logo Drosophila genes listed by biochemical function
Transmembrane proteins

G-protein coupled receptors

Receptor tyrosine kinases and phosphatases and serine/threonine kinases

Transmembrane adhesion proteins

Miscellaneous transmembrane proteins


RECEPTOR TYROSINE KINASES AND PHOSPHATASES AND SERINE/THREONINE KINASES

Alk
transmembrane protein - receptor tyrosine kinase - the ligand Jelly belly activates Alk
to specify a select group of visceral muscle precursors as muscle-patterning pioneers

baboon
transmembrane protein - Type 1 activin-A-receptor - receptor serine/threonine kinase

breathless
transmembrane receptor, fgf-r homolog

DER (preferred name: EGF-R, common alternative name: Torpedo)
receptor- tk - EGF-R homology

derailed
receptor TK

Dlar
receptor tyrosine phosphatase - axon guidance

Dror
receptor tyrosine kinase - trk homolog

Eph receptor tyrosine kinase
receptor tyrosine kinase

Epidermal growth factor receptor (common alternative name: Torpedo)
receptor tyrosine kinase

fgf-receptor homolog 1 (common alternative name: heartless or DFR1)
transmembrane - receptor - Ig superfamily

heartless (commonly known as Fibroblast growth factor receptor 1 or DFR-1)
receptor tyrosine kinase

Insulin-like receptor
receptor tyrosine kinase

off-track
CCK-4 family of 'dead' receptor tyrosine kinases, Ig-domains - required for lamina-specific targeting of R1-R6 axons -
associates with Plexin, the receptor for Semaphorin ligand

PDGF- and VEGF-receptor related
Ig C-2 type domain receptor tyrosine kinase - required for border cell migration

Protein tyrosine phosphatase 69D
receptor tyrosine phosphatase

punt
receptor for DPP - type II receptor serine/threonine kinase

saxophone
receptor serine/threonine kinase - a DPP receptor

sevenless
receptor tyrosine kinase - Boss receptor

thickveins
receptor serine/threonine kinase for DPP

torpedo (preferred name: Epidermal growth factor receptor, common alternative name: ellipse)
receptor-tk egf-r homology

torso
receptorTK

wishful thinking
type II TGFß receptor - functions presynaptically to regulate synaptic size at the neuromuscular junction - receptor serine/threonine kinase



TRANSMEMBRANE ADHESION PROTEINS

Basigin
conserved IgCAM required pre- and post-synaptically at neuromuscular junctions to restrict synaptic bouton size,
controls distribution of synaptic vesicles and organization of the presynaptic cortical actin cytoskeleton

Cadherin-E (preferred name: shotgun)
cadherin - cell aggregation

Cadherin-N
transmembrane receptor, cadherin homolog

Cad99C
receptor - cadherin superfamily - expressed in follicle cells - regulator of microvillus length

commissureless
novel transmembrane protein

capricious
leucine-rich repeat transmembrane protein involved in selective synapse formation;
contributes to formation of the affinity boundary between dorsal and ventral compartments of the wing

Contactin
required for organization of septate junctions and for function of the paracellular barrier -
Forms a tripartite complex with Neuroglian and Neurexin

crumbs
egf repeats - laminin A homolog

dachsous
cadherin superfamily

DE-cadherin (preferred name: shotgun)
E-cadherin homolog

Delta
EGF family - Notch ligand

dumbfounded (preferred name: kin of irre)
IG superfamily - required for myoblast aggregation and fusion

Dystroglycan
transmembrane receptor for extracellular matrix molecules - required for cellular polarity in epithelial cells and the oocyte

Dscam
multiple Ig domain protein

E-cadherin (preferred name: shotgun)
tm - E-cadherin homolog

echinoid & friend of echinoid
cell-adhesion molecules (CAMs) - Ig and fibronectin domains proteins - The genes are adjacent to one another and co-ordinately regulated - Echinoid acts to antagonize Egf receptor signaling - Friend of echinoid exhibits interaction with the Notch pathway

18 wheeler
transmembrane protein with with leucine-rich motif (LRR)

Fasciclin I
cam - lipid linked to membrane - novel

Fasciclin II
NCAM homolog - Ig superfamily

Fasciclin III
cam - novel

fat
cadherin domain transmembrane receptor that negatively controls cell proliferation - also functions in planar polarity

furrowed
selectin (carbohydrate binding protein)

