EGF receptor

REFERENCES (part 1/2)

Adrain, C., Strisovsky, K., Zettl, M., Hu, L., Lemberg, M.K., and Freeman, M. (2011). Mammalian EGF receptor activation by the rhomboid protease RHBDL2. EMBO Rep. 12(5): 421-7. PubMed Citation: 21494248

Alvarado, D., Rice, A. H. and Duffy, J. B. (2004a). Knockouts of Kekkon1 define sequence elements essential for Drosophila Epidermal growth factor receptor inhibition. Genetics 166: 201-211. 15020418

Alvarado, D., Rice, A. H. and Duffy, J. B. (2004b). Bipartite inhibition of Drosophila epidermal growth factor receptor by the extracellular and transmembrane domains of Kekkon1. Genetics. 2004 May;167(1):187-202. 15166146

Alvarado, D., Klein, D. E. and Lemmon, M. A. (2009). ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor. Nature 461(7261): 287-91. PubMed Citation: 19718021

Alvarado, D., Klein, D. E. and Lemmon, M. A. (2010). Structural basis for negative cooperativity in growth factor binding to an EGF receptor. Cell 142: 568-579. PubMed Citation: 20723758

Amin, A., Li, Y. and Finkelstein, R. (1999). Hedgehog activates the EGF receptor pathway during Drosophila head development. Development 126(12): 2623-2630. 10331974

Anton, E. S., et al. (2004). Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat. Neurosci. 7(12): 1319-28. 15543145

Assaker, G., Ramel, D., Wculek, S. K., Gonzalez-Gaitan, M. and Emery, G. (2010). Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration. Proc. Natl. Acad. Sci. 107(52): 22558-63. PubMed Citation: 21149700

Astigarraga, S., et al. (2007). A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling. EMBO J. 26(3): 668-77. Medline abstract: 17255944

Atit, R., Conlon, R. A. and Niswander, L. (2003). EGF signaling patterns the feather array by promoting the interbud fate. Dev. Cell 4: 231-240. 12586066

Arora, D., Stopp, S., Bohmer, S. A., Schons, J., Godfrey, R., Masson, K., Razumovskaya, E., Ronnstrand, L., Tanzer, S., Bauer, R., Bohmer, F. D. and Muller, J. P. (2011). Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling. J Biol Chem 286: 10918-10929. PubMed ID: 21262971

Bai, J., Chiu, W., Wang, J., Tzeng, T., Perrimon, N. and Hsu, J. (2001). The cell adhesion molecule Echinoid defines a new pathway that antagonizes the Drosophila EGF receptor signaling pathway. Development. 128(4): 591-601. 11171342

Baker, N. E., Bhattacharya, A. and Firth, L. C. (2009). Regulation of Hh signal transduction as Drosophila eye differentiation progresses. Dev. Biol. 335(2): 356-66. PubMed Citation: 19761763

Baonza, A., Casci, T. and Freeman, M. (2001). A primary role for the epidermal growth factor receptor in ommatidial spacing in the Drosophila eye. Curr. Biol. 11: 396-404. 11301250

Barbieri, M. A., et al. (2000). Epidermal growth factor and membrane trafficking: EGF receptor activation of endocytosis requires Rab5a. J. Cell Bio. 151: 539-550. 11062256

Baumann, P. and Skaer, H. (1993). The Drosophila EGF receptor homologue (DER) is required for Malpighian tubule development. Dev Suppl : 65-75. PubMed Citation: 8049489

Bergmann, A., Tugentman, M., Shilo, B.-Z. and Steller, H. (2002). Regulation of cell number by MAPK-dependent control of apoptosis: A mechanism for trophic survival signaling. Dev. Cell 2: 159-170. 11832242

Bersell, K., Arab, S., Haring, B. and Kühn, B. (2009). Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 138(2): 257-70. PubMed Citation: 19632177

Berset, T. A., Hoier, E. F. and Hajnal, A. (2005). The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions. Genes Dev 19: 1328-1340. PubMed ID: 15901674

Bianco, A., et al. (2007). Two distinct modes of guidance signalling during collective migration of border cells. Nature 448: 362-365. PubMed Citation: 17637670

Biteau, B. and Jasper, H. (2011). EGF signaling regulates the proliferation of intestinal stem cells in Drosophila. Development 138(6): 1045-55. PubMed Citation: 21307097

Bourbon, H. M., et al. (2000). A P-insertion screen identifying novel X-linked essential genes in Drosophila. Mech. Dev. 110(1-2): 71-83. PubMed citation: 11744370

Boyle, M. J., et al (2010). Division of labor: subsets of dorsal-appendage-forming cells control the shape of the entire tube. Dev. Biol. 346 68-79. PubMed Citation: 20659448

Brodu, V., Elstob, P. R. and Gould, A. P. (2004). EGF receptor signaling regulates pulses of cell delamination from the Drosophila ectoderm. Dev. Cell 7: 885-895. 15572130

Brodu, V. and Casanova, J. (2006). The RhoGAP crossveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invagination. Genes Dev. 20(13): 1817-28. 16818611

Brown, K. E., Baonza, A. and Freeman, M. (2006). Epithelial cell adhesion in the developing Drosophila retina is regulated by Atonal and the EGF receptor pathway. Dev. Biol. 300(2): 710-21. Medline abstract: 16963016

Buff, E., et al. (1998). Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors. Development 125: 2075-2086. 9570772

Burgess, A. W., et al. (2003). An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Mol. Cell 12: 541-552. PubMed Citation: 14527402

