Abl oncogene

non receptor tyrosine kinase with SH2 and SH3 domains

act up (preferred name: capulet)

cyclase-associate protein homolog

alpha-Adaptin

necessary for the formation of clathrin-coated pits and participates in the dynamin-dependent release of coated vesicles from the membrane surface as a prelude to vesicle recycling -

acts downstream of Numb in the determination of alternative cell fates in asymmetric cell division

Adenomatous polypopsis coli tumor suppressor homolog 2

involved in the wingless pathway

A kinase anchor protein 200

Involved in Protein kinase A localization - PKA in turn regulates the function of specialized actin structures during oogenesis

Akt1

S/T kinase with Src homology 2 domain - promotes cell survival

Amphiphysin

SH3 domain protein that functions in membrane morphogenesis - involved in cellularization and plays a role in establisment of proper localization of postsynaptic proteins

Apaf-1-related-killer

CED-4 domain protein that links mitochondrial events to activation of caspases during programmed cell death

APC-like

adenomatous polyposis coli homolog involved in the wingless pathway

archipelago

F box component of an SCF-ubiquitin ligase - negatively regulates the levels and activity of Drosophila Myc by linking Myc to a protein degradation pathway -

also negatively regulates Cyclin E and Notch

armadillo

plakoglobin - beta catenin

Arrestin 2

a protein that interacts stoichiometrically with activated rhodopsin, inhibiting its ability to interact with the G protein, transducin, thus terminating the visual response

aurora (alternative name: aurora A)

kinase required for centrosome separation - functions in asymmetric protein localization during mitosis

aurora B (preferred name: IplI-aurora-like kinase)

signaling protein involved in chromatin condensation during mitosis

Axin

scaffolding protein

basket

MAP kinase homolog - Jun amino terminal kinase

Borealin-related

as a componenet of the chromosomal passenger complex, Borealin-related is a key regulator of mitosis -

functions to control assembly and stability of bipolar spindles and faithful chromosome segregation into daughter cells

borealis

conserved protein required for the activation of Aurora-A at the onset of mitosis -

activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate Aurora-A

Btk family kinase at 29A (common alternative name: Tec29)

protein-tyrosine kinase - necessary for maintaining the equilibrium between monomeric actin and filamentous actin during invagination of the salivary placodes -

functions during oogenesis as a key downstream effector of Src64 during ring canal growth

Bub1

protein serine/threonine kinase - mitotic checkpoint control protein - inhibits ubiquitin ligase activity of anaphase promoting complex (APC) preventing mitosis

until all chromosomes are correctly attached to the mitotic spindle

Bub3

mitotic checkpoint protein that serves as an essential protein required during normal mitotic progression to prevent premature sister chromatid separation, missegreation and aneuploidy

Buffy

pro-survival homolog of the apoptosis regulator Bcl-2 - also regulates cell cycle

cactus

signaling protein - IkappaB homolog - binds Dorsal, the NFkappaB homolog

Calcineurin (preferred name: Protein phosphatase 2B at 14D)

Calcium-dependent protein serine/threonine phosphatase - negatively regulates Egf receptor signaling

Calcium/calmodulin-dependent protein kinase

Caki can act synaptically as a gain controller on the transition to calcium-independence -

affects activity-dependent autophosphorylation of CaMKII

Calcium/calmodulin-dependent protein kinase 1

CaM kinase II - ATP binding motif

Calmodulin

calcium ion binding signaling protein

cAMP-dependent protein kinase 1 (common alternative names: Protein kinase A and PKA)

catalytic subunit of PKA

capulet (Common alternative name: act up)

cyclase-associate protein homolog

Casein kinase II alpha subunit and beta subunit

CkII catalytic and regulatory subunits

Cbl

docking protein

cdc2

a cdc2 kinase - heterdimerizes with cyclin A and cyclin B

Cdc27 (common alternative name makos)

subunit of anaphase-promoting complex (APC) - involved in regulating cell cycle

cdc42

a Ras type GTPase - involved in epithelial cell elongation - facilitates nucleation of actin filaments

centrosomin's beautiful sister

a trans-Golgi protein that links Golgi inheritance to the cell cycle

chickadee

profilin homolog - regulation of actin cytoskeleton

chico

insulin receptor substrate family

chiffon

Dbf4 homolog - regulatory subunit of Cdc7-Dbf4 dimer

citron (preferred name: sticky)

