homothorax


REFERENCES

Aamar, E. and Frank, D. (2004). Xenopus Meis3 protein forms a hindbrain-inducing center by activating FGF/MAP kinase and PCP pathways. Development 131: 153-163.14660437

Abu-Shaar, M. and Mann, R. S. (1998). Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development. Development 125(19): 3821-3830.9729490

Agoston, Z. and Schulte, D. (2009). Meis2 competes with the Groucho co-repressor Tle4 for binding to Otx2 and specifies tectal fate without induction of a secondary midbrain-hindbrain boundary organizer. Development 136: 3311-3322. PubMed ID:19736326

Agoston, Z., Heine, P., Brill, M. S., Grebbin, B. M., Hau, A. C., Kallenborn-Gerhardt, W., Schramm, J., Gotz, M. and Schulte, D. (2014). Meis2 is a Pax6 co-factor in neurogenesis and dopaminergic periglomerular fate specification in the adult olfactory bulb. Development 141: 28-38. PubMed ID: 24284204

Ahn, Y., Zou, J. and Mitchell, P. J. (2011). Segment-specific regulation of theDrosophila AP-2 gene during leg and antennal development. Dev. Biol. 355(2): 336-48. PubMed ID:21575621

Aldaz, S., Morata, G. and Azpiazu, N. (2005). Patterning function ofhomothorax/extradenticle in the thorax of Drosophila. Development 132(3): 439-46.15634705

Ando, M., Totani, Y., Walldorf, U. and Furukubo-Tokunaga, K. (2011). TALE-class homeodomain transcription factors, homothorax and extradenticle, control dendritic and axonal targeting of olfactory projection neurons in the Drosophila brain. Dev. Biol. 358(1): 122-36. PubMed ID:21801717

Aspland, S. E. and White, R. A. H. (1997). Nucleocytoplasmic localization of extradenticle protein is spatially regulated throughout development in Drosophila. Development 124: 741-747.9043089

Athanikar, J. N., Sanchez, H. B. and Osborne, T. F. (1997). Promoter selective transcriptional synergy mediated by sterol regulatory element binding protein and Sp1: a critical role for the Btd domain of Sp1. Mol Cell Biol 17: 5193-5200. PubMed ID: 9271397

Azpiazu, N. and Morata, G. (2000). Function and regulation of homothorax in the wing imaginal disc of Drosophila. Development 127: 2685-2693. PubMed ID:10821766

Bansal, D., et al. (2006). Cdx4 dysregulatesHox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model. Proc. Natl. Acad. Sci. 103(45): 16924-9. PubMed ID:17068127

Berthelsen, J., et al. (1998a). Prep1, a novel functional partner of Pbx proteins. EMBO J. 17(5): 1423-33. PubMed ID:9482739

Berthelsen, J., et al. (1998b). The novel homeoprotein prep1 modulates pbx-Hox protein cooperativity. Embo J. 17(5): 1434-1445. PubMed ID:9482740

Berthelsen, J., et al. (1999). The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH. Genes Dev. 13(8): 946-53. PubMed ID:10215622

Bessa, J., et al. (2002). Combinatorial control of Drosophila eye development by Eyeless, Homothorax, and Teashirt. Genes Dev. 16: 2415-2427.12231630

Brown, J. D., Dutta, S., Bharti, K., Bonner, R. F., Munson, P. J., Dawid, I. B., Akhtar, A. L., Onojafe, I. F., Alur, R. P., Gross, J. M., Hejtmancik, J. F., Jiao, X., Chan, W. Y. and Brooks, B. P. (2009). Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closure. Proc Natl Acad Sci U S A 106: 1462-1467. PubMed ID: 19171890

Bischof, L. J., et al. (1998). Members of the meis1 and pbx homeodomain protein families cooperatively bind a cAMP-responsive sequence (CRS1) from bovine CYP17. J. Biol. Chem. 273(14): 7941-7948. PubMed ID:9525891

Burglin, T. R. (1999). Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals. Nucleic Acids Res. 25(21): 4173-80. PubMed ID:9336443

Capdevila, J., et al. (1999). Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. Mol. Cell 4(5): 839-49. PubMed ID:10619030

Casares, F. and Mann, R. S. (1998). Control of antennal versus leg development in Drosophila. Nature 392(6677): 723-726. PubMed ID:9565034

