Interactive Fly, Drosophila

Drosophila genes listed by biochemical function

Miscellaneous transcription factors and chromatin proteins A - G ||H - O || P - Z

absent, small, or homeotic discs 1

histone methyl transferase that indirectly prevents gene silencing - provides

a specific signal for establishment of active transcription

absent, small, or homeotic discs 2

trithorax family member - maintains active transcription by binding a producer of nuclear phosphoinositides

and downregulating histone H1 hyperphosphorylation

Activating transcription factor-2 (alternative name: Atf-2)

transcription factor - basic leucine zipper protein - regulates fat metabolism and osmotic stress response

Adh transcription factor 1 (common alternative name: Nalyot)

transcription factor - Myb helix-turn-helix family

abnormal chemosensory jump 6 (common alternative name: Ipou)

transcription factor - homeodomain and POU domain

always early

regulator of chromatin structure - a 'meiotic arrest' gene required for transcription

of key G2-M cell cycle control genes and of spermatid differentiation genes

anterior open (common alternative name: pokkuri and yan)

ets domain

anti-silencing factor 1

histone chaperone that assists in chromatin assembly and remodeling during replication, transcription activation,

and gene silencing - contributes to the repression of Notch target genes - directly interacts Hairless

AP-2

transcription factor that plays essential roles in leg and proboscis outgrowth -

involved in development of the adult brain central complex

apontic

novel bZIP transcription factor and RNA-binding protein

ATP-utilizing chromatin assembly and remodeling factor

PHD finger motifs and chromodomain - involved in chromatin assembly

Bearded

proneural - basic amphipathic alpha-helix

Bicoid interacting protein 1 (common alternative name: Sap18)

part of the Sin3A/Rpd3 histone deacetylase complex - helps convert Bicoid from an activator

into a repressor by recruitment of a co-repressor to Bicoid-dependent promoters

biniou

fork head domain transcription factor essential for maintaining the distinction between splanchnic and somatic

mesoderm and for differentiation of the splanchnic mesoderm into midgut musculature

bithoraxoid

produces non-coding RNA that may mediate or counteract epigenetic silencing - bxd RNA mediates recruitment of Ash1

to stimulates gene expression

blistered (common alternative name: Serum response factor)

MADS-box motif

brachyenteron (common alternative name: T-related gene)

brachyury homolog

brahma

trithorax group - SWI2/SNF2 homolog - DNA dependent ATPase - helicase motif

Brf

transcription factor TRF1 forms a complex with the TFIIB-related factor Brf that plays a major role in RNA pol III transcription

bric à brac

transcription factor bearing a BTB/POZ domain

brinker

novel transcription factor bearing weak homology to homeobox domains

bunched (common alternative name: shortsighted)

transcription factor - leucine zipper - dpp pathway

cannonball

TAF_II80, Trp-Asp repeat (WD-repeat) protein expressed only in spermatocytes, where it is required for

transcription of genes required for spermatid differentiation

capicua

transcription factor - HMG box protein

cap'n'collar

basic leucine zipper

Cenp-C

centromere protein required for normal attachment of kinetochores to the spindle

centromere identifier

a variant of histone H3 - chromatin component that plays a key role in assembling the kinetochore at meiosis and mitosis

Centrosomal protein 190kD

BTB/POZ domain and microtubule binding protein that alternatively serves as a chromatin insulator and as a component of centrioles -

involved in axial expansion, the spreading out along the anterior-to-posterior axis during syncytial development

Chip

transcription factor - enhancer facilitator

Chronologically inappropriate morphogenesis

BTB/POZ domain transcription factor - helps specify distinct birth order-dependent cell fates in an extended neuronal lineage -

regulates the time at which neuroblasts undergo Prospero-dependent cell-cycle exit or Reaper/Hid/Grim-dependent apoptosis

cryptocephal

REB/ATF superfamily bZIP domain transcription factor - controls expression of diverse neuropeptides and peptide hormones involved in metamorphosis

cryptochrome

potential transcription factor - light response protein - cryptochrome/photolyase

Chromodomain-helicase-DNA-binding protein

chromodomain protein in the SNF2-like family of ATPases - functions in assembly of active chromatin