Rho effector kinase functioning downstream of pebble - required for cytokinesis

COP9 complex homolog subunit 5

Component of COP9 signalsome - regulates ubiquitin-dependent protein degradation - Jab1/MPN domain metalloenzyme motif

coracle

protein 4.1 homolog - links transmembrane proteins to cytoskeleton

corkscrew

protein tyrosine phosphatase - SH2 domains

Cortactin

cytoskeletal component that acts as a link, via Src, between surface receptors and actin - interacts with F-actin

and can stimulate actin polymerization by direct interaction with the Arp2/3 complex

cortex

a meiosis-specific anaphase-promoting complex/cyclosome activator - functions together Fizzy to target mitotic cyclins for destruction in the egg

costa (common alternative name: costal2)

kinesin like protein - hedgehog signaling

crossveinless c (common alternative name: RhoGAP88C)

required in tissues actively undergoing morphogenesis -- regulates GTPase function of Rho

to promote the coordinated organisation of the actin cytoskeleton

cul4

cullin family protein that regulates cell cycle by controlling degradation of Dacapo and Cyclin E

Cyclin-dependent kinase 4/6

a Cdk involved in control of growth of cells - partners cyclin D

Cyclin-dependent kinase 5

a Cdk involved in control of cell differentiation and morphology

Cyclin-dependent kinase 7

a Cdk-activating kinase and general transcription factor

Cyclin-dependent kinase 9

subunit of P-TEFb, targets RNA polymerase II

Cyclin-dependent kinase subunit 30A

Cyclin-dependent kinase regulatory subunit required for progression through female meiosis and the mitotic divisions of the early embryo

through an interaction with Cdk1 (Cdc2)

Cyclin J

regulates S phase early in embryonic development, partners Cdk2

DC0 (Preferred name: cAMP-dependent protein kinase 1)

PKA catalytic subunit

dacapo

cyclin dependent kinase inhibitor

daughter of sevenless

an adaptor protein that facilitates signal transduction as a downstream component of the receptor tyrosine kinases Sevenless, Egf receptor and Torso

Daughters against dpp

Smad family - inhibits Dpp signal transduction

deltex

E3-ubiquitin ligase - Deltex mediated accumulation of Notch in the late-endosome compartment is required for the Dx-mediated Su(H)-independent Notch signaling

diego

ankyrin repeat protein involved in tissue polarity - helps promote polarized clustering of Flamingo

Disabled

novel signaling protein

dishevelled

novel cytoplasmic protein - wingless pathway

double-time

casein kinase Iepsilon

dreadlocks

SH2 and SH3 domain signal transduction protein

dunce

cyclic AMP phosphodiesterase

dystrophin

the postsynaptically localized scaffolding protein required for appropriate control of neuromuscular synaptic homeostasis

Eb1

microtubule end-binding protein - controls the plus end of growing microtubules - targets other microtubule-associated

proteins to the plus end and thereby regulates interactions of microtubules with the cell cortex, mitotic kinetochores,

and different cellular organelles

Ecdysone-induced protein 63E

cyclin dependent kinase

E(spl) region transcript m4

Bearded family

exo84

exocyst complex 84-kDa subunit Pleckstrin Homology (PH) domain protein - involved in apical polarity of epithelial tissue -

the exocyst complex functions in polarized exocytosis

expanded

Band 4.1 protein with three potential SH3-binding sites

fizzy

WD40 domain protein - required for the activity of the anaphase promoting complex in mitosis - functions to

target the three mitotic cyclins A, B and B3 for destruction in the egg and drive anaphase progression during meiosis

fizzy related (preferred name: retina aberrant in pattern)

