REFERENCES (part 1/2)

Abe, T., Yamazaki, D., Murakami, S., Hiroi, M., Nitta, Y., Maeyama, Y. and Tabata, T. (2014). The NAV2 homolog Sickie regulates F-actin-mediated axonal growth in Drosophila mushroom body neurons via the non-canonical Rac-Cofilin pathway. Development 141: 4716-4728. PubMed ID: 25411210

Abreu-Blanco, M. T., Verboon, J. M. and Parkhurst, S. M. (2013). Coordination of Rho family GTPase activities to orchestrate cytoskeleton responses during cell wound repair. Curr Biol 24(2): 144-55. PubMed ID: 24388847

Agnel, M., et al. (1992). A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteins. Mol. Cell. Biol. 12 (11): 5111-5122. PubMed Citation: 1406685

Akhtar, N. and Hotchin, N. A. (2001). RAC1 regulates adherens junctions through endocytosis of E-cadherin. Mol. Biol. Ce1l 12: 847-862. 11294891

Ahuja, H. S., Zhu, Y. and Zakeri, Z. (1998). Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death. Dev. Genet. 21(4): 258-67. PubMed Citation: 9438340

Albert, M. L., Kim, J. I. and Birge, R. B. (2000). alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells. Nat. Cell Biol. 2(12): 899-905. 11146654

Allen, W. E., et al. (1997). Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages. J Cell Sci 110 ( Pt 6): 707-720. PubMed Citation: 9099945

Allen, M. J., Shan, X. and Murphey, R. K. (2001). A role for Drosophila Drac1 in neurite outgrowth and synaptogenesis in the giant fiber system. Mol. Cell. Neurosci. 16: 754-765. 11124895

Andjelkovic, M., et al. (1995). Developmental regulation of expression and activity of multiple forms of the Drosophila RAC protein kinase. J. Biol. Chem. 270 (8): 4066-4075. PubMed Citation: 7876156

Arber, S., et al. (1998). Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 393: 805-809. PubMed Citation: 9655397

Atfi, A., et al. (1997). Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling. J. Biol. Chem. 272: 1429-1432. PubMed Citation: 8999807

Bahri, S., et al. (2010). The leading edge during dorsal closure as a model for epithelial plasticity: Pak is required for recruitment of the Scribble complex and septate junction formation. Development 137(12): 2023-32. PubMed Citation: 20501591

Bakkers, J., et al. (2003). Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation. Development 131: 525-537. 14729574

Balagopalan, L., et al. (2006). The CDM superfamily protein MBC directs myoblast fusion through a mechanism that requires phosphatidylinositol 3,4,5-triphosphate binding but is independent of direct interaction with DCrk. Mol. Cell. Biol. 26: 9442-9455. PubMed Citation: 17030600

Balasubramanian, N. and Slepak, V. Z. (2003). Light-mediated activation of Rac-1 in photoreceptor outer segments. Curr. Biol. 13: 1306-1310. 12906790

Bashour, A. M., et al. (1997). IQGAP1, a rac- and Cdc42-binding protein, directly binds and cross-links microfilaments. J. Cell Biol. 137(7): 1555-1566. PubMed Citation: 9199170

Bateman, J., Shu, H. and Van Vactor, D. (2000). The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryo. Neuron 26: 93-106. PubMed Citation: 10798395

Bellanger, J. M., et al. (1997). The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo. Oncogene 16(2): 147-152. PubMed Citation: 9464532

Best, A., Ahmed, S., Kozma, R. and Lim, L. (1996). The Ras-related GTPase Rac1 binds tubulin. J. Biol. Chem. 271: 3756-3762. PubMed Citation: 8631991

Bialkowska, K., et al. (2000). Evidence that ß3 integrin-induced rac activation involves the calpain-dependent formation of integrin clusters that are distinct from the focal complexes and focal adhesions that form as rac and rhoa become active. J. Cell Bio. 151: 685-696. 11062268

Bianco, A., et al. (2007). Two distinct modes of guidance signalling during collective migration of border cells. Nature 448: 362-365. PubMed Citation: 17637670

Bidet, Y., et al. (2003). Modifiers of muscle and heart cell fate specification identified by gain-of-function screen in Drosophila. Mech. Dev. 120: 991-1007. 14550529

Biederer, T. and Sudhof, T. C. (2000). Mints as adaptors. Direct binding to neurexins and recruitment of munc18. J Biol Chem 275(51): 39803-39806. PubMed ID: 11036064

Bokoch, G. M., Bohl, B. P. and Chuang, T. H. (1994). Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins. J. Biol. Chem. 269: 31674-31679. PubMed Citation: 7989340

Bokoch, G.M., et al. (1996). Rac GTPase interacts specifically with phosphatidylinositol 3-kinase. Biochem J 315 ( Pt 3): 775-779. PubMed Citation: 8645157

Bourbon, H. M., et al. (2000). A P-insertion screen identifying novel X-linked essential genes in Drosophila. Mech. Dev. 110(1-2): 71-83. PubMed citation: 11744370

Boutros, M., et al. (1998). Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94(1): 109-118. PubMed Citation: 9674432

Braga, V. M. M., et al. (1997). The small GTPases rho and rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol. 137(6):1421-1431. PubMed Citation: 9182672

Brenner, B., et al. (1997a). L-selectin regulates actin polymerization via activation of the small G-protein Rac2. Biochem Biophys Res Commun 231 (3): 802-807