Casares, F. and Mann, R. S. (2000). A dual role forhomothorax in inhibiting wing blade development and specifying proximal wing identities inDrosophila. Development 127: 1499-1508. PubMed ID:10704395

Cecconi, F., et al. (1997). Expression of Meis2, a Knotted-related murine homeobox gene, indicates a role in the differentiation of the forebrain and the somitic mesoderm. Dev. Dyn. 210(2): 184-190. PubMed ID:9337138

Chang, C. P., et al. (1997). Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Mol. Cell. Biol. 17(10): 5679-5687. PubMed ID:9315626

Chang, C. P., et al. (2008). Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract. Development 135(21): 3577-86. PubMed ID:18849531

Choe, S.-K., Vlachakis, N. and Sagerström, C. G. (2002). Meis family proteins are required for hindbrain development in the zebrafish. Development 129: 585-595.11830560

Corsetti, E. and Azpiazu, N. (2013). Functional dissection of the splice variants of the Drosophila gene homothorax (hth). Dev Biol 384: 72-82. PubMed ID: 24075905

Dibner, C., Elias, S. and Frank, D. (2001). XMeis3 protein activity is required for proper hindbrain patterning in Xenopus laevis embryos. Development 128: 3415-3426.11566848

DiMartino, J. F., et al. (2001). The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver. Blood 98(3): 618-26.11468159

Dong, P. D. S., Chu, J. and Panganiban, G. (2000). Coexpression of the homeobox genes Distal-less and homothorax determines Drosophila antennal identity. Development 127: 209-216. PubMed ID:10603339

Dong, P. D. S., Dicks. J. S. and Panganiban, G. (2002).Distal-less andhomothorax regulate multiple targets to pattern the Drosophila antenna. Development 129: 1967-1974.11934862

Duncan, D., Kiefel, P. and Duncan, I. (2010). Control of thespineless antennal enhancer: direct repression of antennal target genes by Antennapedia. Dev. Biol. 347(1): 82-91. PubMed ID:20727877

Ebner, A., Cabernard, C., Affolter, M. and Merabet, S. (2005). Recognition of distinct target sites by a unique Labial/Extradenticle/Homothorax complex. Development 132: 1591-1600.15753213

Elkouby, Y. M., et al. (2010). Mesodermal Wnt signaling organizes the neural plate via Meis3. Development 137(9): 1531-41. PubMed ID:20356957

Emerald, B. S., Curtiss, J., Mlodzik, M. and Cohen, S. M. (2003).distal antenna anddistal antenna related encode nuclear proteins containing pipsqueak motifs involved in antenna development in Drosophila. Development 130: 1171-1180.12571108

Emmons, R. B., Duncan, D. and Duncan, I. (2007). Regulation of the Drosophila distal antennal determinantspineless, Dev. Biol. 302: 412-426. PubMed ID:17084833

Erclik, T., Li, X., Courgeon, M., Bertet, C., Chen, Z., Baumert, R., Ng, J., Koo, C., Arain, U., Behnia, R., Rodriguez, A. D., Senderowicz, L., Negre, N., White, K. P. and Desplan, C. (2017). Integration of temporal and spatial patterning generates neural diversity. Nature [Epub ahead of print]. PubMed ID: 28077877

Estrada, B. and Sánchez-Herrero, E. (2001). The Hox geneAbdominal-B antagonizes appendage development in the genital disc of Drosophila. Development 128: 331-339.11152632

Estella, C., et al. (2003). The role ofbuttonhead andSp1 in the development of the ventral imaginal discs of Drosophila. Development 130: 5929-5941.14561634

Ferretti, E., et al. (1999). The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse. Mech. Dev. 83(1-2): 53-64. PubMed ID:10381567

Ferretti, E., et al. (2000). Segmental expression ofHoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox protein. Development 127: 155-166. PubMed ID:10654609

Filion, G. J., van Bemmel, J. G., Braunschweig, U., Talhout, W., Kind, J., Ward, L. D., Brugman, W., de Castro, I. J., Kerkhoven, R. M., Bussemaker, H. J. and van Steensel, B. (2010). Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. Cell 143: 212-224. PubMed ID: 20888037

Gebelein, B., et al. (2002). Specificity ofDistalless repression and limb primordia development by Abdominal Hox proteins. Developmental Cell 3: 487-498.12408801

