The Interactive Fly

Evolutionarily conserved developmental pathways

The Learning Pathway - Cyclic AMP (cAMP) Second Messenger System

The cyclic AMP second messenger system is a signal transduction cascade tying neurotransmitter signals totranscription factors, bringing about the cellular changes that take placeduring learning. For more information, see the cAMP or LearningPathway site. This pathway is highly conserved in evolution. For example,cellular slime molds use it to transduce cAMP signals to the nucleus resultingin the induction of cell aggregation. Fos and Jun (targets of cAMP signals)and important in growth factor responses, are also activated through theRas pathway.

Drosophila                   Homologs in other species ----------                   ----------------------------Rutabaga                     Mammalian: Type I adenyl cyclaseCa2+-calmodulin              Vertebrates: Ca2+-calmodulincAMP-dependent               Mammalian: cAMP-dependent protein kinase Aprotein kinase 1Dunce                        Vertebrates: cAMP-specific phosphodiesteraseRutabaga                     Mammalian: Type I adenyl cyclaseDCREB2                       Mammalian: CREB, CREM and ATF-1DFos                         Mammalian: cFosDJun                         Mammalian: cJun

date revised: 15 Oct 96

Developmental Pathways conserved in Evolution

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