|
Drosophila genes listed by biochemical function |
Transmembrane proteins
Receptor tyrosine kinases and phosphatases and serine/threonine kinases
Transmembrane adhesion proteins
Miscellaneous transmembrane proteins
G-protein coupled receptors
Odorant receptors
Gustatory (taste) receptors
- RECEPTOR TYROSINE KINASES AND PHOSPHATASES AND SERINE/THREONINE KINASES
- Alk
- transmembrane protein - receptor tyrosine kinase - the ligand Jelly belly activates Alk
- to specify a select group of visceral muscle precursors as muscle-patterning pioneers
- baboon
- transmembrane protein - Type 1 activin-A-receptor - receptor serine/threonine kinase
- breathless
- transmembrane receptor, fgf-r homolog
- DER (preferred name: EGF-R, common alternative name: Torpedo)
- receptor- tk - EGF-R homology
- derailed
- receptor TK
- Dlar
- receptor tyrosine phosphatase - axon guidance
- Dror
- receptor tyrosine kinase - trk homolog
- Eph receptor tyrosine kinase
- receptor tyrosine kinase
- Epidermal growth factor receptor (common alternative name: Torpedo)
- receptor tyrosine kinase
- fgf-receptor homolog 1 (common alternative name: heartless or DFR1)
- transmembrane - receptor - Ig superfamily
- heartless (commonly known as Fibroblast growth factor receptor 1 or DFR-1)
- receptor tyrosine kinase
- Insulin-like receptor
-
receptor tyrosine kinase
- off-track
- CCK-4 family of 'dead' receptor tyrosine kinases, Ig-domains - required for lamina-specific targeting of R1-R6 axons -
- associates with Plexin, the receptor for Semaphorin ligand
- PDGF- and VEGF-receptor related
-
Ig C-2 type domain receptor tyrosine kinase - required for border cell migration
- Protein tyrosine phosphatase 4E
- broadly expressed type III receptor tyrosine phosphatase closely related to Ptp10D - shows synthetic phenotypes with other Pdps
- Protein tyrosine phosphatase 10D
- receptor tyrosine phosphatase - required for embryonic and larval axon guidance - along with Ptp69D regulates segregation
- of the young axons into a single core bundle in the larval mushroom body - mutants are defective in long-term memory formation
- Protein tyrosine phosphatase 69D
- receptor tyrosine phosphatase
- punt
- receptor for DPP - type II receptor serine/threonine kinase
- saxophone
- receptor serine/threonine kinase - a DPP receptor
- sevenless
- receptor tyrosine kinase - Boss receptor
- thickveins
- receptor serine/threonine kinase for DPP
- torpedo (preferred name: Epidermal growth factor receptor, common alternative name: ellipse)
- receptor-tk egf-r homology
- torso
- receptorTK
- wishful thinking
- type II TGFß receptor - functions presynaptically to regulate synaptic size at the neuromuscular junction - receptor serine/threonine kinase
- TRANSMEMBRANE ADHESION PROTEINS
- Basigin
-
conserved IgCAM required pre- and post-synaptically at neuromuscular junctions to restrict synaptic bouton size,
- controls distribution of synaptic vesicles and organization of the presynaptic cortical actin cytoskeleton
- Cadherin-E (preferred name: shotgun)
- cadherin - cell aggregation
- Cadherin-N
- transmembrane receptor, cadherin homolog
- Cad99C
- receptor - cadherin superfamily - expressed in follicle cells - regulator of microvillus length
- commissureless
- novel transmembrane protein
- capricious
- leucine-rich repeat transmembrane protein involved in selective synapse formation;
- contributes to formation of the affinity boundary between dorsal and ventral compartments of the wing
- Contactin
-
required for organization of septate junctions and for function of the paracellular barrier -
- Forms a tripartite complex with Neuroglian and Neurexin
- crumbs
- egf repeats - laminin A homolog
- dachsous
- cadherin superfamily
- DE-cadherin (preferred name: shotgun)
- E-cadherin homolog
- Delta
- EGF family - Notch ligand
- dumbfounded (preferred name: kin of irre)
- IG superfamily - required for myoblast aggregation and fusion
-
Dystroglycan
-
transmembrane receptor for extracellular matrix molecules - required for cellular polarity in epithelial cells and the oocyte
- Dscam
- multiple Ig domain protein
- E-cadherin (preferred name: shotgun)
- tm - E-cadherin homolog
- echinoid & friend of echinoid
-
cell-adhesion molecules (CAMs) - Ig and fibronectin domains proteins - The genes are adjacent to one another and co-ordinately regulated -
- Echinoid acts to antagonize Egf receptor signaling - Friend of echinoid exhibits interaction with the Notch pathway
- 18 wheeler
- transmembrane protein with with leucine-rich motif (LRR)
- Fasciclin I
- cam - lipid linked to membrane - novel
- Fasciclin II
