EGF receptor

REFERENCES (part 2/2)

Nagaraj, R., et al. (1999). Role of EGF receptor pathway in the growth and patterning of the Drosophila wing through the regulation of vestigial. Development 126: 975-985. Medline abstract: 9927598

Nagaraj, R. and Banerjee, U. (2007). Combinatorial signaling in the specification of primary pigment cells in the Drosophila eye. Development 134(5): 825-31. Medline abstract: 17251265

Nakagawa, T., et al. (2005). Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGFalpha family ligands. Dev. Dyn. 233: 1315-1331. PubMed Citation: 15965977

Naylor, S. A. and Diantonio, A. (2011). EGFR signaling modulates synaptic connectivity via Gurken. Dev. Neurobiol. [72(9): 1229-42. PubMed Citation: 22021126

Neubueser, D. and Hipfner, D. R. (2010). Overlapping roles of Drosophila Drak and Rok kinases in epithelial tissue morphogenesis. Mol Biol Cell 21: 2869-2879. PubMed ID: 20573980

Newman, A. P. and Sternberg, P. W. (1996). Coordinated morphogenesis of epithelia during development of the Caenorhabditis elegans uterine-vulva connection. Proc. Natl. Acad. Sci. 93: 9329-33. PubMed Citation: 8790329

Neuman-Silberberg, F. S. and Schupbach, T. (1993). The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGF alpha-like protein. Cell 75: 165-74. PubMed Citation: 7691414

Nestoras, K., Lee, H. and Mohler, J. (1997). Role of knot (kn) in wing patterning in Drosophila. Genetics 147(3): 1203-1212. PubMed Citation: 9383063

Niepielko, M. G. and Yakoby, N. (2014). Evolutionary changes in TGFalpha distribution underlie morphological diversity in eggshells from Drosophila species. Development 141: 4710-4715. PubMed ID: 25468939

Odintsova, E., Sugiura, T. and Berditchevski, F. (2000). Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1. Curr. Biol. 10: 1009-1012. 10985391

Ogiso, H., et al. (2002). Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell 110: 775-787. 12297050

Oishi, K., et al. (2006). Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations. Hum. Mol. Genet. 15(4): 543-53. 16399795

O'Keefe, L., et al. (1997). Spitz and Wingless, emanating from distinct borders, cooperate to establish cell fate across the Engrailed domain in the Drosophila epidermis. Development 124(23): 4837-45. PubMed Citation: 9428420

Ou, C.-Y., Lin, Y.-F. Chen, Y.-J. and Chien, C.-T. (2002). Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. Genes Dev. 16: 2403-2414. PubMed Citation: 12231629

Pai, L. M., et al. (2006). Differential effects of Cbl isoforms on Egfr signaling in Drosophila. Mech. Dev. 123(6): 450-62. 16844358

Palka, H. L., Park, M. and Tonks, N. K. (2003). Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1. J. Biol. Chem. 278: 5728-5735. PubMed Citation: 12475979

Pallavi, S. K. and Shashidhara, L. S. (2003). Egfr/Ras pathway mediates interactions between peripodial and disc proper cells in Drosophila wing discs. Development 130: 4931-4941. 12930782

Pallavi, S. K., Kannan, R. and Shashidhara, L. S. (2006). Negative regulation of Egfr/Ras pathway by Ultrabithorax during haltere development in Drosophila. Dev. Biol. 296(2): 340-52. Medline abstract: 16815386

Palsson, A. and Gibson, G. (2004). Association between nucleotide variation in Egfr and wing shape in Drosophila melanogaster. Genetics 167(3): 1187-98. 15280234

Parrott, B. B., Hudson, A., Brady, R. and Schulz, C. (2012). Control of germline stem cell division frequency--a novel, developmentally regulated role for epidermal growth factor signaling. PLoS One 7(5): e36460. PubMed Citation: 22586473

Porfiri, E. and McCormick, F. (1996). Regulation of epidermal growth factor receptor signaling by phosphorylation of the ras exchange factor hSOS1. J. Biol. Chem. 271: 5871-5877. PubMed Citation: 8621459

Poulton, J. S. and Deng, W. M. (2006). Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyte. Proc. Natl. Acad. Sci. 103(34): 12775-80. Medline abstract: 16908845

