The Interactive Fly
Evolutionarily conserved developmental pathways
The Notch pathway functions in neurogenesis and other developmentalpathways to assure that cell fate is restricted to a limited number ofprogenitors. Notch and Wingless pathways talk to each other through Dishevelled, which is an integral part of the Wingless pathway and physically interactions with the Notch carboxylterminus.
Drosophila Homologs in other species---------- -------------------Notch C. elegans: Glp-1 and Lin-12 Xenopus: Xnotch Chicken: C-Notch-1 Mammalian: Notch1 and Notch2Delta C. elegans: Lag-2, Apx-1 Chicken: C-Delta-1 Mouse: Dll1 (delta-like gene 1)Suppressor of hairless Mammalian: CBF1 (JkappaRBP)DeltexDishevelled Xenopus: Xdsh Mammals: Dvl-1 and Dvl-2 Numb Mammals: NumbEnhancer of split Mammalian: Hairy enhancer of split (HES-1)Serrate Mammalian: C-Serrate-1
date revised: 13 Oct 96
Developmental Pathways conserved in Evolution
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