hedgehog

REFERENCES (part 3/3)

Naski, M. C., et al. (1998). Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Development 125(24): 4977-88.

Nery, S., et al. (2001). Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain. Development 128: 527-540. 11171336

Neumann, C. J., et al. (1999). Transient establishment of anteroposterior polarity in the zebrafish pectoral fin bud in the absence of sonic hedgehog activity. Development 126: 4817-4826.

Niwa, N., et al. (2000). Correlation of diversity of leg morphology in Gryllus bimaculatus (cricket) with divergence in dpp expression pattern during leg development. Development 127: 4373-4381.

Nomura, T. and Fujisawa, H. (2000). Alteration of the retinotectal projection map by the graft of mesencephalic floor plate or Sonic hedgehog. Development 127: 1899-1910. 10751178

Noveen, A., Jiang, T. X. and Chuong, C. M. (1996). cAMP, an activator of protein kinase A, suppresses the expression of sonic hedgehog. Biochem. Biophys. Res. Commun. 219: 180-815

Nussbaumer, U., et al. (2000). Expression of the blistered/DSRF gene is controlled by different morphogens during Drosophila trachea and wing development. Mech. Dev. 96: 27-36.

Nybakken, K., Vokes, S. A., Lin, T. Y., McMahon, A. P. and Perrimon, N. (2005). A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat. Genet. 37(12): 1323-32. 16311596

Odenthal, J., et al. (2000). Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways. Dev. Biol. 219: 350-363.

Ohlmeyer, J. T. and Kalderon, D. (1997). Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos. Genes Dev. 11(17): 2250-2258.

Ohuchi. H., et al. (1997). A chick wingless mutation causes abnormality in maintenance of Fgf8 expression in the wing apical ridge, resulting in loss of the dorsoventral boundary. Mech. Dev. 62 (1): 3-13.

Oliver, T. G., et al. (2003). Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Proc. Natl. Acad. Sci. 100(12): 7331-6. 12777630

Orentas, D. M., et al. (1999). Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors. Development 126: 2419-2429.

Oro, A. E., et al. (1997). Basal cell carcinomas in mice overexpressing sonic hedgehog. Science 276(5313): 817-21.

Paganelli, A. R., et al. (2001). The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis. Mech. Dev. 107: 119-131. 11520668

Page, D. T. (2002). Inductive patterning of the embryonic brain in Drosophila. Development 129: 2121-2128. 11959822

Pallavi, S. K. and Shashidhara, L. S. (2003). Egfr/Ras pathway mediates interactions between peripodial and disc proper cells in Drosophila wing discs. Development 130: 4931-4941. 12930782

Palma, V., and Altaba, A. R. i. (2004). Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex. Development 131: 337-345. 14681189

Palma, V., et al. (2005). Sonic hedgehog controls stem cell behavior in the postnatal and adult brain. Development 132(2): 335-44. 15604099

Panakova, D., Sprong, H., Marois, E., Thiele, C. and Eaton, S. (2005). Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature 435: 58-65. PubMed citation: 15875013

Pankratz, M. J. and Hoch, M. (1995). Control of epithelial morphogenesis by cell signaling and integrin molecules in the Drosophila foregut. Development 121: 1885-1898

Pappu, K. S., et al. (2003). Mechanism of hedgehog signaling during Drosophila eye development. Development 130: 3053-3062. 12756186

Park, H.-C., Shin, J. and Appel, B. (2004). Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling. Development 131: 5959-5969. 15539490

Park, Y., (2003). Drosophila Perlecan modulates FGF and Hedgehog signals to activate neural stem cell division. Dev. Bio. 253: 247-257. 12645928

Pasca di Magliano, M., et al. (2007). Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes Dev. 20: 3161-3173. Medline abstract: 17114586

Pathi, S., et al. (1999). Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation. Dev. Biol. 209(2): 239-53.

Pathi, S., et al. (2001). Comparative biological responses to human Sonic, Indian, and Desert hedgehog. Mech. Dev. 106: 107-117. 11472839

Patten, I., et al. (2003). Distinct modes of floor plate induction in the chick embryo. Development 130: 4809-4821. 12917296

Pauli, T. Seimiya, M., Blanco, J. and Gehring, W. J. (2005). Identification of functional sine oculis motifs in the autoregulatory element of its own gene, in the eyeless enhancer and in the signalling gene hedgehog. Development 132: 2771-2782. 15901665

Pepicelli, C. V., Lewis, P. M. and McMahon, A. P. (1998). Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr. Biol. 8(19): 1083-6.