Povlsen, G. K., Berezin, V. and Bock, E. (2008). Neural cell adhesion molecule-180-mediated homophilic binding induces epidermal growth factor receptor (EGFR) down-regulation and uncouples the inhibitory function of EGFR in neurite outgrowth. J. Neurochem. 104: 624-639. PubMed Citation: 17995934

Price, J. V., Clifford, R.J. and Schupbach, T. (1989). The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog. Cell 56: 1085-1092. PubMed Citation: 2493993

Price, J. V., et al. (1997). Dominant enhancers of Egfr in Drosophila melanogaster: genetic links between the Notch and Egfr signaling pathways. Genetics 147(3): 1139-1153. PubMed Citation: 9383058

Prober, D. A. and Edgar, B. A. (2002). Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing. Genes Dev. 16: 2286-2299. 12208851

Qiu, C., et al. (2008). Mechanism of activation and inhibition of the HER4/ErbB4 kinase. Structure 16: 460-467. PubMed Citation: 18334220

Queenan, A. M., Ghabrial, A. and Schupbach, T. (1997). Ectopic activation of torpedo/Egfr, a Drosophila receptor tyrosine kinase, dorsalizes both the eggshell and the embryo. Development 124(19): 3871-3880. PubMed Citation: 9367443

Radke, K., Johnson, K., Guo, R., Davidson, A. and Ambrosio, L. (2001). Drosophila-raf acts to elaborate dorsoventral pattern in the ectoderm of developing embryos. Genetics 159(3): 1031-44. PubMed citation: 11729151

Ramanan, N., et al. (2005). SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability. Nat. Neurosci. 8(6): 759-67. PubMed Citation: 15880109

Rappl, A., Piontek, G. and Schlegel, J. (2008). EGFR-dependent migration of glial cells is mediated by reorganisation of N-cadherin. J. Cell Sci. 121(Pt 24): 4089-97. PubMed Citation: 19033391

Rawlins, E. L., White, N. M. and Jarman, A. P. (2003), Echinoid limits R8 photoreceptor specification by inhibiting inappropriate EGF receptor signalling within R8 equivalence groups. Development 130: 3715-3724. 12835388

Ray, R. P. and Schüpbach, T. (1996). Intracellular signaling and the polarization of body axes during Drosophila oogenesis. Genes Dev. 10: 1711-23. PubMed Citation: 8698232

Raz, E. and Shilo, B. Z. (1993). Establishment of ventral cell fates in the Drosophila embryonic ectoderm requires DER, the EGF receptor homolog. Genes Dev 7: 1937-48. PubMed Citation: 8406000

Reddy, B. V., Rauskolb, C. and Irvine, K. D. (2010). Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia. Development 137(14): 2397-408. PubMed Citation: 20570939

Reich, A. and Shilo, B. Z. (2002). Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage. EMBO J. 21: 4287-4296. PubMed Citation: 12169631

Reichman-Fried, M., et al. (1994). Elucidation of the role of breathless, a Drosophila FGF receptor homolog, in tracheal cell migration. Genes Dev. 8: 428-39. PubMed Citation: 8125257

Reneker, L. W., et al. (1995). TGF alpha can act as a chemoattractant to perioptic mesenchymal cells in developing mouse eyes. Development 121: 1669-1680. PubMed Citation: 7600984

Ribeiro, C., Ebner, A. and Affolter, M. (2002). In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis. Dev. Cell 2: 677-683. 12015974

Richardson, G. D., et al. (2009). KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin Development 136: 2153-2164. PubMed Citation: 19474150

Rimer, M., et al. (2004). Neuregulin-2 is synthesized by motor neurons and terminal Schwann cells and activates acetylcholine receptor transcription in muscle cells expressing ErbB4. Mol. Cell. Neurosci. 26(2): 271-81. 15207852

Robertson, F., Pinal, N., Fichelson, P. and Pichaud, F. (2012). Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis. Development 139: 3432-3441. PubMed ID: 22874916

Roch, F., et al. (1998). Genetic interactions and cell behaviour in blistered mutants during proliferation and differentiation of the Drosophila wing. Development 125(10): 1823-1832. PubMed Citation: 9550715

Roch, F., Jiménez, G. and Casanova, J. (2002). EGFR signalling inhibits Capicua-dependent repression during specification of Drosophila wing veins. Development 129: 993-1002. 11861482