Gebelein, B., McKay, D. J. and Mann, R. S. (2004). Direct integration of Hox and segmentation gene inputs during Drosophila development. Nature 431: 653-659. PubMed ID:15470419

Glazov E. A., Pheasant M., McGraw E. A., Bejerano G. and Mattick, J. S. (2005). Ultraconserved elements in insect genomes: A highly conserved intronic sequence implicated in the control ofhomothorax mRNA splicing. Genome Res. 15: 800-808.15899965

Glazov, E. A., Pheasant, M., Nahkuri, S. and Mattick, J. S. (2006). Evidence for control of splicing by alternative RNA secondary structures in Dipteranhomothorax pre-mRNA. RNA Biol. 3(1): 36-39.17114937

González-Crespo, S. and Morata, G. (1996). Genetic evidence for the subdivision of the arthropod limb into coxopodite and telopodite. Development 122: 3921-3928. PubMed ID:9012512

Goto, S. and Hayashi, S. (1999). Proximal to distal cell communication in the Drosophila leg provides a basis for an intercalary mechanism of limb patterning. Development 126: 3407-3413. PubMed ID:10393119

Haller, K., Rambaldi, I., Daniels, E. and Featherstone, M. (2004). Subcellular localization of multiple PREP2 isoforms is regulated by actin, tubulin, and nuclear export. J. Biol. Chem. 279(47): 49384-94.15339927

Hasegawa, E., Kitada, Y., Kaido, M., Takayama, R., Awasaki, T., Tabata, T. and Sato, M. (2011). Concentric zones, cell migration and neuronal circuits in the Drosophila visual center. Development 138: 983-993. PubMed ID: 21303851

Hasegawa, E., Kaido, M., Takayama, R. and Sato, M. (2013). Brain-specific-homeobox is required for the specification of neuronal types in the Drosophila optic lobe. Dev Biol 377: 90-99. PubMed ID: 23454478

Henderson, K. D. and Andrew, D. J. (2000). Regulation and function ofScr, exd, andhth in the Drosophila salivary gland. Dev. Biol. 217: 362-374.10625560

Hudry, B., Remacle, S., Delfini, M. C., Rezsohazy, R., Graba, Y. and Merabet, S. (2012). Hox proteins display a common and ancestral ability to diversify their interaction mode with the PBC class cofactors. PLoS Biol 10: e1001351. Pubmed: 22745600

Inbal, A., et al. (2001). Genetic evidence for the transcriptional-activating function of Homothorax during adult fly development. Development 128: 3405-3413.11566847

Inbal, A., Volk, T. and Salzberg, A. (2004). Recruitment of ectodermal attachment cells via an EGFR-dependent mechanism during the organogenesis of Drosophila proprioceptors. Dev. Cell 7: 241-250.15296720

Inoue, Y., et al. (2002). Correlation of expression patterns ofhomothorax, dachshund, andDistal-less with the proximodistal segmentation of the cricket leg bud. Mech. Dev. 113: 141-148.11960702

Jackson, B., et al. (2011). TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier. J. Cell Sci. 124: 1681-1690. PubMed ID:21511732

Jacobs, Y., Schnabel, C. A. and Cleary, M. L. (1999). Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. Mol. Cell. Biol. 19: 5134-5142. PubMed ID:10373562

Jaw, T. J., et al. (2000). Direct interaction of two homeoproteins, Homothorax and Extradenticle, is essential for EXD nuclear localization and function. Mech. Dev. 91: 279-291. PubMed ID:10704852

Janody, F., et al. (2004). A mosaic genetic screen reveals distinct roles fortrithorax andPolycomb group genes in Drosophila eye development. Genetics 166: 187-200.15020417

Kannan, R., Berger, C., Myneni, S., Technau, G. M. and Shashidhara, L. S. (2010). Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system. Mech. Dev. 127(1-2): 137-45. PubMed ID:19799999

Karlsson, D., Baumgardt, M. and Thor, S. (2010). Segment-specific neuronal subtype specification by the integration of anteroposterior and temporal cues. PLoS Biol. 8(5): e1000368. PubMed ID:20485487

Kim, S. K., et al. (2002). Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. Nat. Genet. 30(4): 430-5.11912494