Gliolectin
lectin (carbohydrate binding protein)

Gliotactin
novel serine esterase homolog

hibris
Ig repeat transmembrane protein with fibronectin type III domain - a receptor involved in muscle cell fusion

integrin - beta PS (preferred name: myospheroid)
integrin - beta subunit

kekkon-1
Ig domain protein, Leucine-rich repeat protein

kuzbanian
disintegrin and metalloprotease motifs - neurogenic

Lachesin
GPI-anchored surface immunoglobulin domain cell adhesion molecule required for the proper morphogenesis of the tracheal system

multiple edematous wings *
alpha PS1 integrin - see myospheroid

myospheroid
integrin-beta subunit of PS1 & PS2

Neuroglian
IG superfamily - NgCAM related

Neurotactin
serine esterase homolog

Notch
receptor - neurogenic

pollux
novel cell surface receptor, leucine zipper protein

roughest
Ig-C2-type-domain protein - transmembrane

roundabout
IG and FN repeats protein

semaphorin-1a
axon guidance transmembrane protein

Serrate
EGF homolog - ligand for Notch

scab
alpha integrin

shotgun
E-cadherin

starry night
Cadherin-related 7TM protein

sticks and stones
transmembrane protein expressed on the surface of fusion competent myoblasts - essential for fusion of embryonic myoblasts

strabismus (preferred name: Van Gogh)
novel protein

Tenascin major
tenasin homolog - EGF and Fibronectin repeats

Van Gogh (common alternative name: strabismus)
novel, potentially transmembrane protein



MISCELLANEOUS TRANSMEMBRANE PROTEINS

beta amyloid protein precursor-like
beta amyloid homolog

Anktm1 (common alternative name: dTrpA1)
heat-activated TRP family ion channel that is essential for thermotaxis

arrow
LDL-receptor-related protein (LRP) family - Wingless pathway

Bride of sevenless (Boss)
ligand of Sevenless - 7 transmembrane segments

cacophony
voltage sensitive calcium channel that stimulates neurotransmetter release at the presynaptic terminus at the neuromuscular junction

cornichon
cargo receptor required for transport of the TGFalpha growth factor Gurken to the oocyte surface

death executioner Bcl-2 homologue
Bcl-2/CED-9 family protein involved in regulating apoptosis

dispatched
patched family protein regulating Hedgehog release

domeless
a divergent member of the cytokine class I receptor family - required for segmentation and functions in trachea specification

Dopamine receptor
GPCR - mediates aversive and appetitive learning in pavlovian olfactory conditioning

Dopamine transporter
mediates uptake of dopamine in dopamine positive neurons - functions in regulating sleep and arousal

draper
encoding an EGF-repeat single-pass transmembrane domain receptor - required during metamorphosis for recognition and engulfment of degenerating axon branches by glia

eater
EGF-like repeat transmembrane protein located on phagocytic cells - mediates resistence to bacteria

fear of intimacy
transmembrane domain protein - FICL family - zinc transporter - required in the mesoderm for gonad morphogenesis - required for tracheal branch fusion

four-jointed
type 2 transmembrane protein

frazzled
Ig superfamily - Netrin receptor

frizzled
7 pass G-protein coupled receptor

frizzled2
transmembrane - 7 pass - frizzled family - receptor for Wingless

frizzled3
transmembrane - 7 pass - frizzled family - antagonist of wingless signal

Glutamate receptor IIA and Glutamate receptor IIB
transmembrane Ca2+ channel protein

Gustatory receptor 21a and Gustatory receptor 63a
GPCRs that confer CO2-chemosensation in Drosophila

Gustatory receptor 68a
an essential component of pheromone-driven courtship behavior

inebriated
neurotransmitter:sodium symporter - mutations appear to cause increased excitability of the motor neuron by causing defective reuptake of a substrate neurotransmitter

Inositol 1,4,5,-tris-phosphate receptor
calcium channel

interference Hedgehog
IGcam membrane protein - binds Hedgehog and mediates Hedgehog response

methuselah
G-protein coupled receptor: mutants have increased longevity, are resistent to stress and have increased body weight

Niemann-Pick Type C-1
a transmembrane protein related to the Hedgehog receptor Patched - mutants have a shortage of sterol, and, as a consequence, inadequate ecdysone synthesis