Brenner, B., et al. (1997b). Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of jun N-terminal Kinase/p38 kinases and GADD153. J. Biol. Chem. 272(35): 22173-22181. PubMed Citation: 9268362

Brinkmann, K., Winterhoff, M., Onel, S. F., Schultz, J., Faix, J. and Bogdan, S. (2015). WHAMY is a novel actin polymerase promoting myoblast fusion, macrophage cell motility and sensory organ development. J Cell Sci 129(3):604-20. PubMed ID: 26675239

Brugnera, E. et al. (2002) Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex, Nat. Cell Biol. 4: 574-582. 12134158

Brumby, A. M., Goulding, K. R., Schlosser, T., Loi, S., Galea, R., Khoo, P., Bolden, J. E., Aigaki, T., Humbert, P. O. and Richardson, H. E. (2011). Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis. Genetics 188: 105-125. PubMed ID: 21368274

Buchon, N., Broderick, N. A., Chakrabarti, S. and Lemaitre, B. (2009). Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev 23: 2333-2344. PubMed ID: 19797770

Burbelo, P. D., Drechsel, D. and Hall, A. (1995). A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J Biol Chem 270 (49): 29071-29074. PubMed Citation: 7493928

Busche, S., Descot, A., Julien, S., Genth, H. and Posern, G. (2008). Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling. J. Cell Sci. 121(Pt 7): 1025-35. PubMed Citation: 18334560

Bustos, R. I., Forget, M. A., Settleman, J. E. and Hansen, S. H. (2008). Coordination of Rho and Rac GTPase function via p190B RhoGAP. Curr. Biol. 18(20): 1606-11. PubMed Citation: 18948007

Cerikan, B., Shaheen, R., Colo, G.P., Gläßer, C., Hata, S., Knobeloch, K.P., Alkuraya, F.S., Fässler, R. and Schiebel, E. (2016). Cell-intrinsic adaptation arising from chronic ablation of a key rho GTPase regulator. Dev Cell [Epub ahead of print]. PubMed ID: 27693507

Cervantes-Sandoval, I., Davis, R. L. and Berry, J. A. (2020). Rac1 impairs forgetting-induced cellular plasticity in mushroom body output neurons. Front Cell Neurosci 14: 258. PubMed ID: 33061890

Chang, H. Y. and Ready, D. F. (2000). Rescue of photoreceptor degeneration in rhodopsin-null Drosophila mutants by activated Rac1. Science 290(5498): 1978-80. 11110667

Chen, G. C., Gajowniczek, P. and Settleman, J. (2004). Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis. Curr. Biol. 14: 309-313. 14972681

Chen, G. C., et al. (2005). Regulation of Rho and Rac signaling to the actin cytoskeleton by Paxillin during Drosophila development. Molec. Cell. Biol. 25: 979-987. 15657426

Chen, W., et al. (1996). The Caenorhabditis elegans p21-activated kinase (CePAK) colocalizes with CeRac1 and CDC42Ce at hypodermal cell boundaries during embryo elongation. J Biol Chem 271 : 26362-26368. PubMed Citation: 8824291

Chihara, T., et al. (2003). Rac promotes epithelial cell rearrangement during tracheal tubulogenesis in Drosophila. Development 130: 1419-1428. 12588856

Chou, M. M. and Blenis, J. (1996). The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. Cell 85: 573-583. 8653792

Chung, C. Y., et al. (2000). Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells. Proc. Natl. Acad. Sci. 97: 5225-5230.. PubMed Citation: 10805781

Clark, E. A., et al. (1998). Integrin-mediated signals regulated by members of the rho family of GTPases. J. Cell Biol. 142(2): 573-86. PubMed Citation: 9679153

Clarke, N., et al. (1998). Epidermal growth factor induction of the c-jun promoter by a Rac pathway. Mol. Cell. Biol. 18(2): 1065-1073. PubMed Citation: 9448004

Collins, L. R., et al. (1996). Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac. J Biol Chem 271 (29): 17349-17353. PubMed Citation: 8663428

Conder, R., et al. (2004). dPak is required for integrity of the leading edge cytoskeleton during Drosophila dorsal closure but does not signal through the JNK cascade. Dev. Biol. 276: 378-390. 15581872

Cong, J., Geng, W., He, B., Liu, J., Charlton, J. and Adler, P.N. (2001). The furry gene of Drosophila is important for maintaining the integrity of cellular extensions during morphogenesis. Development 128: 2793-2802. 11526084

Coso, O.A., et al. (1995). The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81 (7): 1137-1146. PubMed Citation: 7600581

Cote, J. F. and Vuori, K. (2002). Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. J. Cell Sci. 115: 4901-4913. PubMed Citation: 12432077

Cox, E. A., Sastry, S. K. and Huttenlocher, A. (2001). Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the rho family of GTPases. Mol. Biol. Cell 12: 265-277. 11179414

Crespo, P., et al. (1996). Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav. Oncogene 13 (3): 455-460. PubMed Citation: 8760286

Denholm, B., Brown, S., Ray, R. P., Ruiz-Gomez, M., Skaer, H and Hombria, J. C. (2005). crossveinless-c is a RhoGAP required for actin reorganisation during morphogenesis. Development 132(10): 2389-400. 15843408

Dang, I., et al. (2013). Inhibitory signalling to the Arp2/3 complex steers cell migration. Nature 503: 281-284. PubMed ID: 24132237

