Drosophila gene families: FGF receptor signalling

The Interactive Fly

Zygotically transcribed genes

Bub1

protein serine/threonine kinase - mitotic checkpoint control protein - inhibits ubiquitin ligase activity

of anaphase promoting complex (APC) preventing mitosis until all chromosomes are correctly attached to the mitotic spindle

Bub3

mitotic checkpoint protein that serves as an essential protein required during normal mitotic progression to prevent premature sister

chromatid separation, missegreation and aneuploidy

grapes

Chk1 homolog that functions in a developmentally regulated DNA replication/damage checkpoint operating

during the late syncytial divisions

loki

Chk2 homolog that functions in both the G1 and G2 checkpoint responses

meiotic 41

ATM/ATR kinase, phosphatidylinositol 3-kinase - essential for the DNA damage checkpoint in larval imaginal discs and neuroblasts -

required to delay mitosis in response to incomplete DNA replication in early nuclear divisions -

monitors double-strand-break repair during meiotic crossing over

nbs

encodes a multifunctional protein that plays critical roles in the response to DNA damage and telomere maintenance -

part of the MRN complex that which includes Mre11 and Rad50 - MRN senses DNA strand breaks and amplifies the signal and then conveys it to

downstream effectors, such as ATM (Telomere fusion in Drosophila) and p53, that regulate cell cycle checkpoints and DNA repair

okra

DNA helicase involved in DNA repair - required for meiosis - the Drosophila homolog of the yeast DNA-repair protein Rad54

p53

Transcription factor regulating cell cycle, DNA repair and apoptosis

Rad51-like (common alternative name: spindle A)

checkpoint protein essential for recombinational repair of double-stranded DNA breaks (DSBs) in somatic cells

and during meiosis in germ cells

telomere fusion (common alternative name: ATM)

a large, multifunctional protein kinase that regulates responses required for surviving DNA damage,

including functions such as DNA repair, apoptosis, and cell cycle checkpoints -

required for maintenance of normal telomeres and chromosome stability