Chromatin assembly factor 1 subunit

A histone chaperone protein

clockwork orange

a transcriptional repressor that synergizes with Per and inhibits Clk-mediated activation -

acts preferentially to help terminate Clk-Cyc-mediated transcription of direct target genes

corto

Chromodomain protein - partners with CycG which regulates the activity of Corto at chromatin - acts alternatively as an enhancer of TrxG and an Enhancer of PcG

cramped

A novel Polycomb group protein

CrebB-17A (common alternative name: dCREB2)

cAMP response element binding protein

CREB-binding protein (preferred name: nejire)

CBP, a transcriptional co-activator

crocodile

winged helix, forkhead family

cryptochrome

potential transcription factor - light response protein - cryptochrome/photolyase

C-terminal binding protein

transcription factor-interacting protein

cut

cut homeodomain

cycle

transcription factor - bHLH, pas domain - photoperiod response

Cyclic-AMP response element binding protein A

basic leucine zipper

dCREB2 (preferred name: CrebB-17A)

basic leucine zipper

dead ringer

transcription factor - ARID domain protein

Deformed epidermal autoregulatory factor-1

SAND and zf-MYND domain transcription factor - involved in embryonic development, Deformed autoregulation and the immune response

Dichaete (preferred name: Sox box protein 70D, common alternative name: fish-hook)

HMG-domain protein - SOX-domain protein

disc proliferation abnormal

Licensing factor component - Zn finger motif - cdc21 homolog - MCM4 homolog - Chromatin component

distal antenna & distal antenna-related

two closely linked genes coding for pipsqueak domain proteins - effector genes that act downstream

of homothorax and Distal-less to control differentiation of distal antennal structures

DJun (preferred name: Jun related antigen)

basic leucine zipper

DNA replication-related element factor

a transcription factor that activates genes involved in cell proliferation

Dorsocross

three closely linked T-box domain transcription factors that are crucial for completion

of differentiation, cell proliferation arrest, and survival of amnioserosa cells

Domina

forkhead/winged-helix class

domino

DNA helicase/adenosine triphosphatase - component of the Tip60 chromatin-remodeling complex

that acetylates nucleosomal phospho-H2Av and exchanges it with an unmodified H2Av

dorsal

NFkappaB/rel homolog

Dorsal related immune factor

NFkappaB/rel homolog

doublesex

novel - sex determination

DP transcription factor

transcription factor - obligate dimerization partner of E2f1 and E2f2 - required for normal cell proliferation,

optimal DNA synthesis, and efficient G₂/M progression

dre4

transcription factor - along with Structure specific recognition protein (Ssrp) forms a protein complex, FACT,

that facilates GAGA factor directed chromatin remodeling

E2F transcription factor

positively regulates genes involved in the S (DNA synthesis) phase of the cell cycle

E2F transcription factor 2

negatively regulates genes involved in the S (DNA synthesis) phase of the cell cycle

Ecdysone-induced protein 74EF (also known as E74A and E74B)

alternatively spliced ets domain transcription factor that controls the timing of gene activation during molting

eggless

SET domain hydroxymethyltransferase required for oogenesis - trimethylates histone H3 at its K9 residue - involved in gene silencing

Eip93F

Pipsqueak family transcription factor - programs a cell death response during larval development

Enhancer of bithorax

nucleosome remodeling factor - NURF301

Enhancer of Polycomb

novel Polycomb group protein and a suppressor of position effect variegation

erect wing

novel transcription factor

extra macrochaetae

HLH non basic

eyelid (preferred name: osa)

Bright family

eyes absent (preferred name: clift)

transcriptional co-activator and protein tyrosine phosphatase - cell survival factor - functions in eye development -

also plays a role in the embryonic determination of somatic gonadal precursor (SGP) cell fate

female sterile (1) homeotic

double-bromodomain protein - trithorax group gene that cooperates with Zeste in Ultrabithorax activation

fork head

forkhead domain

Fos-related antigen (preferred name: kayak)

transcription factor - basic leucine zipper

foxo

forkhead domain transcription factor - a target of the insulin receptor signaling pathway -

modulates growth and proliferation

geminin

limits DNA replication by preventing Mcm loading onto chromatin

germ cell-less

chromatin component - BTB/POZ domain protein- responsible for establishment transcriptional quiescence in germ cells