Butchar, J. P, et al. (2012). New negative feedback regulators of Egfr signaling in Drosophila. Genetics 191(4): 1213-26. PubMed Citation: 22595244

Brachmann, R., et al. (1989). Transmembrane TGF-alpha precursors activate EGF/TGF-alpha receptors. Cell 56(4): 691-700. 89136015

Brand, A. H. and Perrimon. N. (1994). Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis. Genes Dev. 8: 629-639. PubMed Citation: 7926754

Brown, K. E. and Freeman, M. (2003). Egfr signalling defines a protective function for ommatidial orientation in the Drosophila eye. Development 130: 5401-5412. 14507785

Buszczak, M., et al. (1999). Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila. Development 126: 4581-4589. 10498692

Cabernard, C. and Affolter, M. (2005). Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila. Dev. Cell 9(6): 831-42. 16326394

Campbell, G. (2002). Distalization of the Drosophila leg by graded EGF-receptor activity. Nature 418: 781-785. 12181568

Campbell, G. (2005). Regulation of gene expression in the distal region of the Drosophila leg by the Hox11 homolog, C15. Dev. Biol. 278(2): 607-18. 15680373

Cao, L., Zhang, L., Ruiz-Lozano, P., Yang, Q., Chien, K. R., Graham, R. M. and Zhou, M. (1998). A novel putative protein-tyrosine phosphatase contains a BRO1-like domain and suppresses Ha-ras-mediated transformation. J. Biol. Chem. 273: 21077-21083. PubMed Citation: 9694860

Caric, D., et al. (2001). EGFRs mediate chemotactic migration in the developing telencephalon. Development 128: 4203-4216. 11684657

Carmena, A., et al. (1998). Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm. Genes Dev. 12(24): 3910-3922. PubMed Citation: 9869644

Castanieto, A., Johnston, M. J. and Nystul, T. G. (2014). EGFR signaling promotes the identity of follicle stem cells via maintenance of partial cell polarity. Elife 3. PubMed ID: 25437306

Caussanel, V., et al. (1996). Cellular distribution of EGF, TGFalpha and their receptor during postnatal development and spermatogenesis of the boar testis. Mol. Cell. Endocrinol. 123(1): 61-69. PubMed Citation: 8912812

Cela, C. and Llimargas, M. (2006). Egfr is essential for maintaining epithelial integrity during tracheal remodelling in Drosophila. Development 133(16): 3115-25. 16831830

Chabot, C., Spring, K., Gratton, J. P., Elchebly, M. and Royal, I. (2009). New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival. Mol Cell Biol 29: 241-253. PubMed ID: 18936167

Chen, P., Murphy-Ullrich, J. E., and Wells, A. (1996). A role for gelsolin in actuating epidermal growth factor receptor-mediated cell motility. J. Cell Biol. 134: 689-698. 96326674

Choi, J. H., et al. (2003). Cbl competitively inhibits epidermal growth factor-induced activation of phospholipase C-gamma1. Mol. Cells 15(2): 245-55. 12803489

Chou, R. H., et al. (2014). EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4. Dev Cell 30: 224-237. PubMed ID: 25073158

Christensen, C., Lauridsen, J. B., Berezin, V., Bock, E. and Kiselyov, V. V. (2006). The neural cell adhesion molecule binds to fibroblast growth factor receptor 2. FEBS Lett. 580: 3386-3390. PubMed Citation: 16709412

Ciapponi, L., et al. (2001). Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites. Genes Dev. 15: 1540-1553. 11410534

Clandinin, T. R., DeModena, J. A. and Sternberg, P. W. (1998). Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans. Cell 92: 523-533. PubMed Citation: 9491893

Claperon, A. and Therrien, M. (2007). KSR and CNK: two scaffolds regulating RAS-mediated RAF activation. Oncogene 26: 3143-3158. PubMed ID: 17496912

Clifford, R. and Schupbach, T. (1992). The Torpedo (DER) receptor tyrosine kinase is required at multiple times during Drosophila embryogenesis. Development 115: 853-872. PubMed Citation: 1425358

Clifford, R. and Schupbach, T. (1994). Molecular analysis of the Drosophila EGF receptor homolog reveals that several genetically defined classes of alleles cluster in subdomains of the receptor protein. Genetics 137: 531-550. PubMed Citation: 8070664

Corl, A. B., et al. (2009). Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors. Cell 137(5): 949-60. PubMed Citation: 19464045

Costa, M., Wilson, E. T. and Wieschaus, E. (1994). A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation. Cell 76 (6): 1075-1089. PubMed Citation: 8137424

Crozatier, M., Glise B. and Vincent, A. (2002). Connecting Hh, Dpp and EGF signalling in patterning of the Drosophila wing; the pivotal role of collier/knot in the AP organiser. Development 129: 4261-4269. 12183378

Culí, J., Martín-Blanco, E. and Modolell, J. (2001). The EGF receptor and N signalling pathways act antagonistically in Drosophila mesothorax bristle patterning. Development 128: 299-308. 11124124

Dardik, A., Smith, R. M. and Schultz, R. M. (1992). Colocalization of transforming growth factor-alpha and a functional epidermal growth factor receptor (EGFR) to the inner cell mass and preferential localization of the EGFR on the basolateral surface of the trophectoderm in the mouse blastocyst. Dev. Biol. 154(2): 396-409. PubMed Citation: 1426645

Das, A., Chiang, A., Davla, S., Priya, R., Reichert, H., Vijayraghavan, K. and Rodrigues, V. (2011). Identification and analysis of a glutamatergic local interneuron lineage in the adult Drosophila olfactory system. Neural Syst. Circuits 1(1):4. PubMed Citation: 22330097

