Virtual Library-Developmental Biology
This Virtual Library maintained by Society for Developmental Biology.
- Unicellular/Lower Eukaryotes and Prokaryotes
- Melissa Pepling's Lab at Syracuse University studies mouse germ cell development and oogenesis
- Zena Werb's lab at UC San Francisco studies the role of extracellular proteolysis in controlling vascular development and angiogenesis during embryonic development and placental formation, bone development and tumorgenesis.
- Krull Lab at the University of Missouri-Columbia
Cathy Krull's lab studies how the precise patterns of neural circuitry are assembled that underlie functional behaviors, including locomotion, perception, and memory. Specifically, they are interested in cellular and molecular mechanisms that guide motor axons and neural crest to their targets in the periphery.
- Kathryn Tosney's Lab, University of Michigan, Ann Arbor
They study: growth cone motility and guidance; axon guidance, in vivo; muscle differentiation and morphogenesis; neural crest migration; and neural patterning mainly in the chick embryo.
- Claudio Stern's lab studies early development, mainly in the chick embryo. Major current interests are: gastrulation, neural induction and patterning, somite formation.
- Hogan Laboratory at the Vanderbuilt Medical Center
Brigid Hogan's lab focuses on the genetic regulation of inductive tissue interactions in mammalian development by using the mouse as the primary research model.
- The Rossant
Lab, Samuel Lunenfeld Research Institute at the Mount Sinai Hospital
in Toronto, Canada, studies the genetic control of many aspects of early mouse
- Laura Grabel's lab at Wesleyan University studies the role of Integrins in cell migration using EC cells, and the role of Hedgehog genes in early mouse development, using both ES cells and mouse embryos mutant for genes in the hedgehog signalling pathway.
- Hubert Schorle's lab at the University of Bonn - Medical School studies the biology of the transcription factors of the AP-2 family (TFAP2). They generate knockout and transgenic mice in order to address the functional role of AP-2 genes in vertebrate development.
- Rolf Zeller's Laboratory, University of Basel Medical School, Switzerland, studies the molecular basis of cell-cell signalling over time and space in vertebrate embryos. They use predominantly mouse molecular genetics in combination with embryonic manipulation to study the mechanisms which (1) control establishment of the limb bud organiser (polarsing region), (2) morphogenetic signalling and signal relay during limb bud development, (3) the role of cell-cell signalling during CNS development.
- Gary Hunnicutt at the Population Council studies sperm maturation within the epididymis.
- Ramesh Shivdasani's lab, Dana-Farber Cancer Inst./Harvard Med Sch, focuses on the molecular mechanisms of gut development and on how blood platelets are created from megakaryocytes.
- Mark Mercola's lab, Harvard Medical School, works on embryonic heart induction and patterning, left-right asymmetry, and cardiogenesis from stem cells.
- Stephen Duncan's Lab, Medical College of Wisconsin, studies the molecular mechanisms underlying mammalian development.
- The Waschek laboratory, University of California at Los Angeles, investigates the roles and actions of neuropeptides on vertebrate nervous system development and regeneration. Molecular and genetic approaches are used in conjunction with mouse and Xenopus models.
- Michael Ferrari's lab at the University of Missouri Kansas City studies the cellular physiology of muscle development, with a particular focus on calcium regulation of myofibrillogenesis and somitogenesis during skeletal muscle development in Xenopus.
- Soriano Lab at the Fred Hutchinson Cancer Research Center Center in Seattle utilizes a variety of molecular and genetic approaches, including gene trapping and gene targeting, to study growth factor signaling in mouse development.
- John Klingensmith's lab, Department of Cell Biology, Duke University
They study the embryonic organizer and the mechanisms of early pattern
formation in mouse.
Konieczny's Laboratory at Purdue University
His lab is interested in understanding the molecular regulatory circuits that
function during vertebrate development, especially skeletal muscle development.
