The Interactive Fly

Evolutionarily conserved developmental pathways

Axon guidance 1: The role of Netrins and the netrin receptor Frazzled

Netrins are related to the N terminal arm of Laminins, a large protein constituent of the extracellular matrix. The involvement of Netrins and a highly conserved netrin receptor in axon guidance is conserved from worms to mammals.

Drosophila                     Homologs in other species ----------                     ----------------------------Netrin A and Netrin B          C. elegans: Unc6                               Mammals: NetrinsFrazzled                       C. elegans: Unc 40 and Unc5                               Mammals: Deleted in Colorectal Cancer

date revised: 13 Oct 96

Developmental Pathways conserved in Evolution

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