Abbas, T., Sivaprasad, U., Terai, K., Amador, V., Pagano, M. and Dutta, A. (2008). PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev. 22(18): 2496-506. PubMed Citation: 18794347

Asha, H., et al. (2003). Analysis of Ras-induced overproliferation in Drosophila hemocytes. Genetics 163: 203-215. 12586708

Aktas, H., Cai, H. and Cooper, G. M. (1997). Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1. Mol. Cell. Biol. 17(7): 3850-3857. PubMed Citation: 9199319

Amador, V., Ge, S., Santamaria, P. G., Guardavaccaro, D. and Pagano, M. (2007). APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. Mol. Cell 27: 462-473. PubMed Citation: 17679094

Aparicio, R., Simoes Da Silva, C. J. and Busturia, A. (2015). MicroRNA miR-7 contributes to the control of Drosophila wing growth. Dev Dyn 244(1): 21-30. PubMed ID: 25302682

Asada, M., et al. (1999). Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation. EMBO J. 18(5): 1223-34. PubMed Citation: 10064589

Asha, H., Nagy, I., Kovacs, G., Stetson, D., Ando, I. and Dearolf, C. R. (2003). Analysis of Ras-induced overproliferation in Drosophila hemocytes. Genetics 163(1): 203-215. PubMed ID: 12586708

Bastians, H., Townsley, F. M. and Ruderman, J. V. (1998). The cyclin-dependent kinase inhibitor p27(Kip1) induces N-terminal proteolytic cleavage of cyclin A. Proc. Natl. Acad. Sci. 95(26): 15374-81. PubMed Citation: 9860976

Baudino, T. A., et al. (2003). Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss. Molec. Cell 11: 905-914. 12718877

Baugh, L. R. and Sternberg, P. W. (2006). DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest. Curr. Biol. 16(8): 780-5. 16631585

Baumgardt, M., Karlsson, D., Salmani, B. Y., Bivik, C., MacDonald, R. B., Gunnar, E., Thor, S. (2014) Global programmed switch in neural daughter cell proliferation mode triggered by a temporal gene cascade. Dev Cell 30: 192-208. PubMed ID: 25073156

Beckerman, R., et al. (2009). A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Genes Dev. 23(11): 1364-77. PubMed Citation: 19487575

Besson, A., et al. (2004). p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev. 18: 862-876. 15078817

Besson, A., et al. (2007). Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes Dev. 21(14): 1731-46. Medline abstract: 17626791

Besson, A., Dowdy, S. F., and Roberts, J. M. (2008). CDK inhibitors: Cell cycle regulators and beyond. Dev. Cell 14: 159-169. PubMed Citation: 18267085

Betizeau, M., Cortay, V., Patti, D., Pfister, S., Gautier, E., Bellemin-Menard, A., Afanassieff, M., Huissoud, C., Douglas, R. J., Kennedy, H. and Dehay, C. (2013). Precursor diversity and complexity of lineage relationships in the outer subventricular zone of the primate. Neuron 80: 442-457. PubMed ID: 24139044

Blain, S. W., Montalvo, E. and Massagué, J. (1997). Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) with cyclin A-Cdk2 and cyclin D2-Cdk4. J. Biol. Chem. 272(41): 25863-25872. PubMed Citation: 9325318

Boehm, M., et al. (2002). A growth factor-dependent nuclear kinase phosphorylates p27Kip1 and regulates cell cycle progression. EMBO J. 21: 3390-3401. 12093740

Boxem, M. and van den Heuvel, S. (2001). lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1 progression in C. elegans. Development 128: 4349-4359. 11684669

Brenner, C., et al. (2005). Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J. 24: 336-346. 15616584

Bromleigh, V. C. and Freedman, L. P. (2000). p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells. Genes Dev. 14: 2581-2586. PubMed Citation: 11040212

Burton, P. B., et al. (1999). An intrinsic timer that controls cell-cycle withdrawal in cultured cardiac myocytes. Dev. Biol. 216(2): 659-70. PubMed Citation: 10642800

Cai, K. and Dynlacht, B. D. (1998). Activity and nature of p21(WAF1) complexes during the cell cycle. Proc. Natl. Acad. Sci. 95(21): 12254-9. PubMed Citation: 9770473

Carruthers, S., Mason, J. and Papalopulu, N. (2003). Depletion of the cell-cycle inhibitor p27Xic1 impairs neuronal differentiation and increases the number of ElrC+ progenitor cells in Xenopus tropicalis. Mech. Dev. 120: 607-616. 12782277

Casaccia-Bonnefil, P., et al. (1997). Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1. Genes Dev. 11(18): 2335-2346. PubMed Citation: 9308962

