hedgehog

REFERENCES (part 1/3)

Abzhanov, A. and Tabin, C. J. (2004). Shh and Fgf8 act synergistically to drive cartilage outgrowth during cranial development. Dev. Biol. 273: 134-148. 15302603

Adolphe, C., et al. (2004). An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis. Development 131: 5009-5019. 15371305

Aguilar-Hidalgo, D., Becerra-Alonso, D., Garcia-Morales, D. and Casares, F. (2016). Toward a study of gene regulatory constraints to morphological evolution of the Drosophila ocellar region. Dev Genes Evol [Epub ahead of print]. PubMed ID: 27038024

Akiyama-Oda, Y. and Oda, H. (2010). Cell migration that orients the dorsoventral axis is coordinated with anteroposterior patterning mediated by Hedgehog signaling in the early spider embryo. Development 137(8): 1263-73. PubMed Citation: 20332148

Alcedo, J., et al. (1996). The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 86: 221-232. PubMed Citation: 8706127

Alexandre, C., Lecourtois, M. and Vincent, J.-P. (1999). Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals. Development 126: 5689-5698. PubMed Citation: 10572045

Alvarez, J., et al. (2002). TGFß2 mediates the effects of Hedgehog on hypertrophic differentiation and PTHrP expression. Development 129: 1913-1924. 11934857

Alvarez-Medina, R., Le Dreau, G., Ros, M. and Martí, E. (2009). Hedgehog activation is required upstream of Wnt signalling to control neural progenitor proliferation. Development 136(19): 3301-9. PubMed Citation: 19736325

Amanai, K. and Jiang, J. (2001). Distinct roles of Central missing and Dispatched in sending the Hedgehog signal. Development 128: 5119-5127. 11748147

Amano, T., et al. (2009). Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription. Dev. Cell 16(1): 47-57. PubMed Citation: 19097946

Amin, A., Li, Y. and Finkelstein, R. (1999). Hedgehog activates the EGF receptor pathway during Drosophila head development. Development 126(12): 2623-2630. PubMed Citation: 10331974

Amoyel, M., Sanny, J., Burel, M. and Bach, E. A. (2013). Hedgehog is required for CySC self-renewal but does not contribute to the GSC niche in the Drosophila testis. Development 140: 56-65. PubMed ID: 23175633

Amoyel, M., Simons, B. D., Bach, E. A. (2014). Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo. EMBO J. PubMed ID: 25092766

Anderson, E., Devenney, P. S., Hill, R. E. and Lettice, L. A. (2014). Mapping the Shh long-range regulatory domain. Development 141: 3934-3943. PubMed ID: 25252942

Apelqvist, A., Ahlgren, U. and Edlund, H. (1997). Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr. Biol. 7(10): 801-804. PubMed Citation: 9368764

Apidianakis, Y., et al. (2001). Groucho mediates a Ci-independent mechanism of hedgehog repression in the anterior wing pouch. Development 128: 4361-4370. 11684670

Appel, B. and Eisen, J. S. (1997). Regulation of neuronal specification in the zebrafish spinal cord by Delta function. Development 125(3): 371-380. PubMed Citation: 9425133

Arkell, R. and Beddington, R. S. P. (1997). BMP-7 influences pattern and growth of the developing hindbrain of mouse embryos. Development 124: 1-12. PubMed Citation: 9006062

Armstrong, B. E., Henner, A., Stewart, S. and Stankunas, K. (2017). Shh promotes direct interactions between epidermal cells and osteoblast progenitors to shape regenerated zebrafish bone. Development 144(7): 1165-1176. PubMed ID: 28351866

Astorga, J. and Carlsson, P. (2007). Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development 134(20): 3753-61. Medline abstract: 17881493

Aubin, J., et al. (2002). Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling. Development 129: 4075-4087. 12163410

Avanesov, A., Honeyager, S. M., Malicki, J. and Blair, S. S. (2012). The role of glypicans in Wnt inhibitory factor-1 activity and the structural basis of Wif1's effects on Wnt and Hedgehog signaling. PLoS Genet. 8(2): e1002503. PubMed Citation: 22383891

Ayers, K. L., Gallet, A., Staccini-Lavenant, L. and Thérond, P. P. (2010). The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum. Dev Cell 18: 605-620. PubMed Citation: 20412775

Aza-Blanc, P., et al. (2000). Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities. Development 127: 4293-4301. 10976059

Azcoitia, V., Aracil, M., Martinez, A. C. and Torres, M. (2005). The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo. Dev. Biol. 280: 307-320. PubMed citation: 15882575