Daub, H., et al. (1996). Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 379: 557-560. PubMed Citation: 8596637

Daub, H., et al. (1997). Signal characteristics of G protein-transactivated EGF receptor. EMBO J. 16(23): 7032-7044. PubMed Citation: 9384582

Dekel, I., Russek, N., Jones, T., Mortin, M. A. and Katzav, S. (2000). Identification of the Drosophila melanogaster homologue of the mammalian transducer protein, Vav. FEBS Lett. 472: 99-104. PubMed citation: 10781813

Deneault, E., et al. (2009). A functional screen to identify novel effectors of hematopoietic stem cell activity. Cell 137: 369-379. PubMed Citation: 19379700

Deng, W. M. and Bownes, M. (1997). Two signalling pathways specify localised expression of the Broad-Complex in Drosophila eggshell patterning and morphogenesis. Development 124(22): 4639-4647. PubMed Citation: 9409680

Denning, M. F., et al. (1996). Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta. J. Biol. Chem. 271: 5325-5331. PubMed Citation: 8621384

DeWitt, A., et al. (2002). Affinity regulates spatial range of EGF receptor autocrine ligand binding. Dev. Bio. 250: 305-316. 12376105

Diaz-Benjumea, F. J. and Hafen, E. (1994). The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development. Development 120: 569-78. PubMed Citation: 8162856

Di Guglielmo, G. M., et al. (1994). Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma. EMBO J. 13: 4269-77. PubMed Citation: 7925272

Dobens, L. L., et al. (1997). The Drosophila bunched gene is a homologue of the growth factor stimulated mammalian TSC-22 sequence and is required during oogenesis. Mech. Dev. 65(1-2): 197-208. PubMed Citation: 9256356

Dobens, L. L. (2000). Drosophila bunched integrates opposing DPP and EGF signals to set the operculum boundary. Development 127: 745-754. PubMed Citation: 10648233

Dominguez, M., Wasserman, J. D. and Freeman, M. (1998). Multiple functions of the EGF receptor in Drosophila eye development. Curr. Biol. 8(19): 1039-48. PubMed Citation: 9768358

Dong, R. and Jacobs, J. R. (1997). Origin and differentiation of supernumerary midline glia in Drosophila embryos deficient for apoptosis. Dev. Biol. 190(2): 165-177. PubMed Citation: 9344536

Dong, X., et al. (1999). ebi regulates epidermal growth factor receptor signaling pathways in Drosophila. Genes Dev. 13(8): 954-65. PubMed Citation: 10215623

Donlea, J. M., Ramanan, N. and Shaw, P. J. (2009). Use-dependent plasticity in clock neurons regulates sleep need in Drosophila. Science 324(5923): 105-8. PubMed Citation: 19342592

Doroquez, D. B., Orr-Weaver, T. L. and Rebay. I. (2007). Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development. Mech. Dev. 124(9-10): 792-806. PubMed citation: 17588724

Duchek, P. and Rorth, P. (2001a). Guidance of cell migration by EGF receptor signaling during Drosophila oogenesis. Science 291(5501): 131-3. 11141565

Duchek, P., et al. (2001b). Guidance of cell migration by the Drosophila PDGF/VEGF Receptor. Cell 107: 17-26. 11595182

Dumstrei, K., et al. (1998). EGFR signaling is required for the differentiation and maintenance of neural progenitors along the dorsal midline of the Drosophila embryonic head. Development 125(17): 3417-3426. PubMed Citation: 9693145

Dumstrei, K., et al. (2002). Interaction between EGFR signaling and DE-cadherin during nervous system morphogenesis. Development 129: 3983-3994. 12163402

Dworkin, I., Palsson, A., Birdsall, K. and Gibson, G. (2003). Evidence that Egfr contributes to cryptic genetic variation for photoreceptor determination in natural populations of Drosophila melanogaster. Curr. Biol. 13: 1888-1893. 14588245

Etkin, A., et al. (2006). A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context. Neuron 50(1): 127-43. PubMed Citation: 16600861

Ebner, R. and Derynck, R. (1991). Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes. Cell Regul. 2(8): 599-612. PubMed Citation: 1777504

Eisenmann, D. M., et al. (1998). The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development. Development 125(18): 3667-3680. PubMed Citation: 9716532

Eresh, S., et al. (1997). A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction. EMBO J. 16: 2014-22. PubMed Citation: 9155027

Escudero, L. M., et al. (2003). Echinoid synergizes with the Notch signaling pathway in Drosophila mesothorax bristle patterning. Development 130: 6305-6316. 14623820

Ferguson, K. M., et al. (2003). EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Mol. Cell 11: 507-517. 12620237

Figeac, N., Jagla, T., Aradhya, R., Da Ponte, J. P. and Jagla, K. (2010). Drosophila adult muscle precursors form a network of interconnected cells and are specified by the rhomboid-triggered EGF pathway. Development 137(12): 1965-73. PubMed Citation: 20463031

Firth, L. C. and Baker, N. E. (2005). Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev. Cell 8(4): 541-51. 15809036

Flames, N., et al. (2004). Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1. Neuron 44(2): 251-61. 15473965

Foltenyi, K., Greenspan, R. J., and Newport, J. W. (2007). Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila. Nat. Neurosci. 10: 1160-1167. PubMed Citation: 17694052

Foltenyi, K., Greenspan, R. J. and Newport, J. W. (2007). Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila. Nature Neurosci. 10: 1160-1167. Medline abstract: 17694052