- Sonia Pearson-White's lab at the University of Virginia studies how cells respond to cues to proliferate or differentiate, using genetic models in mice. They focus on developing and regenerating skeletal muscle and on T cells undergoing activation. They study the regulation of the Ski/Sno gene family, and how these genes negatively regulate TGF-beta signaling.
- The Transgenic/Targeted
Mutation Database (TBASE), Johns Hopkins University School of Medicine
Gene targeting protocols involving homologous recombination in mouse embryonic
stem cells results in a large number of mutant lines with specific phenotypes
and well-defined DNA structural changes. This Web site is a database of transgenic
animals and targeted mutations generated and analyzed worldwide. It also includes
- The Jackson Laboratory
This site has descriptions of all its mouse strains, as well as, supply sources
and information about education related to the role of genetics in health and
- Embryo Images-Normal and Abnormal Mammalian Development is a tutorial that uses scanning electron micrographs (SEMs) as the primary resource to teach mammalian embryology. Kathleen Sulik and Peter Bream at the University of North Carolina at Chapel Hill built this tutorial.
- The Mouse Atlas and Gene Expression Database Project
The UK MRC Human Genetics Unit in Edinburgh is developing a digital atlas of mouse development and database to be a resource for spatially mapped data such as in situ gene expression and cell lineage. The project is in collaboration with the Department of Anatomy, University of Edinburgh. The gene expression database is being developed as part of the Mouse Gene Expression Information Resource (MGEIR) in collaboration with the Jackson Laboratory, USA.
- The Mouse
and Rat Research Home Page
A central location for Internet resources for researchers using mice or rats in
their work. Includes genome information, development, anatomy and physiology,
laboratory suppliers, regulations and legal issues, technical guides and protocols,
and conference announcements.
- The Kline Lab at Kent
Doug Kline's lab focuses on mammalian oocyte maturation, fertilization, and egg
- Trevor Dale's Laboratory
in the Institute of Cancer Research in London, UK
Their research focuses on Wnt signalling and mammary gland development.
- Gary Wessel's PRIMO Site
at Brown University
Their research focuses on the molecular biology of fertilization and early development
in mice, starfish, and sea urchins.
- Sue Ann Miller's lab at Hamilton College studies potential contributions of differential cell division and cell death in early morphogenesis of chick and mouse embryos in order to place an organismal perspective on dynamics of the cell cycle.
- Atlas of Developmental Abnormalities
in Common Laboratory Mammals This website is designed for rapid access to
the image(s) of developmental abnormalities in common laboratory mammals.
- Tom Reh's Laboratory
University of Washington
The focus of our research is examining the mechanisms that control neuronal proliferation
and differentiation during neurogenesis in the vertebrate CNS. To look at these
questions we are using the retina as a model system.
- Jeffrey Miller's Lab, University of Minnesota, studies the mechanism of Wnt signal transduction and the role of Wnt signaling in vertebrate development, using Xenopus as a model system. Their focus is on understanding the role of Wnt signaling in the establishment of the dorsal-ventral axis and in the regulation of cell movements during gastrulation and neuralation.
- Richard Harland's Lab, U.C. Berkeley, focuses on understanding early vertebrate development at the molecular level. They study this problem in both the amphibian Xenopus, and in the mouse. Xenopus embryos are large and easily manipulated, so that the function of various macromolecules, such as RNA and protein, can be assayed by microinjection into living embryos. Functional assays in Xenopus can then be complemented by genetic knockouts in the mouse, to gain fuller understanding of the normal requirements for gene action in the developing embryo.
- Monte Westerfield's laboratory in the Institute of Neuroscience at the University of Oregon studies cell fate specification and patterning using zebrafish.