Pepinsky, R.B., Zeng, C., Wen, D., Rayhorn, P., Baker, D.P., Williams, K.P., Bixler, S.A., Ambrose, C.M., Garber, E.A., and Miatkowski, K. et al. (1998). Identification of a palmitic acid-modified form of human Sonic hedgehog. J. Biol. Chem. 273: 14037-14045.

Perriton, C. L., et al. (2002). Sonic hedgehog signaling from the urethral epithelium controls external genital development. Dev. Bio. 247: 26-46. 12074550

Perron, M., et al. (2003). A novel function for Hedgehog signalling in retinal pigment epithelium differentiation. Development 130: 1565-1577. 12620982

Pierani, A., et al. (1999). A Sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Cell 97: 903-915.

Piepenburg, O., Vorbruggen, G., Jackle, H. (2000). Drosophila segment borders result from unilateral repression of hedgehog activity by wingless signaling. Mol. Cell 6(1): 203-9. 10949042

Pielage, J., Kippert, A., Zhu, M. and Klämbt C. (2004). The Drosophila transmembrane protein Fear-of-intimacy controls glial cell migration. Dev. Biol. 275(1): 245-57. 15464587

Pirskanen, A., Kiefer, J. C. and Hauschka, S. D. (2000). IGFs, insulin, Shh, bFGF, and TGF-beta1 interact synergistically to promote somite myogenesis in vitro. Dev. Bio. 224: 189-203.

Pituello, F. et al. (1999). Activation of Pax6 depends on somitogenesis in the chick embryo cervical spinal cord. Development. 126: 587-596.

Platt, K. A., Michaud, J. and Joyner, A. L. (1997). Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice. Mech. Dev. 62 (2): 121-135.

Podlasek, C. A., et al. (1999). Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium. Dev. Biol. 209(1): 28-39.

Poncet, C., et al. (1996). Induction of oligodendrocyte progenitors in the trunk neural tube by ventralizing signals: effects of notochord and floor plate grafts, and of sonic hedgehog. Mech. Dev. 60(1): 13-32. 97177542

Pons, S. and Marti, E. (2000). Sonic hedgehog synergizes with the extracellular matrix protein Vitronectin to induce spinal motor neuron differentiation. Development 127: 333-342.

Pons, S., et al. (2001). Vitronectin regulates Sonic hedgehog activity during cerebellum development through CREB phosphorylation. Development 128: 1481-1492. 11290288

Ponzielli, R., et al. (2002). Heart tube patterning in Drosophila requires integration of axial and segmental information provided by the Bithorax Complex genes and hedgehog signaling. Development 129: 4509-4521. 12223408

Porter, J. A., et al. (1995). The product of hedgehog autoproteolytic cleavage active in local and long-range signalling. Nature 374(6520): 363-6. 7885476

Porter, J. A., et al. (1996a). Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Cell 86: 21-34

Porter, J. A., Young, K. E. and Beachy, P. A. (1996b). Cholesterol modification of hedgehog signaling proteins in animal development. Science 274: 255-259.

Price, M. H., et al. (2006). Cytoskeletal dynamics and cell signaling during planar polarity establishment in the Drosophila embryonic denticle. J. Cell Sci. 119: 403-415. 16418222

Pringle, N. P., et al. (1996). Determination of neuroepithelial cell fate: induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog. Dev Biol 177(1): 30-42.

Pu, Y., Huang, L. and Prins, G. S. (2004), Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching. Dev. Biol. 273: 257-275. 15328011

Pummila, M., et al. (2007). Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression. Development 134(1): 117-25. Medline abstract: 17164417

Rallu, M., et al. (2002). Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling Development 129: 4963-4974. 12397105

Ramalho-Santos, M., Melton, D. A. and McMahon, A. P. (2000). Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127: 2763-2772.