Casaccia-Bonnefil, P., et al. (1999). Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation. Development 126: 4027-4037. PubMed Citation: 10457012

Chan, H. M., Narita, M., Lowe, S. W. and Livingston, D. M. (2005). The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway. Genes Dev. 19: 196-201. PubMed citation: 15655109

Chen, I. T., et al. (1995). Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction. Oncogene 12: 595-607. PubMed Citation: 8637717

Chen, J., et al. (1995). Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 374: 386-388. PubMed Citation: 7885482

Chen, P. and Segil, N. (1999). p27Kip1 links cell proliferation to morphogenesis in the developing organ of Corti. Development 126: 1581-1590. PubMed Citation: 10079221

Chen, X., Lu, C., Morillo Prado, J. R., Eun, S. H. and Fuller, M. T. (2011). Sequential changes at differentiation gene promoters as they become active in a stem cell lineage. Development 138: 2441-2450. PubMed ID: 21610025

Chen, Y., Zhang, L. and Jones, K. A. (2011). SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing. Genes Dev. 25(7): 701-16. PubMed Citation: 21460037

Cheng, M., et al. (1998). Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1). Proc. Natl. Acad. Sci. 95: 1091-1096. PubMed Citation: 9448290

Cheng, M., et al. (1999). The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J. 18(6): 1571-1583. PubMed Citation: 10075928

Cheng, T., et al. (2000). Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287: 1804-1808. PubMed Citation: 10710306

Chu, I., et al. (2007). p27 phosphorylation by Src regulates inhibition of Cyclin E-Cdk2. Cell 128: 281-294. Medline abstract: 17254967

Chuang, L. S., et al. (1997). Human DNA-(Cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1. Science 277(5334): 1996-2000. PubMed Citation: 9302295

Coats, S., et al. (1996) Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science 272: 877-880. PubMed Citation: 8629023

Coats, S., et al. (1999). A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells. Curr. Biol. 9(4): 163-73. PubMed Citation: 10074425

Colonques, J., Ceron, J., Reichert, H. and Tejedor, F. J. (2011). A transient expression of Prospero promotes cell cycle exit of Drosophila postembryonic neurons through the regulation of Dacapo. PLoS One. 6(4): e19342. PubMed Citation: 21552484

Coqueret, O., Berube, G. and Nepveu, A. (1998). The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21(WAF1/CIP1/SDI1) in S phase. EMBO J. 17(16): 4680-4694. PubMed Citation: 9707427

De Luca, A., et al. (1997). A unique domain of pRb2/p130 acts as an inhibitor of Cdk2 kinase activity. J. Biol. Chem. 272(34): 20971-20974

de Nooij, J. C., Graber, K. H. and Hariharan, I. K. (2000). Expression of the cyclin-dependent kinase inhibitor Dacapo is regulated by Cyclin E. Mech. Dev. 97: 73-83. PubMed ID: 11025208

Deng, C., et al. (1995). Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82: 675-684

de Nooij, J. C. and Hariharan, I.K. (1995). Uncoupling cell fate determination from patterned cell division in the Drosophila eye. Science 270: 983-985

de Nooij, J. C., Letendre, M. A. and Hariharan, I. K. (1996). A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis. Cell 87: 1237-47

Devgan, V., et al. (2005). p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev. 19: 1485-1495. 15964998

Di Cunto, F., et al. (1998). Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control. Science 280(5366): 1069-1072

Du, W., et al. (1996). RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10: 1206-1218

Durand, B., Gao, F.-B. and Raff, M. C. (1977). Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation. EMBO J. 16: 306-317

Duronio, R. J. and O'Farrell, P. H. (1995). Developmental control of the G1 to S transition in Drosophila: Cyclin E is a limiting downstream target of E2F. Genes Dev. 9: 1456-68

Dyer, M. A. and Cepko, C. L. (2000). p57 Kip2 regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina. Development 127: 3593-3605

Espinosa, J. M. and Emerson, B. M. (2001). Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol. Cell 8: 57-69. 11511360

Espinosa, J. M., Verdun, R. E. and Emerson, B. M. (2003). p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage. Molec. Cell 12: 1015-1027. 14580351

Farah. M. H., et al. (2000). Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. Development 127: 693-702.