- Joseph Yost's Lab, Huntsman Cancer Institute at the University of Utah, lab utilizes zebrafish and Xenopus to study Left-Right axis formation in the heart, gut, and brain. These pathways include midline (notochord and neural) development, TGF-beta cell-cell signaling, non-canonical Wnt signaling, and the roles of syndecans in cell signaling, cell migration, fibrillogenesis and heart formation. In addition, we are developing the use of zebrafish genetics to identify modifier genes in cancer development. Collaborative studies extrapolate our results in zebrafish to human genetics, using Utah human genetic databases to discover new genes in cardiovascular development.
- The Lessman Lab at The University of Memphis focuses on oocyte maturation at both the molecular and cell physiology levels. Model systems include: the leopard frog (Rana pipiens), zebrafish (Brachydanio rerio), goldfish (Carassius auratus) and the african clawed frog (Xenopus laevis). At present we are particularly interested in large macromolecular complexes in oocytes.
- Sally Moody's Laboratory
at George Washington University, Washington, DC, studies: the role of maternal
determinant molecules in establishing the dorsal axis/central nervous system;
the identification of the upstream regulatory regions of a neuron-specific
beta-tubulin gene; the determination of amacrine cell fates in the retina;
fate maps in Xenopus laevis.
- Igor Dawid's Lab, National Institute of Child Health and Human Development, is interested in molecular mechanisms underlying differentiation and pattern formation in the early vertebrate embryo, in particular with respect to the establishment of the body pattern at gastrulation. These questions are being pursued in Xenopus laevis and in the zebrafish.
- Elba Serrano's lab, Biology, New Mexico State University, focuses on the development of the nervous system in Xenopus, with an emphasis on the sensory systems responsible for hearing and balance. The lab is interested in mechanosensory hair cell differentiation and innervation during inner ear organogenesis and morphogenesis. As part of this effort the lab studies ion channel expression during acoustico-vestibular development.
- The Sive Lab, in the MIT
Biology Department, studies anteroposterior patterning in the frog Xenopus laevis
and the fish Danio Rerio.
- Sue Bryant's Laboratory in
the Department of Developmental and Cell Biology, University of California, Irvine.
Their area of research is pattern formation in regenerating and developing vertebrate
- Xenopus Research at the
Sokol Lab Their research is focused on different aspects of signal transduction
during patterning in the frog, Xenopus laevis.
- Randy Moon's Lab at the University of Washington works on the mechanisms of signal transduction by the Wnt gene family, and the functions of these signaling pathways during development in Xenopus and zebrafish. These functions include specification of the dorsal-ventral axis following fertilization, and specification of cell fate in the nervous system.
- The stages of Xenopus embryonic development. Pictures from The Normal Table of Xenopus Laevis (Daudin), Pieter D Nieuwkoop and J. Faber (Eds).
- Xenopus Molecular Marker Resource Peter Vize maintains this site for access
to information on molecular markers used in research with Xenopus embryos. There
are also useful anatomical figures and the Nieuwkoop and Faber stage series at
- Bill Wasserman's Lab
at Loyola University Chicago His research is on molecular events in amphibian
oocytes that prepare them for fertilization and subsequent embryonic development.
- Leon Browder's Lab
at the University of Calgary His lab works on the mechanisms that control
protein synthesis during oogenesis and early embryonic development of Xenopus
- The Spitzer Lab at UC San Diego focuses on the question, what are the mechanisms by which neurons differentiate to achieve the spectacular complexity of the brain? Voltage-dependent ion channels and neurotransmitter receptors are expressed at early stages of development, substantially before synapse formation, suggesting that ion channel activity participates in signal transduction that directs subsequent steps of development. They want to understand the mechanisms of generation of spontaneous calcium transients and the mechanisms by which they exert their effects, and at determining the molecular basis of regulation of potassium currents.
- Christof Niehrs's
lab at the German Cancer Research Center in Heidelberg studies the molecular biology
of early embryogenesis in Xenopus laevis. The major focus is on Spemann-organizer
function and mesodermal patterning.
