Drosophila Genes

Drosophila genes listed by biochemical function

Secreted proteins and ligands A - N ||P - Z

Accessory gland peptide 70A (common alternative name: sex-peptide)

male ejaculate accessory gland protein - decreases female receptivity and stimulates egg production in the first mating of virgin females

activin-β

TGFβ ligand of Baboon - required for tiling of photoreceptor R7 axon terminals

Adipokinetic hormone-like

metabolic neuropeptide, made in the corpora cardiaca, that mediates mobilization of energy substrates from the fat body - regulates starvation-induced foraging behavior

amalgam

IG superfamily

amnesiac

pacap-like neuropeptide

anachronism

secreted glial glycoprotein

argos (common alternative name: giant lens)

ligand for EGF-receptor/Torpedo

beaten path

secreted - Ig superfamily

BM-40-SPARC (common alternative name: Sparc)

basement membrane component required for basal lamina maturation and condensation of the ventral nerve cord

Boss (Preferred name: Bride of sevenless)

transmembrane ligand for sevenless

boudin

glycosylphosphatidylinositol anchored membrane protein - essential for tracheal morphogenesis -

contributes to the maintenance of the paracellular barrier and the organisation of the septate junctions -

required for septate junction organisation in chordotonal organ glial cells

branchless

FGF homolog - ligand for Breathless

bursicon

neuropeptide hormone that controls cuticle sclerotization and wing expansion behavior

Cardioacceleratory peptide

a neuropeptide - controls behavior during molting

Connectin

Leucine rich repeat cell adhesion protein

Collagen type IV

the main component of basement membranes - synthesized by the fat body, secreted to the hemolymph,

and incorporated into the BM - determines organ shape - regulates BMP signaling

convoluted

fly ortholog of the vertebrate insulin-like growth factor-binding protein acid-labile subunit (ALS) -

antagonizes Dilp function to control animal growth and carbohydrate and fat metabolism

crossveinless

twisted gastrulation family member - along with Short gastrulation, Crossveinless promotes BMP signaling

by transporting a Dpp/Gbb heterodimer from the longitudinal veins into the crossvein regions

crossveinless 2

chordin-like cysteine rich domain protein

dawdle

TGF-ß superfamily ligand - Tolloid-related, by activating Dawdle, provides a permissive signal for axon guidance

decapentaplegic

ligand - tgf-beta homolog

Delta

EGF family - Notch ligand

Drosomycin

inducible antifungal peptide

Ecdysis triggering hormone

regulates the process of preecdysis and ecdysis behaviors in the process shedding of the old cuticle

Ecdysone-inducible gene L2

a secreted protein that binds Drosophila insulin-like peptide 2 and inhibits growth non-autonomously

Eclosion hormone

neuropeptide

eiger

TNF superfamily; type II membrane protein - ligand that induces cell death by activating the JNK pathway

Ephrin

functions as a ligand for Eph receptor - expressed on the surface of neuron cell bodies -

acts to confine Eph receptor bearing axons to longitudinal tracts by repulsion

eyes shut

a proteoglycan secreted into the ommatidial apical matrix - critical for the formation of epithelial lumina in the fly retina -

forms an extracellular shield that guards mechanosensory neurons from environmental insult

faint sausage

Ig superfamily

Fasciclin I

cam - lipid linked to membrane and secreted - novel

FMRFamide-related

neuropeptide

folded gastrulation

secreted - novel protein - gastrulation

fringe

secreted - novel protein - boundary formation

Fs (common alternative name: Follistatin)

modulates TGF-β ligand signaling - inhibits activin-β signaling but activates Dawdle

glass bottom boat (common alternative name: Transforming growth factor beta at 60A)

TGF-beta superfamily - BMP 7 homolog

Gram-negative bacteria binding protein 3

a pattern recognition receptor that is required for the detection of fungal cell wall components -

required for Toll pathway activation in response to fungal infections

Growth-blocking peptide

a secreted cytokine that mediates acute innate immune reactions through association with IMD - activates Phospholipase C

which promotes increases in the levels of inositol phosphates involved in intracellular signaling - regulates larval growth

gurken

TGF alpha homolog - EGF-R ligand

hedgehog

Hedgehog N-terminal signaling domain and C-terminal autoprocessing domain

hikaru genki

synaptic protein - IG superfamily - complement binding domains

hugin

controls growth and metabolism - encodes at least two distinct neuropeptides; one, hug-γ, has homology

to an ecdysone triggering hormone and a second, Drm-PK-2, is a pyrokinin with myostimulatory activity

Insulin-like peptide 6

an insulin-like peptide that is produced by the fat body - induced by metabolic stress -

promotes growth in conditions of nutritional deprivation or following developmentally induced cessation of feeding

Insulin-like peptide 8

ensures developmental stability and robustness - delays metamorphosis by inhibiting ecdysone biosynthesis thus slowing growth

in the imaginal discs - coordinates tgrowth status of tissues with developmental timing

Insulin-related peptide

Insulin-like growth factor that functions as a growth stimulator - regulates of trehalose metabolism

jelly belly

a secreted ligand that contains an LDL receptor repeat - required for visceral mesoderm development

