Drosophila genes listed by biochemical function

G-protein coupled receptors

Odorant receptors

Gustatory (taste) receptors

Receptor tyrosine kinases and phosphatases and serine/threonine kinases

Transmembrane adhesion proteins

Miscellaneous transmembrane proteins

RECEPTOR TYROSINE KINASES AND PHOSPHATASES AND SERINE/THREONINE KINASES

Alk

transmembrane protein - receptor tyrosine kinase - the ligand Jelly belly activates Alk

to specify a select group of visceral muscle precursors as muscle-patterning pioneers

baboon

transmembrane protein - Type 1 activin-A-receptor - receptor serine/threonine kinase

breathless

transmembrane receptor, fgf-r homolog

DER (preferred name: EGF-R, common alternative name: Torpedo)

receptor- tk - EGF-R homology

derailed

receptor TK

Dlar

receptor tyrosine phosphatase - axon guidance

Dror

receptor tyrosine kinase - trk homolog

Eph receptor tyrosine kinase

receptor tyrosine kinase

Epidermal growth factor receptor (common alternative name: Torpedo)

receptor tyrosine kinase

fgf-receptor homolog 1 (common alternative name: heartless or DFR1)

transmembrane - receptor - Ig superfamily

heartless (commonly known as Fibroblast growth factor receptor 1 or DFR-1)

receptor tyrosine kinase

Insulin-like receptor

receptor tyrosine kinase

Ionotropic receptor 8a

a member of a novel family of chemosensory receptor ion channels - variant ionotropic glutamate receptor-like protein - expressed on antennal neurons

off-track

CCK-4 family of 'dead' receptor tyrosine kinases, Ig-domains - required for lamina-specific targeting of R1-R6 axons -

associates with Plexin, the receptor for Semaphorin ligand

PDGF- and VEGF-receptor related

Ig C-2 type domain receptor tyrosine kinase - required for border cell migration

Protein tyrosine phosphatase 4E

broadly expressed type III receptor tyrosine phosphatase closely related to Ptp10D - shows synthetic phenotypes with other Pdps

Protein tyrosine phosphatase 10D

receptor tyrosine phosphatase - required for embryonic and larval axon guidance - along with Ptp69D regulates segregation

of the young axons into a single core bundle in the larval mushroom body - mutants are defective in long-term memory formation

Protein tyrosine phosphatase 69D

receptor tyrosine phosphatase

punt

receptor for DPP - type II receptor serine/threonine kinase

saxophone

receptor serine/threonine kinase - a DPP receptor

sevenless

receptor tyrosine kinase - Boss receptor

thickveins

receptor serine/threonine kinase for DPP

torpedo (preferred name: Epidermal growth factor receptor, common alternative name: ellipse)

receptor-tk egf-r homology

torso

receptorTK

wishful thinking

type II TGFß receptor - functions presynaptically to regulate synaptic size at the neuromuscular junction - receptor serine/threonine kinase

TRANSMEMBRANE ADHESION PROTEINS

Basigin

conserved IgCAM required pre- and post-synaptically at neuromuscular junctions to restrict synaptic bouton size,

controls distribution of synaptic vesicles and organization of the presynaptic cortical actin cytoskeleton

Cadherin-E (preferred name: shotgun)

cadherin - cell aggregation

Cadherin-N

transmembrane receptor, cadherin homolog

Cad99C

receptor - cadherin superfamily - expressed in follicle cells - regulator of microvillus length

commissureless

novel transmembrane protein

capricious

leucine-rich repeat transmembrane protein involved in selective synapse formation;

contributes to formation of the affinity boundary between dorsal and ventral compartments of the wing

Contactin

required for organization of septate junctions and for function of the paracellular barrier -

Forms a tripartite complex with Neuroglian and Neurexin

crumbs

egf repeats - laminin A homolog

dachsous

cadherin superfamily

DE-cadherin (preferred name: shotgun)

E-cadherin homolog

Delta

EGF family - Notch ligand

dumbfounded (preferred name: kin of irre)