Trp-Asp repeat (WD-repeat) protein - negatively regulates the levels of cyclins A, B and B3 thus promoting mitosis

Focal adhesion kinase-like

involved in integrin signaling

foraging

cGMP-dependent protein kinase - controls feeding behavior and locomotory behavior

Fps oncogene analog

Fes/Fer non-receptor tyrosine kinases - regulates cell adhesion and cytoskeletal reorganisation through the modification

of adherens junctions - regulates dorsal closure

frayed

serine/threonine kinase required for normal axonal ensheathment

fused

s/t kinase - segment polarity gene

furry

conserved protein that is required for Tricornered activity in control of wing hair and bristle morphology -

controls dendritic branching and tiling in sensory neurons

GTPase-activating protein 1

Ras GTPase-activating protein with PH domain and C2-domain

gastrulation-defective

serine protease that functions maternally to activate the Toll cascade and consequently to regulate dorsal/ventral polarity of the embryo

Genghis Kahn

similar to myotonic dystrophy protein kinase

gigas

Rap1 GAP domain protein - tuberous sclerosis-2 homolog

G protein-coupled receptor kinase 2

Serine/threonine protein kinase - involved in a receptor-mediated signaling pathway that utilizes cAMP as a second messenger - involved in oogenesis and implicated in learning

G protein αi subunit 65A

G protein α subunit involved in regulating asymmetric cell division

G protein oα 47A

G protein α subunit

Grasp65

signaling protein that exhibits a dynamic association to the membrane of the early exocytic pathway and is involved building the Golgi stack

grapes

kinase - Chk1 homolog - cell cycle checkpoint protein

grim

pro-apoptotic protein whose N-terminus functions by disrupting IAP binding to caspases -
an additional mitochondrial-dependent apoptotic function carried out by a centrally located GH3 domain

Guanylyl cyclase at 76C

cGMP production - receptor-type protein possessing a single transmembrane domain - required for Semaphorin-1a-Plexin A directed repulsive axon guidance

Grip

Scaffolding and signaling protein - participates in the reception of an attractive signal that emanates from muscle epidermal attachment sites to direct the motility of developing muscles

heartbroken

novel signal transduction protein functioning downstream of two FGF receptors

hemiperous

MapKK - JunKK involved in dorsal closure

highwire

synaptic protein - B-box zinc finger superfamily - a negative regular of synaptic growth

hippo

a serine/threonine kinase - acts in conjunction with Salvador and Warts to restrict cell growth - promotes cell death by decreasing the level of Thread, an inhibitor of apoptosis

homer

scaffolding protein required for the function of neural networks controlling locomotor activity and behavioral plasticity

hopscotch

janus family TK

hyrax

the Cdc73 component of the Polymerase-Associated Factor 1 (PAF1) complex - required for nuclear transduction of the Wnt/Wg signal -

manifests its effects on transcription through modulating chromatin structure

hu-li tai shao

homolog of mammalian adducin - required for ring canal formation during oogenesis

ik2 (common alternative name: DmIKKε)

IKK-related kinase - a regulator of caspase activation in a nonapoptotic context - promotes degradation of DIAP1 (Thread)

through direct phosphorylation - required for proper sensory organ precursor development -

acts on the cytoskeleton to regulate egg DV and AP polarity

imaginal discs arrested

homolog of APC5, a subunit of the anaphase-promoting complex (APC/cyclosome) - required for proliferation of imaginal disc cells -

required for the localisation of Miranda and its associated cargo proteins to the neuroblast basal cortex

immune deficiency

a death domain protein involved in signal transduction during antibacterial immune response

Inner centromere protein

a component of the chromosome passenger complex - regulates activity of Aurora B kinase through a positive-feedback

loop - as a microtubule-binding protein Incenp has a well-defined centromere-targeting domain at its

N-terminus, suggesting a role in targeting the kinase to particular locations within the mitotic cell

inactivation no afterpotential D

scaffolding protein - PDZ domain protein - involved in visual signal transduction

