logo Drosophila genes listed by biochemical function
Secreted proteins and ligands A - N ||P - Z

Accessory gland peptide 70A (common alternative name: sex-peptide)
male ejaculate accessory gland protein - decreases female receptivity and stimulates egg production in the first mating of virgin females

Adipokinetic hormone-like
metabolic neuropeptide, made in the corpora cardiaca, that mediates mobilization of energy substrates from the fat body - regulates starvation-induced foraging behavior

amalgam
IG superfamily

amnesiac
pacap-like neuropeptide

anachronism
secreted glial glycoprotein

argos (common alternative name: giant lens)
ligand for EGF-receptor/Torpedo

beaten path
secreted - Ig superfamily

bursicon
neuropeptide hormone that controls cuticle sclerotization and wing expansion behavior

Boss (Preferred name: Bride of sevenless)
transmembrane ligand for sevenless

branchless
FGF homolog - ligand for Breathless

Cardioacceleratory peptide
a neuropeptide - controls behavior during molting

Connectin
Leucine rich repeat cell adhesion protein

crossveinless 2
chordin-like cysteine rich domain protein

dawdle
TGF-ß superfamily ligand - Tolloid-related, by activating Dawdle, provides a permissive signal for axon guidance

decapentaplegic
ligand - tgf-beta homolog

Delta
EGF family - Notch ligand

Drosomycin
inducible antifungal peptide

Ecdysis triggering hormone
Regulates the process of preecdysis and ecdysis behaviors in the process shedding of the old cuticle

Eclosion hormone
neuropeptide

eiger
TNF superfamily; type II membrane protein - ligand that induces cell death by activating the JNK pathway

Ephrin
functions as a ligand for Eph receptor - expressed on the surface of neuron cell bodies - acts to confine Eph receptor bearing axons to longitudinal tracts by repulsion

faint sausage
Ig superfamily

Fasciclin I
cam - lipid linked to membrane and secreted - novel

FMRFamide-related
neuropeptide

folded gastrulation
secreted - novel protein - gastrulation

fringe
secreted - novel protein - boundary formation

glass bottom boat (common alternative name: Transforming growth factor beta at 60A)
TGF-beta superfamily - BMP 7 homolog

Glutactin
basement membrane protein - secreted - carboxesterase domain

gurken
tgf alpha homolog - EGF-R ligand

glutactin
basement membrane protein - secreted - carboxesterase domain

hedgehog
Hedgehog N-terminal signaling domain and C-terminal autoprocessing domain

hikaru genki
synaptic protein - IG superfamily - complement binding domains

hugin
controls growth and metabolism - encodes at least two distinct neuropeptides; one, hug-γ, has homology
to an ecdysone triggering hormone and a second, Drm-PK-2, is a pyrokinin with myostimulatory activity

jelly belly
a secreted ligand that contains an LDL receptor repeat - required for visceral mesoderm development

Laminin A
laminin - extracellular matrix protein

lush
olfactant-binding-protein, lipocalin family

Netrin-A and Netrin-B
secreted factor involved in axonogenesis

neuropeptide F
peptide hormone - developmentally programmed to modify foraging and social behavior in Drosophila larvae

outstretched
a novel ligand - potential activator of JAK/STAT signaling pathway

PDGF- and VEGF-related factor 1
ligands that orchestrate migratory patterns of hemocytes at the embryonic ventral midline - essential cell autonomously for proper positioning of the salivary glands - border cell migration
PDGF- and VEGF-related factor 2 and PDGF- and VEGF-related factor 3
ligand - orchestrate migratory patterns of hemocytes - essential cell autonomously for proper positioning of the salivary glands

Pigment-dispersing factor
neuropeptide

pyramus and thisbe
FGFs involved in mesodermal development - ligands for Heartless

scabrous
secreted - fibrinogen family

screw
TGF-ß superfamily - DPP signaling

semaphorin II
secreted - Ig superfamily - axon guidance

Serrate
transmembrane - EGF homolog - ligand for Notch

sex-peptide (preferred name: Accessory gland peptide 70A)
male ejaculate accessory gland protein - decreases female receptivity and stimulates egg production in the first mating of virgin females
shifted
ortholog of the human Wnt inhibitory factor - required for Hh stability and for lipid-modified Hh diffusion -
colocalizes with Hh in the extracellular matrix and interacts with the heparan sulfate proteoglycans

short gastrulation
chordin homolog - segment polarity

slit
extracellular - egf like

spätzle
secreted - ligand for toll

spitz
ligand for Egf-r - egf/tgf alpha homolog

takeout
secreted ligand-binding protein

terribly reduced optic lobes
extracellular matrix component - homolog of perlecan - regulates larval neuroblast division by modulating both FGF and Hedgehog signaling

thisbe and pyramus
FGFs involved in mesodermal development - ligands for Heartless

Thrombospondin
extracellular matrix ligand produced by tendon cells - essential for the formation of the integrin-mediated myotendinous junction

Tiggrin
secreted - extracellular matrix

tolkin common alternative name: tolloid-related-1
BMP-1 homolog - metalloprotease

tolloid
secreted BMP-1 homolog - metalloprotease

tolloid-related-1 (preferred name: tolkin)
secreted BMP-1 homolog - metalloprotease

Transforming growth factor beta at 60A (preferred name: glass bottom boat)
TGF-beta superfamily - BMP 7 homolog

trunk
secreted - ligand for torso

twisted gastrulation
secreted growth factor

vein
EGF domain and Ig domain - ligand for EGF-receptor

wingless
ligand - wnt family - segment polarity

Wnt8 (common alternative name: WntD)
Wnt family ligand - involved in establishment dorsal/ventral patterning and the immune response

Wnt oncogene analog 2
ligand - Wnt family

Wnt oncogene analog 4
ligand - TGF-B homolog - mesodermal

Wnt oncogene analog 5
Wnt superfamily ligand involved in axon guidance and salivary gland morphogenesis

* genes currently without individual sites in The Interactive Fly

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Drosophila genes listed by biochemical function

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