Fero, M. L., et al. (1996). A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell 85: 733-744

Fero, M. L., et al. (1998). The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature 396(6707): 177-80

Firth, L. C. and Baker, N. E. (2005). Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev. Cell 8(4): 541-51. 15809036

Franklin, D. S., et al. (1998). CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes Dev. 12(8): 2899-2911

Fukuyama, M., et al. (2003). Essential embryonic roles of the CKI-1 cyclin-dependent kinase inhibitor in cell-cycle exit and morphogenesis in C. elegans. Dev. Biol. 260: 273-286. 12885569

Garcia-Campmany, L. and Marti, E. (2007). The TGFbeta intracellular effector Smad3 regulates neuronal differentiation and cell fate specification in the developing spinal cord. Development 134(1): 65-75. Medline abstract: 17138664

Gévry, N., et al. (2007). p21 transcription is regulated by differential localization of histone H2A.Z. Genes Dev. 21(15): 1869-81. Medline abstract: 17671089

Gomes, W. A. and Kessler, J. A. (2001). Msx-2 and p21 mediate the pro-apoptotic but not the anti-proliferative effects of BMP4 on cultured sympathetic neuroblasts. Dev. Bio. 237: 212-221. 11518517

Gomez Lahoz, E., et al. (1999). Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo. Mol. Cell. Biol. 19(1): 353-63

Gomez-Lamarca, M. J., Cobreros-Reguera, L., Ibanez-Jimenez, B., Palacios, I. M. and Martin-Bermudo, M. D. (2014). Integrins regulate epithelial cell differentiation by modulating Notch activity. J Cell Sci [Epub ahead of print]. PubMed ID: 25179603

Gotz, C., et al. (1996). p21WAF1/CIP1 interacts with protein kinase CK2. Oncogene 13(2): 391-398

Grimmler, M., et al. (2007). Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. Cell 128: 269-280. Medline abstract: 17254966

Gu, M., Lynch, J. and Brecher, P. (2000). Nitric oxide increases p21(Waf1/Cip1) expression by a cGMP-dependent pathway that includes activation of extracellular signal-regulated kinase and p70(S6k). J. Biol. Chem. 275: 11389-96.

Guillemette, B., Bataille, A.R., Gévry, N., Adam, M., Blanchette, M., Robert, F. and Gaudreau, L. (2005). Variant histone H2A.Z is globally localized to the promoters of inactive yeast genes and regulates nucleosome positioning. PLoS Biol. 3: e384. Medline abstract: 16248679

Hämmerle, B., et al. (2011). Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling. Development 138(12): 2543-54. PubMed Citation: 21610031

Han, Z. and Bodmer, R. (2003). Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division. Development 130: 3039-3051. 12756185

Halevy, O., et al. (1995). Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science 267: 1018-1021. PubMed Citation: 7863327

Hardcastle, Z. and Papalopulu, N. (2000). Distinct effects of XBF-1in regulating the cell cycle inhibitor p27 XIC1 and imparting a neural fate. Development 127: 1303-1314. PubMed Citation: 10683182

Harper, J. W., et al. (1995). Inhibition of cyclin-dependent kinases by p21. Mol. Biol. Cell 6: 387-400. PubMed Citation: 7626805

Hengst, L., et al. (1998). Complete inhibition of Cdk/cyclin by one molecule of p21. Genes Dev. 12(24): 3882-8. PubMed Citation: 9869641

Herold, S., et al. (2002). Negative regulation of the mammalian UV response by Myc through association with Miz-1. Molec. Cell 10: 509-521. 12408820

Higa, L. A., et al. (2006). Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation. Cell Cycle. 5(1): 71-7. 16322693

Hong, A., et al. (2003). The p27cip/kip ortholog dacapo maintains the Drosophila oocyte in prophase of meiosis I. Development 130: 1235-1242. 12588841

Hong, Y., Roy, R. and Ambros, V. (1998). Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegans. Development 125(18): 3585-3597. PubMed Citation: 9716524

Hsu, H. J., LaFever, L. and Drummond-Barbosa, D. (2008). Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila. Dev. Biol. 313: 700-712. PubMed Citation: 18068153

Huang, S., Chen, C. S. and Ingber, D. E. (1998). Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension. Mol. Biol. Cell 9(11): 3179-93

Huang, S., et al. (2003). Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21Cip1. Mol. Cell 11: 1491-1501. 12820963

Iovino, N., Ciabrelli, F. and Cavalli, G. (2013). PRC2 Controls Drosophila Oocyte Cell Fate by Repressing Cell Cycle Genes. Dev Cell 26: 431-439. PubMed ID: 23932903

Ishida, A., et al. (1999). Tumor suppressor p53 but not cGMP mediates NO-induced expression of p21(Waf1/Cip1/Sdi1) in vascular smooth muscle cells. Mol. Pharmacol. 56: 938-46

Iulianella, A., et al. (2008). Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis. Development 135: 729-741. PubMed Citation: 18223201

Jackson, P. K., et al. (1995). Early events in DNA replication require cyclin E and are blocked by p21CIP1. J. Cell Biol. 130: 755-769

Jernvall, J., et al. (1998). The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot. Development 125(2): 161-169

Jiang, H., Chou, H. S. and Zhu, L. (1998). Requirement of cyclin E-Cdk2 inhibition in p16(INK4a)-mediated growth suppression. Mol. Cell. Biol. 18(9): 5284-90

Jiang, Z., et al. (2000). E2F1 and p53 are dispensable, whereas p21 Waf1/Cip1 cooperates with Rb to restrict endoreduplication and apoptosis during skeletal myogenesis. Dev. Bio. 227: 28-41.