Ramírez-Weber, F.-A., et al. (2000). Hedgehog signal transduction in the posterior compartment of the Drosophila wing imaginal disc. Molec. Cell 6: 479-485

Rangarajan, R., Courvoisier, H. and Gaul, U. (2001). Dpp and Hedgehog mediate neuron-glia interactions in Drosophila eye development by promoting the proliferation and motility of subretinal glia. Mech. Dev. 108: 93-103. 11578864

Reddy, S., et al. (2001). Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech. Dev. 107: 69-82. 11520664

Revest, J.-M., et al. (2001). Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4. Dev. Bio. 231: 47-62. 11180951

Riccomagno, M. M., et al. (2002). Specification of the mammalian cochlea is dependent on Sonic hedgehog. Genes Dev. 16: 2365-2378. 12231626

Riem, K. F., Jessell, T. M. and Briscoe, J. (2000). Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites. Development 127: 4855-4866

Rietveld A., Neutz S., Simons K. and Eaton S. (1999). Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains. J. Biol. Chem. 274: 12049-12054. 10207028

Rios, I., et al. (2004). Bmp2 antagonizes sonic hedgehog-mediated proliferation of cerebellar granule neurones through Smad5 signalling. Development 131: 3159-3168. 15197161

Robertson, C. P., Gibbs, S. M. and Roelink, H. (2001). cGMP enhances the Sonic hedgehog response in neural plate cells. Dev. Bio. 238: 157-167

Roessler, E., et al. (1996). Mutations in the human Sonic hedgehog gene cause holoprosencephaly. Nature Genet. 14: 357-360

Rogers, E. M., Brennan, C. A., Mortimer, N. T., Cook, S., Morris, A. R. and Moses. K. (2005). Pointed regulates an eye-specific transcriptional enhancer in the Drosophila hedgehog gene, which is required for the movement of the morphogenetic furrow. Development 132(21): 4833-43. 16207753

Rohatgi, R., Milenkovic, L. and Scott, M. P. (2007). Patched1 regulates hedgehog signaling at the primary cilium. Science 317(5836): 372-6. Medline abstract: 17641202

Rohr, K. B., Schulte-Merker, S. and Tautz, D. (1999). Zebrafish zic1 expression in brain and somites is affected by BMP and Hedgehog signalling. Mec. Dev. 85(1-2): 147-159.

Rohr, K. B., et al. (2001). The nodal pathway acts upstream of hedgehog signaling to specify ventral telencephalic identity. Neuron 29: 341-351. 11239427

Roy, S., Wolff, C. and Ingham, P. W. (2001a). The u-boot mutation identifies a Hedgehog-regulated myogenic switch for fiber-type diversification in the zebrafish embryo. Genes Dev. 15: 1563-1576. 11410536

Roy, S., et al. (2001b). Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo. Curr. Biol. 11: 1358-1363. 11553330

Royet, J. and Finkelstein, R. (1996). hedgehog, wingless and orthodenticle specify adult head development in Drosophila. Development 122: 1849-58

Royet, J. and Finkelstein, R. (1997). Establishing primordia in the Drosophila eye-antennal imaginal disc: the roles of decapentaplegic, wingless and hedgehog. Development 124(23): 4793-4800.

Rubin, J. B. Choi, Y. and Segal, R. A. (2002). Cerebellar proteoglycans regulate sonic hedgehog responses during development. Development 129: 2223-2232. 11959830

Sagai, T., Hosoya, M., Mizushina, Y., Tamura, M. and Shiroishi, T. (2005). Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb. Development 32(4): 797-803. 15677727

Sampedro, J. and Guerrero, I. (1991). Unrestricted expression of the Drosophila gene patched allows a normal segment polarity. Nature 353: 187-90

S·nchez, L., et al. (1997). The genital disc of Drosophila melanogaster II. Role of the genes hedgehog, decapentaplegic and wingless. Dev. Genes Evol. 207: 229-241

Sánchez-Herrero, E., et al. (1996). The fu gene discriminates between pathways to control dpp expression in Drosophila imaginal discs. Mech. Dev. 55: 159-170

Sanson, B., et al. (1999). Engrailed and Hedgehog make the range of Wingless asymmetric in Drosophila embryos. Cell 98: 207-216.

Sanz-Ezquerro, J. J. and Tickle, C. (2000). Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarizing activity during chick limb development. Development 127: 4811-4823

Sbrogna, J. L., Barresi, M. J. F. and Karlstrom, R. O. (2003). Multiple roles for Hedgehog signaling in zebrafish pituitary development. Dev. Bio. 254: 19-35. 12606279

Schafer, M., et al. (2005). Hedgehog and retinoid signalling confines nkx2.2b expression to the lateral floor plate of the zebrafish trunk. Mech. Dev. 122(1): 43-56. 15582776

Schauerte, H. E., et al. (1998). Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish. Development 125(15): 2983-2993.

