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Evolutionarily conserved developmental pathways

Compartmentalization: The roles of Wingless in adherens junction dynamics and in the targeting of LIM domain proteins and Engrailed

Wingless acts both within compartments and between compartment boundaries to promote a seamless transition between the alternative fates of neighboring cells. Wingless functions in Drosophila as a segment polarity gene. Frizzled is a seven-pass transmembrane receptor involved in tissue patterning and symmetry. Other proteins listed are part of the adherens junction that functions to connect the homophilic cell adhesion protein E-cadherin to the cell's cytoskeleton. Drosophila Wingless and Vertebrate Wnts target engrailed in brain compartmentalization and they target apterous (Vertebrate homologs: LIM domain proteins) and engrailed in limb compartmentalization. Notch and Wingless pathways talk to each other through Dishevelled, which is an integral part of the Wingless pathway and physically interactions with the Notch carboxyl terminus.

Drosophila                  Homologs in other species 
----------                  -------------------
Wingless                    C. elegans: Lin-44 
                            Mammals: Wnt-1 and Wnt-7a 

Frizzled2                   C. elegans: Lin-17

Dishevelled                 Xenopus: Xdsh
                            Mammals: Dvl-1 and Dvl-2 

Shaggy/Zeste white 3        Xenopus: Xgsk-3
                            Mammals: Glycogen synthase kinase 3

Armadillo                   Vertebrates: ß-catenin - Plakoglobin

Singed                      Other species: Fascin

D alpha-catenin             Vertebrates: alpha-catenin

APC-like                    Human: Adenomatous polyposis coli 

Discs large                 Human: DLG

Shotgun (E-cadherin)        Mammals: E-cadherin

DLAR                        Human: LAR

Engrailed                   Mammals: Engrailed1

Apterous                    Mammals: LMX1

date revised: 13 Oct 96

Developmental Pathways conserved in Evolution

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