- NCAM homolog - Ig superfamily
- Fasciclin III
- cam - novel
- fat
- cadherin domain transmembrane receptor that negatively controls cell proliferation - also functions in planar polarity
- furrowed
- selectin (carbohydrate binding protein)
- Gliolectin
- lectin (carbohydrate binding protein)
- Gliotactin
- novel serine esterase homolog
- hibris
- Ig repeat transmembrane protein with fibronectin type III domain - a receptor involved in muscle cell fusion
- integrin - beta PS (preferred name: myospheroid)
- integrin - beta subunit
- kekkon-1
-
Ig domain protein, Leucine-rich repeat protein
- kuzbanian
-
disintegrin and metalloprotease motifs - neurogenic
- Lachesin
-
GPI-anchored surface immunoglobulin domain cell adhesion molecule required for the proper morphogenesis of the tracheal system
- multiple edematous wings *
- alpha PS1 integrin - see myospheroid
- myospheroid
- integrin-beta subunit of PS1 & PS2
- Neuroglian
- IG superfamily - NgCAM related
- neuroligin-1 and neuroligin-2
-
Postsynaptic receptor that interacts with presynaptic Neurexins - recruits scaffolding proteins for organization of postsynaptic neurotransmitter receptors -
- mediates the precise apposition of presynaptic and postsynaptic membranes
- Neurotactin
- serine esterase homolog
- Notch
- receptor - neurogenic
- pollux
- novel cell surface receptor, leucine zipper protein
- roughest
- Ig-C2-type-domain protein - transmembrane
- roundabout
- IG and FN repeats protein
- semaphorin-1a
- axon guidance transmembrane protein
- Serrate
- EGF homolog - ligand for Notch
- scab
- alpha integrin
- shotgun
- E-cadherin
- starry night
- Cadherin-related 7TM protein
- sticks and stones
- transmembrane protein expressed on the surface of fusion competent myoblasts - essential for fusion of embryonic myoblasts
- strabismus (preferred name: Van Gogh)
- novel protein
- tartan
- Leucine-rich repeat transmembrane protein - along with Capricious, contributes to the adhesive properties of the cells
- in the morphogenetic furrow, thus regulating control of spacing ommatidial clusters - regulates boundary formation in the leg and wing -
- regulates tracheal branching
- Tenascin major
- transmembrane protein that acts together with the Filamin Cheerio to influence growth cone progression
- Van Gogh (common alternative name: strabismus)
- novel, potentially transmembrane protein
- MISCELLANEOUS TRANSMEMBRANE PROTEINS
- Adipokinetic hormone receptor (preferred name: Gonadotropin-releasing hormone receptor)
- GPCR - involved in storage-fat mobilization - essential to adjust normal body fat content
- and ensure lifelong fat-storage homeostasis - functional analog of the mammalian glucagon receptor
- beta amyloid protein precursor-like
- beta amyloid homolog
- Anktm1
(common alternative name: dTrpA1)
- heat-activated TRP family ion channel that is essential for thermotaxis
- arrow
- LDL-receptor-related protein (LRP) family - Wingless pathway
- atlastin
- dynamin-family transmembrane GTPase that drives endoplasmic reticulum membrane fusion in a GTP-dependent fashion - self-associating protein
- that is able to form trans-oligomeric complexes - required for normal growth of muscles and synapses at the neuromuscular junction
- Bride of sevenless (Boss)
- ligand of Sevenless - 7 transmembrane segments
- cacophony
- voltage sensitive calcium channel that stimulates neurotransmetter release at the presynaptic terminus at the neuromuscular junction
- cornichon
- cargo receptor required for transport of the TGFalpha growth factor Gurken to the oocyte surface
- death executioner Bcl-2 homologue
- Bcl-2/CED-9 family protein involved in regulating apoptosis
- dispatched
-
patched family protein regulating Hedgehog release
- domeless
-
a divergent member of the cytokine class I receptor family - required for segmentation and functions in trachea specification
- Dopamine receptor
- GPCR - mediates aversive and appetitive learning in pavlovian olfactory conditioning
- Dopamine transporter
- mediates uptake of dopamine in dopamine positive neurons - functions in regulating sleep and arousal
- draper
-
encoding an EGF-repeat single-pass transmembrane domain receptor - required during metamorphosis for recognition and engulfment of degenerating axon branches by glia
- Dscam2
- immunoglobulin superfamily - Dscam2 homophilic interactions mediate repulsion between neurites of L1 laminar cells in neighbouring columns of the optic lobe
- eater
- EGF-like repeat transmembrane protein located on phagocytic cells - mediates resistence to bacteria
- Excitatory amino acid transporter 1