Schilling, T. F., Concordet, J. P. and Ingham, P. W. (1999). Regulation of left-right asymmetries in the zebrafish by Shh and BMP4. Dev. Biol. 210(2): 277-87.

Schlichting, K., Demontis, F. and Dahmann, C. (2005). Cadherin Cad99C is regulated by Hedgehog signaling in Drosophila. Dev. Biol. 279: 142-154. 15708564

Schmidt, M., Tanaka, M. and Mönsterberg, A. (2000). Expression of beta-catenin in the developing chick myotome is regulated by myogenic signals. Development 127: 4105-4113

Schnapp, E., Kragl, M., Rubin, L. and Tanaka, E. M. (2005). Hedgehog signaling controls dorsoventral patterning, blastema cell proliferation and cartilage induction during axolotl tail regeneration. Development 132(14): 3243-53. 15983402

Schuske, K., Hooper J. E. and Scott, M. P. (1994). patched overexpression causes loss of wingless expression in Drosophila embryos. Dev Biol 164: 300-311

Sedkov, Y., et al. (2003). Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila. Nature 426(6962): 78-83. 14603321

Sekimizu, K., et al. (2004). The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling. Development 131: 2521-2532. 15115751

Selleck, M. A., et al. (1998). Effects of Shh and Noggin on neural crest formation demonstrate that BMP is required in the neural tube but not ectoderm. Development 125(24): 4919-30.

Sharpe, J., et al. (1999). Identification of Sonic hedgehog as a candidate gene responsible for the polydactylous mouse mutant Sasquatch. Curr. Biol. 9(2): 97-100.

Shimamura, K. and Rubenstein, J. L. (1997). Inductive interactions direct early regionalization of the mouse forebrain. Development 124(14): 2709-2718.

Shimeld, S. M. (1999). The evolution of the hedgehog gene family in chordates: insights from amphioxus hedgehog. Dev. Genes Evol. 209(1): 40-7.

Shkumatava, A., et al. (2004). Sonic hedgehog, secreted by amacrine cells, acts as a short-range signal to direct differentiation and lamination in the zebrafish retina. Development 131: 3849-3858. 15253932

Soula, C., et al. (2001). Distinct sites of origin of oligodendrocytes and somatic motoneurons in the chick spinal cord: oligodendrocytes arise from Nkx2.2-expressing progenitors by a Shh-dependent mechanism. Development 128: 1369-1379. 11262237

Spassky, N., et al. (2001). Sonic hedgehog-dependent emergence of oligodendrocytes in the telencephalon: evidence for a source of oligodendrocytes in the olfactory bulb that is independent of PDGFRalpha signaling. Development 128: 4993-5004. 11748136

Spence, J. R., et al. (2004). The hedgehog pathway is a modulator of retina regeneration. Development 131: 4607-4621. 15342484

Sriram, V., Krishnan, K. S. and Mayor, S. (2003). deep-orange and carnation define distinct stages in late endosomal biogenesis in Drosophila melanogaster. J. Cell Biol. 161(3): 593-607. 12743107

St-Jacques, B., et al. (1998). Sonic hedgehog signaling is essential for hair development. Curr. Biol. 8(19): 1058-68.

Stenkamp, D. L., et al. (2000). Function for hedgehog genes in zebrafish retinal development. Dev. Biol. 220: 238-252

Stenkamp, D. L. and Frey, R. A. (2003). Extraretinal and retinal hedgehog signaling sequentially regulate retinal differentiation in zebrafish. Dev. Biol. 258: 349-363. 12798293

Stratford, T. H., Kostakopoulou, K. and Maden, M. (1997). Hoxb-8 has a role in establishing early anterior-posterior polarity in chick forelimb but not hindlimb. Development 124(21): 4225-4234.

Strigini, M. and Cohen, S. M. (1997). A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. Development 124(22): 4697-4705.