Jin, J., Cai, Y., Florens, L., Swanson, S. K., Kusch, T., Li, B., Workman, J. L., Washburn, M. P., Conaway, R. C. and Conaway, J. W. (2005). The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. J. Biol. Chem. 280: 13665-13670. Medline abstract: 16230350

Jin, Y., Zeng, S. X., Sun, X. X., Lee, H., Blattner, C., Xiao, Z. and Lu, H. (2008). MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2. Mol. Cell. Biol. 28: 1218-1229. PubMed Citation: 18086887

Kagawa, S., et al. (1997). p53 expression overcomes p21WAF1/CIP1-mediated G1 arrest and induces apoptosis in human cancer cells. Oncogene 15(16): 1903-1909

Kalamarz, M. E., Paddibhatla, I., Nadar, C. and Govind, S. (2012). Sumoylation is tumor-suppressive and confers proliferative quiescence to hematopoietic progenitors in Drosophila melanogaster larvae. Biol Open 1: 161-172. PubMed ID: 23213407

Kamura, T., et al. (2003). Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. Proc. Natl. Acad. Sci. 100(18): 10231-6. 12925736

Kaplan, M. H., et al. (1998). Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression. Mol. Cell. Biol. 18(4): 1996-2003

Kardassis, D., et al. (1999). c-Jun transactivates the promoter of the human p21WAF1/Cip1 gene by acting as a superactivator of the ubiquitous transcription factor Sp1. J. Biol. Chem. 274: 29572-29581

Kawada, M., et al. (1997). Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway. Oncogene 15(6): 629-637

Kedde, M., et al. (2010). A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility. Nat. Cell Biol. 12(10): 1014-20. PubMed Citation: 20818387

Kim, J., Feng, H. and Kipreos, E. T. (2007). C. elegans CUL-4 prevents rereplication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathway. Curr. Biol. 17: 966-972. Medline abstract: 17509881

Kim, Y., Starostina, N. G. and Kipreos, E. T. (2008). The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. Genes Dev. 22(18): 2507-19. PubMed Citation: 18794348

Kippin, T. E., Martens, D. J. and van der Kooy D. (2005). p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity. Genes Dev. 19(6): 756-67. 15769947

Kiyokawa, H., et al. (1996). Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). Cell 85: 721-732

Knoblich, J. A., et al. (1994). Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation. Cell 77: 107-20

Khoury, M. J. and Bilder, D. (2020). Distinct activities of Scrib module proteins organize epithelial polarity. Proc Natl Acad Sci U S A 117(21): 11531-11540. PubMed ID: 32414916

Koshiji, M. and Huang, L. E. (2004). Dynamic balancing of the dual nature of HIF-1alpha for cell survival. Cell Cycle 3(7): 853-4. 15190211

Kossatz, U., et al. (2004). Skp2-dependent degradation of p27kip1 is essential for cell cycle progression. Genes Dev. 18: 2602-2607. 15520280

Kullmann, M., et al. (2002). ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR. Genes Dev. 16: 3087-3099. 12464637

LaBaer, J., et al. (1997). New functional activities for the p21 family of CDK inhibitors. Genes Dev. 11: 847-862

Ladha, M. H., et al., (1998). Regulation of exit from quiescence by p27 and cyclin D1-CDK4. Mol. Cell. Biol. 18(11): 6605-15

Lagger, G., et al. (2002). Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J. 21: 2672-2681. 12032080

Lane, M. E., et al. (1996). Dacapo, a cyclin-dependent kinase inhibitor, stops cell poliferation during Drosophila development. Cell 87: 1225-1235

Lecona, E., Rojas, L. A., Bonasio, R., Johnston, A., Fernandez-Capetillo, O. and Reinberg, D. (2013). Polycomb Protein SCML2 Regulates the Cell Cycle by Binding and Modulating CDK/CYCLIN/p21 Complexes. PLoS Biol 11: e1001737. PubMed ID: 24358021