Daniels, R. H., Hall, P. S. and Bokoch, G. M. (1998). Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. EMBO J. 17: 754-764. PubMed Citation: 9451000

deBakker, C. D., et al. (2004). Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO. Curr. Biol. 14: 2208-2216. PubMed Citation: 15620647

Dekel, I., Russek, N., Jones, T., Mortin, M. A. and Katzav, S. (2000). Identification of the Drosophila melanogaster homologue of the mammalian transducer protein, Vav. FEBS Lett. 472: 99-104. PubMed citation: 10781813

Delorme, V., et al. (2007). Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks. Dev. Cell 13(5): 646-62. PubMed citation: 17981134

Denholm, B., Brown, S., Ray, R. P., Ruiz-Gomez, M., Skaer, H and Hombria, J. C. (2005). crossveinless-c is a RhoGAP required for actin reorganisation during morphogenesis. Development 132(10): 2389-400. 15843408

de Torres-Jurado, A., Manzanero-Ortiz, S. and Carmena, A. (2022). Glial-secreted Netrins regulate Robo1/Rac1-Cdc42 signaling threshold levels during Drosophila asymmetric neural stem/progenitor cell division. Curr Biol 32(10): 2174-2188. PubMed ID: 35472309

de Wit, J., Sylwestrak, E., O'Sullivan, M. L., Otto, S., Tiglio, K., Savas, J. N., Yates, J. R., 3rd, Comoletti, D., Taylor, P. and Ghosh, A. (2009). LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation. Neuron 64(6): 799-806. PubMed ID: 20064388

Doherty, J., Sheehan, A. E., Bradshaw, R., Fox, A. N., Lu, T. Y. and Freeman, M. R. (2014). PI3K signaling and Stat92E converge to modulate glial responsiveness to axonal injury. PLoS Biol 12: e1001985. PubMed ID: 25369313

Dong, T., He, J., Wang, S., Wang, L., Cheng, Y. and Zhong, Y. (2016). Inability to activate Rac1-dependent forgetting contributes to behavioral inflexibility in mutants of multiple autism-risk genes. Proc Natl Acad Sci U S A 113: 7644-7649. Exp Neurobiol 25: 33-39. PubMed ID: 27335463

Duan, R., Jin, P., Luo, F., Zhang, G., Anderson, N. and Chen, E. H. (2012). Group I PAKs function downstream of Rac to promote podosome invasion during myoblast fusion in vivo. J Cell Biol 199: 169-185. PubMed ID: 23007650

Duchek, P., et al. (2001). Guidance of cell migration by the Drosophila PDGF/VEGF receptor, Cell 107: 17-26. PubMed Citation: 11595182

Dzamba, B. J., et al. (2009). Cadherin adhesion, tissue tension (acting through Rac), and noncanonical Wnt signaling regulate fibronectin matrix organization. Dev. Cell 16(3): 421-32. PubMed Citation: 19289087

Eaton, S., Wepf, R. and Simons, K. (1996). Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila. J. Cell Biol. 135(5): 1277-89. 8947551

Eden, S., et al. (2002). Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature 418(6899): 790-3. 12181570

Ehrlich, J. S., Hansen, M. D. H. and Nelson, W. J. (2002). Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion. Dev. Cell 3: 259-270. 12194856

Fullard, J. F. and Baker, N. E. (2014). A modifier screen in Drosophila melanogaster implicates cytoskeletal regulators, Jun N-terminal kinase, and Yorkie in Draper signaling. Genetics 199(1):117-34. PubMed ID: 25395664

Kovacs, E. M., Ali. R. G., McCormack, A. J. and Yap, A. S. (2002). E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts. J. Biol. Chem. 277(8): 6708-18. 11744701

del Pozo, M. A., et al. (2000). Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK. EMBO J.19: 2008-2014. PubMed Citation: 10790367

Diekmann, D., et al. (1995). Rac GTPase interacts with GAPs and target proteins through multiple effector sites. EMBO J 14 (21): 5297-5305. PubMed Citation: 7489719

Dobens, L. L., et al. (2001). Drosophila puckered regulates Fos/Jun levels during follicle cell morphogenesis. Development 128: 1845-1856. 11311164

Dolfi, F., et al. (1998). The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway. Proc. Natl. Acad. Sci. 95(26): 15394-9. PubMed Citation: 9860979

Driessens, M. H. E., et al. (2001). Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho Curr. Biol. 11: 339-344. PubMed citation: 11267870

D'Souza-Schorey, C., et al. (1997). A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements. EMBO J. 16(17): 5445-5454. PubMed Citation: 9312003

D'Souza-Schorey, C., Boettner, B. and Van Aelst, L. (1998). Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes. Mol. Cell. Biol. 18(7): 3936-3946. PubMed Citation: 9632778

Duchek, P., et al. (2001). Guidance of cell migration by the Drosophila PDGF/VEGF Receptor. Cell 107: 17-26. 11595182

Eaton, S., et al. (1995). CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium. J. Cell Biol. 131: 151-164. PubMed Citation: 7559772

Eaton, S., Wepf, R., and Simons, K. (1996). Roles for Rac1 and Cdc42 in planar polarizaion and hair outgrowth in the wing of Drosophila. J. Cell Biol. 135: 1277-1289. PubMed Citation: 8947551

Eby, J. J., et al. (1998). Actin cytoskeleton organization regulated by the PAK family of protein kinases. Curr. Biol. 8(17): 967-70. PubMed Citation: 9742399

