The Interactive Fly

Genes involved in tissue and organ development

The Drosophila Brain

• Brain structure
• Segment polarity and DV patterning gene expression reveals segmental organization of brain
• Molecular markers for identified neuroblasts in the developing brain of Drosophila
• Embryonic origin of the brain and development of the mushroom body
• Fate mapping of brain progenitors using photoactivated gene expression
• Development of the optic lobe and visual centers
• The color-vision circuit in the medulla of Drosophila
• Peripheral visual circuits functionally segregate motion and phototaxis behaviors in the fly
• Embryonic brain tract formation
• Excitatory and inhibitory switches for courtship in the brain
• Uncoupling of brain activity from movement defines arousal states in Drosophila
• Odorant receptors and olfactory receptor neurons, and olfactory learning
• An internal thermal sensor determining temperature preference in Drosophila

*** indicates a special link to brain specific information

Please note: (o) = expression in optic lobe

Transcription factors Adh transcription factor 1 abnormal chemosensory jump 6 AP-2 apterous araucan Arrowhead asense (o) BarH1 and BarH2 Beadex brahma buttonhead castor/ming caupolican Chx1 and Chx2 Clock clockwork orange collier CrebA cryptocephal cryptochrome cubitus interruptus Dachshund | *** dbx dimmed disconnected and disco-related dissatisfaction distal antenna & distal antenna-related Dichaete Distal-less Domina Dorsocross dysfusion e2f Ecdysone-induced protein 74EF empty spiracles | *** Enhancer of split (o) E(spl) region transcript m7 (o) extradenticle eyeless fruitless glass Goosecoid grain grainy head (o) Grunge Hormone receptor-like in 38 intermediate neuroblasts defective ISWI jing klumpfuss labial | *** lady bird early and lady bird late lethal of scute (o) Lim1 longitudinal lacking (o) lozenge (o) moira Myb oncogene-like muscle segment homeobox Myocyte enhancer factor 2 neuralized (o) odd-skipped onecut Optix optomotor blind (o) orthodenticle | *** period | *** polyhomeotic Rfx Rx scalloped scratch scribbler sequoia shuttle craft sine oculis (o) single minded SoxNeuro sparkling Tbp-related factor timeless | *** tailless | *** tango TORC ventral nervous system defective vrille vielfaltig zeste Zn finger homeodomain 2 Ras pathway signaling proteins DRK (Grb 2 homolog) (See EGF-R) Epidermal growth factor receptor | *** Gap1 (See EGF-R) heartbroken Ras D-Raf (See EGF-R) pointed rhomboid rolled (synonym: MAPK) Shc adaptor protein (See EGF-R) spitz (o) | *** Son of sevenless Star twins yan Learning and Memory pathways amnesiac | *** CrebB-17A | *** calcineurin calmodulin CaM kinase II | *** Dopamine receptor dunce | *** genderblind G protein-coupled receptor kinase 2 G protein salpha | *** homer leonardo | *** protein kinase A | *** Protein kinase C | *** radish Resistant to dieldrin rutabaga | ***

Cell surface and secreted proteins activin-β Alk beta amyloid protein precursor-like argos (o) anachronism (o) Anktm1 (alternative name: dTRPA1) baboon beaten path (o) bursicon cacophony Cardioacceleratory peptide commissureless | *** Connectin dachsous (o) dawdle decapentaplegic (o) derailed | *** division abnormally delayed (o) Dopamine receptor Dopamine transporter draper dror Dscam2 Eclosion hormone | *** eiger Eph receptor tyrosine kinase Ephrin Fasciclin 2 | *** frazzled (o) frizzled3 heartless hibris hikaru genki (o) | *** hugin Insulin-like receptor Insulin-related peptide Laminin A | *** Netrin-A and Netrin-B (o) neuropeptide F NMDA receptor 1 and NMDA receptor 2 Notch (o) Ora transientless pickpocket Pigment-dispersing factor Presenilin Protein tyrosine phosphatase 4E Protein tyrosine phosphatase 10D Protein tyrosine phosphatase 69D roughest scab  | *** Serotonin receptor 1A and Serotonin receptor 1B shifted short neuropeptide F precursor slit slowpoke spinster Star (o) terribly reduced optic lobes thick veins tolloid tolloid related 1 (o) wingless wishful thinking Wnt oncogene analog 5 Other genes abnormal spindle Adenomatous polypopsis coli tumor suppressor homolog 2 adrift alicorn bantam basket (o) Borealin-related Borealin-related brain tumor Bub1 Buffy bunched (common alternative name: shortsighted) (o) Calcium/calmodulin-dependent protein kinase Calmodulin Cdc27 chromosome bows citron comatose commissureless dacapo dachshund disc proliferation abnormal death executioner Bcl-2 homologue Death related ced-3/Nedd2-like protein diaphanous dreadlocks dystrophin easily shocked ebony egghead Fmr1 FMRFamide-related | *** Focal adhesion kinase-like four-jointed Fps oncogene analog G protein oalpha 47A headcase hephaestus imaginal discs arrested Inositol 1,4,5,-tris-phosphate receptor kette Kinesin associated protein 3 (o) latheo lethal (2) giant larvae Microcephalin microRNA encoding gene let-7 LIM-kinase1 Lissencephaly-1 minibrain | *** (o) miranda mastermind (o) Merlin MICAL microtubule star Moesin-like morula musashi mushroom bodies tiny mushroom body defect nemo Niemann-Pick Type C-1 Niemann-Pick Type C-2 Nitric oxide synthase | *** (o) non-stop (o) no receptor potential A Nucleostemin3 O-fucosyltransferase 1 pale parkin partner of drosha pebble pericentrin-like protein (cp309) polo Ptpmeg quick-to-court ran RhoGAP rho-type guanine exchange factor RNA on the X-1 (o and other brain neurons) | *** rugose sarah Sas-4 sec15 Separase sex peptide receptor shibire sickle slipper Smad on X smallminded snoN spastin Spd-2 Src oncogene 1 Src oncogene at 42A staufen synaptotagmin Syntaxin 1A takeout TNF-receptor-associated factor 1 trio trol ß3 tubulin (o) twinstar Tyramine β hydroxylase varicose wee

Brain structure

The Interactive database Flybrain provides data and maps on the brain of Drosophila and describes its major brain centers. These include 1) the antennal lobes, serving as first order neuropils of the olfactory chemosensory pathway; 2) the mushroom bodies, lobate neuropils mainly supplied by antennal lobe projection neurons, that are thought to be involved in learning and memory; 3) the central body complex, which comprises the ellipsoid body lying anterior to the fan shaped body and superior arch, both above the paired noduli. All these neuropils are associated with the protocerebral bridge and the protocerebrum; 4) the protocerebrum, a collection of discrete interlinked neuropils, the functions of which are not elucidated but which comprise substantial parts of the central brain; 5) the posterior slope and lateral deutocerebrum, which comprise mechanosensory and visual neuropils, the latter supplied by efferents from the optic lobes; 6) the optic lobes which comprise four successive neuropils serving the compound eye: the lamina, the outer and inner medulla, lobula, and lobula plate (update courtesy of Flybrain, 8/96).

Glia and axonogenesis

Separate sections of The Interactive Fly group genes according to their involvement in glia morphogenesis and axonogenesis.

genes expressed in brain morphogenesis

Genes involved in organ development

Home page: The Interactive Fly © 1995, 1996 Thomas B. Brody, Ph.D.

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