Azpiazu, N., et al. (1996). Segmentation and specification of the Drosophila mesoderm. Genes Dev. 10: 3183-94. PubMed Citation: 8985186

Babcock, D. T., Shi, S., Jo, J., Shaw, M., Gutstein, H. B. and Galko, M. J. (2011). Hedgehog signaling regulates nociceptive sensitization. Curr Biol 21: 1525-1533. PubMed ID: 21906949

Bai, J. and Montell, D. (2002). Eyes absent, a key repressor of polar cell fate during Drosophila oogenesis. Development 129: 5377-5388. 12403709

Baker, N. E., Bhattacharya, A. and Firth, L. C. (2009). Regulation of Hh signal transduction as Drosophila eye differentiation progresses. Dev. Biol. 335(2): 356-66. PubMed Citation: 19761763

Bare, Y., Matusek, T., Vriz, S., Deffieu, M. S., Therond, P. P. and Gaudin, R. (2023). TMED10 mediates the loading of neosynthesised Sonic Hedgehog in COPII vesicles for efficient secretion and signalling. Cell Mol Life Sci 80(9): 266. PubMed ID: 37624561

Barresi, M. J. F., Stickney, H. L. and Devoto, S. H. (2000). The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity. Development 127: 2189-2199. PubMed Citation: 10769242

Barretta, A. L., Kruegera, S. and Datta, S. (2008). Branchless and Hedgehog operate in a positive feedback loop to regulate the initiation of neuroblast division in the Drosophila larval brain. Dev. Biol. 317: 234-245. PubMed Citation: 18353301

Bastida, M. F., Sheth, R. and Ros, M. A. (2009). A BMP-Shh negative-feedback loop restricts Shh expression during limb development. Development 136(22): 3779-89. PubMed Citation: 19855020

Bayly, R. D., et al. (2007). Regulation of ventral midbrain patterning by Hedgehog signaling. Development 134: 2115-2124. Medline abstract: 17507412

Becker, S., et al. (1997). A role for Indian hedgehog in extraembryonic endoderm differentiation in F9 cells and the early mouse embryo. Dev. Biol. 187(2): 298-310. PubMed Citation: 9242425

Belloni, E., et al. (1996). Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nature Genet. 14: 353-356. PubMed Citation: 8896571

Bellaiche, Y., The, I., Perrimon, N. (1998). Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature 394(6688): 85-88. PubMed Citation: 9665133

Bellusci, S., et al. (1996). Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development 124: 53-63. PubMed Citation: 9006067

Benlali, et al. (2000). act up controls actin polymerization to alter cell shape and restrict Hedgehog signaling in the Drosophila eye disc. Cell 101: 271-281. PubMed Citation: 10847682

Benmimoun, B., Polesello, C., Waltzer, L., Haenlin, M. (2012). Dual role for Insulin/TOR signaling in the control of hematopoietic progenitor maintenance in Drosophila. Development 139(10): 1713-7. PubMed Citation: 22510984

Bhat, K. M. and Schedl, P. (1997). Requirement for engrailed and invected genes reveals novel regulatory interactions between engrailed/invected, patched, gooseberry and wingless during Drosophila neurogenesis. Development 124: 1689-1698. PubMed Citation: 9165117

Bilder, D. and Scott, M. P. (1998). Hedgehog and Wingless induce metameric pattern in the Drosophila visceral mesoderm. Dev. Biol. 201(1): 43-56. PubMed Citation: 9733572

Bilioni, A., Sanchez-Hernandez, D., Callejo, A., Gradilla, A. C., Ibanez, C., Mollica, E., Carmen Rodriguez-Navas, M., Simon, E. and Guerrero, I. (2013). Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif. Dev Biol 376: 198-212. PubMed ID: 23276604

Bischoff, M., Gradilla, A. C., Seijo, I., Andres, G., Rodriguez-Navas, C., Gonzalez-Mendez, L. and Guerrero, I. (2013). Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia. Nat Cell Biol. PubMed ID: 24121526

Bitgood, M. J. and McMahon, M. P. (1995). Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol 172: 126-138. PubMed Citation: 7589793

Blader, P., et al. (1997). The activity of Neurogenin1 is controlled by local cues in the zebrafish embryo. Development 124(22): 4557-4569. PubMed Citation: 9409673

Blagden, C. S., et al. (1997). Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog. Genes Dev. 11(17): 2163-2175. PubMed Citation: 9303533

Blank, M. C., et al. (2011). Multiple developmental programs are altered by loss of Zic1 and Zic4 to cause Dandy-Walker malformation cerebellar pathogenesis. Development 138(6): 1207-16. PubMed Citation: 21307096