Ledford, A. W., et al. (2002). Deregulated expression of the homeobox gene Cux-1 in transgenic mice results in downregulation of p27kip1 expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia. Dev. Biol. 245: 157-171. 11969263

Lee, S. and Helfman, D. M. (2003). Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/Cofilin pathway. J. Biol. Chem. 279: 1885-1891. 14559914

Legent, K., Dutriaux, A., Delanoue, R. and Silber, J. (2006). Cell cycle genes regulate vestigial and scalloped to ensure normal proliferation in the wing disc of Drosophila melanogaster. Genes Cells 11(8): 907-18. 16866874

Lessard, J., Schumacher, A., Thorsteinsdottir, U., van Lohuizen, M., Magnuson, T. and Sauvageau, G. (1999). Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation. Genes Dev 13: 2691-2703. PubMed ID: 10541555

Levine, E. M., et al. (2000). p27Kip1 regulates cell cycle withdrawal of late multipotent progenitor cells in the mammalian retina. Dev. Biol. 219: 299-314.

Li, B., Pattenden, S. G., Lee, D., Gutierrez, J., Chen, J., Seidel, C., Gerton, J. and Workman, J. L. (2005). Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling. Proc. Natl. Acad. Sci. 102: 18385-18390. Medline abstract: 16344463

Li, N., et al. (2005). Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli. EMBO J. 24: 1942-1953. Medline abstract: 15889143

Li, X., Perissi, V., Liu, F., Rose, D. W. and Rosenfeld, M. G. (2002). Tissue-specific regulation of retinal and pituitary precursor cell proliferation. Science 297: 1180-1183. 12130660

Ligon, K. L. et al. (2007). Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron 53: 503-517. Medline abstract: 17296553

Linares-Cruz, G., et al. (1998). p21WAF-1 reorganizes the nucleus in tumor suppression. Proc. Natl. Acad. Sci. 95: 1131-1135

Lowenheim, H., et al. (1999). Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti. Proc. Natl. Acad. Sci. 96(7):4084-8

Machida, S., Spangenburg, E. E. and Booth, F. W. (2003). Forkhead transcription factor FoxO1 transduces insulin-like growth factor's signal to p27Kip1 in primary skeletal muscle satellite cells. J. Cell Physiol. 196(3): 523-31. 12891709

Macip, S., et al. (2002). Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence. EMBO J. 21: 2180-2188. 11980715

Mammucari, C., et al. (2005). Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Dev. Cell 8(5): 665-76. 15866158

Mantela, J., et al. (2005). The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear. Development 132: 2377-2388. 15843406

Martins, C. P. and Berns. A. (2002). Loss of p27Kip1 but not p21Cip1 decreases survival and synergizes with MYC in murine lymphomagenesis. EMBO J. 21: 3739-3748. 12110586

Medema, R. H., Kops, G. J., Bos, J. L. and Burgering, B. M. (2000). AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404(6779): 782-7. 10783894

Meyer, C. A., et al. (2002). Drosophila p27Dacapo expression during embryogenesis is controlled by a complex regulatory region independent of cell cycle progression. Development 129: 319-328. 11807025

Miranda-Carboni, G. A., et al. (2008). A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 22(22): 3121-34. PubMed Citation: 19056892

Minella, A. C. (2002). p53 and p21 form an inducible barrier that protects cells against Cyclin E-cdk2 deregulation. Curr. Biol. 12: 1817-1827. 12419181

Montagnoli, A., et al. (1999). Ubiquitination of p27 is regulated by cdk-dependent phosphorylation and trimeric complex formation. Genes Dev. 13(9): 1181-9

Morachis, J. M., Murawsky, C. M. and Emerson, B. M. (2010). Regulation of the p53 transcriptional response by structurally diverse core promoters. Genes Dev. 24(2): 135-47. PubMed Citation: 20040571

Morelli, G., Even, A., Gladwyn-Ng, I., Le Bail, R., Shilian, M., Godin, J. D., Peyre, E., Hassan, B. A., Besson, A., Rigo, J. M., Weil, M., Brone, B. and Nguyen, L. (2018). p27(Kip1) modulates axonal transport by regulating alpha-Tubulin acetyltransferase 1 stability. Cell Rep 23(8): 2429-2442. PubMed ID: 29791853

Morris, T. A., DeLorenzo, R. J. and Tombes, R. M. (1998). CaMK-II inhibition reduces cyclin D1 levels and enhances the association of p27kip1 with Cdk2 to cause G1 arrest in NIH 3T3 cells. Exp. Cell Res. 240(2): 218-227

Moustakas, A. and Kardassis, D. (1998). Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members. Proc. Natl. Acad. Sci. 95(12): 6733-6738