giant

basic leucine zipper - gap gene

glial cells missing

novel

gluon

condensin subunit SMC4 - involved in mitotic chromatin condensation

groucho

WD40 domain - E(spl) comples

Grunge

transcriptional cofactor for Even-skipped - homolog of mammalian Atrophin

H15 and midline

T-box transcription factors that participate in cardiac fate specificity

Hairless

novel basic protein - interacts with Suppressor of Hairless

Heat shock factor

leusine zipper

heterochromatin protein 1 (preferred name: Suppressor of variegation 205)

chromodomain - Polycomb group - chromatin binding protein

High mobility group protein - d

HMG domain protein

Hira (alternative name Sesame)

histone chaperone - required for nucleosome assembly during sperm nucleus decondensation - GAGA factor and

FACT-dependent replacement of methylated histone H3 by H3.3 occurs through association with Hira

Histone H1

Chromatin component - linker histone

Histone H2A variant

replacement histone participates in an ordered cascade of events leading to the

establishment of heterochromatin

Histone H3

Nucleosome component - core histone

Histone H3.3A

H3 histone subtype - deposition is coupled to transcription and continues while a gene is active -

histone replacement suggests a mechanism to maintain both the structure of chromatin and access to DNA at active genes

Histone H4

Nucleosome component - core histone

Holes in muscle

WRPW motif protein that binds Groucho to inhibit both muscle differentiation and Mef2 activity during development

HP1c

HP1 family member - mchromatin interactor and organizer - physically interacts with DNA-binding zinc-finger transcription factors

Without children and Relative-of-WOC to act as a transcriptional activator

hyrax

the Cdc73 component of the Polymerase-Associated Factor 1 (PAF1) complex - required for nuclear transduction of the Wnt/Wg signal -

manifests its effects on transcription through modulating chromatin structure

Imitation SWI (common alternative name: ISWI)

ATPase domain - chromatin remodeler

Jun related antigen (common alternative name:: DJun)

jun homolog

kayak (common alternative name: Fos-related antigen)

transcription factor - basic leucine zipper

kismet

member of the SWI2/SNF2 family of ATP-dependent chromatin-remodeling factors -

facilitates an early step in transcriptional elongation by Pol II

knot

EBF/Olf-1 homolog, HLH protein

Lamin

an intermediate filament protein - chromatin associated protein

lilliputian

transcription factor - Fragile X mental retardation 2 (Fmr2) family

little imaginal discs

trimethyl H3K4 demethylase - physically interacts with Myc to regulator Myc-induced cell growth

lola like

BTB/POZ domain protein - partner of Trithorax-like in maintaining gene repression

lozenge

AML-1 homolog

maleless

DEAH-box subfamily ATP-dependent helicase

male-specific lethal-1

chromatin component - dosage compensation - basic motif, leucine zipper-like motif, glycine-rich motif protein that directly binds DNA

male-specific lethal-2

chromatin component - dosage compensation - ring finger - metallothionein motif

male-specific lethal 3

chromatin component - dosage compensation - MRG family, chromo-barrel domain

males absent on the first

histone acetyltransferase involved in dosage compensation

marelle (preferred name: STAT)

stat homolog

mastermind

novel - neurogenic

MBD-like

methyl-DNA binding protein involved in methylation dependent transcriptional repression

Medea

Smad family member

Menin 1

conserved chromatin factor that modulates Jun activity in a manner dependent on the cellular context - tumor suppressor that functions

in maintenance of genomic integrity - controls stress responses

Mi-2

ATP dependent DNA helicase - Zinc finger, C4HC3 type (PHD finger)

Microcephalin

a conserved regulator of cell cycle, co-ordination of centrosome and nuclear division cycles, and maintenance of chromosome condensation

midline and H15

T-box transcription factors that participate in cardiac fate specificity

modifier of mdg4

GAGA-like, BTB domain - interacts with suppressor of Hairy wing on gypsy insulator element

modulo

RRM-containing domain - modifier of PEV promoting chromatin compaction and inactivation - controls cellular growth rate downstream of dMYC

moira

Trithorax-complex protein - SWI3 homolog - chromatin remodeling protein

Mothers against dpp

presumptive novel transcription factor - downstream of DPP

myocyte enhancer factor 2

mads box

Myb oncogene-like

Myb DNA-binding domain

nab

transcriptional cofactor - co-activator of Squeeze in CNS neurons - co-repressor of Rotund in wing