Bok, J., et al. (2007). Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear. Development 134(9): 1713-22. Medline abstract: 17395647

Bokor, P. and DiNardo, S. (1996). The roles of hedgehog, wingless and lines in patterning the dorsal epidermis of Drosophila. Development 122: 1083-92. PubMed Citation: 8620835

Bornemann, D. J., Duncan, J. E., Staatz, W., Selleck, S. and Warrior, R. (2004). Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways. Development 131(9): 1927-38. 15056609

Borod, E. R. and Heberlein, U. (1998). Mutual regulation of decapentaplegic and hedgehog during the initiation of differentiation in the Drosophila retina. Dev. Biol. 197(2): 187-197. PubMed Citation: 9630745

Borycki, A.-G., Mendham, L. and Emerson, C. P. (1998). Control of somite patterning by Sonic hedgehog and its downstream signal response genes. Development 125(4): 777-790. PubMed Citation: 9435297

Borycki, A.-G., Brown, A. M. C. and Emerson, C. P. (2000). Shh and Wnt signaling pathways converge to control Gli gene activation in avian somites. Development 127: 2075-2087. 10769232

Borycki, A.-G., et al. (1999). Sonic hedgehog controls epaxial muscle determination through Myf5 activation. Development 126: 4053-4063. PubMed Citation: 10457014

Bossing, T and Brand, A. H. (2006). Determination of cell fate along the anteroposterior axis of the Drosophila ventral midline. Development 133: 1001-1012. 16467357

Bras-Pereira, C., Bessa, J. and Casares, F. (2006). Odd-skipped genes specify the signaling center that triggers retinogenesis in Drosophila. Development 133(21): 4145-9. PubMed citation: 17021046

Briscoe, J., et al. (1999). Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature 398(6728): 622-7. PubMed Citation: 10217145

Briscoe, J., et al. (2000). A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube. Cell 101: 435-445. PubMed Citation: 10830170

Briscoe, J., et al. (2001). A Hedgehog-insensitive form of Patched provides evidence for direct long-range morphogen activity of Sonic hedgehog in the neural tube. Mol. Cell 7: 1279-1291. 11430830

Bruneau, S., Rosa, F. M. (1997). Dynamo, a new zebrafish DVR member of the TGF-beta superfamily is expressed in the posterior neural tube and is up-regulated by Sonic hedgehog. Mech Dev 61 (1-2): 199-212. PubMed Citation: 9076689

Buescher, M., Svendsen, P. C., Tio, M., Miskolczi-McCallum, C., Tear, G., Brook, W. J. and Chia, W. (2004). Drosophila T box proteins break the symmetry of hedgehog-dependent activation of wingless. Curr. Biol. 14(19): 1694-702. 15458640

Buratovich, M. A., et al. (2000). DWnt-4 and Wingless have distinct activities in the Drosophila dorsal epidermis. Dev. Genes Evol. 210: 111-119. PubMed Citation: 11180811

Burke, R. and Basler, K. (1996). Hedgehog-dependent patterning in the Drosophila eye can occur in the absence of Dpp signaling. Dev. Biol. 179 (2): 360-368. PubMed Citation: 8903352

Buscher, D., et al. (1997). Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mech. Dev. 62 (2): 175-182. PubMed Citation: 9152009

Buscher, D. and Ruther, U. (1998). Expression profile of Gli family members and Shh in normal and mutant mouse limb development. Dev. Dyn. 211(1):88-96. PubMed Citation: 9438426

Buttitta, L., et al. (2003). Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development 130: 6233-6243. 14602680

Byrd, N., et al. (2002). Hedgehog is required for murine yolk sac angiogenesis. Development 129: 361-372. 11807029

Caballero, I. M., Manuel, M. N., Molinek, M., Quintana-Urzainqui, I., Mi, D., Shimogori, T. and Price, D. J. (2014). Cell-autonomous repression of Shh by transcription factor Pax6 regulates diencephalic patterning by controlling the central diencephalic organizer. Cell Rep 8: 1405-1418. PubMed ID: 25176648

Callejo, A., Torroja, C., Quijada, L. and Guerrero, I. (2006). Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix. Development 133(3): 471-83. 16396909

Callejo, A., Culi, J. and Guerrero, I. (2008). Patched, the receptor of Hedgehog, is a lipoprotein receptor. Proc Natl Acad Sci U S A 105: 912-917. PubMed ID: 18198278