Kim, S. N., Jung, K. I., Chung, H. M., Kim, S. H. and Jeon, S. H. (2008). Thepleiohomeotic gene is required for maintaining expression of genes functioning in ventral appendage formation inDrosophila melanogaster. Dev. Biol. 319(1): 121-9. PubMed ID:18495104

Knoepfler, P. S., et al. (1997). Meis1 and pKnox1 bind DNA cooperatively with pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-pbx1. Proc. Natl. Acad. Sci. 94(26): 14553-14558. PubMed ID:9405651

Kobayashi, M., et al. (2003). Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila. Development 130: 741-751.12506004

Kondo, T., Isono, K., Kondo, K., Endo, T. A., Itohara, S., Vidal, M. and Koseki, H. (2014). Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer. Dev Cell 28: 94-101. PubMed ID: 24374176

Kroon, E., et al. (1998).Hoxa9 transforms primary bone marrow cells through specific collaboration withMeis1a but notPbx1b. EMBO J. 17(13): 3714-3725. PubMed ID:9649441

Kurant, E., et al. (1998). dorsotonals/ homothorax, the Drosophila homologue ofmeis1, interacts with extradenticle in patterning of the embryonic PNS. Development 125, 1037-1048. PubMed ID:9463350

Kurant, E., Eytan, D. and Salzberg, A. (2001). Mutational analysis of the Drosophilahomothorax gene. Genetics 157: 689-698.11156989

LaRonde-LeBlanc, N. A. and Wolberger, C. (2003). Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior. Genes Dev. 17: 2060-2072. PubMed ID:12923056

Li, X., Erclik, T., Bertet, C., Chen, Z., Voutev, R., Venkatesh, S., Morante, J., Celik, A. and Desplan, C. (2013). Temporal patterning of Drosophila medulla neuroblasts controls neural fates. Nature 498: 456-462. PubMed ID: 23783517

Li-Kroeger, D., Witt, L. M., Grimes, H. L., Cook, T. A. and Gebelein, B. (2008). Hox and senseless antagonism functions as a molecular switch to regulate EGF secretion in the Drosophila PNS. Dev. Cell 15(2): 298-308. PubMed ID:18694568

Maeda, R., Ishimura, A., Mood, K., Park, E. K., Buchberg, A. M. and Daar, I. O (2002). Xpbx1b and Xmeis1b play a collaborative role in hindbrain and neural crest gene expression in Xenopus embryos. Proc. Natl. Acad. Sci. 99(8): 5448-53.11960001

Manley, N. R., Selleri, L., Brendolan, A., Gordon, J. and Cleary, M. L. (2004). Abnormalities of caudal pharyngeal pouch development inPbx1 knockout mice mimic loss ofHox3 paralogs. Dev. Biol. 276(2): 301-12.15581866

Mann, R. S. and Abu-Shaar, M. (1996). Nuclear import of the homeodomain protein Extradenticle in response to Wg and Dpp signalling. Nature 383(6601): 630-633. PubMed ID:8857540

McDonald, E. C., Xie, B., Workman, M., Charlton-Perkins, M., Terrell, D. A., Reischl, J., Wimmer, E. A., Gebelein, B. A. and Cook, T. A. (2010). Separable transcriptional regulatory domains within Otd control photoreceptor terminal differentiation events. Dev Biol 347: 122-132. PubMed ID: 20732315

McGlinn, E., Richman, J. M., Metzis, V., Town, L., Butterfield, N. C., Wainwright, B. J. and Wicking, C. (2008). Expression of the NET family member Zfp503 is regulated by hedgehog and BMP signaling in the limb. Dev Dyn 237: 1172-1182. PubMed ID: 18351672

McKay, D. J., Estella, C. and Mann, R. S. (2009). The origins of the Drosophila leg revealed by the cis-regulatory architecture of the Distalless gene. Development 136(1): 61-71. PubMed ID:19036798

Mercader, N., et al. (2000). Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes. Development 127: 3961-3970

Mercader, N., Tanaka, E. M. and Torres, M. (2005). Proximodistal identity during vertebrate limb regeneration is regulated by Meis homeodomain proteins. Development 132(18): 4131-42.16107473

Morata, G. and Sanchez-Herrero, E. (1998). Pulling the fly's leg. Nature 392(6677): 657-658 . PubMed ID:

