Ras oncogene at 85D
Drk, an adaptor protein homologous to vertebrate Grb-2
Ras GTPase-activating proteins (GAPs)
Raf, a serine/threonine kinase (part 1/2)
Raf, a serine/threonine kinase (part 2/2)
Kinase repressor of Ras (Ksr)
Table of Contents
Sos, a guanine nucleotide exchange/release factor
C3g, a potential guanine nucleotide exchange/release factor for Ras
Ras is ubiquitinated: Impairment of ubiquitylation by mutation in Drosophila E1 promotes both cell-autonomous and non-cell-autonomous Ras-ERK activation in vivo
RalGDS, an effector protein for Ras
Sprouty: a Ras pathway antagonist that binds Drk and Gap1
DOS, a presumptive adaptor protein
PI3K
Raf acts to elaborate dorsoventral pattern in the ectoderm of developing embryos
Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism
CNK, a RAF-binding multidomain protein required for RAS signaling
Leonardo and 14-3-3eta, 14-3-3 isoforms
Canoe, a scaffolding protein
Antagonistic feedback loops involving rau and sprouty in the Drosophila eye control neuronal and glial differentiation
Ras85D:
Biological Overview
| Evolutionary Homologs
| Regulation
| Effects of Mutation
| Ras as Oncogene
| References
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