Callejo, A., Bilioni, A., Mollica, E., Gorfinkiel, N., Andres, G., Ibanez, C., Torroja, C., Doglio, L., Sierra, J. and Guerrero, I. (2011). Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium. Proc Natl Acad Sci U S A 108: 12591-12598. PubMed ID: 21690386

Camp, D., He, B. H., Li, S., Althaus, I. W., Holtz, A. M., Allen, B. L., Charron, F. and van Meyel, D. J. (2014). Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand. Development 141(20):3879-88. PubMed ID: 25231763

Capdevila, J., Tabin, C. and Johnson, R. L. (1998). Control of dorsoventral somite patterning by Wnt-1 and beta-Catenin. Dev. Biol. 193(2): 182-194. PubMed Citation: 9473323

Caruccio, N. C., et al. (1999). Constitutive activation of sonic hedgehog signaling in the chicken mutant talpid(2): Shh-independent outgrowth and polarizing activity. Dev. Biol. 212(1): 137-149. PubMed Citation: 10419691

Capurro, M. I., et al. (2008), Glypican-3 inhibits Hedgehog signaling during development by competing with Patched for Hedgehog binding. Dev. Cell 14: 700-711. PubMed Citation: 18477453

Caspary, T., et al. (2002). Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling. Curr. Biol. 12: 1628-1632. 12372258

Caspary, T., Larkins, C. E. and Anderson, K. V. (2007). The graded response to Sonic Hedgehog depends on cilia architecture. Dev. Cell 12(5): 767-78. PubMed citation: 17488627

Casso, D. J. Biehs, B. and Kornberg, T. B. (2011). A novel interaction between hedgehog and Notch promotes proliferation at the anterior-posterior organizer of the Drosophila wing. Genetics 187(2): 485-99. PubMed Citation: 21098717

Cavodeassi, F., et al. (1999). Compartments and organizing boundaries in the Drosophila eye: the role of the homeodomain Iroquois proteins. Development 126: 4933-4942. PubMed Citation: 10529412

Chai, P. C., Liu, Z., Chia, W. and Cai, Y. (2013). Hedgehog signaling acts with the temporal cascade to promote neuroblast cell cycle exit. PLoS Biol 11: e1001494. PubMed ID: 23468593

Chamoun, Z., et al. (2001). Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science 293: 2080-2084. 11486055

Chan, D. C., Wynshaw-Boris, A. and Leder, P. (1995). Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of fgf-4 and shh in the limb bud. Development 121(10): 3151-62. PubMed Citation: 7588050

Chang, B. E., et al. (1997). Axial (HNF3ß) and retinoic acid receptors are regulators of the zebrafish sonic hedgehog promoter. EMBO J. 16(13): 3955-3964. PubMed Citation: 9233805

Chang, T., et al. (2001). Dpp and Hh signaling in the Drosophila embryonic eye field. Development 128: 4691-4704. 11731450

Charite, J., McFadden, D. G. and Olson, E. N. (2000). The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development. Development 127: 2461-2470. PubMed Citation: 10804186

Charrier, J.-B., et al. (2001). Anti-apoptotic role of Sonic hedgehog protein at the early stages of nervous system organogenesis. Development 128: 4011-4020. 11641224

Charron, F., et al. (2003). The morphogen Sonic hedgehog is an axonal chemoattractant that collaborates with Netrin-1 in midline axon guidance. Cell 113: 11-23. 12679031

Chen, W., Huang, H., Hatori, R. and Kornberg, T. B. (2017). Essential basal cytonemes take up Hedgehog in the Drosophila wing imaginal disc. Development 144(17):3134-3144. PubMed ID: 28743798

Chen, Y. and Struhl, G. (1996). Dual roles for Patched in sequestering and transducing. Cell 87: 553-663. PubMed Citation: 8898207

Chen, Y. and Struhl, G. (1998). In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex. Development 125: 4943-4948. 9811578

Chen, Y., et al. (1999). Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling. Development 126: 3607-3616. PubMed Citation: 10409506

Cheng, C. W., et al. (2006). The homeobox gene irx1a is required for the propagation of the neurogenic waves in the zebrafish retina. Mech. Dev. 123(3): 252-63. 16457994

Chou, Y. H., Zheng, X., Beachy, P. A. and Luo, L. (2010). Patterning axon targeting of olfactory receptor neurons by coupled hedgehog signaling at two distinct steps. Cell 142(6): 954-66. PubMed Citation: 20850015

Chiang, C. and Beachy, P. A. (1994). Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila. Mech. Dev. 47: 225-239. PubMed Citation: 7848870

Chiang, C., et al. (1996). Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383: 407-413. PubMed Citation: 8837770

