotrophic receptor gene, encodes a Drosophila homolog of the vertebrate Ror family of Trk-related receptor tyrosine kinases. Proc. Natl. Acad. Sci. 90: 7109-7113

Zirrgiebel, U., et al. (1995). Characterization of TrkB receptor-mediated signaling pathways in rat cerebellar granule neurons: involvement of protein kinase C in neuronal survival. J Neurochem 65: 2241-2250

dror: Biological Overview | Evolutionary Homologs | Developmental Biology

date revised: 30 May 2008

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