Eden, S., et al. (2002). Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature 418: 790-793. 12181570

Emoto, K., He, Y., Ye, B., Grueber, W. B., Adler, P. N., Jan, L. Y. and Jan, Y. N. (2004). Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons. Cell 119: 245-256. 15479641

Erickson, M. R. S., Galletta, B. J. and Abmayr, S. M. (1997). Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organization. J. Cell Biol. 138(3): 589-603. PubMed Citation: 9245788

Fan, W. T., et al. (1998). The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways. Curr. Biol. 8(16): 935-8. PubMed Citation: 9707409

Fan, X., Labrador, J. P., Hing, H. and Bashaw, G. J. (2003). Slit stimulation recruits Dock and Pak to the Roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline. Neuron 40: 113-127. 14527437

Fanger, G. R., Johnson, N. L. and Johnson, G. L. (1997). MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. EMBO J. 16(16): 4961-4972. PubMed Citation: 9305638

Fanto, M., et al. (2000). Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye. Curr. Biol. 10: 979-988. PubMed Citation: 10985385

Faure, S., et al. (1997). A member of the Ste20/PAK family of protein kinases is involved in both arrest of Xenopus oocytes at G2/prophase of the first meiotic cell cycle and in prevention of apoptosis. EMBO J. 16(18): 5550-5561. PubMed Citation: 9312014

Fernandez-Espartero, C. H., Ramel, D., Farago, M., Malartre, M., Luque, C. M., Limanovich, S., Katzav, S., Emery, G. and Martin-Bermudo, M. D. (2013). GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation. J Cell Sci 126: 2285-2293. PubMed ID: 23525006

Foley, E. and O'Farrell, P. H. (2004). Functional dissection of an innate immune response by a genome-wide RNAi screen. PLoS Biol 2: E203. PubMed ID: 15221030

Fritz, J. L. and VanBerkum, M. F. A. (2002). Regulation of rho family GTPases is required to prevent axons from crossing the midline. Dev. Bio. 252: 46-58. 12453459

Frost, J. A., et al. (1996). Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. Mol Cell Biol 16 (7): 3707-3713. PubMed Citation: 8668187

Frost, J. A., et al. (1997). Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J. 16(21): 6426-6438. PubMed Citation: 9351825

Fukata, M., et al. (2002). Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell 109: 873-885. 12110184

Gao, Y., Shuai, Y., Zhang, X., Peng, Y., Wang, L., He, J., Zhong, Y. and Li, Q. (2019). Genetic dissection of active forgetting in labile and consolidated memories in Drosophila. Proc Natl Acad Sci U S A. 116(42):21191-21197. PubMed ID: 31488722

Gauthier-Rouviere, C., et al. (1998). RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42Hs. Mol. Biol. Cell 9(6): 1379-1394. PubMed Citation: 9614181

Geisbrecht, E. R., et al. (2008). Drosophila ELMO/CED-12 interacts with Myoblast city to direct myoblast fusion and ommatidial organization. Dev. Biol. 314(1): 137-49. PubMed ID: 18163987

Geisbrecht, E. R., Sawant, K., Su, Y., Liu, Z. C., Silver, D. L., Burtscher, A., Wang, X., Zhu, A. J. and McDonald, J. A. (2013). Genetic interaction screens identify a role for hedgehog signaling in Drosophila border cell migration. Dev Dyn 242: 414-431. PubMed ID: 23335293

Geng, W., He, B., Wang, M. and Adler, P. N. (2000). The tricornered gene, which is required for the integrity of epidermal cell extensions, encodes the Drosophila nuclear DBF2-related kinase. Genetics 156: 1817-1828. 11102376

Georgiou, M. and Baum, B. (2010). Polarity proteins and Rho GTPases cooperate to spatially organise epithelial actin-based protrusions. J. Cell Sci. 123(Pt 7): 1089-98. PubMed Citation: 20197404

Girardin, S. E. and Yaniv, M. (2001). A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation. EMBO J. 20: 3437-3446. 11432831

Gitai, Z., et al. (2003). The netrin receptor UNC-40/DCC stimulates axon attraction and outgrowth through Enabled and, in parallel, Rac and UNC-115/AbLIM. Neuron 37: 53-65. 12526772

Glaven, J. A., et al. (1996). Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein. J. Biol. Chem. 271(44): 27374-27381. PubMed Citation: 8910315

Glise, B. and Noselli, S. (1997). Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis. Genes Dev. 11:1738-1747. PubMed Citation: 9224722

Gombos, R., Migh, E., Antal, O., Mukherjee, A., Jenny, A. and Mihaly, J. (2015). The formin DAAM functions as molecular effector of the planar cell polarity pathway during axonal development in Drosophila. J Neurosci 35: 10154-10167. PubMed ID: 26180192

Grimsley, C. M., et al. (2004). Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. J. Biol. Chem. 279: 6087-6097. PubMed Citation: 14638695

Gu, J., et al. (2001). Laminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathway. J. Biol. Chem. 276(29): 27090-7. 11369773

Guichard, A., Bergeret, E., and Griffin-Shea, R. (1997). Overexpression of RnRacGAP in Drosophila melanogaster deregulates cytoskeletal organization in cellularising embryos and induces discrete imaginal phenotypes. Mech. Dev. 61: 49-62. PubMed Citation: 9076677

