cdc2

EVOLUTIONARY HOMOLOGS
Table of Contents

page 1

Drosophila cyclin dependent kinases
cdc2 function in yeast
Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression
cdc2 function in invertebrates

page 2

cdc2 function in G1
Phosphorylation of cdc2 early in the cell cycle
Cdc2 interaction with a homolog of Cdc6
Cdk1 association with a replication competent complex

page 3

Function and regulation of Wee1 kinase and Myt1, inhibitory kinases that prevents entry into M - The G2 checkpoint
LATS/Warts, a negative regulator of cdc2

page 4

Cdc2 and the G2-->M transition
Dissociation of CDC2 and Cyclin B at the end of M phase
MAP kinase and CDC2 at the G2-M transition
Cdc2, meiosis, egg maturation and egg activation
Cdc2 and Src family kinases

page 5

Targets of cdc2 involved directly in mitosis
Cdc2 and the mitotic spindle and mitotic spindle checkpoint
Cdc2 and reactivation of transcription at the end of mitosis
Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2

NURF facilitates the progesterone-mediated recruitment of Cdk2/CyclinA, which is required for histone H1 displacement
Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA

page 6

Miscellaneous cell cycle dependent proteins phosphorylated by cdc2
Cdc2 targets N-myc
Cdc2 and damage checkpoint control
Cdc2 and meiotic maturation
Cdc2 and vacuole inheritance

page 7

Regulation of cdc2 transcription
Regulation of cdc2 protein level
Developmental biology of cdc2
The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit
Cdc2 and tumorogenesis

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