Rodrigues, A. B., Werner, E. and Moses, K. (2005). Genetic and biochemical analysis of the role of Egfr in the morphogenetic furrow of the developing Drosophila eye. 132(21): 4697-707. 16207755

Rogge, R., et al. (1995). The role of yan in mediating the choice between cell division and differentiation. Development 121: 3947-3958. PubMed Citation: 8575295

Rohrbaugh, M., et al. (2002). Notch activation of yan expression is antagonized by RTK/Pointed signaling in the Drosophila eye. Curr. Biol. 12: 576-581. 11937027

Rosen, L. B. and Greenberg, M. E. (1996). Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels. Proc. Natl. Acad. Sci. 93: 1113-1118. PubMed Citation: 8577724

Roth, S. and Schupbach, T. (1994). The relationship between ovarian and embryonic dorsoventral patterning in Drosophila. Development 120: 2245-2257. PubMed Citation: 7925025

Roth, S., et al. (1995). cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila. Cell 81: 967-978. PubMed Citation: 7540118

Rozakis-Adcock, M., et al. (1993). The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Nature 363: 83-85. PubMed Citation: 8479540

Ruhe, J. E., Streit, S., Hart, S. and Ullrich, A. (2006). EGFR signaling leads to downregulation of PTP-LAR via TACE-mediated proteolytic processing. Cell Signal. [Epub ahead of print]. 16478662

Ruohola-Baker, H., et al. (1993). Spatially localized rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis. Cell 73: 953-65. PubMed Citation: 8500182

Sapir, A., Schweitzer, R. and Shilo, B. Z. (1998). Sequential activation of the EGF receptor pathway during Drosophila oogenesis establishes the dorsoventral axis. Development 125(2): 191-200. PubMed Citation: 9486793

Sardi, S. P., Murtie, J., Koirala, S., Patten, B. A. and Corfas, G. (2006). Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell 127: 185-197. PubMed Citation: 17018285

Sarkar, A., et al. (2007). Antagonistic roles of Rac and Rho in organizing the germ cell microenvironment. Curr. Biol. 17(14): 1253-8. PubMed citation: 17629483

Sasaoka, T., et al. (1994). The signaling pathway coupling epidermal growth factor receptors to activation of p21ras. J. Biol. Chem. 269: 32621-5. PubMed Citation: 7798267

Sato, M. and Kornberg, T. B. (2002). FGF is an essential mitogen and chemoattractant for the air sacs of the Drosophila tracheal system. Dev. Cell 3: 195-207. 12194851

Sawamoto, K., Yamada, C., Kishida, S., Hirota, Y., Taguchi, A., Kikuchi, A. and Okano, H. (1999). Ectopic expression of constitutively activated Ral GTPase inhibits cell shape changes during Drosophila eye development. Oncogene 18: 1967-1974. 10208418

Sawano, A., et al. (2002). Lateral propagation of EGF signaling after local stimulation is dependent on receptor density. Dev. Cell 3: 245-257. 12194855

Schejter, E. D., et al. (1986). Alternative 5' exons and tissue-specific expression of the Drosophila EGF receptor homolog transcripts. Cell 46: 1091-1101. PubMed Citation: 3093080

Schmidt, M. H., Hoeller, D., Yu, J., Furnari, F. B., Cavenee, W. K., Dikic, I. and Bogler, O. (2004). Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. Mol. Cell. Biol. 24: 8981-8993. PubMed Citation: 15456872

Schnepp, B., et al. (1996). Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. Genes Dev. 10: 2302-13. PubMed Citation: 8824589

Schober, M., Rebay, I. and Perrimon. N. (2005). Function of the ETS transcription factor Yan in border cell migration. Development 132(15): 3493-504. 16014514

Schoenherr, J. A., et al. (2012). Drosophila activated Cdc42 kinase has an anti-apoptotic function. PLoS Genet. 8(5): e1002725. PubMed ID: 22615583

Scholz, H., et al. (1997). Control of midline glia development in the embryonic Drosophila. Mech. Dev. 62: 79-91. PubMed Citation: 9106169

Schulz, C., et al. (2002). Signaling from germ cells mediated by the rhomboid homolog stet organizes encapsulation by somatic support cells. Development 129: 4523-4534. 12223409

Schweitzer, R., et al. (1995). Inhibition of Drosophila EGF receptor activation by the secreted protein Argos. Nature 376: 699-702. PubMed Citation: 7651519