Muller, D., et al. (2000). Cyclin E-mediated elimination of p27 requires its interaction with the nuclear pore-associated protein mNPAP60, EMBO J. 19: 2168-2180

Nakano, K., et al. (1997). Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line. J. Biol. Chem. 272(35): 22199-22206

Nakayama, K., et al., (1996). Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85: 707-720

Nakayama, K., et al. (2004). Skp2-mediated degradation of p27 regulates progression into mitosis. Dev. Cell 6: 661-672. 15130491

Narbonne-Reveau, K. and Lilly, M. (2009). The Cyclin-dependent kinase inhibitor Dacapo promotes genomic stability during premeiotic S phase. Mol Biol Cell 20: 1960-1969. PubMed ID: 19211840

Neumuller, R. A., Betschinger, J., Fischer, A., Bushati, N., Poernbacher, I., Mechtler, K., Cohen, S. M. and Knoblich, J. A. (2008). Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage. Nature 454: 241-245. PubMed Citation: 18528333

Nguyen, H., Gitig, D. M. and Koff, A. (1999). Cell-free degradation of p27(kip1), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome. Mol. Cell. Biol. 19(2): 1190-201

Niculescu, A. B., et al. (1998). Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol. Cell. Biol. 18(1): 629-643.

Nishio, H. and Walsh, M. J. (2004). CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription. Proc. Natl. Acad. Sci. 101(31): 11257-62. 15269344

O'Hagan, R. C., et al. (2000). Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. Genes Dev. 14: 2185-2191

Ohnuma, S.-i., et al. (1999). p27Xic1, a Cdk inhibitor, promotes the determination of glial cells in Xenopus retina. Cell 99: 499-510.

Olson, M. F., Paterson, H. F. and Marshall, C. J. (1998). Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1. Nature 394: 295-299.

Paddibhatla, I., Lee, M. J., Kalamarz, M. E., Ferrarese, R. and Govind, S. (2010). Role for sumoylation in systemic inflammation and immune homeostasis in Drosophila larvae. PLoS Pathog 6: e1001234. PubMed ID: 21203476

Park, M. S., et al. (1999). p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice. Proc. Natl. Acad. Sci. 96(11):6382-7

Parker, S. B., et al. (1995). p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells Science 267: 1024-1027

Parry D., et al. (1999). Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors. Mol. Cell. Biol. 19(3): 1775-83

Patel, R., Bartosch, B. and Blank, J. L. (1998). p21WAF1 is dynamically associated with JNK in human T-lymphocytes during cell cycle progression. J. Cell Sci. 111( Pt 15): 2247-2255

Perez-Roger, I., et al. (1999). Cyclins D1 and D2 mediate Myc-induced proliferation via sequestration of p27Kip1 and p21Cip1. EMBO J. 18: 5310-5320

Perkins, N. D., et al. (1997). Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator. Science 275: 523-627.

Poluha, W., et al. (1997). A novel, nerve growth factor-activated pathway involving nitric oxide, p53, and p21(WAF1) regulates neuronal differentiation of PC12 Cells. J. Biol. Chem. 272(38): 24002-24007

Potente, M., Fisslthaler, B., Busse, R. and Fleming, I. (2003). 11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1. J. Biol. Chem. 278(32): 29619-25. 12773534

Prabhu, S., et al. (1997). Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins. Mol. Cell. Biol. 17(10): 5888-5896

Radeva, G., et al. (1997). Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression. J. Biol. Chem. 272 (21): 13937-13944

Raisner, R. M., Hartley, P. D., Meneghini, M. D., Bao, M. Z., Liu, C. L., Schreiber, S. L., Rando, O. J., and Madhani, H. D. (2005). Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. Cell 123: 233-248. Medline abstract: 16239142

Rangarajan, A., et al. (2001). Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J. 20: 3427-3436. 11432830

Resnitzky, D. (1997). Ectopic expression of cyclin D1 but not cyclin E induces anchorage-independent cell cycle progression. Mol. Cell. Biol. 17(9): 5640-5647.