Integrin linked kinase

s/t kinase with ankyrin repeats - required for integrin-mediated adhesion - links the cytoskeleton via integrins to the plasma membrane

IplI-aurora-like kinase (alternative name: Aurora B)

signaling protein involved in chromatin condensation during mitosis

jak kinase (preferred name: hopscotch)

signaling protein involved in JAK-STAT pathway

jetlag

an F-box protein with leucine-rich repeats (LRRs), a putative component of a SCF E3 ubiquitin ligase complex -

essential for resetting the clock by transmitting light signals from Cryptochrome to Timeless resulting in the degredation of Timeless

JIL-1

protein serine/threonine kinase involved in dosage compensation

Jun amino terminal kinase (JNK) (preferred name: basket)

MAP kinase homolog

kette (preferred name: HEM-protein)

alternatively a membrane associated and a cytosolic protein that transduces information to the neuronal cytoskeleton affecting axon guidance

kinase suppressor of ras

Ras pathway scaffolding protein - Ksr associates independently with Raf and Mek, and these interactions facilitate formation of a RAF/MEK complex

thus promoting signaling through the Ras pathway

large tumor suppressor (lats) (preferred name: warts)

kinase - regulates cell cycle

licorne

a MAP kinase kinase targeting p38 MAP kinase

LIM-kinase1

serine/threonine kinase - functions via cytoskeleton to confer the added synapse-stabilizing activity of the BMP receptor Wishful thinking

liquid facets

an epsin: a family of cargo-selective adapters that link mono-ubiquitinated cell-surface proteins with the endocytic machinery -

regulates Notch ligand Delta's subcellular localization and activity

lkb1

Par-4 kinase - required for the early A-P polarity of the oocyte and for the repolarization of the oocyte cytoskeleton that defines the embryonic A-P axis

locomotion defects (common alternative name: loco)

regulators of G-protein signalling (RGS) protein - a GTPase-activating protein (GAP) acting on alpha subunit of G-proteins

loki (common alternative name: chk2)

Homolog of mammalian Chk2 - a serine/threonine kinase required required for DNA damage-mediated cell cycle arrest and apoptosis

mad2

mitotic checkpoint protein that blocks mitotic exit by sequestering Cdc20/Fizzy - required to delay progression through early stages of prometaphase

so that cells have time to fully engage the spindle assembly checkpoint

mago nashi

novel - potential signal transduction protein

Map kinase (preferred name: rolled)

signaling - MAP kinase

marelle (Preferred name: STAT)

transcription factor - stat homolog - cytoplasmic signal transducing protein

mats

physically associates with cell cycle regulator Warts to stimulate its catalytic activity and associates with tissue polarity factor Tricornered to regulate denticle development

Medea

Smad family member

meiotic 41

ATM/ATR kinase, phosphatidylinositol 3-kinase - essential for the DNA damage checkpoint in larval imaginal discs and neuroblasts -

required to delay mitosis in response to incomplete DNA replication in early nuclear divisions - monitors double-strand-break repair during meiotic crossing over

Merlin

ERM family, protein 4.1 superfamily

Microcephalin

a conserved regulator of cell cycle, co-ordination of centrosome and nuclear division cycles, and maintenance of chromosome condensation

minibrain

serine/threonine kinase

misshapen

SPS1 family kinase

Mitochondrial Rho

transmembrane Rho GTPase required for controlling anterograde transport of mitochondria and their proper distribution within nerve terminals

Moesin-like

the sole Drosophila ERM protein - functions to promote cortical actin assembly and apical-basal polarity

Mothers against dpp

novel transducer of DPP signals

mushroom bodies tiny

PAK kinase - downstream effector of Cdc42 - regulates cell adhesion dependent processes during photoreceptor cell differentiation

Myd88

Death domain protein - Encodes an essential component of the Toll pathway in dorsoventral pattern formation - involved in signal transduction in the immune response