Sen, A., Kuruvilla, D., Pinto, L., Sarin, A. and Rodrigues, V. (2004). Programmed cell death and context dependent activation of the EGF pathway regulate gliogenesis in the Drosophila olfactory system. Mech. Dev. 121: 65-78. 14706701

Shamloula, H. K., et al. (2002). rugose (rg), a Drosophila A kinase anchor protein, is required for retinal pattern formation and interacts genetically with multiple signaling pathways. Genetics 161(2): 693-710. 12072466

Sheikh, M. S., et al. (1997). Identification of an additional p53-responsive site in the human epidermal growth factor receptor gene promotor. Oncogene 15(9): 1095-1101. PubMed Citation: 9285564

Shelly, M., et al. (2003). Polar expression of ErbB-2/HER2 in epithelia: bimodal regulation by Lin-7. Dev. Cell 5: 475-486. 12967566

Sibilia, M., et al. (1998). A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor. EMBO J. 17: 719-731. PubMed Citation: 9450997

Sibilia, M., et al. (2000). The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Cell 102: 211-220. PubMed Citation: 10943841

Sibilia, M., et al. (2003). Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart. Development 130: 4515-4525. 12925580

Sieglitz, F., Matzat, T., Yuva-Adyemir, Y., Neuert, H., Altenhein, B. and Klambt, C. (2013). Antagonistic feedback loops involving rau and sprouty in the Drosophila eye control neuronal and glial differentiation. Sci Signal 6: ra96. PubMed ID: 24194583

Sigismund, S., Woelk, T., Puri, C., Maspero, E., Tacchetti, C., Transidico, P., Di Fiore, P. P. and Polo, S. (2005). Clathrin-independent endocytosis of ubiquitinated cargos. Proc. Natl. Acad. Sci. USA 102: 2760-2765. 15701692

Sigismund, S., et al. (2008). Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation. Dev. Cell 15: 209-219. PubMed Citation: 18694561

Simoes Sde, M., Blankenship, J. T., Weitz, O., Farrell, D. L., Tamada, M., Fernandez-Gonzalez, R. and Zallen, J. A. (2010). Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation. Dev Cell 19: 377-388. PubMed ID: 20833361

Skeath, J. B. (1998). The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of the Drosophila embryo. Development 125(17): 3301-3312

Sonnenfeld, M. J., Barazesh, N., Sedaghat, Y. and Fan, C. (2004). The jing and ras1 pathways are functionally related during CNS midline and tracheal development. Mech. Dev. 121: 1531-1547. 15511644

Sorkin, A., et al. (2000). Interaction of EGF receptor and Grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy. Curr. Biol. 10: 1395-1398. 11084343

Sotillos, S. and Campuzano, S. (2000). DRacGAP, a novel Drosophila gene, inhibits Egfr/Ras signaling in the developing imaginal wing disc. Development 127: 5427-5438.

Soubeyran, P., et al. (2002). Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. Nature 416: 183-187. 11894095

Spencer, S. A., et al. (1998). Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina. Development 125: 4777-4790

Spencer, S. A. and Cagan, R. L. (2003). Echinoid is essential for regulation of Egfr signaling and R8 formation during Drosophila eye development. Development 130: 3725-3733. 12835389

Stamos, J., Sliwkowski, M. X. and Eigenbrot, C. (2002). Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. J. Biol. Chem. 277: 46265-46272. PubMed Citation: 12196540

Stemerdink, C. and Jacobs, J. R. (1997). Argos and Spitz group genes function to regulate midline glial cell number in Drosophila embryos. Development 124(19): 3787-3796

Stephan, R., Grevelhörster, A., Wenderdel, S., Klämbt, C. and Bogdan, S. (2008). Abi induces ectopic sensory organ formation by stimulating EGFR signaling. Mech. Dev. 125(3-4): 183-95. PubMed Citation: 18221859

Strand, M. and Micchelli, C. A. (2013). Regional control of Drosophila gut stem cell proliferation: EGF establishes GSSC proliferative set point & controls emergence from quiescence. PLoS One 8: e80608. PubMed ID: 24236188

Sturtevant, M. A, Bier E (1995). Analysis of the genetic hierarchy guiding wing vein development in Drosophila. Development 121(3): 785-801

Sudarsan, V., et al. (2002). A genetic hierarchy establishes mitogenic signaling and mitotic competence in the renal tubules of Drosophila. Development 129: 935-944. 11861476