Guidato, S., et al. (1998). Cyclin D2 interacts with cdk-5 and modulates cellular cdk-5/p35 activity. J. Neurochem. 70(1): 335-40. PubMed Citation: 9422379

Guillemot, L., Paschoud, S., Jond, L., Foglia, A. and Citi, S. (2008). Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions. Mol. Biol. Cell 19(10): 4442-53. PubMed Citation: 18653465

Gumienny, T. L., et al. (2001). Ced-12/elmo, a novel member of the crkii/dock180/rac pathway, is required for phagocytosis and cell migration. Cell 107(1):27-41. 11595183

Guo, D., et al. (2007). A Rac-cGMP signaling pathway. Cell 128(2): 341-55. Medline abstract: 17254971

Hakeda-Suzuki, S., et al. (2002). Rac function and regulation during Drosophila development. Nature 416: 438-442. 11919634

Halet, G. and Carroll, J. (2007). Rac activity is polarized and regulates meiotic spindle stability and anchoring in mammalian oocytes. Dev. Cell 12(2): 309-17. Medline abstract: 17276347

Hansen, M. D. H. and Nelson, W. J. (2001). Serum-activated assembly and membrane translocation of an endogenous Rac1:effector complex. Curr. Biol. 11: 356-360.11267873

Haralalka, S., et al. (2011). Asymmetric Mbc, active Rac1 and F-actin foci in the fusion-competent myoblasts during myoblast fusion in Drosophila. Development 138(8): 1551-62. PubMed Citation: 21389053

Harden, N., et al. (1995). A dominant inhibitory version of the small GTP-binding protein Rac disrupts cytoskeletal structures and inhibits developmental cell shape changes in Drosophila. Development 121: 903-914. PubMed Citation: 7720592

Harden, N., et al. (1996). A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures. Mol. Cell. Biol. 16: 1896-1908. PubMed Citation: 8628256

Harden, N., et al. (1999). Participation of small GTPases in dorsal closure of the Drosophila embryo: distinct roles for Rho subfamily proteins in epithelial morphogenesis. J. Cell Sci. 112: 273-84. 99104229

Harden, N., et al (2002). Drac1 and Crumbs participate in amnioserosa morphogenesis during dorsal closure in Drosophila. J. Cell Sci. 115: 2119-2129. 11973353

He, H., et al. (1998). Role of phosphatidylinositol 4,5-bisphosphate in Ras/Rac-induced disruption of the cortactin-actomyosin II complex and malignant transformation. Mol. Cell. Biol. 18(7): 3829-3837. PubMed Citation: 9632767

He, Y., Fang, X., Emoto, K., Jan, Y. N. and Adler, P. N. (2005). The Tricornered Ser/Thr protein kinase is regulated by phosphorylation and interacts with Furry during Drosophila wing hair development. Mol. Biol. Cell. 16(2): 689-700. 15591127

Heo, W. D. and Meyer, T. (2003). Switch-of-function mutants based on morphology classification of ras superfamily small GTPases. Cell 113: 315-328. 12732140

Higuchi, M., et al. (2001). Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells. Curr. Biol. 11: 1958-1962. 11747822

Hill, C. S., Wynne, J. and Treisman, R. (1995). The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 81 (7): 1159-1170 (1995. PubMed Citation: 7600583

Ho, E., Irvine, T., Vilk, G. J., Lajoie, G., Ravichandran, K. S., D'Souza, S. J. and Dagnino, L. (2009). Integrin-linked kinase interactions with ELMO2 modulate cell polarity. Mol Biol Cell 20: 3033-3043. PubMed ID: 19439446

Hoemann, C. D., et al. (1996). Alternative splicing of the Drosophila melanogaster rotundRacGAP gene. Gene 168 (2): 135-141. PubMed Citation: 8654933

Hordijk, P. L., et al. (1997). Inhibition of invasion of epithelial cells by Tiam1-Rac signaling. Science 278(5342): 1464-1466. PubMed Citation: 9367959

Hornstein, I., Mortin, M. A. and Katzav, S. (2003). DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the Rac and DER pathways. Oncogene 22: 6774-6784. PubMed citation: 14555990

Hooshmand-Rad, R., et al. (1997). Involvement of phosphatidylinositide 3'-kinase and Rac in platelet-derived growth factor-induced actin reorganization and chemotaxis. Exp. Cell Res. 234(2): 434-441. PubMed Citation: 9260914

Hoshino, M., et al. (1999). Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac1. J. Biol. Chem. 274: 17837-17844. PubMed Citation: 10364228

Hozumi, S., et al. (2006). An unconventional myosin in Drosophila reverses the default handedness in visceral organs. Nature 440: 798-802. PubMed Citation: 16598258

Hu, H., Marton, T. F. and Goodman, C. S. (2001). Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling. Neuron 32: 39-51. 11604137

Hu, H., et al. (2005). Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion, Proc. Natl. Acad. Sci. 102: 4613-4618. Medline abstract: 15755809

Hummel, T., Leifker, K. and Klämbt, C. (2000). The Drosophila HEM-2/NAP1 homolog KETTE controls axonal pathfinding and cytoskeletal organization. Genes Dev. 14: 863-873. 10766742

Illenberger, D., et al. (1998). Stimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1. EMBO J. 17(21): 6241-6249. PubMed Citation: 9799233

Innocenti, M., et al. (2002). Mechanisms through which Sos-1 coordinates the activation of Ras and Rac. J. Cell Biol. 156: 125-136. Medline abstract: 11777939