Myosin binding subunit

regulatory subunit of myosin phosphatase - involved in dorsal closure

Myt1

Wee1-like kinase that specifically regulates Cdk1 (Cdc2) activity in the cytoplasm

naked cuticle

EF-hand calcium-binding domain protein involved in Wingless pathway

nemo

protein serine/threonine kinase involved in establishing epithelial planar polarity

nervous wreck

a member of a family of adaptor proteins - controls synapse morphology by interacting with Wasp - regulates actin dynamics

Neurofibromin 1

GAP-related domain protein functioning in the PKA pathway

neuralized

cytoplasmic zinc finger signaling protein - neurogenic

nbs

encodes a multifunctional protein that plays critical roles in the response to DNA damage and telomere maintenance -

part of a protein complex, MRN, that senses DNA strand breaks and amplifies the signal and then conveys it to

downstream effectors, such as ATM and p53, that regulate cell cycle checkpoints and DNA repair

Nipped-A

Homologue of the yeast Tra1 and human TRRAP proteins - a key component of both the SAGA and Tip60 (NuA4) chromatin-modifying complexes -

required for Mastermind function during wing development

nuclear fallout

pericentrosomal protein which, along with Rab11, is involved in membrane trafficking and actin remodeling

during membrane furrow formation during cellularization - involved in endosomal-mediated membrane delivery to the site of furrow formation

numb

Notch antagonist - functions during asymmetric cell division to determine alternative cell fates

Origin recognition complex subunit 1

A subunit of the Origin recognition complex, regulating the initiation of DNA replication - Orc1 is degraded by APC at the cell's exit from mitosis and reaccumulates at the end of G₁

p38b

a MAP kinase

PAK-kinase

p21-activated kinase

pan gu

serine/threonine kinase - permits the accumulation of Cyclin B duuring early mitotic divisions

par-1

serine/threonine kinase involved in cell polarization

pebble

Rho GEF - regulates cytokinesis

pelle

s/t kinase - dorsal group

Phosphotidylinositol 3 kinase 92E

signal transduction - influence cell growth functioning as a target of the insulin pathway

polo

protein kinase - regulates mitosis

Protein Kinase A (preferred name: cAMP-dependent protein kinase 1 and DC0)

PKA catalytic subunit

Protein Kinase C

serine/threonine kinase, Diacylglycerol binding protein

atypical protein kinase C

kinase regulating asymmetic cell division

Protein phosphatase 2A at 85F (preferred name: twins)

B subunit of PP2A

Protein phosphatase 2B at 14D (alternative name: Calcineurin)

Calcium-dependent protein serine/threonine phosphatase - negatively regulates Egf receptor signaling

Pten

lipid and protein phosphatase acting in insulin pathway

Ptpmeg

protein tyrosine phosphatase involved in neuronal circuit formation the central brain - regulates establishment

and the stabilization of axonal projection patterns

puckered

dual specificity phosphatase KH-1 subfamily

Rab-protein 6

small GTPase required for membrane trafficking - required for organization and growth of the egg chamber and the polarization of the microtubule cytoskeleton and

localization of oskar mRNA - involved in trafficking Notch protein during bristle development and rhodopsin the the eye

Rab-protein 11

Rab family GTPase - required in endocytic recycling and in the organization of posterior membrane compartments during oogenesis -

functions in membrane trafficking during furrow formation during cellularization -

functions in post-Golgi transport of rhodopsin to the rhabdomeric membranes of photoreceptors, and in analogous transport processes in other cells

Rac1

GTPase of the Ras superfamily

RacGAP50C

cytoskeletal regulator required for cytokinesis - connects the contractile ring to cortical microtubules at the site of furrowing in dividing cells -

negatively regulates the wingless pathway during Drosophila embryonic development - required for neuroblast proliferation and limits axon growth

radish

rapidly evolving gene encoding a protein that contains multiple phosphorylation sites - required for anaesthesia resistent memory

ran

Ran GTPase activity required nucleo-cytoplasmic transport - also required for microtubule organization during mitosis and for alignment of chromosomes at the metaphase plate