Chiang, C., et al. (1999). Essential role for sonic hedgehog during hair follicle morphogenesis. Dev. Biol. 205(1): 1-9. PubMed Citation: 9882493

Chiang, C., et al. (2001). Manifestation of the limb prepattern: Limb development in the absence of Sonic Hedgehog function. Dev. Bio. 236: 421-435. 11476582

Cho, K.-O., et al. (2000). Novel signaling from the peripodial membrane Is essential for eye disc patterning in Drosophila. Cell 103: 331-342. PubMed Citation: 11057905

Chu, T., Chiu, M., Zhang, E. and Kunes, S. (2006). A C-terminal motif targets Hedgehog to axons, coordinating assembly of the Drosophila eye and brain. Dev. Cell 10: 635-646. PubMed Citation: 16678778

Chuang, P. T. and McMahon, A. P. (1999). Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature 397(6720): 617-21

Clement, V., et al. (2007). HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr. Biol. 17: 165-172. Medline abstract: 17196391

Cobourne, M. T., Miletich, I. and Sharpe, P. T. (2004). Restriction of sonic hedgehog signalling during early tooth development. Development 131: 2875-2885. 15151988

Colnot, C., et al. (2005). Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development. Development 132(5): 1057-67. 15689378

Colosimo, P. F. and Tolwinski, N. S. (2006). Wnt, Hedgehog and junctional Armadillo/beta-catenin establish planar polarity in the Drosophila embryo. PLoS ONE 1:e9. PubMed citation: 17183721

Cooper, M. K., et al. (1998). Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280(5369): 1603-1607

Cornesse, Y., Pieler, T. and Hollemann, T. (2005). Olfactory and lens placode formation is controlled by the hedgehog-interacting protein (Xhip) in Xenopus. Dev. Biol. 277(2): 296-315. 15617676

Corrales, J., et al. (2004). Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development. Development 131: 5581-5590. 15496441

Corrigall, D., et al. (2007). Hedgehog signaling is a principal inducer of myosin-II-driven cell ingression in Drosophila epithelia. Dev. Cell 13: 730-742. PubMed Citation: 17981140

Cortes, M., Baria, A. T. and Schwartz, N. B. (2009). Sulfation of chondroitin sulfate proteoglycans is necessary for proper Indian hedgehog signaling in the developing growth plate. Development 136(10): 1697-706. PubMed Citation: 19369399

Coutelle, O., et al. (2001). Hedgehog signalling is required for maintenance of myf5 and myod expression and timely terminal differentiation in zebrafish adaxial myogenesis. Dev. Bio. 236: 136-150. 11456450

Craven, S. E., et al. (2004). Gata2 specifies serotonergic neurons downstream of Sonic hedgehog. Development 131: 1165-1173

Crozatier, M. and Vincent, V. (1999b). Requirement for the Drosophila COE transcription factor Collier in formation of an embryonic muscle: transcriptional response to Notch signalling. Development 126: 1495-1504 . PubMed Citation: 10068642

Crozatier, M., et al. (1999b). Head versus trunk patterning in the Drosophila embryo; collier requirement for formation of the intercalary segment. Development 126: 4385-4394. PubMed Citation: 10477305

Crozatier, M., Glise, B., Khemici, V. and Vincent, A. (2003). Vein-positioning in the Drosophila wing in response to Hh; new roles of Notch signaling. Mech. Dev. 120: 529-535. 12782270

Crozatier M., et al. (2004). Cellular immune response to parasitization in Drosophila requires the EBF orthologue collier. PLoS Biol. 2: E196. PubMed Citation: 15314643

Curtiss, J. and Mlodzik, M. (2000). Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent. Development 127: 1325-1336. PubMed Citation: 10683184

Dahmane, N. and Ruiz i Altaba, A. (1999). Sonic hedgehog regulates the growth and patterning of the cerebellum. Development 126: 3089-3100

Dahmane, N., et al. (2001). The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development 128: 5201-5212. 11748155

Dai, P., et al. (1999). Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem. 274(12): 8143-52

Dakubo, G. D., et al. (2003). Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development. Development 130: 2967-2980. 12756179

Dale, J. K., et al. (1997). Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm. Cell 90(2): 257-269

D'Alessio, M. D. and Frasch, M. (1996). msh may play a conserved role in dorsoventral patterning of the neuroectoderm and mesoderm. Mech. Dev. 58: 217-231

Danesin, C., et al. (2009). Integration of telencephalic Wnt and Hedgehog signaling center activities by Foxg1. Dev. Cell 16: 576-587. PubMed Citation: 19386266