- tranmembrane excitatory amino acid transporter expressed in glial cells - tightly regulates
- extracellular glutamate levels to control neurotransmission functions in locomotor behavior
- fear of intimacy
-
transmembrane domain protein - FICL family - zinc transporter - required in the mesoderm for gonad morphogenesis - required for tracheal branch fusion
- four-jointed
-
type 2 transmembrane protein
- frazzled
-
Ig superfamily - Netrin receptor
- frizzled
- 7 pass G-protein coupled receptor
- frizzled2
- transmembrane - 7 pass - frizzled family - receptor for Wingless
- frizzled3
- transmembrane - 7 pass - frizzled family - antagonist of wingless signal
- genderblind
- glutamate permease - regulates ambient extracellular glutamate to suppress glutamatergic synapse strength - controls mate choice
- Glutamate receptor IIA and Glutamate receptor IIB
- transmembrane Ca2+ channel protein
- Golden goal
-
transmembrane receptor that is dynamically expressed in all photoreceptor neurons and localizes predominantly to growth cones - regulates axon-axon
- and axon-target interactions in R8 photoreceptor axon - acts as a functional partner of Flamingo for R8 photoreceptor axon targeting in the medulla
- Gonadotropin-releasing hormone receptor (common alternative name: Adipokinetic hormone receptor)
- GPCR - involved in storage-fat mobilization - essential to adjust normal body fat content
- and ensure lifelong fat-storage homeostasis - functional analog of the mammalian glucagon receptor
- Gustatory receptor 21a and Gustatory receptor 63a
- GPCRs that confer CO2-chemosensation in Drosophila
- Gustatory receptor 64a
- taste receptor - response to sugar
- Gustatory receptor 66a
- 7 transmembrane protein - taste receptor - mediates aversion to bitter taste in the labellum, pharynx, legs, wings, and abdomen
- - mediates suppression of feeding behavior by the insect repellent DEET - mediates aversion to caffeine
- Gustatory receptor 68a
- an essential component of pheromone-driven courtship behavior
- inebriated
-
neurotransmitter:sodium symporter - mutations appear to cause increased excitability of the motor neuron by causing defective reuptake of a substrate neurotransmitter
- Inositol 1,4,5,-tris-phosphate receptor
- calcium channel
- inactive
- transient receptor potential vanilloid channel - expressed in chordotonal neurons where it is involved in temperature preference -
- expressed in antenna were it is involved in hearing
- interference Hedgehog
- IGcam membrane protein - binds Hedgehog and mediates Hedgehog response
- Ionotropic receptor 8a
-
a member of a novel family of chemosensory receptor ion channels - variant ionotropic glutamate receptor-like protein - expressed on antennal neurons
- Ionotropic receptor 64a
- chemosensory receptor ion channel, responds to acid
- Ionotropic receptor 84a
- chemosensory ionotropic glutamate receptor family protein, regulation of male courtship behavior, response to aromatic odors
-
kon-tiki
- conserved multi-domain transmembrane receptor required cell autonomously for myotubes to recognize their tendon cell targets -
- signals through the intracellular adaptor Grip in a conserved molecular pathway
- kugelei (common alternative names: fat-like, fat2)
- a cadherin related to Fat - required for the planar polarity of actin filament orientation
- at the basal side of ovarian follicle cells - acts non-autonomously in follicle cells in the transmission of polarity information
- required for morphogenesis and maintenance of tubular structures of ectodermal origin
- Leucokinin receptor
- G-protein coupled receptor expressed in brain neurons - regulation of meal size and meal frequency - regulation of fluid balance in Malpighian tubules
- metabotropic GABA-B receptor subtype 1
- G-protein coupled receptor - expressed by pheromone-sensing olfactory receptor neurons which as a consequence exhibit strong presynaptic inhibition -
- mediates inter-glomerular inhibition - responsible for decreased intracellular calcium of clock neurons blocking their calcium cycling
- metabotropic glutamate receptor
- G-protein coupled receptor - modulates presynaptic excitability properties and synaptic architecture -
- acts in conjunction with FMRP to regulate presynaptic properties
- methuselah
- G-protein coupled receptor: mutants have increased longevity, are resistent to stress and have increased body weight
- moody
- G-protein coupled receptor - expressed in glia and required for blood-brain barrier formation
- Neither inactivation nor afterpotential E (common alternative name: Rh1)