Ras oncogene at 85D (common alternative name: Ras1)

ras homolog

Ras-related protein

Ras-like GTPase - counters apoptotic programs to support cell fate determination by acting as a negative regulator of JNK activity

and a positive activator of p38 MAP kinase

reaper

death domain protein functioning in apoptosis

Regulator of cyclin A1

a novel signaling protein that prevents cyclin degredation in G2 by interacting with Fizzy-related

- inhibits Fizzy-related's activation of protein degradation machinery - mutants exhibit premature cyclin destruction

Rheb

Ras superfamily of G-proteins - functions downstream of the tumor suppressors Tsc1 and Tsc2 (Gigas in Drosophila),

with Tsc2 functioning as a GAP for Rheb - signals to the growth regulator known as Target of rapamycin (TOR)

Rho1

rho-subfamily GTPase

rho-associated kinase

Rho-kinase - plays a role in planar cell polarity

RhoGAP

part of an axon retraction pathway from Rho to myosin in mature neurons - inactivation of RhoGAP leads to axon retraction

rho-type guanine exchange factor

RhoGEF - homolog of mammalian Pix - regulates postsynaptic structure and protein localization at the glutamatergic neuromuscular junction

rolled (common alternative name: MAP kinase)

signaling - MAP kinase

rolling pebbles

RING-finger motif, ankyrin repeat and TR repeat protein - a signaling protein that interacts with the cytoplasmic domain of Dumbfounded and with Myoblast city -

functions to integrate initial myoblast fusion with myotube structural organization

RPS6-protein kinase-II (common alternative name: dRSK)

negatively regulates ERK-mediated developmental processes and gene expressions by blocking the nuclear localization of ERK

RPS6-p70-protein kinase (common alternative name: S6k)

signaling - growth response - targets ribosomal protein S6

rugose

protein kinase A anchor protein - required for correct retinal pattern formation through its interactions with Egfr and Notch pathways

rutabaga

Ca++/Calmodulin dependent adenyl cyclase

SAK

(common alternative name: Plk4)

member of the polo-like kinase family - required for centriole duplication and for formation of basal bodies and flagella

salvador

restricts cell numbers in vivo by functioning as a dual regulator of cell proliferation and apoptosis - physically interacts with Warts

sarah

regulates female meiosis by controlling calcineurin activity in the germline

SCAR

promotes actin polymerization via Arp2/3 protein complex

sec5

promotes vesicular trafficking involved in cell growth and membrane protein insertion -

required for membrane traffic and polarity in the oocyte

sec15

functions in polarized exocytosis/secretion - involved in targeting photoreceptor axons that involves localization of specific cell adhesion and signaling molecules

shaggy (common alternative name: zeste white 3)

glycogen synthase kinase - segment polarity

skittles

1- phosphatidylinositol-4 phosphate kinase

slingshot

phosphatase - plays a pivotal role in actin dynamic by reactivating the actin depolymerizing factor cofilin

slipper

mixed lineage kinase - signal transduction protein conveying information about changes in cytoskeleton to the nucleus

Smad on X

Dpp signaling pathway - Smad2 and Smad3 homolog

small wing

phosphatidylinositol-specific phospholipase C gamma, Src homology 2 and 3 domain protein

snoN

mediator of Baboon signaling - antagonizes Dpp signaling -

physically interacts with Medea - inhibits growth when overexpressed

Son of sevenless

a dual specificity GEF that regulates both Ras and Rho family GTPases - integrates signals that affect gene expression and cytoskeletal reorganization

spaghetti squash

EF-hand, calcium binding motif protein that serves as the regulatory light chain of nonmuscle myosin II

Spindly

conserved mitotic checkpoint protein - regulator of mitotic dynein - functions to target dynein to kinetochores

spire

Wiscott-Aldrich syndrome protein (WASP) homology domain 2 (WH2) family

Src homology 2, ankyrin repeat, tyrosine kinase

Known as Shark kinase this signaling protein is required for dorsal closure upstream of Dpp - also required during oogenesis for dorsal-appendage morphogenesis