Fowler, K. J., et al., (1995). A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation. Proc. Natl. Acad. Sci. 92: 1465-1469. PubMed Citation: 7533293

Francavilla, C., Loeffler, S., Piccini, D., Kren, A., Christofori, G. and Cavallaro, U. (2007). Neural cell adhesion molecule regulates the cellular response to fibroblast growth factor. J. Cell Sci. 120: 4388-4394. PubMed Citation: 18042627

Freeman, M. (1994). The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor. Mech Dev 48: 25-33. PubMed Citation: 7833286

Freeman, M. (1996). Reiterative use of the EGF Receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87: 651-660. PubMed Citation: 8929534

Freeman, M. and Bienz, M. (2001). EGF receptor/Rolled MAP kinase signalling protects cells against activated Armadillo in the Drosophila eye. EMBO Reports 2: 157-162. 11258709

Fuchs, A., et al. (2012). Transcriptional interpretation of the EGF receptor signaling gradient. Proc. Natl. Acad. Sci. 109(5): 1572-7. PubMed Citation: 22307613

Gabay, L., et al. (1996). EGF receptor signaling induces pointed P1 and inactivates Yan protein in the Drosophila embryonic ventral ectoderm. Development 122: 3355-3362. PubMed Citation: 8951052

Gabay, L., Seger, R. and Shilo, B. Z. (1997). MAP kinase in situ activation atlas during Drosophila embryogenesis. Development 124: 3535-3541. PubMed Citation: 9342046

Gaengel, K. and Mlodzik, M. (2003). Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6. Development 130: 5413-5423. 14507782

Galisteo, M. L., et al. (1995). Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation. J. Biol. Chem. 270: 20242-20245. PubMed Citation: 7657591

Gallio, M., et al. (2004). Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline. Development 131: 3605-3614. 15229181

Garcia-Alonso, L., Romani, S. and Jimenez, F. (2000). The EGF and FGF receptors mediate Neuroglian function to control growth cone decisions during sensory axon guidance in Drosophila. Neuron 28: 741-752. PubMed Citation: 11163263

Garoia, F., Grifoni, D., Trotta, V., Guerra, D., Pezzoli, M. C. and Cavicchi, S. (2005). The tumor suppressor gene fat modulates the EGFR-mediated proliferation control in the imaginal tissues of Drosophila melanogaster. Mech. Dev. 122(2): 175-87. 15652705

Garrett, T. P. J., et al. (2002). Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha. Cell 110: 763-773. 12297049

Gaul, U., Mardon, G. and Rubin, G.M. (1992). A putative Ras GTPase activating protein acts as a negative regulator of signaling by the sevenless receptor tyrosine kinase. Cell 68: 1007-1019. PubMed Citation: 1547500

Geiger, J. A., Carvalho, L., Campos, I., Santos, A. C. and Jacinto, A. (2011). Hole-in-one mutant phenotypes link EGFR/ERK signaling to epithelial tissue repair in Drosophila. PLoS One 6: e28349. Pubmed: 22140578

Ghashghaei, H. T., et al. (2006). The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone. Proc. Natl. Acad. Sci. [Epub ahead of print]. 16446434

Ghiglione, C., et al. (1999). The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis. Cell 96(6): 847-56. 99200395

Ghiglione, C., et al. (2003). Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1. Development 130: 4483-4493. 12900463

Gilboa, L. and Lehmann, R. (2006). Soma-germline interactions coordinate homeostasis and growth in the Drosophila gonad. Nature 443: 97-100. Medline abstract: 16936717

Gohla, A., Harhammer, R., and Schultz, G. (1998). The G-protein G13 but not G12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho. J. Biol. Chem. 273(8): 4653-4659. PubMed Citation: 1547500

Goishi, K., et al. (2003). Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects. Mech. Dev. 120: 811-822. 12915231

Goldman, B., Mach, A. and Wurzel, J. (1996). Epidermal growth factor promotes a cardiomyoblastic phenotype in human fetal cardiac myocytes. Exp. Cell Res. 228(2): 237-245. PubMed Citation: 8912716

Golembo, M., et al. (1996). Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop. Development 122: 223-230. PubMed Citation: 8565833

Gonzalez-Reyes, A., Elliott, H. and St Johnston, D. (1995). Polarization of both major body axes in Drosophila by gurken-torpedo signalling. Nature 375: 654-658. PubMed Citation: 7791898

Gonzalez-Reyes, A. and Johnston, D. S. (1998). Patterning of the follicle cell epithelium along the anterior-posterior axis during Drosophila oogenesis. Development 125(15): 2837-2846. PubMed Citation: 9655806

Goode, S., Wright, D. and Mahowald, A. P. (1992). The neurogenic locus brainiac cooperates with the Drosophila EGF receptor to establish the ovarian follicle and to determine its dorsal-ventral polarity. Development 116: 177-92. PubMed Citation: 1483386

Goto, S., and Hayashi, S. (1997). Specification of the embryonic limb primordium by graded activity of Decapentaplegic. Development 124: 125-132. PubMed Citation: 9006073

Gotoh, N. et al. (1992). A highly conserved tyrosine residue at codon 845 within the kinase domain is not required for the transforming activity of human epidermal growth factor receptor. Biochem. Biophys. Res. Commun. 186: 768-774. PubMed Citation: 1323290

Gotoh, N., et al. (1994). Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity. Proc. Natl. Acad. Sci. 91: 167-171. PubMed Citation: 7506413

Gotoh, N., et al. (1995). The SH2 domain of Shc seppresses EGF-induced mitogenesis in a dominant negative manner. Oncogene 11: 2525-2533. PubMed Citation: 8545109

