Bennett, D., Szoor, B. and Alphey, L. (1999). The chaperone-like properties of mammalian Inhibitor-2 are conserved in a Drosophila homologue. Biochemistry 38: 16276-16282. PubMed ID: 10587451

Bennett, D. and Alphey, L. (2002). PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster. Nature Genetics 31(4): 419-423. PubMed ID: 12134149

Bennett, D., et al. (2003). Ectopic expression of inhibitors of protein Phosphatase Type 1 (PP1) can be used to analyze roles of PP1 in Drosophila development. Genetics 164: 235-245. PubMed ID: 12750335

Bottinger, E. P., et al. (1997). Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas. EMBO J. 16 (10): 2621-2633. PubMed ID: 9184209

Brummel, T., et al. (1999). The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development. Genes Dev. 13(1): 98-111. PubMed ID: 9887103

Burke, R. and Basler, K. (1996a). Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing. Development 122: 2261-69 . PubMed ID: 8681806

Burke, R. and Basler, K. (1996b). Hedgehog-dependent patterning in the Drosophila eye can occur in the absence of Dpp signaling. Dev. Biol. 179 (2): 360-368. PubMed ID: 8903352

Chai, Y., et al. (1999). Inhibition of transforming growth factor-beta type II receptor signaling accelerates tooth formation in mouse first branchial arch explants. Mech. Dev. 86(1-2): 63-74. PubMed ID: 10446266

Chang, C., et al. (1997). A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis. Development 124: 827-837 . PubMed ID: 9043064

Chen, Y. G., Liu, F. and Massague, J. (1997). Mechanism of TGFbeta receptor inhibition by FKBP12. EMBO J. 16(13): 3866-3876. PubMed ID: 9233797

Childs, S. R., et al. (1993). Identification of a Drosophila activin receptor. Proc. Natl. Acad. Sci: 90: 9475-79. PubMed ID: 8415726

Das, P., et al. (1999). Drosophila dSmad2 and Atr-I transmit activin/TGFbeta signals. Genes to Cells 4: 123-134. PubMed ID: 10320478

Dyson, S. and Gurdon, J. B. (1998). The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors. Cell 93(4): 557-568. PubMed ID: 9604931

Fujise, M., et al. (2001). Regulation of dally, an integral membrane proteoglycan, and its function during adult sensory organ formation of Drosophila. Dev. Bio. 235: 433-448. PubMed ID: 11437449

Gibert, J. M., Marcellini, S., David, J. R., Schlotterer, C. and Simpson, P. (2005). A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription factor Poils-au-dos, a repressor of achaete-scute. Dev. Biol. 288(1): 194-205. PubMed ID: 16216235

Greenwald, J., et al. (2003). The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly Mol. Cell 11: 605-617. PubMed ID: 12667445

Henderson, K. D., Isaac, D. D. and Andrew, D. J. (1999). Cell fate specification in the Drosophila salivary gland: the integration of homeotic gene function with the DPP signaling cascade. Dev. Biol. 205(1): 10-21. PubMed ID: 9882494

Ishikawa, T., et al. (1995). Truncated type II receptor for BMP-4 induces secondary axial structures in Xenopus embryos. Biochem. Biophys. Res. Commun. 216(1): 26-33. PubMed ID: 7488098

Jack, J. and Myette, G. (1999). Mutations that alter the morphology of the Malpighian tubules in Drosophila. Dev. Genes Evol. 209: 546-554. PubMed ID: 10502111

Khalsa, O., et al. (1998). TGF-beta/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing. Development 125: 2723-2734. PubMed ID: 9636086

Krishna, S., Maduzia, L. L. and Padgett, R. W. (1999). Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans. Development 126(2): 251-260. PubMed ID: 9847239

Lawler, S., et al. (1997). The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues. J. Biol. Chem. 272 (23): 14850-14859. PubMed ID: 9169454

Lebrun, J. J. and Vale, W. W. (1997). Activin and Inhibin Have Antagonistic Effects on Ligand-Dependent Heteromerization of the Type I and Type II Activin Receptors and Human Erythroid Differentiation. Mol. Cell. Biol. 17: 1682-91. PubMed ID: 9032295

Letsou, A., et al. (1995). Drosophila Dpp signaling is mediated by the punt gene product: a dual ligand-binding type II receptor of the TGF beta receptor family. Cell 80: 899-908 7697720

Lin, H. Y., et al. (1995). The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands. J Biol Chem 270: 2747-2754 . PubMed ID: 7852346

Luo, K. and Lodish, H. F. (1997). Positive and negative regulation of type II TGF-ß receptor signal transduction by autophosphorylation on multiple serine residues. EMBO J. 16: 1970-81. PubMed ID: 9155023

Massagué, J. (1996). TGFß signaling: Receptors, transducers and Mad proteins. Cell 85: 947-950. PubMed ID: 8674122

Matunis, E., et al. (1997). punt and schnurri regulate a somatically derived signal that restricts proliferation of committed progenitors in the germline. Development 124(21): 4383-4391. PubMed ID: 9334286