Negative elongation factor E

RNA-binding protein - along with other factors, NELF causes polymerase to pause in the promoter proximal region of heat shock genes

nejire

CREB-binding protein, a transcriptional co-activator

nervy

probable transcriptional co-repressor- described as an AKAP binding protein, zinc finger protein expressed in the CNS and involved in axon guidance

Nipped-A

Homologue of the yeast Tra1 and human TRRAP proteins - a key component of both the SAGA and Tip60 (NuA4) chromatin-modifying complexes -

required for Mastermind function during wing development

Nipped-B

a DNA-binding transcription factor regulates gene expression by controlling cohesin dynamics - regulates of sister chromatid cohesion

NURF301 (preferred name: Enhancer of bithorax

Major subunit of Nucleosome remodeling factor

Nucleosome assembly protein

Histone chaperone - chromatin assembly

optomotor-blind (common alternative name: bifid)

brachyury T homolog

orientation disrupter

rapidly evolving gene - involved in meiotic cohesion, chromosome core maintenance and homologous recombination

Origin recognition complex 2

A subunit of the Origin recognition complex, involved in initiation of DNA replication

osa (common alternative name: eyelid)

Bright family

p53

DNA repair pathway and apoptosis transcription factor

Paired box neuro

paired domain - no homeodomain is present

Paf1

Part of a protein complex that directs the histone methyltransferase activity and links active transcription and modifications of chromatin structure.

pangolin

transcription factor - HMG domain - segment polarity

PAR-domain protein 1

PAR-domain bZIP transcription factor

Pcaf (common alternative name: Gcn5)

a major histone H3 acetylase in Drosophila that plays a key role in the control of specific morphogenetic cascades during developmental transitions

period

transcription factor - pas domain - photoperiod response

pipsqueak

BTB domain & Psq motif transcription factor that targets a Polycomb group protein complex to Polycomb response elements

pointed

ets family

pokkuri (preferred name: anterior open, common alternative name: yan)

ets domain

Polycomb

transcription factor - chromo domain - Polycomb group - chromatin binding

Polycomblike

a member of a distinct chromatin complex - functions downstream of Pleiohomeotic in the assembly of a repressive complex

that generates high levels of H3-K27 trimethylation in Polycomb target genes

Pox meso

Pax family transcription factor - demarcates the 'Poxm competence domain', a domain of competence for ventral and lateral muscle development

and for the determination of at least some adult muscle precursor cells

Pre-mRNA cleavage complex 2 protein Pcf11

forms a bridge between the RNA polymerase C-terminal domain and RNA- dismantles elongation

complexes by a C-terminal domain-dependent but nucleotide-independent mechanism

pr-set

Set domain protein - methyltransferase that targets Histone H4 - helps maintain silent chromatin by a histone modification

that precludes neighboring acetylation of the H4 tail

ptip

BRCT (BRCA1 carboxy terminal) domain protein that can bind to phosphorylated serine residues - chromatin-binding protein implicated in epigenetic control

of development and differentiation - potential trithorax gene cofactor - potential interactor with transcription factors that also serves as a modifier of histones

pygopus

nuclear PHD-finger protein - a core component of the Wingless signaling pathway that acts downstream of or at the level of Pangolin

Relish

Ankyrin-repeat and NFkappaB domain protein

Retinoblastoma-family protein

cell cycle regulator

Retinoblastoma-family protein 2

cell cycle and developmental regulator - functions in concert with E2F2 to repress the expression of differentiation markers

in ovaries and embryos where RBF2 is highly expressed

Rfx

transcription factor - RFX DNA-binding domain - essential regulator of ciliated sensory neuron differentiation

ribbon

BTB/POZ domain transcription factor - a regulator of epithelial morphogenesis that promotes cell migration

RNA on the X-1

X chomosome associated RNA

RNA polymerase II 215kD subunit

large subunit of the enzyme that catalyzes the synthesis of a complementary strand of RNA from a DNA template

Rpd3

histone deacetylase

Rtf1

functions as part of a protein complex in the monoubiquitination of histone H2B and the consequent methylation of histone H3 - functions in Notch signaling

runt

novel - pair rule gene

Smrter

SMRT-related ecdysone receptor-interacting protein

scalloped

human TEF-1 homolog

Scm-related gene containing four mbt domains

PcG protein - Pleiohomeotic interactor that binds mono- and di-methylated H3-K9 and H4-K20

and acts to maintain a Polycomb-repressed chromatin state

Serum response factor (preferred name: blistered)