Grazia Lampugnani, M., Zanetti, A., Corada, M., Takahashi, T., Balconi, G., Breviario, F., Orsenigo, F., Cattelino, A., Kemler, R., Daniel, T. O. and Dejana, E. (2003). Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J Cell Biol 161: 793-804. PubMed ID: 12771128

Grigorian, M., Mandal, L., Hakimi, M., Ortiz, I. and Hartenstein, V. (2011). The convergence of Notch and MAPK signaling specifies the blood progenitor fate in the Drosophila mesoderm. Dev Biol. 353(1): 105-18. PubMed Citation: 21382367

Haglund, K., et al. (2005). Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. EMBO Rep. 6(7): 635-41. 15962011

Hahn, I., Fuss, B., Peters, A., Werner, T., Sieberg, A., Gosejacob, D. and Hoch, M. (2013). The Drosophila Arf GEF Steppke controls MAPK activation in EGFR signaling. J Cell Sci 126: 2470-2479. PubMed ID: 23549788

Hajnal, A., Whitfield, C. W. and Kim, S. K. (1997). Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase. Genes Dev. 11(20): 2715-2728

Hammerle, B. and Tejedor, F. J. (2007). A novel function of DELTA-NOTCH signalling mediates the transition from proliferation to neurogenesis in neural progenitor cells. PLoS One 2: e1169. PubMed ID: 18000541

Hannan, F., et al. (2006). Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras. Human Mol. Genet. 15(7): 1087-1098. 16513807

Held, L. I., Jr. (2002). Bristles induce bracts via the EGFR pathway on Drosophila legs. Mech. Dev. 117: 225-234. 12204262

Helman, A., Lim, B., Andreu, M. J., Kim, Y., Shestkin, T., Lu, H., Jimenez, G., Shvartsman, S. Y. and Paroush, Z. (2012). RTK signaling modulates the Dorsal gradient. Development 139: 3032-3039. PubMed ID: 22791891

Herranz, H., Weng, R., Cohen, S. M. (2014) Crosstalk between epithelial and mesenchymal tissues in tumorigenesis and imaginal disc development. Curr Biol 24: 1476-1484. PubMed ID: 24980505

Hime, G. R., et al. (1997). D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites. Oncogene 14(22): 2709-19

Hopper, N. A. (2006). The adaptor protein soc-1/Gab1 modifies growth factor receptor output in C. elegans. Genetics 173(1): 163-75. 16547100

Hornstein, I., Mortin, M. A. and Katzav, S. (2003). DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the Rac and DER pathways. Oncogene 22: 6774-6784. PubMed citation: 14555990

Hsu, T., et al. (1996). The transcription factor CF2 is a mediator of EGF-R-activated dorsoventral patterning in Drosophila oogenesis. Genes Dev. 10: 1411-21

Huang, F. and Sorkin, A. (2005). Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis. Mol. Biol. Cell 16(3): 1268-81. 15635092

Hwang, H. J. and Rulifson, E. (2011). Serial specification of diverse neuroblast identities from a neurogenic placode by Notch and Egfr signaling. Development 138(14): 2883-93. PubMed Citation: 21653613

Huang, Z., Shilo, B.-Z. and Kunes, S. (1998). A retinal axon fascicle uses Spitz, an EGF Receptor ligand, to construct a synaptic cartridge in the brain of Drosophila. Cell 95: 693-703. PubMed Citation: 9845371

Ichioka, F., Takaya, E., Suzuki, H., Kajigaya, S., Buchman, V. L., Shibata, H. and Maki, M. (2007). HD-PTP and Alix share some membrane-traffic related proteins that interact with their Bro1 domains or proline-rich regions. Arch. Biochem. Biophys. 457: 142-149. PubMed Citation: 17174262

Inbal, A., Volk, T. and Salzberg, A. (2004). Recruitment of ectodermal attachment cells via an EGFR-dependent mechanism during the organogenesis of Drosophila proprioceptors. Dev. Cell 7: 241-250. 15296720

Inda, M. M., et al. (2010). Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes Dev. 24(16): 1731-45. PubMed Citation: 20713517

Irie M., et al. (1999). Isolation and characterization of mammalian homologues of Caenorhabditis elegans lin-7: localization at cell-cell junctions. Oncogene 18(18): 2811-7. PubMed Citation: 10362251

Islam, R., Wei, S. Y., Chiu, W. H., Hortsch, M. and Hsu, J. C. (2003). Neuroglian activates Echinoid to antagonize the Drosophila EGF receptor signaling pathway. Development. 130(10): 2051-9. 12668620

Jazwinska, A., Ribeiro, C. and Affolter, M. (2003). Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein. Nat. Cell Biol. 5: 895-901. 12973360

Jekely, G., Sung, H. H., Luque, C. M. and Rorth, P. (2005). Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration. Dev. Cell 9(2): 197-207. 16054027

Jeon, M., Nguyen, H., Bahri, S. and Zinn, K. (2008). Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily. Neural Dev 3: 3. PubMed ID: 18237413

Jeon, M. and Zinn, K. (2009). Receptor tyrosine phosphatases control tracheal tube geometries through negative regulation of Egfr signaling. Development 136(18): 3121-9. PubMed Citation: 19675131

Jeon, M., Scott, M. P. and Zinn, K. (2012). Interactions between Type III receptor tyrosine phosphatases and growth factor receptor tyrosine kinases regulate tracheal tube formation in Drosophila. Biol Open 1: 548-558. PubMed ID: 23213447