Moskow, J. J., et al. (1995). Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. Mol. Cell. Biol. 15(10): 5434-5443. PubMed ID:7565694

Nagao, T., et al. (2000). Patterning defects in the primary axonal scaffolds caused by the mutations of theextradenticle andhomothorax genes in the embryonicDrosophila brain. Dev. Genes Evol. 210: 289-299. PubMed ID:11180834

Nakamura, T., et al. (1996a). Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias. Nat. Genet. 12(2): 149-153. PubMed ID:8563752

Nakamura, T., Jenkins, N. A. and Copeland, N. G. (1996b). Identification of a new family of Pbx-related homeobox genes. Oncogene 13(10): 2235-2242. PubMed ID:8950991

Neto, M., Aguilar-Hidalgo, D. and Casares, F. (2016). Increased avidity for Dpp/BMP2 maintains the proliferation of progenitors-like cells in the Drosophila eye. Dev Biol 418(1):98-107 . PubMed ID: 27502436

Noro, B., Culi, J., McKay, D. J., Zhang, W. and Mann, R. S. (2006). Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax. Genes Dev. 20(12): 1636-50.16778079

Okano, H. and Temple, S. (2009). Cell types to order: temporal specification of CNS stem cells. Curr. Opin. Neurobiol. 19: 112-119. PubMed ID:19427192

Oulad-Abdelghani, M., et al. (1997). Meis2, a novel mouse Pbx-related homeobox gene induced by retinoic acid during differentiation of P19 embryonal carcinoma cells. Dev. Dyn. 210(2): 173-183. PubMed ID:9337137

Pai, C.-Y., et al. (1998). The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, Extradenticle, and suppresses eye development in Drosophila Genes Dev. 12(3): 435-446. PubMed ID:9450936

Peng, H. W., Slattery, M. and Mann, R. S. (2009). Transcription factor choice in the Hippo signaling pathway:homothorax andyorkie regulation of the microRNAbantam in the progenitor domain of the Drosophila eye imaginal disc. Genes Dev. 23(19): 2307-19. PubMed ID:19762509

Pereira-Castro, I., Costa, A. M., Oliveira, M. J., Barbosa, I., Rocha, A. S., Azevedo, L. and da Costa, L. T. (2013). Characterization of human NLZ1/ZNF703 identifies conserved domains essential for proper subcellular localization and transcriptional repression. J Cell Biochem 114: 120-133. PubMed ID: 22886885

Pichaud, F. and Casares, F. (2000).homothorax andiroquois-C genes are required for the establishment of territories within the developing eye disc. Mech. Dev. 96: 15-25. PubMed ID:10940621

Prpic, N. M., Janssen, R., Wigand, B., Klingler, M. and Damen, W. G. (2003). Gene expression in spider appendages reveals reversal ofexd/hth spatial specificity, altered leg gap gene dynamics, and suggests divergent distal morphogen signaling. Dev. Biol. 264(1): 119-40.14623236

Rauskolb, C. (2001). The establishment of segmentation in the Drosophila leg. Development 128: 4511-4521.11714676

Ribisi, S., et al. (2000). Ras-mediated FGF signaling is required for the formation of posterior but not anterior neural tissue inXenopus laevis. Dev. Bio. 227: 183-196. PubMed ID:11076686.

Rieckhof, G. E., et al. (1997). Nuclear translocation of Extradenticle requireshomothorax, which encodes an Extradenticle-related homeodomain protein. Cell 91: 171-183. PubMed ID:9346235

Rodriguez, D. d. A., et al. (2002). Different mechanisms initiate and maintainwingless expression in the Drosophila wing hinge. Development 129: 3995-4004.12163403

Rogers, W. A., Grover, S., Stringer, S. J., Parks, J., Rebeiz, M. and Williams, T. M. (2014). A survey of the trans-regulatory landscape for Drosophila melanogaster abdominal pigmentation. Dev Biol 385: 417-432. PubMed ID: 24269556

Rowan, S., et al. (2010). Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity. Genes Dev. 24(10): 980-5. PubMed ID:20413611

Runko, A. P. and Sagerstrom, C. G. (2004). Isolation of nlz2 and characterization of essential domains in Nlz family proteins. J Biol Chem 279: 11917-11925. PubMed ID: 14709556

Ryoo, H. D., et al. (1999). Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex. Development 126: 5137-5148. PubMed ID:10529430