Daniele, J. R., Chu, T. and Kunes, S. (2017a). A novel proteolytic event controls Hedgehog intracellular sorting and distribution to receptive fields. Biol Open [Epub ahead of print]. PubMed ID: 28298318

Daniele, J. R., Baqri, R. M. and Kunes, S. (2017b). Analysis of axonal trafficking via a novel live imaging technique reveals distinct Hedgehog transport kinetics. Biol Open [Epub ahead of print]. PubMed ID: 28298319

Dassule, H. R., et al. (2000). Sonic hedgehog regulates growth and morphogenesis of the tooth. Development 127: 4775-4785. 11044393

Davies, J. E. and Miller, R. H. (2001). Local Sonic hedgehog signaling regulates oligodendrocyte precursor appearance in multiple ventricular zone domains in the chick metencephalon. Dev. Bio. 233: 513-525. 11336511

de Celis, J. F. and Ruilz-Gomez, M. (1995). groucho and hedgehog regulate engrailed expression in the anterior compartment of the Drosophila wing. Development 121: 3467-76

de Celis, J. F., Barrio, R. and Kafatos, F. C. (1999). Regulation of the spalt/spalt-related gene complex and its function during sensory organ development in the Drosophila thorax. Development 126(12): 2653-2662

Desbordes, S. C. and Sanson, B. (2003). The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila. Development 130: 6245-6255. 14602684

Deshpande, G., et al. (2001). Hedgehog signaling in germ cell migration. Cell 106: 759-769. 11572781

Deshpande, G. and Schedl, P. (2005). HMGCoA reductase potentiates hedgehog signaling in Drosophila melanogaster. Dev. Cell 9(5): 629-38. 16256738

Diaz-Benjumea, F. U. (1994).Cell interactions between compartments establishes the proximal-distal axis of Drosophila legs. Nature 372: 175-179

diIorio, P. J., et al. (2002). Sonic hedgehog is required early in pancreatic islet development. Dev. Biol. 244: 75-84. 11900460

Domínguez, M., et al. (1996). Sending and receiving the Hedgehog signal: Control by the Drosophila Gli protein Cubitus interruptus. Science 272: 1621-1625

Domínguez, M. and Hafen, E. (1997). Hedgehog directly controls initiation and propagation of retinal differentiation in the Drosophila eye. Genes Dev. 11(23): 3254-3264

Dominguez, M. (1999). Dual role for Hedgehog in the regulation of the proneural gene atonal during ommatidia development. Development 126: 2345-2353

Dorsett, D., et al. (2005). Effects of sister chromatid cohesion proteins on cut gene expression during wing development in Drosophila. Development 132: 4743-4753. PubMed Citation: 16207752

Drossopoulou, G., et al. (2000). A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signaling and Bmp signaling. Development 127: 1337-1348.

Du, S. J., et al. (1997). Positive and negative regulation of muscle cell identity by members of the hedgehog and TGF-beta gene families. J. Cell Biol. 139(1): 145-156

Duprez, D., Fournier-Thibault, C. and Le Douarin, N. M. (1998). Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb. Development 125(3): 495-505

Dutton, R., et al. (1999). Sonic hedgehog promotes neuronal differentiation of murine spinal cord precursors and collaborates with neurotrophin 3 to induce islet-1. J. Neurosci. 19(7): 2601-8

Dyer, M. A., et al. (2001). Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo. Development 128(10): 1717-30. 11311154

Emmons-Bell, M. and Hariharan, I. K. (2021). Membrane potential regulates Hedgehog signalling in the Drosophila wing imaginal disc. EMBO Rep: e51861. PubMed ID: 33629503

Epps, J. L., Jones, J. B. and Tanda, S. (1997). oroshigane, a new segment polarity gene of Drosophila melanogaster, functions in Hedgehog signal transduction. Genetics 145 (4): 1041-1052

Epstein, D. J., et al. (1996). Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development 122: 2885-94

Epstein, D. J., McMahon, A. P. and Joyner, A. L. (1999). Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms. Development 126(2): 281-292

Epstein, D. J., et al. (2000). Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS. Development 127: 4701-4709

Ericson, J., et al. (1996). Two critical periods of Sonic hedgehog signaling required for the specification of motor neuron identity. Cell 87: 661-673

Ericson, J., et al. (1997). Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell 90(1): 169-180

Escudero, L. M., Bischoff, M. and Freeman, M. (2007). Myosin II regulates complex cellular arrangement and epithelial architecture in Drosophila. Dev. Cell 13: 717-729. PubMed Citation: 17981139