Jhaveri, D., et al. (2000). Sense organ identity in the Drosophila antenna is specified by the expression of the proneural gene atonal. Mech. Dev. 99: 101-111. PubMed Citation: 11091078

Jiang, H. and Edgar, B. A. (2009). EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. Development 136(3): 483-93. PubMed Citation: 19141677

Jones, P. L., Crack, J. and Rabinovitch, M. (1997). Regulation of Tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alphavbeta3 Integrin to promote epidermal growth factor receptor phosphorylation and growth. J. Cell Biol. 139: 279-293. PubMed Citation: 9314546

Jura, N., et al. (2009). Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell 137(7): 1293-307. PubMed Citation: 19563760

Kaech, S. M., Whitfield, C. W. and Kim, S. K. (1998). The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Cell 94(6): 761-71. PubMed Citation: 9753323

Kagesawa, T., et al. (2008). Distinct activation patterns of EGF receptor signaling in the homoplastic evolution of eggshell morphology in genus Drosophila. Mech. Dev. 125(11-12): 1020-32. PubMed Citation: 18762251

Kaplan, M., Narasimhan, S., de Heus, C., Mance, D., van Doorn, S., Houben, K., Popov-Celeketic, D., Damman, R., Katrukha, E. A., Jain, P., Geerts, W. J., Heck, A. J., Folkers, G. E., Kapitein, L. C., Lemeer, S., van Bergen En Henegouwen, P. M. and Baldus, M. (2016). EGFR dynamics change during activation in native membranes as revealed by NMR. Cell 167(5): 1241-1251. PubMed ID: 27839865

Kappert, K., Paulsson, J., Sparwel, J., Leppanen, O., Hellberg, C., Ostman, A. and Micke, P. (2007). Dynamic changes in the expression of DEP-1 and other PDGF receptor-antagonizing PTPs during onset and termination of neointima formation. FASEB J 21: 523-534. PubMed ID: 17158785

Kashiwagi, M., Kuroki, T. and Huh, N. H. (1997). Specific inhibition of hair follicle formation by epidermal growth factor in an organ culture of developing mouse skin. Dev. Biol. 189(1): 22-32

Kashimata, M. and Gresik, E. W. (1997). Epidermal growth factor system is a physiological regulator of development of the mouse fetal submandibular gland and regulates expression of the alpha6-integrin subunit. Dev. Dyn. 208(2): 149-161

Kashimata, M., et al. (2000). The ERK-1/2 signaling pathway is involved in the stimulation of branching morphogenesis of fetal mouse submandibular glands by EGF. Developmental Biology 220: 183-196

Kashiwagi, M., Kuroki, T. and Huh, N. (1997). Specific inhibition of hair follicle formation by epidermal growth factor in an organ culture of developing mouse skin. Dev. Biol. 189(1): 22-32.

Katz, W. S., et al. (1996). A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog. Mol. Cell. Biol. 16: 529-537

Katzen, A. L., Kornberg, T. and Bishop, J. M. (1991). Expression during Drosophila development of DER, a gene related to erbB-1 and neu: correlations with mutant phenotypes. Dev Biol 145: 287-301

Kawamori, H., Tai, M., Sato, M., Yasugi, T. and Tabata, T. (2011). Fat/Hippo pathway regulates the progress of neural differentiation signaling in the Drosophila optic lobe. Dev. Growth Differ. 53(5): 653-67. PubMed Citation: 21671914

Kelley, R. L. (1993). Initial organization of the Drosophila dorsoventral axis depends on an RNA-binding protein encoded by the squid gene. Genes Dev 7: 948-60

Kent, D., Bush, E. W. and Hooper, J. E. (2006). Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus. Development 133: 2001-2010. PubMed Citation: 16651542

Kerber, B., Fellert, S. and Hoch, M., (1998). Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney. Genes Dev. 12(12): 1781-1786

Kim, H. J., Taylor, L. J. and Bar-Sagi, D. (2007). Spatial regulation of EGFR signaling by Sprouty2. Curr. Biol. 17: 455-461. Medline abstract: 17320394

Kim, H.J., Ahn, H.J., Lee, S., Kim, J.H., Park, J., Jeon, S.H. and Kim, S.H. (2015). Intrinsic dorsoventral patterning and extrinsic EGFR signaling genes control glial cell development in the Drosophila nervous system. Neuroscience 307:242-52. PubMed ID: 26318336

Kim, J., Sitaraman, S., Hierro, A., Beach, B. M., Odorizzi, G. and Hurley, J. H. (2005). Structural basis for endosomal targeting by the Bro1 domain. Dev. Cell 8: 937-947. PubMed Citation: 15935782

Kim, S. H. and Crews, S. T. (1993). Influence of Drosophila ventral epidermal development by the CNS midline cells and spitz class genes. Development 118: 893-901. PubMed ID: 8076524

Kim, S.K., and Horvitz, H.R. (1990). The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates. Genes Dev. 4: 357-371. PubMed ID: 2159938

Kim, S. Y., Kim, J. Y., Malik, S., Son, W., Kwon, K-S., et al. (2012). Negative Regulation of EGFR/MAPK Pathway by Pumilio in Drosophila melanogaster. PLoS ONE 7(4): e34016. PubMed ID: 22514614

Kiselyov, V. V., Skladchikova, G., Hinsby, A. M., Jensen, P. H., Kulahin, N., Soroka, V., Pedersen, N., Tsetlin, V., Poulsen, F. M., Berezin, V. et al. (2003). Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP. Structure 11: 691-701. PubMed Citation: 15326546