- Jonathan Slack's
laboratory at the University of Bath is part of a Developmental Biology Programme
working on Xenopus, mouse and zebrafish.
- The Gard Lab, Department of
Biology, University of Utah.
They study cytoskeletal organization during oogenesis and early development in
- The Sánchez Laboratory
They study the molecular events that lead to pattern formation in amphibian and
- FishScope A WWW archive
of time-lapse recordings and confocal images of developing fish and other aquatic
organisms from the lab of Mark Cooper at the University of Washington.
- Stainier Lab at UC San Francisco
They take a genetic approach in zebrafish to study vertebrate endoderm, heart and blood vessel formation and function. They are working with several mutations that affect distinct aspects of endodermal and/or cardiovascular development.
- Zebrafish Information Server This Zebrafish
WWW server is for the Zebrafish Research Community; it's maintained at the University
of South Carolina.
- The Erez Raz Lab, MPI for Biophysical Chemistry, Germany, studies primordial germ cell development in zebrafish.
- The Raymond Laboratory, Department of Anatomy and Cell Biology, University of Michigan, Ann Arbor, studies the development and regeneration of the vertebrate retina using both goldfish and zebrafish as model systems. They are especially interested in neurogenesis (the formation of neurons) and neuronal specificity (the expression of differentiated cellular features).
- Walter Gilbert Laboratory,
Harvard Biolabs The zebrafish (Brachydanio rerio) is a small aquarium fish
used as a model system for vertebrate developmental biology.
- THE FISH NET--An access to Zebrafish Research
Databases A service to the zebrafish research community provided by the Institute
of Neuroscience at the University of Oregon.
- THE ZEBRAFISH
BOOK A guide for the laboratory use of zebrafish, Danio rerio
- The Brant Weinstein
Lab at NIH
They study the embryonic origins of the vertebrate circulatory system, using the
zebrafish as their experimental system.
- The Brand Lab at the Max Planck Institute, Dresden, studies the establishment of neuronal cell diversity in the zebrafish neural plate.
- MEDAKAFISH HOMEPAGE The
aim of this server is to provide an online information service for MF reseachers.
Includes images of Medaka development.
- Indiana University
Axolotl Colony The IU Axolotl Colony is a genetic stock center for the Mexican
axolotl (Ambystoma mexicanum) supported by the National Science Foundation.
This Web site provides information about the axolotl and about the services offered
by the Axolotl Colony.
- The Ettensohn Lab, Carnegie Mellon, studies early patterning and morphogenetic cell movements in sea urchin embryos.
- The McGinnis Lab, Department of Biology, UC San Diego, works on the evolutionary origins of Hox proteins. A long term objective of their research is to understand the molecular interactions that underlie functional specificity in the Hox patterning system.
- Ethan Bier's Lab at UC San Diego is interested in how the Dpp and EGF-R signaling pathways interact to define the neurogenic region of the Drosophila blastoderm embryo, and how these two pathways then collaborate to promote wing vein development during early metamorphosis. They use a combination of molecular and genetic approaches to investigate these developmental questions.
- Chris Doe's Lab in the Institute of Neuroscience and Institute of Molecular Biology at the University of Oregon works on neural patterning, neural stem cells, and neural cell lineage in Drosophila.
- The Carroll Lab at the University of Wisconsin, Madison has several foci: the elaboration of the developmental genetics underlying wing formation in Drosophila, the use of hox genes across animal phyla; and the patterning and prepatterning of butterfly wing color patterns.
- Tumor Suppressor Genes in Drosophila and Their Human Homologs; Genetics of Development in Drosophila The objective of research in Peter J. Bryant's laboratory (UC Irvine) is to understand how cell proliferation is controlled during development, and how genetic mutations lead to growth abnormalities and cancer. They approach this problem using a genetic approach in Drosophila, by identifying and characterizing tumor suppressor genes, in which mutations cause excessive cell proliferation in the developing organs of mutant larvae. Efforts from this lab and others have led to the identification of over 60 of these genes, and over 20 of them have been cloned. Almost all of them have human homologs whose potential roles in cancer are now being investigated.