Innocenti, M., et al. (2003). Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1. J. Cell Biol. 160: 17-23. Medline abstract: 12515821

Ishimaru, S., et al. (2004). PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis. EMBO J. 23: 3984-3994. PubMed Citation: 15457211

Iwasato, T., et al. (2007). Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. Cell 130(4): 742-53. PubMed citation: 17719550

Iyer, S. C., Wang, D., Iyer, E. P., Trunnell, S. A., Meduri, R., Shinwari, R., Sulkowski, M. J. and Cox, D. N. (2012). The RhoGEF trio functions in sculpting class specific dendrite morphogenesis in Drosophila sensory neurons. PLoS One 7: e33634. PubMed ID: 22442703

Joneson T., et al. (1998). Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors. J. Biol. Chem. 273(13): 7743-7748. PubMed Citation: 9516483

Jou, T. S. and Nelson, W. J. (1998a). Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity. J. Cell Biol. 142(1): 85-100. PubMed Citation: 9660865

Jou, T. S, Schneeberger, E. E. and Nelson, W. J. (1998b). Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases. J. Cell Biol. 142(1): 101-15. PubMed Citation: 9660866

Katoh, H. and Negishi, M. (2003). RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo. Nature 424: 461-464. PubMed Citation: 12879077

Kaufmann, N., Wills, Z. C. and Vactor, D. V. (1998). Drosophila Rac1 controls motor axon guidance. Development 125(3): 453-461. PubMed Citation: 9425140

Kawauchi, T., et al. (2003). The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration. EMBO J. 22: 4190-4201. 12912917

Keely, P. J., et al. (1997). Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 390(6660): 632-636. 98065954

Khosravi-Far, R., et al. (1995). Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol. Cell. Biol. 15: 6443-6453. PubMed Citation: 7565796

Kim, M. D., et al. (2003). Isolation of Rho GTPase effector pathways during axon development. Dev. Biol. 262: 282-293. 14550791

King, A. J., et al. (1998). The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. Nature 396(6707): 180-3. PubMed Citation: 9823899

Kishore, R. S. and Sundaram, M. V. (2002). ced-10 Rac and mig-2 function redundantly and act with unc-73 trio to control the orientation of vulval cell divisions and migrations in Caenorhabditis elegans. Dev Biol. 241(2): 339-48. 11784116

Kitamura, Y., Kitamura, T., Sakaue, H., Maeda, T., Ueno, H., Nishio, S., Ohno, S., Osada, S., Sakaue, M., Ogawa, W. et al. (1997). Interaction of Nck associated protein 1 with activated GTP binding protein Rac. Biochem. J. 322: 873-878. 9148763

Kiyokawa, E., et al. (1998b). Activation of Rac1 by a Crk SH3-binding protein, DOCK180. Genes Dev. 21: 3331-3336. PubMed Citation: 9808620

Klippel, A., et al. (1996). Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol Cell Biol 16 (8): 4117-4127. PubMed Citation: 8754810

Ko, J., Fuccillo, M. V., Malenka, R. C. and Sudhof, T. C. (2009). LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation. Neuron 64(6): 791-798. PubMed ID: 20064387

Kobayashi, K., Kuroda, S., Fukata, M., Nakamura, T., Nagase, T., Nomura, N., Matsuura, Y., Yoshida-Kubomura, N., Iwamatsu, A. and Kaibuchi, K. (1998). p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase. J. Biol. Chem. 273: 291-295. 9417078

Kobayashi, S., et al. (2001). Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3. Biochem. J. 354: 73-78. PubMed Citation: 11171081

Kozma, R., et al. (1996). The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia. Mol Cell Biol 16 (9): 5069-5080. PubMed Citation: 8756665

Kozma, R., et al. (1997). Rho family GTPases and neuronal growth cone remodelling: Relationship between increased complexity induced by Cdc42Hs, Rac1, and Acetylcholine and collapse induced by RhoA and lysophosphatidic acid. Mol. Cell. Biol. 17: 1201-1211. PubMed Citation: 9032247

Kuhn, T. B., et al. (1999). Myelin and collapsin-1 induce motor neuron growth cone collapse through different pathways: inhibition of collapse by opposing mutants of rac1. J. Neurosci. 19(6): 1965-75. PubMed Citation: 10066250

Kulkarni, S., et al. (1999). Calpain mediates integrin-induced signaling at a point upstream of Rho family members. J. Biol. Chem. 274(30): 21265-75. 10409684

Kunisaki, Y., et al. (2006). DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis. J. Cell Biol. 174(5): 647-52. Medline abstract: 16943182

Kuroda S., et al. (1998). Role of IQGAP1, a target of the small GTPases cdc42 and rac1, in regulation of E-cadherin- mediated cell-cell adhesion. Science 282(5378): 832-835. PubMed Citation: 9694656

Lagana, A., et al. (2010). A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A. Nat. Cell Biol. 12(12): 1186-93. PubMed Citation: 21102442

Lamarche, N., et al. (1996). Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK Map kinase cascade. Cell 87: 519-528. PubMed Citation: 8898204

Lapouge, K., et al. (2000). Structure of the TPR domain of p67phox in complex with Rac-GTP. Molecular Cell, Vol. 6: 899-907. PubMed Citation: 11090627