Knöll, B., et al. (2006). Serum response factor controls neuronal circuit assembly in the hippocampus. Nat. Neurosci. 9(2): 195-204. PubMed Citation: 16415869

Kockel, L., et al. (1997). Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways. Genes Dev. 11:1748-1758. PubMed ID: 9224723

Kojima, T., Tsuji, T. and Saigo, K. (2005). A concerted action of a paired-type homeobox gene, aristaless, and a homolog of Hox11/tlx homeobox gene, clawless, is essential for the distal tip development of the Drosophila leg. Dev. Biol. 279(2): 434-45. 15733670

Kondo, T. and Hayashi, S. (2013). Mitotic cell rounding accelerates epithelial invagination. Nature 494: 125-129. PubMed ID: 23334416

Kopp, A., Blackman, R. K. and Duncan, I. (1999). Wingless, Decapentaplegic and EGF Receptor signaling pathways interact to specify dorso-ventral pattern in the adult abdomen of Drosophila. Development 126: 3495-3507. PubMed ID: 10409497

Krejci, A., et al. (2009). Direct response to Notch activation: signaling crosstalk and incoherent logic. Sci. Signal. 2: ra1. PubMed Citation: 19176515

Kuang, B., Wu, S. C., Shin, Y., Luo L. and Kolodziej, P. (2000). split ends encodes large nuclear proteins that regulate neuronal cell fate and axon extension in the Drosophila embryo. Development 127: 1517-1529. PubMed Citation: 10704397

Kubota, K., et al. (2000). EGF receptor attenuates Dpp signaling and helps to distinguish the wing and leg cell fates in Drosophila. Development 127: 3769-3776

Kumar, J. P., et al. (1998). Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation. Development 125(19): 3875-3885

Kumar, J. P. and Moses, K. (2001). EGF receptor and Notch signaling act upstream of Eyeless/Pax6 to control eye specification. Cell 104: 687-697. 11257223

Kuo, Y. M., et al. (1996). Salivary duct determination in Drosophila: roles of the EGF receptor signaling pathway and the transcription factors Fork head and Trachealess. Development 122: 1909-17

Kurada, P. and White, K. (1998). Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95(3): 319-29

Lai, K. M.., et al. (1995). A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase. Mol Cell Biol 15: 4810-4818

Larkin, M. K., et al. (1999). Role of Notch pathway in terminal follicle cell differentiation during Drosophila oogenesis. Dev. Genes Evol. 209: 301-311

Layalle, S., et al. (2004). Control of bract formation in Drosophila: poxn, kek1, and the EGF-R pathway. Genesis 39: 246-255. Medline abstract: 15286997

Lazarovici, P., et al. (1997). Down-regulation of Epidermal Growth Factor Receptors by Nerve Growth Factor in PC12 Cells Is p140(trk)-, Ras-, and Src-dependent. J Biol Chem 272 (17): 11026-11034

Lemberg, M. K. and Freeman, M. (2007). Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases. Genome Res. 17: 1634-1646. PubMed Citation: 17938163

Levkowitz, G., et al. (1999). Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol. Cell 4(6): 1029-40.

Lemmon, M. A., et al. (1997). Two EGF molecules contribute additively to stabilization of the EGFR dimer. EMBO J. 16: 281-294

Lesokhin, A. M., et al. (1999). Several levels of EGF receptor signaling during photoreceptor specification in wild-type, Ellipse, and null mutant Drosophila. Dev. Biol. 205(1): 129-44

Li, M. Y., Lai, P. L., Chou, Y. T., Chi, A. P., Mi, Y. Z., Khoo, K. H., Chang, G. D., Wu, C. W., Meng, T. C. and Chen, G. C. (2014). Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation. Oncogene [Epub ahead of print]. PubMed ID: 25263444

Lill, N. L., et al. (2000). The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor. J. Biol. Chem. 275(1): 367-77

Lillien, L. (1995). Changes in retinal fate induced by overexpression of EGF receptor. Nature 377: 158-162

Lillien, L. and Wancio, D. (1998). Changes in epidermal growth factor receptor expression and competence to generate glia regulate timing and choice of differentiation in the retina. Mol. Cell. Neurosci. 10: 296-308

Lillien, L. and Raphael, H. (2000). BMP and FGF regulate the development of EGF-responsive neural progenitor cells. Development 127: 4993-5005

Lim, J. and Choi, K.-W. (2004). Induction and autoregulation of the anti-proneural gene Bar during retinal neurogenesis in Drosophila. Development 131: 5573-5580. 15496446

Lim, Y. M., et al. (1997). Dominant mutations of Drosophila MAP kinase kinase and their activities in Drosophila and yeast MAP kinase cascades Genetics 146 (1): 263-273

Liu, B. and Neufeld, A. H. (2004). Activation of epidermal growth factor receptors directs astrocytes to organize in a network surrounding axons in the developing rat optic nerve. Dev. Biol. 273: 297-307. 15328014

Liu, P., et al. (2012). A single ligand is sufficient to activate EGFR dimers. Proc. Natl. Acad. Sci. 109(27): 10861-6. PubMed Citation: 22699492

Lloyd, T. E., et al. (2002). Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila. Cell 108: 261-269. 11832215

Lu, Q., et al. (2003). TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation. Proc. Natl. Acad. Sci. 100(13): 7626-31. 12802020

Lu, X., et al. (1994). Genetic and molecular analyses of mutations involved in Drosophila raf signal transduction. EMBO J 13: 2592-9

Luetteke, N. C., et al. (1994). The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev 8: 399-413

Luetteke, N. C., et al. (1999). Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. Development 126(12): 2739-2750