- The GIFTS Server (Gene Interactions in the Fly Transworld Server) is a Web server which is mainly devoted to offer resources (databases, references, useful links) to people interested in molecular and genetic interactions. It is the home of GIF_DB (Gene Interactions in the Fly database), a new database of gene interactions involved in Drosophila pattern formation and development.
- The Interactive Fly--A cyberspace guide to Drosophila genes and their roles in development.
- World-Wide Web Virtual Library: Drosophila
- FlyBase is a database of genetic and molecular data for Drosophila
- FlyView is a Drosophila image database
- FlyBrain, an online atlas and database of the Drosophila nervous system
- Berkeley Drosophila Genome Project (BDGP) They are building an Encyclopaedia of Drosophila, that's a collaborative effort of the BDGP and FlyBase. A Genome Borwser and Annotated Sequence Viewer is coming soon to their site.
- Wnt Genes in Drosophila Roel Nusse's lab at Stanford University studies the role of the highly conserved Wnt genes in development. Wnt gene mutations affect many biological processes and Nusse's lab studies how they affect the segmentation of Drosophila embryos, as seen in Drosophila embryos mutant for the segment polarity gene, wingless. His lab studies the genetics and biochemistry of wingless in Drosophila.
- Howard Lipshitz's Lab, Sick Children & Univ. Toronto, research focuses on mechanisms of cytoplasmic RNA localization and the genetic control of morphogenesis using Drosophila as a model.
- J.A. Campos-Ortega's Lab studies the cellular, genetic and molecular bases of neurogenesis in Drosophila and the zebra fish.
- A.Martinez Arias's research group in The Department of Zoology at the University of Cambridge, Cambridge (UK). Their main interest is the role of cell interactions in pattern formation. Their studies focus on the genes wingless and Notch and they use Drosophila as a model system.
- Gary Wessel's PRIMO Site at Brown University
Their research focuses on the molecular biology of fertilization and early development in mice, starfish, and sea urchins.
- UrchiNet contains information on the function and regulation of genes controlling development in the sea urchin Strongylocentrotus purpuratus. There's information on 50 genes, 26 regulatory regions and 23 gene interactions.
- BioMarCell, a site about reproduction , fertilization and development of sea urchins, ascidians, cnidarians, ctenophores, and chaetognaths.
- Marine Models Electronic Record A peer-reviewed electronic journal and database on aquatic organisms of special value in biomedical research, published by the Marine Biological Laboratory, Woods Hole, MA. Not all articles are developmentally relevant, but some are and many future articles will be.
- Sea Urchin Embryology. This site presents a set of laboratory modules that use sea urchins to demonstrate fertilization and early development. Developed for use in courses for high school, junior college, or lower division college biology labs, the site presents comprehensive resources including lab exercises, overheads and handouts, and extra information for the instructor.
- The Epel Lab at Hopkins Marine Station David Epel's lab works on fertilization and how developmental programs in eggs are initiated. Besides the work going on in Dave Epel's lab, there are also links to several other sea urchin development labs.
- The Sánchez Laboratory, studies the molecular events that lead to pattern formation in amphibian and planarian regeneration.
- Cnidaria WWW Server, maintained by Rob Steele at UC Irvine - is a site for researchers who use cnidarians as research systems. This site also includes a link to the Cnidaria Newsgroup.
- Thomas C.G. Bosch's Developmental Biology of Cnidarians Lab Website. Their research focuses on cellular and molecular aspects of pattern formation and cell differentiation in Cnidaria.
- Bob Goldstein's Lab, University of North Carlina-Chapel Hill, focuses on the the early development in C. elegans. This site includes C. elegans movies and links to movies made by C. elegans researchers worldwide.