Reynisdóttir, I. and Massagué, J. (1997). The subcellular locations of p15Ink4b and p27Kip1 coordinate their inhibitory interactions with cdk4 and cdk2. Genes Dev. 11: 492-503

Richardson, H. E., et al. (1995). Ectopic Cyclin E expression induces premature entry into S phase and disrupts pattern formation in the Drosophila eye imaginal disc. Development 121: 3371-79

Richter, C., Oktaba, K., Steinmann, J., Muller, J. and Knoblich, J. A. (2011). The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. Nat Cell Biol 13: 1029-1039. PubMed ID: 21857667

Rodier, G., et al. (2001). p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J. 20: 6672-6682. 11726503

Rodriguez-Fernandez, I. A., Qi, Y. and Jasper, H. (2019). Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction. Nat Commun 10(1): 1050. PubMed ID: 30837466

Ruhl, D. D., Jin, J., Cai, Y., Swanson, S., Florens, L., Washburn, M. P., Conaway, R. C., Conaway, J. W., and Chrivia, J. C. (2006). Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. Biochemistry 45: 5671-5677. Medline abstract: 16634648

Saha, P., et al. (1997). p21CIP1 and Cdc25A: competition between an inhibitor and an activator of cyclin-dependent kinases. Mol. Cell. Biol. 17: 4338-4345

Sahai, E., Olson, M. F. and Marshall, C. J. (2001). Cross-talk between Ras and Rho signaling pathways in transformation favours proliferation and increased motility. EMBO J. 20: 755-766. 11179220

Santini, M. P., et al. (2001). Cross talk among calcineurin, Sp1/Sp3, and NFAT in control of p21WAF1/CIP1 expression in keratinocyte differentiation Proc. Natl. Acad. Sci. 98: 9575-9580. 11493684

Sauer, K., et al. (1995). Distinct modes of Cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis. Genes Dev. 9: 1327-1339

Sauvageau, M. and Sauvageau, G. (2010). Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. Cell Stem Cell 7: 299-313. PubMed ID: 20804967

Seoane, J., et al. (2004). Integration of Smad and Forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117: 211-223. 15084259

Shaulian, E., et al. (2000). The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell 103: 897-907.

Shcherbata, H. R., et al. (2004). The mitotic-to-endocycle switch in Drosophila follicle cells is executed by Notch-dependent regulation of G1/S, G2/M and M/G1 cell-cycle transitions. Development 131: 3169-3181. 15175253

Sheaff, R. J., et al. (1997). Cyclin E-CDK2 is a regulator of p27Kip1. Genes Dev. 11(11): 1464-1478

Sheaff, R. J., et al. (2000). Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination. Molec. Cell 5: 403-410

Smith, R. C., et al. (1997). p21CIP1-mediated inhibition of cell proliferation by overexpression of the gax homeodomain gene. Genes Dev. 11:1674-1689

Seoane, J., Le, J. V. and Massagué, J. (2002). Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 419: 729-734. 12384701

Somasundaram, K., et al. (1997). Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1. Nature 389(6647):187-190

Spencer, S. L., Cappell, S. D., Tsai, F. C., Overton, K. W., Wang, C. L. and Meyer, T. (2013). The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell 155(2): 369-83. PubMed ID: 24075009

Spruck, C., et al. (2001). A CDK-independent function of mammalian Cks1: Targeting of SCFSkp2 to the CDK inhibitor p27Kip1. Mol. Cell 7: 639-650. PubMed ID: 11463388

St. Croix, B., et al. (1998). E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1). J. Cell Biol. 142(2): 557-71

Stewart, Z. A., Leach, S. D. and Pietenpol, J. A. (1999). p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption. Mol. Cell. Biol. 19(1): 205-15

Strausfeld, U. P., et al. (1994). CIP1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases. Curr. Biol. 4: 876-883

Su, T. T. and O'Farrell, P. H. (1997). Chromosome association of minichromosome maintenance proteins in Drosophila mitotic cycles. J. Cell Biol. 139(1): 13-21

Takuwa, N. and Takuwa, Y. (1997). Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts. Mol. Cell. Biol. 17(9): 5348-5358

Tanaka, H., Yamashita, T., Asada, M., Mizutani, S., Yoshikawa, H. and Tohyama, M. (2002). Cytoplasmic p21Cip1/Waf1 regulates neurite remodeling by inhibiting Rho-kinase activity. J. Cell. Biol. 158: 321-329. 12119358

Timchenko, N. A., et al. (1997). CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice. Mol. Cell. Biol. 17(12): 7353-7361

Tokumoto, Y. M., et al. (2002). Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation. Dev. Biol. 245: 224-234. 11969268

Tomoda, K., Kubota, Y. and Kato, J. (1999). Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1. Nature 398(6723): 160-5.