Sturtevant, M. A., et al. (1997). The spalt gene links the A/P compartment boundary to a linear adult structure in the Drosophila wing. Development 124: 21-32 (1997)

Stone, D. M., et al. (1996). The tumor-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384: 129-34

Struhl, G., Barbash, D. A. and Lawrence, P. A. (1997a). Hedgehog organizes the pattern and polarity of epidermal cells in the Drosophila abdomen. Development 124 (11): 2143-2154.

Struhl, G., Barbash, D. A. and Lawrence, P. A. (1997b). Hedgehog acts by distinct gradient and signal relay mechanisms to organize cell type and cell polarity in the Drosophila abdomen. Development 124 (11): 2155-2165.

Strutt, D. I., Wiersdorff, W. and Mlodzik M. (1995a). Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A. Nature 373: 705-709

Strutt, D. I. and Mlodzik, M. (1995b). Ommatidial polarity in the Drosophila eye is determined by the direction of furrow progression and local interactions. Development 121: 4247-4256

Strutt, D. I. and Mlodzik, M. (1996). The regulation of hedgehog and decapentaplegic during Drosophila eye imaginal disc development. Mech. Dev. 58: 39-50

Strutt, D. I. and Mlodzik, M. (1997). Hedgehog is an indirect regulator of morphogenetic furrow progression in the Drosophila eye disc. Development 124(17): 3233-3240.

Strutt, H., et al. (2001). Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation Curr. Biol. Vol 11: 608-613. 11369206

Sukegawa, A., et al. (2000). The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium. Development 127: 1971-1980

Sun, Y., Jan, L. Y. and Jan, Y. N. (1998). Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system. Development 125: 3731-3740.

Sussel, L., et al. (1999). Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development 126: 3359-3370.

Suzuki, T. and Saigo, K. (2000). Transcriptional regulation of atonal required for Drosophila larval eye development by concerted action of Eyes absent, Sine oculis and Hedgehog signaling independent of Fused kinase and Cubitus interruptus. Development 127: 1531-1540.

Suzuki, T., et al. (2004). Tbx genes specify posterior digit identity through Shh and BMP signaling. Dev. Cell 6: 43-53. 14723846

Svärd, J., et al. (2006). Genetic elimination of Suppressor of Fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev. Cell 10: 187-197. 16459298

Tabata, T. and Kornberg, T. B. (1994). Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 76: 89-102

Takahashi, M., et al. (1998). The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development. Development 125(22): 4417-4425

Takashima, S. and Murakami, R. (2001). Regulation of pattern formation in the Drosophila hindgut by wg, hh, dpp, and en. Mech. Dev. 101: 79-90. 11231061

Takei, Y., et al. (2004). Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans. Development 131: 73-82. 14645127

Take-uchi, M., Clarke, J. D. W. and Wilson, S. W. (2003). Hedgehog signalling maintains the optic stalk-retinal interface through the regulation of Vax gene activity. Development 130: 955-968. 12538521

Tanabe, Y., William, C. and Jessell, T. M. (1998). Specification of motor neuron identity by the MNR2 homeodomain protein. Cell 95(1): 67-80.

Tanimoto, H., et al. (2000). Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs. Molec. Cell 5: 59-71.

Tashiro, S., et al. (1993). Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication. Gene 124: 183-9

Taylor, K. M. and Nicholson, R. I. (2003). The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta. 2003 Apr 1;1611(1-2):16-30. 12659941

Teillet, M. A., Lapointe, F., Le Douarin, N. M. (1998). The relationships between notochord and floor plate in vertebrate development revisited. Proc. Natl. Acad. Sci. 95(20): 11733-8.

ten Berge, D., et al. (2001). Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis. Development 128: 2929-2938. 11532916

Tenzen, T., Allen, B. L., Cole, F., Kang, J. S., Krauss, R. S. and McMahon, A. P. (2006). The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev. Cell 10(5): 647-56. Medline abstract: 16647304

Thesleff, I. and Sharpe, P. (1997). Signalling networks regulating dental development. Mech. Dev. 67(2): 111-123.

Thérond, P. P., et al. (1996). Phosphorylation of the fused protein kinase in response to signaling from hedgehog. Proc. Natl. Acad. 93: 4224-28.