Src oncogene at 42A

Src homolog - a protein tyrosine kinase with SH3 and SH2 domains - essential for cell-cell matching during dorsal closure -

involved in adherins junction stabilization

Src oncogene at 64B

Src homolog - a protein tyrosine kinase with SH3 and SH2 domains

STAT (common alternative name: marelle)

transcription factor - STAT homolog

sticky (alternative name: citron)

Rho effector kinase functioning downstream of pebble - required for cytokinesis

string

protein tyrosine phosphatase - activates cyclin dependent kinase for mitotic entry

Suppressor of fused

novel protein with PEST sequence - Hedgehog signaling pathway

Suppressor of profilin 2

A component of the Arp2/3 complex - involved in catalyzing actin filament nucleation - essential to cap expansion and pseudocleavage furrow during cellularization -

required for ring canal expansion during oogenesis

Target of rapamycin

Phosphatidylinositol 3-kinase - involved in perception of nutrient status - pivotal member of the TOR pathway involved in regulation of growth and cell proliferation

Tec29 (preferred name: Btk family kinase at 29A)

protein-tyrosine kinase - necessary for maintaining the equilibrium between monomeric actin and filamentous actin during invagination of the salivary placodes -

functions during oogenesis as a key downstream effector of Src64 during ring canal growth

TGF-ß activated kinase 1

serine/threonine kinase required for morphogenetic changes that take place during the fusion of the epithelial wing disc cell layers (thoracic closure),

acting in the context of JNK signaling - required for Relish cleavage and antibacterial immunity

Thor (common alternative name: d4E-BP)

messenger RNA 5' cap binding protein - regulates translation during environmental stress

thread (common alternative name: Diap1)

ubiquitin ligase that functions as an inhibitor of apoptosis - Thread inhibition of caspase function is counteracted by proapoptotic proteins Hid, Grim and Reaper

TNF-receptor-associated factor 1

Traf domain protein - involved in signal transduction in the JNK pathway

transforming acidic coiled-coil protein (common name: tacc)

centrosomal protein that stabilizes microtubules during mitosis by recruiting the microtubule plus end binding protein Minispindles

Transportin-Serine/Arginine rich

an importin-ß family member responsible for transporting SR protein splice factors into the nucleus

tribbles

serine/threonine kinase-like domain - regulates cell cycle

tricornered

Ndr serine/threonine kinase - required for the normal morphogenesis of epidermal hairs, bristles, laterals, and dendrites

trio

Rac guanyl-nucleotide exchange factor

tube

cofactor with pelle to activate Dorsal

tumor suppressor protein 101 (common alternative name: erupted)

binds monoubiquitinated substrates predicted to be ubiquitinated cytoplasmic tails of membrane bound proteins;

this interaction delivers cargos to the lysosome via multivesicular bodies

twins

Protein phosphatase 2A - B subunit

unc-13

a scaffold protein with a C1 lipid-binding motif and two C2 calcium-binding motifs - mediates signals to control synaptic vesicle exocytosis

vav

a signal transducing protein that participates in EGF receptor pathways and functions as a GEF for Rac

Verprolin 1

facilitator of myoblast fusion - homolog of the conserved Verprolin/WASp Interacting Protein family of WASp-binding proteins -

recruits the actin-polymerization machinery to sites of myoblast attachment and fusion

vps25

a component of the ESCRT machinery that regulates endocytic sorting of signaling receptors

warts

kinase - regulates cell cycle

WASp

Wiskott-Aldrich syndrome protein: regulates actin polymerization

wee

protein tyrosine kinase that targets Cdc2 thus preventing premature activation of the mitotic program

zeste white 3 (preferred name: shaggy)

cytoplasmic - segment polarity

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Drosophila genes listed by biochemical function

Home page: The Interactive Fly © 1995, 1996 Thomas B. Brody, Ph.D.

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