Sullivan, K. M. C. and Rubin, G. M. (2002). The Ca2+-calmodulin-activated protein phosphatase calcineurin negatively regulates Egf receptor signaling in Drosophila development. Genetics 161: 183-193. 12019233

Sun, Y., Goderie, S. K. and Temple, S. (2005). Asymmetric distribution of EGFR receptor during mitosis generates diverse CNS progenitor cells. Neuron 45(6): 873-86. 15797549

Szuts, D., Freeman, M. and Bienz, M. (1997). Antagonism between EGFR and Wingless signalling in the larval cuticle of Drosophila. Development 124(16): 3209-3219

Szuts, D., Eresh, S. and Bienz, M. (1998). Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction. Genes Dev. 12(13): 2022-2035.

Szuts, D., and Bienz, M. (2000). An autoregulatory function of Dfos during Drosophila endoderm induction. Mech. Dev. 98: 71-76.

Tang, J., Feng, G. S. and Li, W. (1997). Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor. Oncogene 15(15): 1823-1832

Tarcic, G., Boguslavsky, S. K., Wakim, J., Kiuchi, T., Liu, A., Reinitz, F., Nathanson, D., Takahashi, T., Mischel, P. S., Ng, T. and Yarden, Y. (2009). An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis. Curr Biol 19: 1788-1798. PubMed ID: 19836242

Thiel, K. W. and Carpenter, G. (2007). Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation. Proc. Natl. Acad. Sci. 104: 19238-19243. PubMed Citation: 18042729

Thien, C. B. F., Walker, F. and Langdon, W. Y. (2001). RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation. Molec. Cell 7: 355-365

Tio, M., Ma, C. and Moses, K. (1994). spitz, a Drosophila homolog of transforming growth factor-alpha, is required in the founding photoreceptor cells of the compound eye facets. Mech Dev 48: 13-23

Tran, D. D. (2003). CAML is required for efficient EGF receptor recycling. Dev. Cell 5: 245-256. 12919676

Toyooka, S., Ouchida, M., Jitsumori, Y., Tsukuda, K., Sakai, A., Nakamura, A., Shimizu, N. and Shimizu, K. (2000). HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3. Biochem. Biophys. Res. Commun. 278: 671-678. PubMed Citation: 11095967

Udolph G., et al. (1998). Differential effects of EGF receptor signalling on neuroblast lineages along the dorsoventral axis of the Drosophila CNS. Development 125(17): 3291-3299

Urban, S., Brown, G. and Freeman, M. (2004). EGF receptor signalling protects smooth-cuticle cells from apoptosis during Drosophila ventral epidermis development. Development 131: 1835-1845. 15084467

Van Buskirk, C. and Sternberg, P. W. (2007). Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans. Nature Neurosci. 10: 1300-1307. Medline abstract: 17891142

Van Buskirk C. and Sternberg P. W. (2007). Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans. Nat. Neurosci. 10: 1300-1307. PubMed Citation: 17891142

van de Poll, M. L., et al. (1997). Insertion of Argos sequences into the B-loop of epidermal growth factor results in a low-affinity ligand with strong agonistic activity. Biochemistry 36(24): 7425-7431. PubMed Citation: 9200690

van der Heyden, M. A., et al. (1997a). The actin binding domain of the epidermal growth factor receptor is required for EGF-stimulated tissue invasion. Exp. Cell Res. 234(2): 521-526. PubMed Citation: 9260923

van der Heyden, M. A., et al. (1997b). Epidermal growth factor-induced activation and translocation of c-Src to the cytoskeleton depends on the actin binding domain of the EGF-receptor. Biochim. Biophys. Acta 1359(3): 211-221. PubMed Citation: 9434127

Von Ohlen, T. and Doe, C. Q. (2000). Convergence of Dorsal, Dpp, and Egfr signaling pathways subdivides the Drosophila neuroectoderm into three dorsal-ventral columns. Dev. Biol. 224: 362-372. PubMed Citation: 10926773

Wahlström, G., Norokorpi, H. L. and Heino, T. I. (2006). Drosophila alpha-actinin in ovarian follicle cells is regulated by EGFR and Dpp signalling and required for cytoskeletal remodelling. Mech. Dev. 123(11): 801-18. PubMed citation: 17008069

Wappner, P., Gabay, L. and Shilo, B. Z. (1997). Interactions between the EGF receptor and DPP pathways establish distinct cell fates in the tracheal placodes. Development 124(22): 4707-4716

Walker, F., et al. (1998). Activation of the Ras/Mitogen-activated protein kinase pathway by kinase-defective Epidermal growth factor receptors results in cell survival but not proliferation. Mol. Cell. Biol. 18(12): 7192-7204

Wang, S.-H., Simcox, A. and Campbell, G. (2000). Dual role for Drosophila epidermal growth factor receptor signaling in early wing disc development. Genes Dev. 14: 2271-2276.