- rhodopsin expressed in photoreceptors R1-R6, response to light intensity, phototransduction, thermotaxis
- Neuropilin and tolloid-like (common alternative name: Neto)
- transmembrane protein - auxiliary subunit of ionic Glutamate receptor required for clustering of ionotropic glutamate receptors
- at the neuromuscular junction, for organization of postsynaptic densities and for synapse functionality
- Niemann-Pick Type C-1
- a transmembrane protein related to the Hedgehog receptor Patched - mutants have a shortage of sterol, and, as a consequence, inadequate ecdysone synthesis
- Neurexin
- multifunctional protein located at septate junctions
- Nimrod C1
- EGF-like repeat transmembrane protein located on phagocytic cells - mediates resistence to bacteria
- nervana 1 and nervana 2
- β subunit of Na,K-ATPase, plays an ion-pump-independent role in junction formation and tracheal morphogenesis
- NMDA receptor 1 and NMDA receptor 2
- voltage/Mg2+-dependent Ca2+ channels activated by glutamate - required for olfactory learning
- no mechanoreceptor potential C
- a mechanosensitive Ca2+ TRP family channel, mediates locomotion related proprioception (touch sensation)
- in PNS localized neurons - mediates sound detection in Johnston's organ
- Odorant receptor 22a and Odorant receptor 22b
- G-protein coupled receptors - Or22a responds to ethyl butyrate - localized to dendritic membranes of 22 cells of the basomedial region of the antenna
- Odorant receptor 65a
- G-protein coupled receptor - courtship behavior - confers aversive response to cis-vaccenyl acetate
- Odorant receptor 67d
- G-protein coupled receptor - courtship behavior - the male-specific pheromone 11-cVA acts through Or67d to regulate both male and female mating behavior
- Odorant receptor 83b
- G-protein coupled receptor - broadly expressed receptor of unknown function - required for dendritic localization of conventional odorant receptors -
- mutation disrupts behavioral and electorphysiological responses to many odorants
- Octopamine receptor in mushroom bodies
- G-protein coupled receptor - activated in mated females and functions during ovulation
- in the oviduct epithelium to facilitate egg-laying - expressed in mushroom bodies
- olf186-F (common alternative name: Orai)
- store-operated Ca2+ channel involved in rhythmic firing of the flight motoneurons - physically interacts with
- the Ca2+ store sensor Stim (Stromal interaction molecule) to form the Ca2+ release-activated Ca2+ (CRAC) channel
- Ora transientless
- histamine-gated chloride channel required for synaptic transmission at the photoreceptor-large monopolar cells synapse and
- for orientation and motion vision - responsible for synaptic transients in electroretinograms -
- modulates temperature preference and controls tolerance of low and high temperature
- painless
- calcium channel - nociceptor - mutant is pain response defective
- patched
- segment polarity gene
-
perdido (common alternative name: Kon-tiki)
-
conserved multi-domain transmembrane receptor required cell autonomously for myotubes to recognize their tendon cell targets -
- signals through the intracellular adaptor Grip in a conserved molecular pathway
-
pickpocket
-
subunit of the epithelial sodium channel (ENaC) family - plays an essential role in controlling rhythmic locomotion
- by providing mechanosensory signal transduction of proprioceptive sensory information
-
pickpocket 23, pickpocket 25 and pickpocket 28
- DEG/ENaC sodium channel subunits - required for activation of courtship behavior by chemosensory perception of female pheromones
- pickpocket 28
- amiloride-sensitive Na+ channel - osmosensitive ion channel that mediates response to water -
- expressed in labellar gustatory chemosensory bristles
- plexin A
- semaphorin domain protein, semaphorin receptor
- plexin B
- semaphorin domain protein, receptor for the secreted semaphorin Sema-2a -
- regulates axon extension from the sensory neuron cell body in regions of direct contact with oenocytes
- Peptidoglycan recognition protein LC
- transmembrane receptor involved in antimicrobial response, recognizes bacterial toxins, expressed in fat body and midgut
- Presenilin
-
transmembrane protein involved in proteolysis of Notch
- Resistant to dieldrin
-
GABA-A receptor that negatively modulates olfactory associative learning, possibly by gating the input of olfactory information
- into the mushroom bodies - regulates the length of time required to fall asleep
- rhomboid (preferred name: veinlet)
- serine protease - transmembrane protein involved with Epidermal growth factor receptor signaling - required for the production or processing of Spitz, the Egfr ligand