Salvany, L., Aldaz, S., Corsetti, E. and Azpiazu, N. (2009). A new role for hth in the early pre-blastodermic divisions in Drosophila. Cell Cycle 8: 2748-2755. PubMed ID: 19652544

Schnabel, C. A., Selleri, L. and Cleary, M. L. (2003). Pbx1 is essential for adrenal development and urogenital differentiation. Genesis 37(3): 123-30.14595835

Shen, W. F., et al. (1997). AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. Mol. Cell. Biol. 17(11): 6448-6458. PubMed ID:9343407

Singh, A., Kango-Singh, M. and Sun, Y. H. (2002). Eye suppression, a novel function ofteashirt, requires Wingless signaling. Development 129: 4271-4280.12183379

Slattery, M., Voutev, R., Ma, L., Negre, N., White, K. P. and Mann, R. S. (2013). Divergent transcriptional regulatory logic at the intersection of tissue growth and developmental patterning. PLoS Genet 9: e1003753. PubMed ID: 24039600

Slorach, E. M., Chou, J. and Werb, Z. (2011). Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. Genes Dev 25: 471-484. PubMed ID: 21317240

Smith, F. W. and Jockusch, E. L. (2014). Hox genes require homothorax and extradenticle for body wall identity specification but not for appendage identity specification during metamorphosis of Tribolium castaneum. Dev Biol 395(1): 182-97. PubMed ID: 25195194

Steelman, S., et al. (1997). Identification of a conserved family of Meis1-related homeobox genes. Genome Res. 7(2): 142-156. PubMed ID:9049632

Stultz, B. G., Jackson, D. G., Mortin, M. A., Yang, X., Beachy, P. A. and Hursh, D. A. (2006). Transcriptional activation by Extradenticle in the Drosophila visceral mesoderm. Dev. Biol. 290(2): 482-94.16403493

Stultz, B. G., Lee, H., Ramon, K. and Hursh, D. A. (2006). Decapentaplegic head capsule mutations disrupt novel peripodial expression controlling the morphogenesis of the Drosophila ventral head. Dev Biol 296: 329-339. Pubmed: 16814276

Stultz, B. G., Park, S. Y., Mortin, M. A., Kennison, J. A. and Hursh D. A. (2012). Hox proteins coordinate peripodial decapentaplegic expression to direct adult head morphogenesis in Drosophila. Dev. Biol. 369(2): 362-76. PubMed ID: 22824425

Shukla, V., Habib, F., Kulkarni, A. and Ratnaparkhi, G. S. (2013). Gene duplication, lineage specific expansion and sub-functionalization in the MADF-BESS family patterns the Drosophila wing-hinge. Genetics 196(2): 481-96. PubMed ID: 24336749

Sun, B., Hursh, D. A., Jackson, D. and Beachy, P. A. (1995). Ultrabithorax protein is necessary but not sufficient for full activation ofdecapentaplegic expression in the visceral mesoderm. EMBO J. 14: 520-535.7859741

Suzanne, M., Estella, C., Calleja, M. and Sánchez-Herrero, E. (2003). Thehernandez andfernandez genes of Drosophila specify eye and antenna. Dev. Bio. 260: 465-483.12921746

Suzuki, T., Kaido, M., Takayama, R. and Sato, M. (2013). A temporal mechanism that produces neuronal diversity in the Drosophila visual center. Dev Biol 380: 12-24. PubMed ID: 23665475

Swift, G. H., et al. (1998). An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2). Mol. Cell. Biol. 18(9): 5109-20. PubMed ID:9710595

Toresson, H., Parmar, M. and Campbell, K. (2000). Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation. Mech. Dev. 94: 183-187. PubMed ID:10842069

Tucker, E. S., et al. (2010). Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium. Development 137(15): 2471-81. PubMed ID:20573694

Van Auken, K., et al. (2002). Roles of the Homothorax/Meis/Prep homolog UNC-62 and the Exd/Pbx homologs CEH-20 and CEH-40 in C. elegans embryogenesis. Development 129: 5255-5268.12399316

Vennemann, A., Agoston, Z. and Schulte, D. (2008). Differential and dose-dependent regulation of gene expression at the mid-hindbrain boundary by Ras-MAP kinase signaling. Brain Res. 1206: 33-43. PubMed ID:18343356

