The Interactive Fly

Genes regulating behavior

Behavioral paradigms

Aggressive behavior

Fighting fruit flies: a model system for the study of aggression

Gender-selective patterns of aggressive behavior in Drosophila melanogaster

Aggression-like head interactions between fruitless mutant males

Aggression-like head interactions between fruitless mutant males

Learning and memory associated with aggression in Drosophila melanogaster

The neuromodulator octopamine is necessary for Drosophila males to coordinate sensory cue information presented by a second male and respond with the appropriate behavior: aggression rather than courtship

Anaesthesia sensitivity and resistance

Volatile general anesthetics reveal a neurobiological role for the white and brown genes of Drosophila melanogaster

Genetic effects on an anesthetic-sensitive pathway in the brain of Drosophila

Circadian behavior

Proteins involved in photoperiod response

Courtship and reproductive behavior

Genes affecting courtship behavior including courship conditioning

Temporal mating isolation driven by genetic variation in period

Courtless, the Drosophila UBC7 Homolog, is involved in male courtship behavior and spermatogenesis

dissatisfaction encodes a Tailless-like nuclear receptor expressed in a subset of CNS neurons controlling Drosophila sexual behavior

Pickpocket 25, a sodium channel subunit required for activation of courtship behavior by chemosensory perception of female pheromones

Cholinergic control of male reproductive characters in Drosophila

Excitatory and inhibitory switches for courtship in the brain

Sex-peptide decreases female receptivity and stimulates egg production in the first mating of virgin females

Fruitless directs neural circuitry that governs Drosophila male courtship behavior

The role of cuticular pheromones in courtship conditioning of Drosophila males

Generalization of courtship learning in Drosophila is mediated by cis-vaccenyl acetate

Modulation of Drosophila male behavioral choice; neuromodulator octopamine is necessary for males to coordinate sensory cue information presented by a second male and respond with the appropriate behavior

The sex-determination genes fruitless and doublesex specify a neural substrate required for courtship song

Convulsive behavior

Potassium bromide, an anticonvulsant, is effective at alleviating seizures in the Drosophila bang-sensitive mutant bang senseless

A Drosophila temperature-sensitive seizure mutant in phosphoglycerate kinase disrupts ATP generation and alters synaptic function

Electroconvulsive seizure behavior in Drosophila: analysis of the physiological repertoire underlying a stereotyped action pattern in bang-sensitive mutants

Equilibrium

Haltere-mediated equilibrium reflexes of the fruit fly, Drosophila melanogaster

A comparison of visual and haltere-mediated equilibrium reflexes in the fruit fly Drosophila melanogaster

Feeding behavior

The Drosophila takeout gene is a novel molecular link between circadian rhythms and feeding behavior

LUSH odorant-binding protein mediates chemosensory responses to alcohols in Drosophila melanogaster

Suppression of food intake and growth by amino acids in Drosophila: the role of pumpless, a fat body expressed gene with homology to vertebrate glycine cleavage system

Natural behavior polymorphisms of foraging affect feeding behavior

Developmental control of foraging and social behavior by the Drosophila neuropeptide Y-like system

hugin neurons undertake the role of integrating gustatory sensory signals with higher brain functions and feeding behavior

Ecdysis behavior

Molting

Targeted ablation of CCAP neuropeptide-containing neurons of Drosophila causes specific defects in execution and circadian timing of ecdysis behavior

Mutations in the Drosophila glycoprotein hormone receptor, rickets, eliminate neuropeptide-induced tanning and selectively block a stereotyped behavioral program

A command chemical triggers an innate behavior (pre-ecdysis, ecdysis, and postecdysis) by sequential activation of multiple peptidergic ensembles

Geotaxis

Identification of genes involved in Drosophila melanogaster geotaxis, a complex behavioral trait

Gustatory behavior

Taste receptors

Taste perception and coding in Drosophila

Defective proboscis extension response (DPR), a member of the Ig superfamily required for the gustatory response to salt

Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory receptor gene Gr5a

Habituation

Fruit flies like crack?

Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion

Drosophila melanogaster, a genetic model system for alcohol research

Requirement of circadian genes for cocaine sensitization in Drosophila. Science

Stereotypic behavioral responses to free-base cocaine and the development of behavioral sensitization in Drosophila

High-resolution analysis of ethanol-induced locomotor stimulation in Drosophila

Functional dissection of neuroanatomical loci regulating ethanol sensitivity in Drosophila

Drosophila fasciclinII is required for the formation of odor memories and for normal sensitivity to alcohol

Drosophila GABA_B receptors are involved in behavioral effects of gamma-hydroxybutyric acid (GHB): amnesiac mutation results in heightened sensitivity to GHB

Learning and memory behavior

Cyclic AMP Second Messenger System - The Learning Pathway

Tissue-specific expression of a type I adenylyl cyclase rescues the rutabaga mutant memory defect: in search of the engram

latheo, a Drosophila gene involved in learning, regulates functional synaptic plasticity

foraging modifies habituation-like response decrement of the giant fiber escape circuit, a form of nonassociative learning

Hearing

Auditory apparatus of Drosophila

Acoustic communication in Drosophila

Song production in auditory mutants of Drosophila: the role of sensory feedback: Effect of atonal mutation on courtship song production

Kinesin associated protein 3 - the non-motor accessory subunit of Kinesin II - expressed in Johnston's organ and required for hearing

Locomotor behavior

Motor output reflects the linear superposition of visual and olfactory inputs in Drosophila

Tyramine and octopamine have opposite effects on the locomotion of Drosophila larvae

Dynamic analysis of larval locomotion in Drosophila chordotonal organ mutant

Morphometric description of the wandering behavior in Drosophila larvae: a phenotypic analysis of K+ channel mutants

Turning behavior in Drosophila larvae: a role for the small scribbler transcript

Olfactory learning and behavior

Odorant receptors

Dopamine and octopamine differentiate between aversive and appetitive olfactory memories in Drosophila

Scribble is essential for olfactory behavior in Drosophila melanogaster

foraging modifies habituation-like response decrement of the giant fiber escape circuit in Drosophila

Altered representation of the spatial code for odors after olfactory classical conditioning. Memory trace formation by synaptic recruitment

Habituation of an odorant-induced startle response in Drosophila: Habituation is impared in rutabaga mutants

Induction of cAMP response element-binding protein-dependent medium-term memory by appetitive gustatory reinforcement in Drosophila larvae: larval memory depends on both amnesiac and CREB

Pattern recognition

Distinct memory traces for two visual features in the Drosophila brain

Response to pain

painless, a Drosophila gene essential for nociception

Drosophila model for in vivo pharmacological analgesia research

Seizure behavior

Electroconvulsive seizure behavior in Drosophila: analysis of the physiological repertoire underlying a stereotyped action pattern in bang-sensitive mutants

A Drosophila temperature-sensitive seizure mutant in phosphoglycerate kinase disrupts ATP generation and alters synaptic function

Drosophila model for in vivo pharmacological analgesia research

Sleep and rest behavior

Sleep homeostasis in Drosophila melanogaster

Why a fly? Using Drosophila to understand the genetics of circadian rhythms and sleep

Uncoupling of brain activity from movement defines arousal states in Drosophila

Electrophysiological correlates of rest and activity in Drosophila melanogaster

Stress response genes protect against lethal effects of sleep deprivation in Drosophila

Uncoupling of brain activity from movement defines arousal states in Drosophila

Serotonin receptor 1A promotes baseline sleep

A Drosophila model for age-associated changes in sleep:wake cycles

Dopaminergic signaling regulates insect arousal

Changes in sleep are achieved by spatial and temporal enhancement of cyclic-AMP-dependent protein kinase (PKA) activity specifically in the adult mushroom bodies

Thermosensory response

Identification and function of thermosensory neurons in Drosophila larvae

Anktm1 (common alternative name: dTrpA1) - heat-activated TRP family ion channel that is essential for thermotaxis

Visual discrimination behavior

Virtual-reality techniques resolve the visual cues used by fruit flies to evaluate object distances

Building a projection map for photoreceptor neurons in the Drosophila optic lobes

Molecular basis for ultraviolet vision in invertebrates

Visual pattern recognition in Drosophila is invariant for retinal position

Homothorax switches function of Drosophila photoreceptors from color to polarized light sensors

Wing expansion behavior

Bursicon is a developmental hormone that controls wing expansion behavior

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