Keren

ligand for Epidermal growth factor receptor - homolog of Spitz with partially independent functional activity -

provides an autocrine mitogenic stimulus in midgut progenitor cells

Laminin A

laminin - extracellular matrix protein

Laminin B1

extracellular matrix protein - required for normal accumulation of basement membrane components -

involved in morphogenesis of gut, trachea, muscles and nervous system

lush

olfactant-binding-protein, lipocalin family

mind the gap

secreted carbohydrate-binding protein involved in synapse assembly -

modifier of signaling by the ligand Jelly belly and its receptor Alk

myoglianin

secreted Transforming growth factor-beta family ligand - secreted by glial cells

during larval brain development - for neuronal expression of Ecdysone receptor

Netrin-A and Netrin-B

secreted factor involved in axonogenesis

Neurexin 1

ligand of neuroligins involved in development and function of synaptic architecture in the brain and neuromuscular junction - glutamergic synapse

neuropeptide F

peptide hormone - developmentally programmed to modify foraging and social behavior in Drosophila larvae

Neurotrophin 1

secreted ligand that maintains neuronal survival - expression rescues

naturally occurring cell death and enables targeting by motor neurons

outstretched

a novel ligand - potential activator of JAK/STAT signaling pathway

PDGF- and VEGF-related factor 1

ligands that orchestrate migratory patterns of hemocytes at the embryonic ventral midline - essential cell autonomously

for proper positioning of the salivary glands - border cell migration

PDGF- and VEGF-related factor 2 and PDGF- and VEGF-related factor 3

ligand - orchestrate migratory patterns of hemocytes - essential cell autonomously for proper positioning of the salivary glands

Pigment-dispersing factor

neuropeptide

Prothoracicotropic hormone

developmental timing cue involved in promoting larval development and eclosion

pyramus and thisbe

FGFs involved in mesodermal development - ligands for Heartless

scabrous

secreted - fibrinogen family

screw

TGF-ß superfamily - DPP signaling

Semaphorin-2a and Semaphorin-2b

secreted - Ig superfamily - axon guidance

Serrate

transmembrane - EGF homolog - ligand for Notch

sex-peptide (preferred name: Accessory gland peptide 70A)

male ejaculate accessory gland protein - decreases female receptivity and stimulates egg production in the first mating of virgin females

shifted

ortholog of the human Wnt inhibitory factor - required for Hh stability and for lipid-modified Hh diffusion -

colocalizes with Hh in the extracellular matrix and interacts with the heparan sulfate proteoglycans

short gastrulation

chordin homolog - segment polarity

short neuropeptide F precursor

neuropeptide that engenders ERK-mediated insulin expression and thus systemically modulates growth, metabolism and lifespan

sidestep

Ig domain cell adhesion molecule - ligand for Beaten path Ia - axon guidance

slit

extracellular - egf like

spätzle

secreted - ligand for toll

spitz

ligand for Egf-r - egf/tgf alpha homolog

takeout

secreted ligand-binding protein

terribly reduced optic lobes

extracellular matrix component - homolog of perlecan - regulates larval neuroblast division by modulating both FGF and Hedgehog signaling

thisbe and pyramus

FGFs involved in mesodermal development - ligands for Heartless

Thrombospondin

extracellular matrix ligand produced by tendon cells - essential for the formation of the integrin-mediated myotendinous junction

Tiggrin

secreted - extracellular matrix

tolkin common alternative name: tolloid-related-1

BMP-1 homolog - metalloprotease

tolloid

secreted BMP-1 homolog - metalloprotease

tolloid-related-1 (preferred name: tolkin)

secreted BMP-1 homolog - metalloprotease

Transforming growth factor beta at 60A (preferred name: glass bottom boat)

TGF-beta superfamily - BMP 7 homolog

trunk

secreted - ligand for torso

turtle

Ig superfamily - ligand or co-receptor - required to restrain dendrite branch formation in neurons with simple arbors,

and to promote dendrite self-avoidance in neurons with complex arbors - regulates the tiling pattern of R7 photoreceptor terminals

twisted gastrulation

secreted growth factor

Vap-33-1

cleaved secreted ligand for Eph receptors - plays a conserved role in synaptic homeostasis

vein

EGF domain and Ig domain - ligand for EGF-receptor

viking

along with Collagen IV, the main component of basement membranes - synthesized by the fat body,

secreted to the hemolymph, and incorporated into the basement membrane - determines organ shape - regulates BMP signaling

wingless

ligand - wnt family - segment polarity

Wnt8 (common alternative name: WntD)

Wnt family ligand - involved in establishment dorsal/ventral patterning and the immune response

Wnt oncogene analog 2

ligand - Wnt family

Wnt oncogene analog 4

ligand - TGF-B homolog - mesodermal

Wnt oncogene analog 5

Wnt superfamily ligand involved in axon guidance and salivary gland morphogenesis

wrapper

Immunoglobulin domain ligand - present in midline glia - required, along with neuronally-expressed

Neurexin IV, for ensheathment of commissural axons

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Drosophila genes listed by biochemical function

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