Wang, X., He, L., Wu, Y. I., Hahn, K. M. and Montell, D. J. (2010). Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo. Nat. Cell Biol. 12: 591-597. PubMed Citation: 20473296

Ward, C. W., et al. (1996). Systematic mapping of potential binding sites for Shc and Grb2 SH2 domains on insulin receptor substrate-1 and the receptors for insulin, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor. J. Biol. Chem. 271(10): 5603-9

Ware, M. F., et al. (1997). Overexpression of cellular Src in fibroblasts enhances endocytic internalization of epidermal growth factor receptor. J. Biol. Chem. 272(48): 30185-30190

Wasserman, J. D. and Freeman, M. (1998). An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg. Cell 95(3): 355-64

Waterman, H., et al. (2002). A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling EMBO J. 21: 303-313. 11823423

Weber, U., Eroglu, C. and Mlodzik, M. (2003). Phospholipid membrane composition affects EGF Receptor and Notch signaling through effects on endocytosis during Drosophila development. Dev. Cell 5: 559-570. 14536058

Whitfield, C. W., et al. (1999). Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10. Mol. Biol. Cell 10: 2087-2100

Wiesen, J. F., et al. (1999). Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development. Development 126(2): 335-344

Wilde, A., et al. (1999). EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Cell 96(5): 677-87

Williams, E. J., et al. (1997). Selective inhibition of growth factor-stimulated mitogenesis by a cell-permeable Grb2-binding peptide. J. Biol. Chem. 272(35): 22349-22354

Wood, E. R. et al. (2008). 6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases. Proc. Natl. Acad. Sci. 105: 2773-2778. PubMed Citation: 18287036

Xie H., et al. (1998). EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLC(gamma) signaling pathway. J. Cell Sci. 111(5): 615-624. PubMed Citation: 9454735

Xu, N., et al. (2011). EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells. Dev. Biol 354(1): 31-43. PubMed Citation: 21440535

Yagi, Y. and Hayashi, S. (1997). Role of the Drosophila EGF receptor in determination of the dorsoventral domains of escargot expression during primary neurogenesis. Genes Cells 2(1): 41-53

Yagi, Y., Suzuki, T. and Hayashi, S. (1998). Interaction between Drosophila EGF receptor and vnd determines three dorsoventral domains of the neuroectoderm. Development 125(18): 3625-3633

Yajnik, V., et al. (1996). Identification of residues within the SHC phosphotyrosine binding/phosphotyrosine interaction domain crucial for phosphopeptide interaction. J. Biol. Chem. 271 (4): 1813-1816

Yamaguchi, M., et al. (1995). Opposite effects of transforming growth factor alpha and epidermal growth factor on mouse placental lactogen I secretion. Proc. Natl. Acad. Sci. 92: 2830-4

Yamauchi, T., et al. (1997). Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone. Nature 389(6655): 91-96

Yan, Z., Zou, H., Tian, F., Grandis, J. R., Mixson, A. J., Lu, P. Y. and Li, L. Y. (2008). Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth. Mol. Cancer Ther. 7: 1355-1364. PubMed Citation: 18524845

Yang, L. and Baker, N. E. (2001). Role of the EGFR/Ras/Raf pathway in specification of photoreceptor cells in the Drosophila retina. Development 128: 1183-1191. 11245584

Yang, L. and Baker, N. E. (2003). Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye. Developmental Cell 4: 359-369. 12636917

Yarnitzky, T., Min, L. and Volk, T. (1997). The Drosophila neuregulin homolog vein mediates inductive interactions between myotubes and their epidermal attachment cells. Genes Dev. 11(20):2691-2700. PubMed Citation: 9334331