Law, A. L., Vehlow, A., Kotini, M., Dodgson, L., Soong, D., Theveneau, E., Bodo, C., Taylor, E., Navarro, C., Perera, U., Michael, M., Dunn, G. A., Bennett, D., Mayor, R. and Krause, M. (2013). Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo. J Cell Biol. 203(4): 673-89. PubMed ID: 24247431

Lebreton, G. and Casanova, J. (2013). Specification of leading and trailing cell features during collective migration in the Drosophila trachea. J Cell Sci. 127(Pt 2): 465-74. PubMed ID: 24213534

Lee, A., et al. (2003). Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Rac1. Development 130: 5543-5552. 14530299

Lee, N., et al. (1997). Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis. Proc. Natl. Acad. Sci. 94(25): 13642-13647. PubMed Citation: 9391079

Lee, M.-J., et al. (2001). Akt-mediated phosphorylation of the G Protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Molec. Cell 8: 693-704. 11583630

Leeuwen, F. N., et al. (1997). The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; Opposing roles for the small GTPases Rac and Rho. J. Cell Biol. 139: 797-807. PubMed Citation: 9348295

Leeuw, T., et al. (1998). Interaction of a G-protein beta-subunit with a conserved sequence inSte20/PAK family protein kinases. Nature 391(6663): 191-195. PubMed Citation: 9428767

Li, G., et al. (1997). Uncoupling of Membrane Ruffling and Pinocytosis during Ras Signal Transduction. J. Biol Chem 272 (16): 10337-10340. PubMed Citation: 9099668

Li, T., Tian, Y., Li, Q., Chen, H., Lv, H., Xie, W. and Han, J. (2015). The Neurexin/N-Ethylmaleimide-sensitive Factor (NSF) Interaction Regulates Short Term Synaptic Depression. J Biol Chem 290(29): 17656-17667. PubMed ID: 25953899

Li, Z., Aizenman, C. D. and Cline, H. T. (2002). Regulation of Rho GTPases by crosstalk and neuronal activity in vivo. Neuron 33: 741-750. 11879651

Li, X., Meriane, M., Triki, I., Shekarabi, M., Kennedy, T. E., Larose, L. and Lamarche-Vane, N. (2002a). The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism. J. Biol. Chem. 277: 37788-37797. 12149262

Li, X., Saint-Cyr-Proulx, E., Aktories, K. and Lamarche-Vane, N. (2002b). Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells. J. Biol. Chem. 277: 15207-15314. 11844789

Liliental, J., et al. (2000). Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr. Biol. 10: 401-404.

Liu, Z. C., and Geisbrecht, E. R. (2011). Moleskin is essential for the formation of the myotendinous junction in Drosophila. Dev. Biol. 359: 176-189. PubMed ID: 21925492

Liu, Z. C., Odell, N. and Geisbrecht, E. R. (2013). Drosophila Importin-7 functions upstream of the Elmo signaling module to mediate the formation and stability of muscle attachments. J Cell Sci. PubMed ID: 24046451

Lores, P., Visvikis, O., Luna, R., Lemichez, E. and Gacon, G. (2010). The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt. FEBS J 277: 1453-1464. PubMed ID: 20148946

Losick, V. P., Fox, D. T. and Spradling, A. C. (2013). Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium. Curr Biol. 23(22): 2224-32. PubMed ID: 24184101

Lu, M., et al. (2004). PH domain of ELMO functions in trans to regulate Rac activation via Dock180. Nat. Struct. Mol. Biol. 11: 756-762. PubMed Citation: 15247908

Lu, T. Y., Doherty, J. and Freeman, M. R. (2014). DRK/DOS/SOS converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris. Proc Natl Acad Sci U S A. PubMed ID: 25099352

Lindqvist, M., et al. (2010). Vang-like protein 2 and Rac1 interact to regulate adherens junctions. J Cell Sci. 123(Pt 3): 472-83. PubMed Citation: 20067994

Liu, Y., Du, S., Lv, L., Lei, B., Shi, W., Tang, Y., Wang, L. and Zhong, Y. (2016). Hippocampal activation of Rac1 regulates the forgetting of object recognition memory. Curr Biol 26: 2351-2357. PubMed ID: 27593377

Lu, M., et al. (2005). A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs. Curr. Biol. 15: 371-377. PubMed Citation: 15723800

Lu, M. and Ravichandran, K. S. (2006). Dock180-ELMO cooperation in Rac activation. Methods Enzymol. 406: 388-402. PubMed Citation: 16472672

Lu, S., Hernan, R., Marcogliese, P. C., Huang, Y., Gertler, T. S., Akcaboy, M., Liu, S., Chung, H. L., Pan, X., Sun, X., Oguz, M. M., Oztoprak, U., de Baaij, J. H. F., Ivanisevic, J., McGinnis, E., Guillen Sacoto, M. J., Chung, W. K. and Bellen, H. J. (2022). Loss-of-function variants in TIAM1 are associated with developmental delay, intellectual disability, and seizures. Am J Hum Genet 109(4): 571-586. PubMed ID: 35240055

Lundström, A., et al. (2004). Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons. Genes Dev. 18: 2161-2171. 15342493

Lundquist, E. A., et al. (2001). Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. Development 128: 4475-4488. 11714673

Lu, S., Hernan, R., Marcogliese, P. C., Huang, Y., Gertler, T. S., Akcaboy, M., Liu, S., Chung, H. L., Pan, X., Sun, X., Oguz, M. M., Oztoprak, U., de Baaij, J. H. F., Ivanisevic, J., McGinnis, E., Guillen Sacoto, M. J., Chung, W. K. and Bellen, H. J. (2022). Loss-of-function variants in TIAM1 are associated with developmental delay, intellectual disability, and seizures. Am J Hum Genet 109(4): 571-586. PubMed ID: 35240055