Veraksa, A., et al. (2000). Cap'n'collar B cooperates with a small Maf subunit to specify pharyngeal development and suppress Deformed homeotic function in the Drosophila head. Development 127: 4023-4037. PubMed ID:10952900

Vlachakis, N., Choe, S.-K. and Sagerstrom, C. G. (2001). Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish. Development 128: 1299-1312.11262231

Walsh, C. M. and Carroll, S. B. (2007). Collaboration between Smads and a Hox protein in target gene repression. Development 134: 3585-3592. PubMed ID:17855427

Wang, G. G., Pasillas, M. P. and Kamps, M. P. (2006). Persistent transactivation by meis1 replaces hox function in myeloid leukemogenesis models: evidence for co-occupancy of meis1-pbx and hox-pbx complexes on promoters of leukemia-associated genes. Mol. Cell. Biol. 26(10): 3902-16. PubMed ID:16648484

Waskiewicz, A. J., et al. (2001). Zebrafish Meis functions to stabilize Pbx proteins and regulate hindbrain patterning. Development 128: 4139-4151.11684652

Wassef, M. A., et al. (2008). Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors. Development 135: 3369-3378. PubMed ID:18787068

Weihe, U., et al. (2004). Proximodistal subdivision of Drosophila legs and wings: Theelbow-no ocelli gene complex. Development 131: 767-774. PubMed ID:14757638

Wernet, M. F., et al. (2003). Homothorax switches function of Drosophila photoreceptors from color to polarized light sensors. Cell 115: 267-279.14636555

Wernet, M. F., Meier, K. M., Baumann-Klausener, F., Dorfman, R., Weihe, U., Labhart, T. and Desplan, C. (2014). Genetic dissection of photoreceptor subtype specification by the Drosophila melanogaster zinc finger proteins Elbow and No ocelli. PLoS Genet 10: e1004210. PubMed ID: 24625735

Whitworth, A. J. and Russell, S. (2003). Temporally dynamic response to Wingless directs the sequential elaboration of the proximodistal axis of the Drosophila wing, Dev. Bio. 254: 277-288.12591247

Williams, T. M., Williams, M. E. and Innis, J. W. (2005). Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction. Dev. Biol. 277(2): 457-71.15617687

Wong, P., et al. (2007). Meis1 is an essential and rate-limiting regulator ofMLL leukemia stem cell potential. Genes Dev. 21(21): 2762-74. PubMed ID:17942707

Wu, J. and Cohen, S. M. (1999). Proximodistal axis formation in theDrosophila leg: subdivision into proximal and distal domains by Homothorax and Distal-less. Development 126: 109-117. PubMed ID:9834190

Wu, J. and Cohen, S. M. (2000). Proximal distal axis formation in the Drosophila leg: distinct functions of Teashirt and Homothorax in the proximal leg. Mech. Dev. 94: 47-56. PubMed ID:10842058

Wu, J. and Cohen, S. M. (2002). Repression of Teashirt marks the initiation of wing development. Development 129: 2411-2418.11973273

Yang, Y., Hwang, C. K., D'Souza, U. M., Lee, S. H., Junn, E. and Mouradian, M. M. (2000). Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription. J. Biol. Chem. 275: 20734-20741.10764806

Yang, L., Sym, M. and Kenyon, C. (2005). The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development. Development 132(6): 1413-28.15750187

Yao, L. C., et al. (1999). A common mechanism for antenna-to-leg transformation inDrosophila: suppression of homothorax transcription by four HOM-C genes. Dev. Biol. 211(2): 268-76. PubMed ID:10395787

Zhang, T., Zhou, Q. and Pignoni, F. (2011). Yki/YAP, Sd/TEAD and Hth/MEIS control tissue specification in the Drosophila eye disc epithelium. PLoS One 6(7): e22278. PubMed ID:21811580

Zhang, X., et al. (2002). Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis. Genes Dev. 16: 2097-2107.12183364

Zirin, J. D. and Mann, R. S. (2004). Differing strategies for the establishment and maintenance ofteashirt andhomothorax repression in theDrosophila wing. Development 131: 5683-5693.15509768


homothorax: Biological Overview |Evolutionary Homologs |Regulation |Targets of Activity |Protein Interactions |Developmental Biology |Effects of Mutation

date revised: 5 February 2015

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