Touitou, R., et al. (2001). A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome. EMBO J. 20: 2367-2375. 11350925

Uren, A., et al. (1997). Carboxyl-terminal domain of p27(Kip1) activates CDC2. J. Biol. Chem. 272(35): 21669-21672

van de Wetering, M., et al. (2002). The ß-Catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111: 241-250. 12408868

Vaziri, H., et al. (1997). ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J. 16(19): 6018-33. 9312059

Ventura, G., Moreira, S., Barros-Carvalho, A., Osswald, M. and Morais-de-Sa, E. (2020). Lgl cortical dynamics are independent of binding to the Scrib-Dlg complex but require Dlg-dependent restriction of aPKC. Development 147(15). PubMed ID: 32665243

Vernon, A. E. and Philpott, A. (2003a). A single cdk inhibitor, p27Xic1, functions beyond cell cycle regulation to promote muscle differentiation in Xenopus. Development 130: 71-83. 12441292

Vernon, A. E., Devine, C. and Philpott, A. (2003b). The cdk inhibitor p27Xic1 is required for differentiation of primary neurones in Xenopus. Development 130: 85-92. 12441293

Vlach, J., Hennecke, S. and Amati, B. (1997). Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J. 16(17): 5334-5344

Waga, S. and Stillman, B. (1998). Cyclin-dependent kinase inhibitor p21 modulates the DNA primer-template recognition complex. Mol. Cell. Biol. 18(7): 4177-4187

Wallace, K., Liu, T. H. and Vaessin, H. (2000). The pan-neural bHLH Proteins Deadpan and Asense regulate mitotic activity and cdk inhibitor dacapo expression in the Drosophila larval optic lobes. Genesis 26: 77-85. 10660675

Wang, Y. A. , Elson, A., Leder, P. (1997). Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice. Proc. Natl. Acad. Sci. 94(26): 14590-14595. PubMed Citation: 9405657

Watanabe, H., et al. (1998). Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57(KIP2 )requires binding to proliferating cell nuclear antigen. Proc. Natl. Acad. Sci. 95(4): 1392-1397. PubMed Citation: 9465025

Wigle, J. T., et al. (1999). Prox1 function is crucial for mouse lens-fibre elongation. Nat. Genet. 21(3): 318-22. PubMed Citation: 10080188

Woods, D., et al. (1997). Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol. Cell. Biol. 17(9): 5598-5611. PubMed Citation: 9271435

Xu, Y., et al. (1998). Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice. Mol. Cell. Biol. 18(7): 4385-4390. PubMed Citation: 9632822

Yamaguchi, T., et al. (2010). Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression. Genes Dev. 24(5): 455-69. PubMed Citation: 20194438

Yan, Y., et al. (1997). Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes Dev. 11: 973-983

Yokoo, T., Toyoshima, H., Miura, M., Wang, Y., Iida, K. T., Suzuki, H., Sone, H., Shimano, H., Gotoda, T., Nishimori, S., et al. (2003). p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus. J. Biol. Chem. 278: 52919-52923. 14530263

Yu, Z. K., Gervais, J. L. and Zhang, H. (1998). Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins. Proc. Natl. Acad. Sci. 95(19): 11324-9. 9736735

Yu, J. Y., et al. (2009). Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells. Development 136(9): 1497-507. PubMed Citation: 19336466

Zalc, A., Hayashi, S., Aurade, F., Brohl, D., Chang, T., Mademtzoglou, D., Mourikis, P., Yao, Z., Cao, Y., Birchmeier, C. and Relaix, F. (2014). Antagonistic regulation of p57kip2 by Hes/Hey downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest. Development 141: 2780-2790. PubMed ID: 25005473

Zerfass-Thome, K., et al. (1997). p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression. Mol. Cell. Biol. 17: 407-415

Zhang, H., Roberts, D. N., and Cairns, B. R. (2005). Genome-wide dynamics of Htz1, a histone H2A variant that poises repressed/basal promoters for activation through histone loss. Cell 123: 219-231. Medline abstract: 16239141

Zhang, P., et al. (1997). Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome. Nature 387 (6629): 151-158

Zhang, P., et al. (1998). Cooperation between the cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development. Genes Dev. 12(20): 3162-7

Zhang, P., et al. (1999). p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step. Genes Dev. 13(2): 213-224

Zhang, Y., Lin, Y., Bowles, C. and Wang, F. (2004). Direct cell cycle regulation by the FGFR kinase through phosphorylation-dependent release of Cks1 from FRS2. J. Biol. Chem. [Epub ahead of print]. 15513912

Zheng, Y. L., et al. (2010). Phosphorylation of p27Kip1 at Thr187 by Cyclin-dependent kinase 5 modulates neural stem cell differentiation. Mol. Biol. Cell 21(20): 3601-14. PubMed Citation: 20810788

Zhu, L., Harlow, E. and Dynlacht, B. D. (1995a). p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes Dev. 9: 1740-52

Zhu, L., et al. (1995b). The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. EMBO J. 14: 1904-13

dacapo: Biological Overview | Evolutionary Homologs | Regulation | Developmental Biology | Effects of Mutation

date revised: 10 August 2014

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