Tian, H., Tenzen, T. and McMahon, A. P. (2004). Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse. Development 131: 4021-4033. 15269168

Torroja, C., Gorfinkiel, N. and Guerrero, I. (2004). Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction. Development 131: 2395-2408. 15102702

Toyoda, H., Kinoshita-Toyoda, A. and Selleck, S. B. (2000). Structural analysis of glycosaminoglycans in Drosophila and Caenorhabditis elegans and demonstration that tout-velu, a Drosophila gene related to EXT tumor suppressors, affects heparan sulfate in vivo. J. Biol. Chem. 275(4): 2269-75.

Treier, M., et al. (2001). Hedgehog signaling is required for pituitary gland development. Development 128: 377-386. 11152636

Trousse1,, F., et al. (2001). Control of retinal ganglion cell axon growth: a new role for Sonic hedgehog. Development 128: 3927-3936. 11641217

Tümpel, S., et al. (2002). Regulation of Tbx3 expression by anteroposterior signalling in vertebrate limb development. Dev. Bio. 250: 251-262. 12376101

Tworoger, M. et al. (1999). Mosaic analysis in the Drosophila ovary reveals a common Hedgehog-inducible precursor stage for stalk and polar cells Genetics 151: 739-748.

Umetsu, D., Murakami, S., Sato, M. and Tabata, T. (2006). The highly ordered assembly of retinal axons and their synaptic partners is regulated by Hedgehog/Single-minded in the Drosophila visual system. Development 133(5): 791-800. 16439478

Ungos, J. M., Karlstrom, R. O. and Raible, D. W. (2003). Hedgehog signaling is directly required for the development of zebrafish dorsal root ganglia neurons. Development 130: 5351-5362. 13129844

Vaillant, C., et al. (2007). Protease nexin 1 and its receptor LRP modulate SHH signalling during cerebellar development. Development 134(9): 1745-54. Medline abstract: 17409116

van den Heuvel, M. and Ingham, P. W. (1996). smoothened encodes a receptor-like serpentine protein required for hedgehog signaling. Nature 382: 547-551

Van Ohlen, T., et al. (1997). Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proc. Natl. Acad. Sci. 94: 2404-09

Vasiliauskas, D., Hancock, S., and Stern, C. D. (1999). SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development. Mech. Dev. 82(1-2): 79-94.

Vervoort, M., Crozatier, M., Valle, D. and Vincent, A. (1999). The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing. Curr. Biol. 9(12): 632-9.

Vidal, V. P., Chaboissier, M. C., Lutzkendorf, S., Cotsarelis, G., Mill, P., Hui, C. C., Ortonne, N., Ortonne, J. P. and Schedl, A. (2005). Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr. Biol. 15: 1340-1351. PubMed citation: 16085486

Vied, C. and Horabin, J. I. (2001). The sex determination master switch, Sex-lethal, responds to Hedgehog signaling in the Drosophila germline. Development 128: 2649-2660. 11526072

Vied, C., Halachmi, N., Salzberg, A. and Horabin, J. I. (2003). Antizyme is a target of Sex-lethal in the Drosophila germline and appears to act downstream of Hedgehog to regulate Sex-lethal and Cyclin B. Dev. Bio. 253: 214-229. 12645926

Vokes, S. A., et al. (2004). Hedgehog signaling is essential for endothelial tube formation during vasculogenesis. Development 131: 4371-4380. 15294868

Vokes, S. A., et al. (2007). Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development 134(10): 1977-89. Medline abstract: 17442700

Vrailas, A. D. and Moses, K. (2006). smoothened, thickveins and the genetic control of cell cycle and cell fate in the developing Drosophila eye. Mech. Dev. 123(2): 151-65. 16412615

Wada, N., et al. (2005). Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull. Development 132: 3977-3988. 16049113

Wallace, V. A. (1999a). Purkinje-cell-derived sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum. Curr. Biol. 9(8): 445-8.

Wallace, V. A. and Raff, M. C. (1999b). A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve. Development 126: 2901-2909.

Wang, M. Z., et al. (1995). Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein. Nat. Med, 1(11): 1184-8.

Wang, S., et al. (2004). Chick Pcl2 regulates the left-right asymmetry by repressing Shh expression in Hensen's node. Development 131: 4381-4391. 15294861

Watanabe, Y., et al. (1998). Two domains in vertebral development: antagonistic regulation by SHH and BMP4 proteins. Development 125(14): 2631-2639.

Watanabe, Y. and Nakamura, H. (2000). Control of chick tectum territory along dorsoventral axis by Sonic hedgehog. Development 127: 1131-1140.