Yarnitzky, T., Min, L. and Volk, T. (1998). An interplay between two EGF-receptor ligands, Vein and Spitz, is required for the formation of a subset of muscle precursors in Drosophila Mech. Dev. 79(1-2): 73-82. PubMed Citation: 10349622

Yasugi, T., Umetsu, D., Murakami, S., Sato, M. and Tabata, T. (2008). Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT. Development 135: 1471-1480. PubMed ID: 18339672

Yasugi, T., Sugie, A., Umetsu, D. and Tabata, T. (2010). Coordinated sequential action of EGFR and Notch signaling pathways regulates proneural wave progression in the Drosophila optic lobe. Development 137: 3193-3203. PubMed ID: 20724446

Yokouchi, M., et al. (1999). Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7. J. Biol. Chem. 274(44): 31707-12. PubMed Citation: 10531381

Yu, S.-Y., et al. (2002). A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye. Development 129: 3269-3278. 12070100

Yu, Y., et al. (2012). Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster. Mol. Cell Biol. 32(18): 3610-23. PubMed Citation: 22778134

Zartman, J. J., et al. (2011). Pattern formation by a moving morphogen source. Phys Biol. 8(4): 045003. PubMed Citation: 21750363

Zhang, Q., et al. (2006). A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Dev. Cell 10: 719-729. PubMed Citation: 16740475

Zecca, M. and Struhl, G. (2002a). Subdivision of the Drosophila wing imaginal disc by EGFR-mediated signaling. Development 129: 1357-1368. 11880345

Zecca, M. and Struhl, G. (2002b). Control of growth and patterning of the Drosophila wing imaginal disc by EGFR-mediated signaling. Development 129: 1369-1376. 11880346

Zenz, R., et al. (2003). c-Jun regulates eyelid closure and skin tumor development through EGFR signaling. Dev. Cell 4: 879-889. 12791272

Zettl, M., et al. (2011). Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling. Cell 145: 75-91. PubMed Citation: 21439629

Zhang, Q., Zheng, Q. and Lu, X. (1999). A genetic screen for modifiers of Drosophila Src42A identifies mutations in Egfr, rolled and a novel signaling gene. Genetics 151: 697-711. PubMed Citation: 9927462

Zhang, X., et al. (2006). An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell 125: 1137-1149. PubMed Citation: 16777603

Zhao, D., Woolner, S. and Bownes, M. (2000). The Mirror transcription factor links signalling pathways in Drosophila oogenesis. Dev. Genes Evol. 210: 449-457. PubMed Citation: 11180850

Zhao, G. and Skeath, J. B. (2002). The Sox-domain containing gene Dichaete/fish-hook acts in concert with vnd and ind to regulate cell fate in the Drosophila neuroectoderm. Development 129: 1165-1174. 11874912

Zhao, G., Wheeler, S. R. and Skeath, J. B. (2007). Genetic control of dorsoventral patterning and neuroblast specification in the Drosophila central nervous system. Int. J. Dev. Biol. 51(2): 107-15. Medline abstract: 17294361

Zou, H., et al. (2009). Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells. FASEB J. 23: 425-432. PubMed Citation: 18832597

Zschatzsch, M., Oliva, C., Langen, M., De Geest, N., Ozel, M. N., Williamson, W. R., Lemon, W. C., Soldano, A., Munck, S., Hiesinger, P. R., Sanchez-Soriano, N. and Hassan, B. A. (2014). Regulation of branching dynamics by axon-intrinsic asymmetries in tyrosine kinase receptor signaling. Elife 3: e01699. PubMed ID: 24755286

zur Lage, P., Jan, Y. N. and Jarman, A. P. (1997). Requirement for EGF receptor signalling in neural recruitment during formation of Drosophila chordotonal sense organ clusters. Curr. Biol. 7: 166-175. PubMed Citation: 9395407

zur Lage, P. and Jarman, A. P. (1999). Antagonism of EGFR and Notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors. Development 126: 3149-3157. PubMed Citation: 10375505

Zwick, E., et al. (1997). Critical role of calcium- dependent epidermal growth factor receptor transactivation in PC12 cell membrane depolarization and bradykinin signaling. J. Biol. Chem. 272(40): 24767-24770. PubMed Citation: 9312072

Return: References part 1/2

EGF receptor : Biological Overview | Evolutionary Homologs | Regulation | Protein Interactions | Developmental Biology | Effects of Mutation

date revised: 10 June 2014
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