IG superfamily - required for myoblast aggregation and fusion

Dystroglycan

transmembrane receptor for extracellular matrix molecules - required for cellular polarity in epithelial cells and the oocyte

Dscam

multiple Ig domain protein

E-cadherin (preferred name: shotgun)

tm - E-cadherin homolog

echinoid & friend of echinoid

cell-adhesion molecules (CAMs) - Ig and fibronectin domains proteins - The genes are adjacent to one another and co-ordinately regulated - Echinoid acts to antagonize Egf receptor signaling - Friend of echinoid exhibits interaction with the Notch pathway

18 wheeler

transmembrane protein with with leucine-rich motif (LRR)

Fasciclin I

cam - lipid linked to membrane - novel

Fasciclin II

NCAM homolog - Ig superfamily

Fasciclin III

cam - novel

fat

cadherin domain transmembrane receptor that negatively controls cell proliferation - also functions in planar polarity

furrowed

selectin (carbohydrate binding protein)

Gliolectin

lectin (carbohydrate binding protein)

Gliotactin

novel serine esterase homolog

hibris

Ig repeat transmembrane protein with fibronectin type III domain - a receptor involved in muscle cell fusion

integrin - beta PS (preferred name: myospheroid)

integrin - beta subunit

kekkon-1

Ig domain protein, Leucine-rich repeat protein

kuzbanian

disintegrin and metalloprotease motifs - neurogenic

Lachesin

GPI-anchored surface immunoglobulin domain cell adhesion molecule required for the proper morphogenesis of the tracheal system

multiple edematous wings *

alpha PS1 integrin - see myospheroid

myospheroid

integrin-beta subunit of PS1 & PS2

Neuroglian

IG superfamily - NgCAM related

Neurotactin

serine esterase homolog

Notch

receptor - neurogenic

pollux

novel cell surface receptor, leucine zipper protein

roughest

Ig-C2-type-domain protein - transmembrane

roundabout

IG and FN repeats protein

semaphorin-1a

axon guidance transmembrane protein

Serrate

EGF homolog - ligand for Notch

scab

alpha integrin

shotgun

E-cadherin

starry night

Cadherin-related 7TM protein

sticks and stones

transmembrane protein expressed on the surface of fusion competent myoblasts - essential for fusion of embryonic myoblasts

strabismus (preferred name: Van Gogh)

novel protein

tartan

Leucine-rich repeat transmembrane protein - along with Capricious, contributes to the adhesive properties of the cells

in the morphogenetic furrow, thus regulating control of spacing ommatidial clusters - regulates boundary formation in the leg and wing -

regulates tracheal branching

Tenascin major

tenasin homolog - EGF and Fibronectin repeats

Van Gogh (common alternative name: strabismus)

novel, potentially transmembrane protein

MISCELLANEOUS TRANSMEMBRANE PROTEINS

Adipokinetic hormone receptor (preferred name: Gonadotropin-releasing hormone receptor)

GPCR - involved in storage-fat mobilization - essential to adjust normal body fat content

and ensure lifelong fat-storage homeostasis - functional analog of the mammalian glucagon receptor

beta amyloid protein precursor-like

beta amyloid homolog

Anktm1 (common alternative name: dTrpA1)

heat-activated TRP family ion channel that is essential for thermotaxis

arrow

LDL-receptor-related protein (LRP) family - Wingless pathway

Bride of sevenless (Boss)

ligand of Sevenless - 7 transmembrane segments

cacophony

voltage sensitive calcium channel that stimulates neurotransmetter release at the presynaptic terminus at the neuromuscular junction

cornichon

cargo receptor required for transport of the TGFalpha growth factor Gurken to the oocyte surface

death executioner Bcl-2 homologue

Bcl-2/CED-9 family protein involved in regulating apoptosis

dispatched

patched family protein regulating Hedgehog release

domeless

a divergent member of the cytokine class I receptor family - required for segmentation and functions in trachea specification

Dopamine receptor

GPCR - mediates aversive and appetitive learning in pavlovian olfactory conditioning