Wechsler-Reya, R. J. and Scott, M. P. (1999). Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22(1): 103-14.

Weigmann, K. and Cohen, S. M. (1999). Lineage-tracing cells born in different domains along the PD axis of the developing Drosophila leg. Development 126: 3823-3830. 10433911

Wessells, R. J., et al. (1999). Tissue-specific regulation of vein/EGF receptor signaling in Drosophila. Dev. Biol. 216(1): 243-59.

Wijgerde, M., et al. (2002). A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev. 16: 2849-2864. 12435628

Wolff, C., Roy, A. and Ingham, P. W. (2003). Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo. Curr. Biol. 13: 1169-1181. 12867027

Wu, S. C.-Y.., et al. (1998). Mouse Mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis. Mech. Dev. 70: 3-13.

Xiao, H., Hrdlicka, L. A. and Nambu, J. R. (1996). Alternate functions of single-minded and rhomboid genes in development of the Drosophila Mech. Dev. 58: 65-74

Xu, Q., Wonders, C. P. and Anderson, S. A. (2005). Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon. Development 132(22): 4987-98. 16221724

Yang, Y., et al. (1997). Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. Development 124(21): 4393-4404.

Yang Y., et al. (1998). Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian hedgehog signaling. Development 125(16): 3123-3132.

Yao, S., Lum. L. and Beachy, P. (2006). The ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Cell 125: 343-357. Medline abstract: 16630821

Ybot-Gonzalez, P., et al. (2002). Sonic hedgehog and the molecular regulation of mouse neural tube closure. Development 129: 2507-2517. 11973280

Yip, G. W., Ferretti, P. and Copp, A. J. (2002). Heparan sulphate proteoglycans and spinal neurulation in the mouse embryo. Development 129: 2109-2119. 11959821

Yoshida, C. A., et al. (2004). Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 18: 952-963. 15107406

Zecca, M.. Basler, K., and Struhl, G. (1995). Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing. Development 121: 2265-2278

Zeltser, L. M. (2005). Shh-dependent formation of the ZLI is opposed by signals from the dorsal diencephalon. Development 132(9): 2023-33. 15788458

Zeng, L., et al. (2002). Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis. Genes Dev. 16: 1990-2005. 12154128

Zeng, X., et al. (2001), A freely diffusible form of Sonic hedgehog mediates long-range signalling. Nature 411: 716-720. 11395778

Zhang, B., et al. (1997). A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line. Nature 390(6659): 477-84.

Zhang, J., et al. (2001). Downregulation of hedgehog signaling is required for organogenesis of the small intestine in Xenopus. Dev. Biol. 229: 188-202. 11133163

Zhang, W., Kang, J. S., Cole, F., Yi, M. J. and Krauss, R. S. (2006). Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Dev. Cell. 10(5): 657-65. Medline abstract: 16647303

Zhang, X.-M. and Yang, X.-J. (2001). Regulation of retinal ganglion cell production by Sonic hedgehog. Development 128: 943-957. 11222148

Zhang, Y., et al. (2000a). A new function of BMP4: dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ. Development 127: 1431-1443.

Zhang, Y. and Kalderon, D. (2000b). Regulation of cell proliferation and patterning in Drosophila oogenesis by Hedgehog signaling. Development 127: 2165-2176. 10769240

Zhang, Y. and Kalderon, D. (2001). Hedgehog acts as a somatic stem cell factor in the Drosophila ovary. Nature 410: 599-604. 11279500

Zhang, Z., et al. (2002). Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis. Development 129: 4135-4146. 12163415

Zhao, Y., Tong, C. and Jiang, J. (2007). Hedgehog regulates smoothened activity by inducing a conformational switch. Nature 450(7167): 252-8. PubMed citation: 17960137

Zhu, G., et al. (1999). Sonic hedgehog and BMP2 exert opposing actions on proliferation and differentiation of embryonic neural progenitor cells. Dev. Biol. 215(1): 118-29.

Zink, D. and Paro, R. (1995). Drosophila Polycomb-group regulated chromatin inhibits the accessibility of a trans-activator to its target DNA. EMBO J. 14: 5660-5671. 8521823

back to hedgehog References part 1/3 | part 2/3

Home page: The Interactive Fly © 1995, 1996 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.