Luschnig, S., Krauss, J., Bohmann, K., Desjeux, I. and Nüsslein-Volhard, C. (2000). The Drosophila SHC adaptor protein is required for signaling by a subset of receptor tyrosine kinases. Mol. Cell 5(2): 231-41. PubMed Citation: 10882065

Lyulcheva, E., Taylor, E., Michael, M., Vehlow, A., Tan, S., Fletcher, A., Krause, M. and Bennett, D. (2008). Drosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation. Dev. Cell 15(5): 680-90. PubMed Citation: 19000833

Macagno, J. P., Diaz Vera, J., Yu, Y., Macpherson, I., Sandilands, E., Palmer, R., Norman, J. C., Frame, M. and Vidal, M. (2014). FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells. PLoS Genet 10: e1004262. PubMed ID: 24676055

Maitra, S., Kulikauskas, R. M., Gavilan, H. and Fehon, R. G. (2006). The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling. Curr. Biol. 16(7): 702-9. 16581517

Malliri, A., et al. (1998). The transcription factor AP-1 Is required for EGF-induced activation of Rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells. J. Cell Biol. 143(4): 1087-1099

Mao, Y. and Freeman, M. (2009). Fasciclin 2, the Drosophila orthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling. Development 136(3): 473-81. PubMed Citation: 19141676

Martin-Blanco, E., et al. (1999). A temporal switch in DER signaling controls the specification and differentiation of veins and interveins in the Drosophila wing. Development 126: 5739-5747

Mathur, D., Bost A., Driver I. and Ohlstein B. (2010). A transient niche regulates the specification of Drosophila intestinal stem cells. Science 327: 210-213. PubMed Citation: 20056890

Mayer, U. and Nusslein-Volhard, C. (1988). A group of genes required for pattern formation in the ventral ectoderm of the Drosophila embryo. Genes Dev. 2: 1496-1511. 3209069

McNeill, H., Craig, G. M. and Bateman, J. M. (2008). Regulation of neurogenesis and epidermal growth factor receptor signaling by the Insulin receptor/Target of rapamycin pathway in Drosophila. Genetics 179: 843-853. PubMed Citation: 18505882

Meisner, H., et al. (1997). Interactions of Drosophila Cbl with Epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development. Mol. Cell. Biol 2217-25

Merabet, S., Hombria, J. C., Hu, N., Pradel, J. and Graba, Y. (2005). Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis. Development 132(13): 3093-3102. 15930099

Miettinen, P. J., et al (1997). Impaired lung branching morphogenesis in the absence of functional EGF receptor. Dev. Biol. 186(2): 224-236

Miettinen, P. J., et al. (2000). Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors. Development 127: 2617-2627

Miller, D. T. and Cagan, R. L. (1998). Local induction of patterning and programmed cell death in the developing Drosophila retina. Development 125: 2327-2335

Miura, G. I., Roignant, J. Y., Wassef, M. and Treisman, J. E. (2008). Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor. Development 135(11): 1913-22. PubMed Citation: 18434417

Moghal, N. and Sternberg. P. W. (2003). A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans. Development 130: 57-69. 12441291

Mohler, J., et al. (2000). Activation of knot(kn) specifies the 3-4 intervein region in the Drosophila wing. Development 127: 55-63.

Monserrate, J. P., Brachmann, C. B. (2006). Identification of the death zone: a spatially restricted region for programmed cell death that sculpts the fly eye. Cell Death Differ. [Epub ahead of print] 16710366

Montgomery, R. B., et al. (1995). Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor. J. Biol. Chem. 270: 30562-30566

Moon, N. S., Di Stefano, L. and Dyson, N. (2006). A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Mol. Cell Biol. 26(20): 7601-15. Medline abstract: 16954388

Morey, M., et al. (2001). Modulation of the Ras/MAPK signaling pathway by the redox function of selenoproteins in Drosophila melanogaster. Dev. Bio. 238: 145-156

Moriai, T., et al. (1994). A variant epidermal growth factor receptor exhibits altered type alpha transforming growth factor binding and transmembrane signaling. Proc. Natl. Acad. Sci. 91: 10217-10221

Moriki, T., Maruyama, H. and Maruyama, I. N. (2001). Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain. J. Mol. Biol. 311: 1011-1026. 11531336

Morimoto, A. M., et al. (1996). Pointed, an ETS domain transcription factor, negatively regulates the EGF receptor pathway in Drosophila oogenesis. Development 122: 3745-3754

Moro L., et al. (1998). Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival. EMBO J. 17(22): 6622-32

Morrison, P., Saltiel, A. R. and Rosner, M. R. (1996). Role of mitogen-activated protein kinase kinase in regulation of the epidermal growth factor receptor by protein kinase C. J. Biol. Chem. 271: 12891-12896. 996278681:

Moscatello, D. K., et al. (1996). Transformational and altered signal transduction by a naturally occurring mutant EGF receptor. Oncogene 13: 85-96

Mosesson, Y., et al. (2009). Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling. Dev Cell. 16(5): 687-98. PubMed Citation: 19460345

Murali, R., et al. (1996). Structural analysis of p185c-neu and epidermal growth factor receptor tyrosine kinases: oligomerization of kinase domains. Proc. Natl. Acad. Sci. 93: 6252-6257

Murillas, R., et al. (1995). Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure. EMBO J 14: 5216-5223

Continued: References part 2/2

EGF receptor : Biological Overview | Evolutionary Homologs | Regulation | Protein Interactions | Developmental Biology | Effects of Mutation

Home page: The Interactive Fly © 1995, 1996 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.