Dopamine transporter

mediates uptake of dopamine in dopamine positive neurons - functions in regulating sleep and arousal

draper

encoding an EGF-repeat single-pass transmembrane domain receptor - required during metamorphosis for recognition and engulfment of degenerating axon branches by glia

Dscam2

immunoglobulin superfamily - Dscam2 homophilic interactions mediate repulsion between neurites of L1 laminar cells in neighbouring columns of the optic lobe

eater

EGF-like repeat transmembrane protein located on phagocytic cells - mediates resistence to bacteria

fear of intimacy

transmembrane domain protein - FICL family - zinc transporter - required in the mesoderm for gonad morphogenesis - required for tracheal branch fusion

four-jointed

type 2 transmembrane protein

frazzled

Ig superfamily - Netrin receptor

frizzled

7 pass G-protein coupled receptor

frizzled2

transmembrane - 7 pass - frizzled family - receptor for Wingless

frizzled3

transmembrane - 7 pass - frizzled family - antagonist of wingless signal

genderblind

glutamate permease - regulates ambient extracellular glutamate to suppress glutamatergic synapse strength - controls mate choice

Glutamate receptor IIA and Glutamate receptor IIB

transmembrane Ca2+ channel protein

Gonadotropin-releasing hormone receptor (common alternative name: Adipokinetic hormone receptor)

GPCR - involved in storage-fat mobilization - essential to adjust normal body fat content

and ensure lifelong fat-storage homeostasis - functional analog of the mammalian glucagon receptor

Gustatory receptor 21a and Gustatory receptor 63a

GPCRs that confer CO₂-chemosensation in Drosophila

Gustatory receptor 64a

taste receptor - response to sugar

Gustatory receptor 68a

an essential component of pheromone-driven courtship behavior

inebriated

neurotransmitter:sodium symporter - mutations appear to cause increased excitability of the motor neuron by causing defective reuptake of a substrate neurotransmitter

Inositol 1,4,5,-tris-phosphate receptor

calcium channel

interference Hedgehog

IGcam membrane protein - binds Hedgehog and mediates Hedgehog response

kon-tiki

conserved multi-domain transmembrane receptor required cell autonomously for myotubes to recognize their tendon cell targets - signals through the intracellular adaptor Grip in a conserved molecular pathway

methuselah

G-protein coupled receptor: mutants have increased longevity, are resistent to stress and have increased body weight

moody

G-protein coupled receptor - expressed in glia and required for blood-brain barrier formation

Niemann-Pick Type C-1

a transmembrane protein related to the Hedgehog receptor Patched - mutants have a shortage of sterol, and, as a consequence, inadequate ecdysone synthesis

Neurexin

multifunctional protein located at septate junctions

Nimrod C1

EGF-like repeat transmembrane protein located on phagocytic cells - mediates resistence to bacteria

NMDA receptor 1 and NMDA receptor 2

voltage/Mg²⁺-dependent Ca²⁺ channels activated by glutamate - required for olfactory learning

Odorant receptor 22a and Odorant receptor 22b

G-protein coupled receptors - Or22a responds to ethyl butyrate - localized to dendritic membranes of 22 cells of the basomedial region of the antenna

Odorant receptor 65a

G-protein coupled receptor - courtship behavior - confers aversive response to cis-vaccenyl acetate

Odorant receptor 67d

G-protein coupled receptor - courtship behavior - the male-specific pheromone 11-cVA acts through Or67d to regulate both male and female mating behavior

Odorant receptor 83b

G-protein coupled receptor - broadly expressed receptor of unknown function - required for dendritic localization of conventional odorant receptors -

mutation disrupts behavioral and electorphysiological responses to many odorants

Ora transientless

histamine-gated chloride channel required for synaptic transmission at the photoreceptor-large monopolar cells synapse and

for orientation and motion vision - responsible for synaptic transients in electroretinograms -

modulates temperature preference and controls tolerance of low and high temperature

painless

calcium channel - nociceptor - mutant is pain response defective

patched

segment polarity gene

perdido (common alternative name: Kon-tiki)

conserved multi-domain transmembrane receptor required cell autonomously for myotubes to recognize their tendon cell targets - signals through the intracellular adaptor Grip in a conserved molecular pathway

pickpocket

subunit of the epithelial sodium channel (ENaC) family - plays an essential role in controlling rhythmic locomotion by providing mechanosensory signal transduction of proprioceptive sensory information

pickpocket 25

DEG/ENaC sodium channel subunit - required for activation of courtship behavior by chemosensory perception of female pheromones

plexin A

semaphorin domain protein, semaphorin receptor

plexin B

semaphorin domain protein, receptor for the secreted semaphorin Sema-2a -

regulates axon extension from the sensory neuron cell body in regions of direct contact with oenocytes