- rhomboid-7
- transmembrane mitochondrial protease required for spermatogenesis and muscle maturation
- roughoid
- EGF pathway
- Ryanodine receptor 44F
- Ca2+-induced Ca2+ release channel located in presynaptic endoplasmic reticulum membranes -
- sustains vesicular mobilization thus enhancing release of transmitters and neuropeptides
- sanpodo
-
encodes a four-pass transmembrane protein that localizes to the cell membrane - specifies Notch-dependent fate - Notch and Numb physically associate with Sanpodo
- semaphorin-1a
- Axon guidance transmembrane protein
- Sensory neuron membrane protein
- CD36-related transmembrane protein - essential for the response of olfactory sensory neurons to cis-vaccenyl acetate,
- a male-specific fatty-acid-derived pheromone that regulates sexual and social aggregation behaviours
- Serotonin receptor 1A and Serotonin receptor 1B (5-HT1A and 5-HT1B)
- seven-pass transmembrane protein, 5-HT1A promotes baseline sleep
- Serotonin receptor 2
- seven-pass transmembrane protein
- Serotonin receptor 7
- seven-pass transmembrane protein implicated in regulation of courtship behavior, mating, olfactory learning and memory
- sex peptide receptor
- G-protein coupled receptor - required in Fruitless plus neurons for post-mating switch in female reproductive behaviour
- Shaker cognate b
- slow delayed rectifier K+ channel - upregulated by light stimulation - functions in light adaptation
- sinuous
- claudin - localizes to septate junctions and is required for junction organization and paracellular barrier function -
- required fo maintenance of cardiac integrity
- slimfast
- Amino acid transporter - downregulation within the fat body causes a global growth defect involving TSC/TOR signaling
- in the fat body and a remote inhibition of organismal growth
- slowpoke
- Ca-activated, voltage-activated potassium channel
- smoothened
- seven-pass transmembrane protein - putative hedgehog receptor
- sneaky
- transmembrane acrosomal protein involved in sperm plasma membrane breakdown; required for sperm activation in the egg cytoplasm
- spinster
- conserved transmembrane protein expressed in glia - mutants exhibit increased neural survival and altered sexual behavior
- spitz
- ligand for Egf-r - egf/tgf beta homolog
- Star
- interacts with EGF-R
- synaptotagmin
-
calcium sensor in synaptic vesicle fusion - functions during exocytosis
- Syndecan
- a heparan sulfate proteoglycan - a necessary component of Slit/Robo signaling required in Slit target cells
- Syntaxin 1A
- vesicular docking protein
- Syntaxin 5
- a Golgi-localized SNARE protein - required for ER-Golgi traffic and Golgi reassembly following cell division - required for steps leading to formation of mature sperm
- Tachykinin-like receptor at 99D
- G-protein coupled receptor activated by tachykinin-related peptides - regulates stress induced insulin production
- and signaling in renal tubules, insulin-producing cells in the adult brain, and presynaptic suppression and
- olfactory behaviors in the antennal lobe of the brain
- Toll
- IL1 homolog
- Tollo
- Toll-like receptor - leucine rich repeat transmembrane protein - expressed in ectoderm
and required for neural-specific expression of the glycan HRP epitope
- transient receptor potential
- visual phototransduction, calcium channel, adaptation to light
- Transient receptor potential A1
- heat-activated TRP family ion channel that is essential for thermotaxis
- trapped in endoderm-1
- G-protein coupled receptor - links cell polarity, modulation of cell adhesion, and invasion during germ cell migration
- Trehalose-sensitivity
- G-protein coupled receptor - Taste receptor
- unc-5
- netrin receptor
- veinlet (common alternative name: rhomboid)
- interacts with EGF-R
- white
- ABC transporter of amines that partners with Brown in determination of eye pigmentation - Behavioral abnormalities in white, brown and scarlet mutants
- could arise from reduced amine levels in neurons
- wengen
- tumor necrosis factor receptor superfamily - forced expression triggers cell death
- wntless
- novel conserved transmembrane protein that acts in the Wnt-sending cells to promote the secretion of Wnt proteins
- zero population growth
-
germline-specific gap junction protein - Innexin 4 - required for survival of differentiating early germ cells
during gametogenesis in both sexes
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* genes currently without individual sites in The Interactive Fly
Drosophila genes listed by biochemical function
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