MADS-box motif

Set2

Histone 3 methyltransferase involved in dosage compensation, puparium formation and adult development

Sex combs extra (common alternative name: Ring)

Polycomb group - protein ubiquitination - a member of a protein complex, termed PRC1 (Polycomb repressive complex 1)

Sex combs on midleg

Polycomb group

shortsighted (preferred name: bunched)

transcription factor - leucine zipper - dpp pathway

shuttle craft

zinc finger, C4HC3 type (PHD finger), and RD-domain protein

Sir2

histone deacetylase required for euchromatic and heterochromatic silencing - interacts genetically and physically with members of the Hairy/Deadpan/E(Spl) family of bHLH euchromatic repressors

sloppy paired 1 and 2

forkhead domain

slow border cells

basic leucine zipper - CCAAT/enhancer-binding protein homolog

snf5-related (common alternative name: snr1)

SWI/SNF family

Sox box protein 15

HMG-domain protein - SOX-domain protein - under the control of the canonical wingless pathway such that

wg and Sox15 regulate each other's transcription through a feedback loop that results in proliferation of wing hinge cells

Sox box protein 70D (common alternative name: Dichaete or fish-hook)

HMG-domain protein - SOX-domain protein

SoxNeuro

HMG1/2 (high mobility group) box transcription factor - essential for the formation of neural

progenitor cells in the central nervous system

Spt6

transcription elongation factor implicated in RNA processing and degradation of improperly processed pre-mRNA

STAT (common alternative name: marelle)

STAT homolog

Structure specific recognition protein

transcription factor - along with Dre4 forms a protein complex, FACT,

that facilates GAGA factor directed chromatin remodeling

Suppressor of hairless

integrase domain - Notch pathway

suppressor of Hairy wing

zinc fingers and leucine zipper - binds gypsy insulator element

Suppressor of variegation 3-3

homolog of the human LSD1 amine oxidase - demethylates H3K4me2 and H3K4me1 and facilitates subsequent H3K9 methylation by SU(VAR)3-9 -

dictates the distinction between euchromatic and heterochromatic domains during early embryogenesis

Suppressor of variegation 3-7

chromatin constituent - C2H2 zinc finger protein - required for X-restricted dosage compensation complex targeting

Suppressor of variegation 3-9

involved in gene silencing - a modifier of position effect variegation - methylates histone H3 thus providing a mark for the association of HP1 to heterochromatin

Suppressor of variegation 205 (common alternative name: heterochromatin protein 1)

chromodomain - Polycomb group - chromatin binding protein

taiman

steroid hormone receptor coactivator

TATA binding protein

general transcription factor - component of TFIID - activates TATA-dependent transcription and represses DPE-dependent transcription

TATA box binding protein-related factor 2

differentially recognizes and regulates a subset of TATA-less promoters

TBP-associated factor 1

general transcription factor - kinase and histone transacetylase activities

Tbp-related factor

general transcription factor - cell type specific TATA-binding protein

TfIIS (RNA polymerase II elongation factor)

critical for efficient release of stalled RNA Pol II from intrinsic stop sites in promoter regions -

promotes transcriptional elongation and decreases pausing

TORC

transcription factor - transducer of regulated CREB activity - starvation triggers TORC activation -

TORC maintains energy balance through induction of CREB target genes in the brain

tre-1, tre-2 and tre-3

noncoding RNAs that mediate transcriptional activation by recruiting the epigenetic regulator Ash1 to template trithorax response elements

T-related gene (preferred name: brachyenteron)

brachyury homolog

timeless

novel with pas domain - photoperiod

vestigial

presumptive transcription factor - novel

vrille

basic leucine zipper transcription factor

yan (preferred name: anterior open)

ets domain - antagonist of ras

yorkie

ortholog of the mammalian transcriptional coactivator yes-associated protein

- transcriptional coactivator that negatively regulates cell-cycle and cell-death regulators

zeste

transcription factor - hlh domain and leucine zipper domain - trithorax group

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Drosophila genes listed by biochemical function

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