Presenilin

transmembrane protein involved in proteolysis of Notch

Resistant to dieldrin

GABA-A receptor that negatively modulates olfactory associative learning, possibly by gating the input of olfactory information

into the mushroom bodies - regulates the length of time required to fall asleep

rhomboid (preferred name: veinlet)

serine protease - transmembrane protein involved with Epidermal growth factor receptor signaling - required for the production or processing of Spitz, the Egfr ligand

rhomboid-7

transmembrane mitochondrial protease required for spermatogenesis and muscle maturation

roughoid

EGF pathway

sanpodo

encodes a four-pass transmembrane protein that localizes to the cell membrane - specifies Notch-dependent fate - Notch and Numb physically associate with Sanpodo

semaphorin-1a

Axon guidance transmembrane protein

Sensory neuron membrane protein

CD36-related transmembrane protein - essential for the response of olfactory sensory neurons to cis-vaccenyl acetate,

a male-specific fatty-acid-derived pheromone that regulates sexual and social aggregation behaviours

Serotonin receptor 1A and Serotonin receptor 1B (5-HT1A and 5-HT1B)

seven-pass transmembrane protein, 5-HT1A promotes baseline sleep

Serotonin receptor 2

seven-pass transmembrane protein

sex peptide receptor

G-protein coupled receptor - required in Fruitless plus neurons for post-mating switch in female reproductive behaviour

Shaker cognate b

slow delayed rectifier K⁺ channel - upregulated by light stimulation - functions in light adaptation

slowpoke

Ca-activated, voltage-activated potassium channel

smoothened

seven-pass transmembrane protein - putative hedgehog receptor

sneaky

transmembrane acrosomal protein involved in sperm plasma membrane breakdown; required for sperm activation in the egg cytoplasm

spinster

conserved transmembrane protein expressed in glia - mutants exhibit increased neural survival and altered sexual behavior

spitz

ligand for Egf-r - egf/tgf beta homolog

Star

interacts with EGF-R

synaptotagmin

calcium sensor in synaptic vesicle fusion - functions during exocytosis

Syndecan

a heparan sulfate proteoglycan - a necessary component of Slit/Robo signaling required in Slit target cells

Syntaxin 1A

vesicular docking protein

Syntaxin 5

a Golgi-localized SNARE protein - required for ER-Golgi traffic and Golgi reassembly following cell division - required for steps leading to formation of mature sperm

Toll

IL1 homolog

Tollo

Toll-like receptor - leucine rich repeat transmembrane protein - expressed in ectoderm
and required for neural-specific expression of the glycan HRP epitope

transient receptor potential

visual phototransduction, calcium channel, adaptation to light

trapped in endoderm-1

G-protein coupled receptor - links cell polarity, modulation of cell adhesion, and invasion during germ cell migration

Trehalose-sensitivity

G-protein coupled receptor - Taste receptor

unc-5

netrin receptor

veinlet (common alternative name: rhomboid)

interacts with EGF-R

white

ABC transporter of amines that partners with Brown in determination of eye pigmentation - Behavioral abnormalities in white, brown and scarlet mutants

could arise from reduced amine levels in neurons

wengen

tumor necrosis factor receptor superfamily - forced expression triggers cell death

wntless

novel conserved transmembrane protein that acts in the Wnt-sending cells to promote the secretion of Wnt proteins

zero population growth

germline-specific gap junction protein - Innexin 4 - required for survival of differentiating early germ cells
during gametogenesis in both sexes

Drosophila genes listed by biochemical function

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