Sex lethal

page 1

Promoter Structure

page 2

Transcriptional Regulation
Sxl is part of the Hedgehog signalling complex
Sex-lethal protein mediates polyadenylation switching in the female germline

page 3

Regulation of splicing by SXL: 1. General considerations
Splicing mechanism of SXL: 2. Sxl's role in Transformer pre-mRNA splicing

page 4

Splicing mechanism of SXL: 3. Proteins involved in splicing of SXL mRNA
Splicing mechanism of SXL: 4. Sxl autoregulation
Sex-lethal promotes female development by negatively regulating the N-signaling pathway
The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila

page 5

Determination of male somatic sex and function of Sxl in XY germ cells
Germ line regulation of Sxl
Factors influencing somatic sex characteristics
Post-splicing regulation of Sxl
Sxl and msl2 splicing
Sxl is in a complex that contains all of the known Hh cytoplasmic components:
       Hh promotes the entry of Sxl into the nucleus in the wing disc
Splicing regulation at the second catalytic step by Sex-lethal involves
      3' splice site recognition by SPF45
Sex lethal and U2 small nuclear ribonucleoprotein auxiliary factor (U2AF65)
      recognize polypyrimidine tracts using multiple modes of binding
Sex-lethal imparts a sex-specific function to UNR by recruiting it to the
      msl-2 mRNA 3' UTR: translational repression for dosage compensation

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