- Geraldine Seydoux's Lab, Johns Hopkins University, focuses on the mechanisms that establish embryonic polarity and germ cell fate in the C. elegans embryo.
- C. elegans Movies A visual introduction to C. elegans and its development. This page has links to timelapse movies made by C. elegans researchers worldwide. For more information about worms, see the C. elegans web page. Contents include: Embryos; RNAi Screens; Larvae and Adults; Techniques
- Bill Wood's Lab in the Department of Molecular, Cellular, and Developmental Biology at the University of Colorado, Boulder, studies the mechanisms by which cell fates and patterns are determined during embryonic development of the nematode Caenorhabditis elegans, using techniques of genetics, cell biology, and molecular biology.
- Jeff Hardin's Lab at the University of Wisconsin, Madison
The Hardin Lab focuses on two major questions: how do cell sheets change shape during morphogenetic movements, and how do freely migrating cells make attachments to specific locations in the embryo? We are using two experimental systems to study these events: (1) The embryonic epidermis, or hypodermis, of the nematode, C. elegans, and (2) the archenteron of the sea urchin gastrula.
- The Strome Lab The research focus of the Strome Lab is on how one-cell embryos generate the diverse array of different tissue types seen in adult organisms. In the nematode, Caenorhabditis elegans, as in many species, this process is guided mainly by maternally supplied factors. They are taking advantage of the powerful genetics available in C. elegans to identify some of the maternal components required for the specification and development of a specific cell type, the germ line.
- Michael Herman's lab, Kansas State University, studies how cell polarity is established and controlled during metazoan development, using the free-living soil nematode Caenorhabditis elegans as a model. As cellular asymmetry is estabished, orientation to the body axis of an animal gives each cell a polarity. It is important both for cells that divide asymmetrically to generate different kinds of daughter cells, and for cells that migrate to be oriented to the body axis.
- Caenorhabditis elegans WWW Server. This Web site contains information useful to those in the C. elegans community. It provides a searchable index of worm literature, including The "Worm Breeder's Gazette," a collection of abstracts about worm development, a list of C. elegans meetings, postdoc position announcements, and links to other C. elegans resources.
- Wormworld, the Kenyon lab at U.C.S.F.'s WWW server
- Wadsworth's Wonderful Worms This is a research laboratory studying developmental neurobiology and the extracellular matrix. The nematode, Caenorhabditis elegans, is used as a model animal for genetic and molecular biology studies. The site includes self-scoring quizes, worm cartoons, and animations for java enabled browsers.
- WormBase is a repository of mapping, sequencing and phenotypic information about the C. elegans nematode.
- Victor Ambros Lab: Developmental Genetics of C. elegans
- Juergen Buening's Lab, University of Erlangen-Nuremberg. The research interests of the Juergen Buening Lab are comparative studies of insect ovaries focussing on early oogenesis, analysis of insect phylogeny and Drosophila oogenesis as a model system..
- Mary Lee Sparling's lab, Calif State Univ Northridge, investigates changes in cell membranes at fertilization and early development, involving lipids and lipid altering enzymes.
Unicellular/Lower Eukaryotes and Prokaryotes
- David Knecht's Dictyostelium Movies
- Mandoli Lab at the University of Washington
They use genetics, physiology, cell biology and, photobiology to understand how Acetabularia (the Mermaid's Wineglass) makes and maintains its elaborate architecture in the absence of cell division.
- Stephen Alexander's laboratory at the University of Missouri uses Dictyiostelim discoideum as a model system for studies on: 1. molecular and cellular mechanisms of resistance to anticancer drugs; 2. regulation of protein secretion during development.
- The Dictyostelium (Cellular Slime Mold) Virtual Library Home Page
- Ira Herskowitz's Yeast Genetics Lab Web site at the University of California San Francisco has protocols, research abstracts, news & views, addresses, and many links to other sites.
- Virtual Library for Yeast
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