Neurexin
multifunctional protein located at septate junctions

Nimrod C1
EGF-like repeat transmembrane protein located on phagocytic cells - mediates resistence to bacteria

NMDA receptor 1 and NMDA receptor 2
voltage/Mg2+-dependent Ca2+ channels activated by glutamate - required for olfactory learning

Odorant receptor 22a and Odorant receptor 22b
G-protein coupled receptors - Or22a responds to ethyl butyrate - localized to dendritic membranes of 22 cells of the basomedial region of the antenna

Odorant receptor 65a
G-protein coupled receptor - courtship behavior - confers aversive response to cis-vaccenyl acetate

Odorant receptor 67d
G-protein coupled receptor - courtship behavior - the male-specific pheromone 11-cVA acts through Or67d to regulate both male and female mating behavior

Odorant receptor 83b
G-protein coupled receptor - broadly expressed receptor of unknown function - required for dendritic localization of conventional odorant receptors -
mutation disrupts behavioral and electorphysiological responses to many odorants

painless
calcium channel - nociceptor - mutant is pain response defective

patched
segment polarity gene

perdido (common alternative name: Kon-tiki)
conserved multi-domain transmembrane receptor required cell autonomously for myotubes to recognize their tendon cell targets - signals through the intracellular adaptor Grip in a conserved molecular pathway

pickpocket
subunit of the epithelial sodium channel (ENaC) family - plays an essential role in controlling rhythmic locomotion by providing mechanosensory signal transduction of proprioceptive sensory information

pickpocket 25
DEG/ENaC sodium channel subunit - required for activation of courtship behavior by chemosensory perception of female pheromones

plexin A
semaphorin domain protein, semaphorin receptor

plexin B
semaphorin domain protein, receptor for the secreted semaphorin Sema-2a -
regulates axon extension from the sensory neuron cell body in regions of direct contact with oenocytes

Presenilin
transmembrane protein involved in proteolysis of Notch

rhomboid (preferred name: veinlet)
serine protease - transmembrane protein involved with Epidermal growth factor receptor signaling - required for the production or processing of Spitz, the Egfr ligand

rhomboid-7
transmembrane mitochondrial protease required for spermatogenesis and muscle maturation

roughoid
EGF pathway

sanpodo
encodes a four-pass transmembrane protein that localizes to the cell membrane - specifies Notch-dependent fate - Notch and Numb physically associate with Sanpodo

semaphorin-1a
Axon guidance transmembrane protein

Serotonin receptor 1A and Serotonin receptor 1B (5-HT1A and 5-HT1B)
seven-pass transmembrane protein, 5-HT1A promotes baseline sleep

Serotonin receptor 2
seven-pass transmembrane protein

sex peptide receptor
G-protein coupled receptor - required in Fruitless plus neurons for post-mating switch in female reproductive behaviour
slowpoke
Ca-activated, voltage-activated potassium channel

smoothened
seven-pass transmembrane protein - putative hedgehog receptor

sneaky
transmembrane acrosomal protein involved in sperm plasma membrane breakdown; required for sperm activation in the egg cytoplasm

spinster
conserved transmembrane protein expressed in glia - mutants exhibit increased neural survival and altered sexual behavior
spitz
ligand for Egf-r - egf/tgf beta homolog

Star
interacts with EGF-R

synaptotagmin
calcium sensor in synaptic vesicle fusion - functions during exocytosis

Syndecan
a heparan sulfate proteoglycan - a necessary component of Slit/Robo signaling required in Slit target cells

Syntaxin 1A
vesicular docking protein

Syntaxin 5
a Golgi-localized SNARE protein - required for ER-Golgi traffic and Golgi reassembly following cell division - required for steps leading to formation of mature sperm

Toll
IL1 homolog

Tollo
Toll-like receptor - leucine rich repeat transmembrane protein - expressed in ectoderm
and required for neural-specific expression of the glycan HRP epitope

transient receptor potential
visual phototransduction, calcium channel, adaptation to light

Trehalose-sensitivity
G-protein coupled receptor - Taste receptor

unc-5
netrin receptor

veinlet (common alternative name: rhomboid)
interacts with EGF-R

zero population growth
germline-specific gap junction protein - Innexin 4 - required for survival of differentiating early germ cells
during gametogenesis in both sexes




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Drosophila genes listed by biochemical function

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