Etheridge, L. A., Crawford, T. Q., Zhang, S. and Roelink, H. (2010). Evidence for a role of vertebrate Disp1 in long-range Shh signaling. Development 137(1): 133-40. PubMed Citation: 20023168

Fan, C. M., et al. (1995). Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway. Cell 81: 457-65

Fan, H., et al. (1997). Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog. Nat. Med. 3(7): 788-92

Fan, Y, and Bergmann, A. (2008). Distinct mechanisms of apoptosis-induced compensatory proliferation in proliferating and differentiating tissues in the Drosophila eye. Dev. Cell 14: 399-410. PubMed Citation: 18331718

Farrington, S. M., Belaoussoff, M. and Baron, M. H. (1997). Winged-helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac. Mech. Dev. 62 (2): 197-211

Fedtsova, N., Perris, R. and Turner, E. E. (2003). Sonic hedgehog regulates the position of the trigeminal ganglia. Dev. Biol. 261: 456-469. 14499653

Felsenfeld, A. L. and Kennison, J. A. (1995). Positional signaling by hedgehog in Drosophila imaginal disc development. Development 121: 1-10. 7867491

Fernandez-L, A., et al. (2009). YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev. 23(23): 2729-41. PubMed Citation: 19952108

Fernandez-Teran, M., et al. (2000). Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway. Development 127: 2133-2142. PubMed Citation: 10769237

Firth, L. C. and Baker, N. E. (2005). Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev. Cell 8(4): 541-51. 15809036

Fitzgerald, D. P. and Bender, W. (2001). Polycomb group repression reduces DNA accessibility. Mol. Cell. Biol. 21: 6585-6597. 11533246

Fleming, J. T., He, W., Hao, C., Ketova, T., Pan, F. C., Wright, C. C., Litingtung, Y. and Chiang, C. (2013). The Purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar precursors. Dev Cell 27: 278-292. PubMed ID: 24229643

Forbes, A. J., et al. (1993). Genetic analysis of hedgehog signalling in the Drosophila embryo. Dev Suppl: 115-124. PubMed Citation: 8049467

Forbes, A. J., et al. (1996). hedgehog is required for the proliferation and specification of ovarian somatic Development 122: 1125-35. PubMed Citation: 8898240

Forget, A., Bihannic, L., Cigna, S. M., Lefevre, C., Remke, M., Barnat, M., Dodier, S., Shirvani, H., Mercier, A., Mensah, A., Garcia, M., Humbert, S., Taylor, M. D., Lasorella, A. and Ayrault, O. (2014). Shh signaling protects Atoh1 from degradation mediated by the E3 ubiquitin ligase Huwe1 in neural precursors. Dev Cell 29: 649-661. PubMed ID: 24960692

Fraidenraich, D., et al. (2000). Activation of Fgf4 gene expression in the myotomes is regulated by myogenic bHLH factors and by sonic hedgehog. Dev. Bio. 225: 392-406. PubMed Citation: 10985858

Franco, P. G., et al. (1999). Functional association of retinoic acid and hedgehog signaling in Xenopus primary neurogenesis. Development 126: 4257-4265. PubMed Citation: 10477294

Fu, W. and Baker, N. E. (2003). Deciphering synergistic and redundant roles of Hedgehog, Decapentaplegic and Delta that drive the wave of differentiation in Drosophila eye development. Development 130: 5229-5239. 12954721

Fuccillo, M., Rallu, M., McMahon, A. P. and Fishell, G. (2004). Temporal requirement for hedgehog signaling in ventral telencephalic patterning. Development 131: 5031-5040. 15371303

Funakoshi, Y., Minami, M. and Tabata, T. (2001). mtv shapes the activity gradient of the Dpp morphogen through regulation of thickveins. Development 128: 67-74. 11092812

Gabilondo, H., et al. (2011). A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. Mech. Dev. 128(3-4): 208-21. PubMed Citation: 21236339

Gallego, M. I., et al. (2002). Differential requirements for Shh in mammary tissue and hair follicle morphogenesis. Dev. Bio. 249: 131-139. 12217324

Gallet, A., Rodriguez, R., Ruel, L. and Therond, P. P. (2003). Cholesterol modification of Hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to Hedgehog. Dev. Cell 4: 191-204. 12586063

Gallet, A. and Therond, P. P. (2005). Temporal modulation of the Hedgehog morphogen gradient by a patched-dependent targeting to lysosomal compartment. Dev. Biol. 277(1): 51-62. 15572139

Gallet, A., Ruel, L., Staccini-Lavenant, L. and Therond, P. P. (2006). Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia. Development 133(3): 407-18. 16396912