Lu, Y. and Settleman, J. (1999). The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis. Genes Dev. 13(9): 1168-80. PubMed Citation: 10323867

Luo, L., et al. (1994). Distinct morphogenetic function of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev. 8: 1787-1802. PubMed Citation: 7958857

Luo, L., et al. (1996). Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines. Nature 379: 837-840. PubMed Citation: 8587609

Machacek, M., et al. (2009). Coordination of Rho GTPase activities during cell protrusion. Nature 461(7260): 99-103. PubMed Citation: 19693013

Makino, Y., et al. (2006). Elmo1 inhibits ubiquitylation of Dock180. J. Cell Sci. 119: 923-932. PubMed Citation: 16495483

Malecz, N., et al. (2000). Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis. Curr. Biol. 10: 1383-1386. 11084340

Malliri, A., et al. (1998). The transcription factor AP-1 is required for EGF-induced activation of rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells. J. Cell Biol. 143(4): 1087-99. PubMed Citation: 9817764

Malosio, M. L., et al. (1997). Differential expression of distinct members of Rho family GTP-binding proteins during neuronal development: identification of Rac1B, a new neural-specific member of the family. J. Neurosci. 17(17): 6717-6728. PubMed Citation: 9254684

Manser, E., et al. (1997). Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes. Mol Cell Biol 17 (3): 1129-1143. PubMed Citation: 9032240

Matsuura, R., Tanaka, H. and Go, M. J. (2004). Distinct functions of Rac1 and Cdc42 during axon guidance and growth cone morphogenesis in Drosophila, Eur. J. Neurosci. 19: 21-31. Medline abstract: 14750960

Maundrell, K., et al. (1997). Bcl-2 undergoes phosphorylation by c-Jun N-terminal Kinase/Stress-activated protein kinases in the presence of the constitutively active GTP-binding protein rac1. J. Biol. Chem. 272(40): 25238-25242. PubMed Citation: 9312139

Mettouchi, A., et al. (2001). Integrin-specific activation of Rac controls progression through the G1 phase of the cell cycle. Mol. Cell 8: 115-127. 11511365

Meller, N., et al. (2005). CZH proteins: a new family of Rho-GEFs. J. Cell Sci. 118: 4937-4946. PubMed Citation: 16254241

Migeotte, I., Grego-Bessa, J. and Anderson, K. V. (2011). Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo. Development 138(14): 3011-20. PubMed Citation: 21693517

Miki, H., Suetsugu, S. and Takenawa, T. (1998). WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac. EMBO J. 17(23): 6932-41. 9843499

Miki, H., Yamaguchi, H., Suetsugu, S. and Takenawa, T. (2000). IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Nature 408(6813): 732-5. 11130076

Minden, A., et al. (1995). Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81 (7): 1147-1157. PubMed Citation: 7600582

Morishita, K., Ozasa, F., Eguchi, K., Yoshioka, Y., Yoshida, H., Hiai, H. and Yamaguchi, M. (2014). Drosophila DOCK family protein Sponge regulates the JNK pathway during thorax development. Cell Struct Funct 39(2):113-24. PubMed ID: 25311449

Moshfegh, Y., Bravo-Cordero, J. J., Miskolci, V., Condeelis, J. and Hodgson, L. (2014). A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly. Nat Cell Biol 16: 574-586. PubMed ID: 24859002

Muhammad, K., Reddy-Alla, S., Driller, J. H., Schreiner, D., Rey, U., Bohme, M. A., Hollmann, C., Ramesh, N., Depner, H., Lutzkendorf, J., Matkovic, T., Gotz, T., Bergeron, D. D., Schmoranzer, J., Goettfert, F., Holt, M., Wahl, M. C., Hell, S. W., Scheiffele, P., Walter, A. M., Loll, B. and Sigrist, S. J. (2015). Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function. Nat Commun 6: 8362. PubMed ID: 26471740

Murakami, S., Minami-Ohtsubo, M., Nakato, R., Shirahige, K. and Tabata, T. (2017). Two components of aversive memory in Drosophila, anesthesia-sensitive and anesthesia-resistant memory, require distinct domains within the Rgk1 small GTPase. J Neurosci 37(22):5496-5510. PubMed ID: 28416593

Murphy, A. M. and Montell, D. J. (1996). Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis. J. Cell Biol. 133: 617-630. PubMed Citation: 8636236

Myant, K. B., Scopelliti, A., Haque, S., Vidal, M., Sansom, O. J., Cordero, J. B. (2013b). Rac1 drives intestinal stem cell proliferation and regeneration. Cell Cycle 12: [Epub ahead of print] PubMed ID: 23974108

Myant, K. B., Cammareri, P., McGhee, E. J., Ridgway, R. A., Huels, D. J., Cordero, J. B., Schwitalla, S., Kalna, G., Ogg, E. L., Athineos, D., Timpson, P., Vidal, M., Murray, G. I., Greten, F. R., Anderson, K. I. and Sansom, O. J. (2013a). ROS production and NF-kappaB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell 12: 761-773. PubMed ID: 23665120

Continued: Rac References part 2/2

Rac1: Biological Overview | Evolutionary Homologs | Regulation | Developmental Biology | Effects of Mutation

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