Nakao, A, et al. (1997). TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J. 16(17): 5353-5362 . PubMed ID: 9311995

Nellen, D., et al. (1996). Direct and long-range action of a DPP morphogen gradient. Cell 85: 357-369. PubMed ID: 8616891

New, H. V., et al. (1997). Differential effects on Xenopus development of interference with type IIA and type IIB activin receptors. Mech. Dev 61: 175-186 . PubMed ID: 9076687

Ng, J. (2008). TGF-β signals regulate axonal development through distinct Smad-independent mechanisms. Development 135(24): 4025-35. PubMed ID: 19004854

Nishitoh, H., et al. (1996). Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. J. Biol. Chem. 271(35): 21345-21352. PubMed ID: 8702914

Nohno, T., et al. (1995). Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors. J. Biol. Chem. 270(38): 22522-22526. PubMed ID: 7673243

Oh, S. P. and Li, E. (1997). The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev. 11(14): 1812-1826. PubMed ID: 9242489

Parker, L., et al., (2002). Functional interaction between NIPP1 and PP1 in Drosophila: consequences of over-expression of NIPP1 in flies and suppression by co-expression of PP1. Biochem. J. 368: 789-797. PubMed ID: 12358598

Parker, L., Ellis, J. E., Nguyen, M. Q. and Arora, K. (2006). The divergent TGF-β ligand Dawdle utilizes an activin pathway to influence axon guidance in Drosophila. Development 133(24): 4981-91. PubMed ID: 17119022

Persson, U., et al. (1997). Transforming growth factor (TGF-beta)-specific signaling by chimeric TGF-beta type II receptor with intracellular domain of activin type IIB receptor. J. Biol. Chem. 272(34): 21187-21194. PubMed ID: 9261125

Ribeiro, C., Ebner, A. and Affolter, M. (202). In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis. Dev. Cell 2: 677-683. PubMed ID: 12015974

Ricos, M. G., et al. (1999). Dcdc42 acts in TGF-beta signaling during Drosophila morphogenesis: distinct roles for the Drac1/JNK and Dcdc42/TGF-beta cascades in cytoskeletal regulation. J. Cell Sci. 112(Pt 8): 1225-1235 . PubMed ID: 10085257

Ruberte, E., et al. (1995) An absolute requirement for both the type II and type I receptors, punt and thick veins for dpp sgnaling in vivo. Cell 80: 889-97. 7697719

Schulz, C., Kiger, A. A., Tazuke, S. I., Yamashita, Y. M., Pantalena-Filho, L. C., Jones, D. L., Wood, C. G. and Fuller, M. T. (2004). A misexpression screen reveals effects of bag-of-marbles and TGF ß class signaling on the Drosophila male germ-line stem cell lineage. Genetics 167(2): 707-23. PubMed ID: 15238523

Serra, R., et al. (1997). Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J. Cell Biol. 139: 541-552. PubMed ID: 9334355

Shivdasani, A. A. and Ingham, P. W. (2003). Regulation of stem cell maintenance and transit amplifying cell proliferation by TGF-ß signaling in Drosophila spermatogenesis. Curr. Biol. 13: 2065-2072. PubMed ID: 14653996

Simin, K., et al. (1998). Genetic analysis of Punt, a type II Dpp receptor that functions throughout the Drosophila melanogaster life cycle. Genetics 148(2): 801-814. PubMed ID: 9504926

Song J., et al. (1999). The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice. Dev. Biol. 213(1): 157-69. PubMed ID: 10452853

Song, X., et al. (2004). Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary. Development 131(6): 1353-64. PubMed ID: 14973291

Vincent, S., et al. (1997). DPP controls tracheal cell migration along the dorsoventral body axis of the Drosophila embryo. Development 124(14): 2741-2750. PubMed ID: 9226445

Wang, X.-J., et al. (1997). Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition. Proc. Natl. Acad. Sci. 94: 2386-91. PubMed ID: 9122204

Wharton, K. A. (1995). How many receptors does it take? Bioessays 17: 13-16. PubMed ID: 7702589

Wang, T., et al. (1996). The immunophilin FKBP12 functions as a common inhibitor of the TGFß family type I receptors. Cell 86: 435-444. PubMed ID: 8756725

Wrana, J. L., et al. (1994). Mechanism of activation of the TGF-beta receptor. Nature 370: 341-347. PubMed ID: 8047140

Zhao, J., et al. (1998). Epithelium-specific adenoviral transfer of a dominant-negative mutant TGF-beta type II receptor stimulates embryonic lung branching morphogenesis in culture and potentiates EGF and PDGF-AA. Mech. Dev. 72(1-2): 89-100. PubMed ID: 9533955

Zheng, X., et al. (2003). TGF-ß signaling activates steroid hormone receptor expression during neuronal remodeling in the Drosophila brain. Cell 112: 303-315. PubMed ID: 12581521

punt: Biological Overview | Evolutionary Homologs | Regulation | Developmental Biology | Effects of Mutation

date revised: 25 August 2009

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.