Gallet, A., Staccini-Lavenant, L. and Thérond, P. P. (2008). Cellular trafficking of the glypican Dally-like is required for full-strength Hedgehog signaling and Wingless transcytosis. Dev. Cell 14: 712-725. PubMed Citation: 18477454

Gallitano-Mendel, A. and Finkelstein, R. (1997). Novel segment polarity gene interactions during embryonic head development in Drosophila. Dev. Biol. 192(2): 599-613. PubMed Citation: 9441692

Garg, V., et al. (2001). Tbx1, a DiGeorge syndrome candidate gene, is regulated by Sonic hedgehog during pharyngeal arch development. Dev. Bio. 235: 62-73. 11412027

Geng, X., et al. (2008). Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev. Cell 15(2): 236-47. PubMed Citation: 18694563

Gering, M. and Patient, R. (2005). Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos. Dev Cell 8(3): 389-400. PubMed Citation: 15737934

Gibson, M. C. and Schubiger, G. (1999). Hedgehog is required for activation of engrailed during regeneration of fragmented Drosophila imaginal discs. Development 126: 1591-1599. PubMed Citation: 10079222

Geisbrecht, E. R., Sawant, K., Su, Y., Liu, Z. C., Silver, D. L., Burtscher, A., Wang, X., Zhu, A. J. and McDonald, J. A. (2013). Genetic interaction screens identify a role for hedgehog signaling in Drosophila border cell migration. Dev Dyn 242: 414-431. PubMed ID: 23335293

Glazer, L. and Shilo, B.-Z. (2001). Hedgehog signaling patterns the tracheal branches. Development 128: 1599-1606. 11290298

Glise, B., Jones, D. L. and Ingham, P. W. (2002). Notch and Wingless modulate the response of cells to Hedgehog signaling in the Drosophila wing. Dev. Bio. 248: 93-106 . 12142023

Glise, B., Miller, C. A., Crozatier, M., Halbisen, M. A., Wise, S., Olson, D. J., Vincent, A. and Blair, S. S. (2005). Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog. Dev. Cell. 8(2):255-66. 15691766

Goddeeris, M. M., et al. (2007). Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development. Development 134: 1593-1604. Medline abstract: 17344228

Goetz, J. A., et al. (2006). A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form. J. Biol. Chem. 281(7): 4087-93. 16339763

Gold, D. A., et al. (2003). RORalpha coordinates reciprocal signaling in cerebellar development through Sonic hedgehog and calcium-dependent pathways. Neuron 40: 1119-1131. 14687547

Goodrich, L. V., et al. (1999). Overexpression of ptc1 inhibits induction of Shh target genes and prevents normal patterning in the neural tube. Dev. Biol. 211(2): 323-34

Gorfinkiel, N., Sanchez, L. and Guerrero, I. (1999). Drosophila terminalia as an appendage-like structure. Mech. Dev. 86(1-2): 113-23. 10446270

Gorfinkiel, N., Sánchez, L. and Guerrero, I. (2003). Development of the Drosophila genital disc requires interactions between its segmental primordia. Development 130: 295-305. 12466197

Gorfinkiel, N., Sierra, J., Callejo, A., Ibanez, C. and Guerrero, I. (2005). The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog. Dev. Cell 8(2): 241-53. 15691765

Greenwood, S. and Struhl, G. (1999). Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway. Development 126: 5795-5808. PubMed Citation: 10572054

Grimaldi, A., et al. (2004). Hedgehog regulation of superficial slow muscle fibres in Xenopus and the evolution of tetrapod trunk myogenesis. Development 131: 3249-3262. 15201218

Gritli-Linde, A., et al. (2001). The whereabouts of a morphogen: Direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev. Bio. 236: 364-386. 11476578

Gritli-Linde, A., et al. (2002). Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development 129: 5323-5337. 12403705

Guillen, I., et al. (1995). The function of engrailed and the specification of Drosophila wing pattern. Development 121: 3447-3456. PubMed Citation: 7588077

Gunhaga, L,, Jessell, T. M. and Edlund, T. (2000). Sonic hedgehog signaling at gastrula stages specifies ventral telencephalic cells in the chick embryo. Development 127: 3283-93. PubMed Citation: 10887084

Gustafsson, M. K., et al. (2002). Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification. Genes Dev. 16: 114-126. 11782449

Guy, R. K. (2000). Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation. Proc. Natl. Acad. Sci. 97: 7307-7312

Continued: see hedgehog References part 2/3 | part 3/3

Home page: The Interactive Fly © 1995, 1996 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.