Drosophila gene families: channels

The Interactive Fly

Zygotically transcribed genes

Channels

Acetylcholine-gated receptor-channel complex

Calcium channels
- Anktm1 (common alternative name: dTrpA1) - heat-activated TRP family ion channel that is essential for thermotaxis
- Inositol 1,4,5,-tris-phosphate receptor - Intracellular calcium-release channel
- nanchung - required for hearing
- NMDA receptor 1 and NMDA receptor 2 - voltage/Mg²⁺-dependent Ca²⁺ channels activated by glutamate
- no mechanoreceptor potential C - mechanically-gated calcium channel
- painless: pain response defective, nociceptor
- Polycystic kidney disease gene-2: non-ligand gated
- Ryanodine receptor 44F - Intracellular calcium-release channel
- transient receptor potential - light-activated calcium channel activity
- trp-like - light-activated calcium channel activity

Connexon channels
- bigbrain

Innexin channels
- innexin3: component of gap junctions

Inwardly rectifying potassium channels
- Inwardly rectifying potassium channel : potassium channel inhibited by cytosolic ATP
- Inwardly rectifying potassium channel 2: G-protein activated inward rectifier potassium channel
- Inwardly rectifying potassium channel 3: ATP-sensitive inward rectifier potassium channel
- Open rectifier K⁺ channel 1: Inwardly and Outwardly rectifying - leak channel with two pore domains

Glutamate receptors
- clumsy - a kainate selective glutamate receptor
- Glutamate receptor I - glutamate gated potassium channel
- Glutamate receptor IB - glutamate gated potassium channel
- Glutamate receptor IIA - glutamate gated potassium channel
- Glutamate receptor IIB - glutamate gated potassium channel
- NMDA receptor 1

Miscellaneous ion channels
- narrow abdomen: cation channel - involved in hearing, behavioral response to cocaine and response to heat

Miscellaneous ligand-gated ion channels
- CNG channel-like
- Cyclic-nucleotide-gated ion channel
- Glycine receptor
- Histamine-gated chloride channel subunit 1
- inactive: required for hearing
- Ligand-gated chloride channel homolog 2
- Ligand-gated chloride channel homolog 3: Neurotransmitter-gated (GABAA-gated)
- Nach : Amiloride-sensitive sodium channel - may have a role in liquid clearance from the tracheal system
- ora transientless; histamine-gated chloride channel - visual behavior defective
- pickpocket: Amiloride-sensitive sodium channel
- Resistant to dieldrin: GABA-A gated chloride channel - negatively modulates olfactory associative learning, possibly by gating the input of olfactory information into the mushroom bodies - regulates the length of time required to fall asleep
- ripped pocket: amiloride-sensitive sodium channel
- small conductance calcium-activated potassium channel

Sodium:neurotransmitter symporter family
- inebriated - controls neuronal excitability and the osmotic stress response

Voltage gated Ca⁺ channels
- cacaphony: voltage-gated calcium channel
- Ca²⁺-channel protein alpha₁ subunit D
- Ca²⁺-channel-protein-alpha₂-subunit
- Ca²⁺-channel-protein-ß-subunit
- Ca-alpha1T

Voltage-gated potassium channel
- ether a go-go
- eag-like K⁺ channel
- Hyperkinetic
- KCNQ potassium channel
- seizure
- Shaker
- Shaker cognate b
- Shaker cognate l
- Shaker cognate w
- slowpoke: calcium-activated voltage-dependent potassium channel

Voltage-gated sodium channels
- Na channel protein 60E: regulates olfactory sensitivity
- paralytic: mutants have paralytic and olfactory phenotype
- temperature-induced paralytic E

Other voltage-gated channels
- porin: ion-selective channel involved in mitochondrial transport

Water channel activity
- Drip

Zygotically transcribed genes

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