The Interactive Fly

Evolutionarily conserved developmental pathways

Dorsal-ventral patterning and the immune response - A commonpathway activates Dorsal and NF-kappaB

Dorsal, the fly NF-kappaB (cRel) homolog is activated in a signal transductioncascade carried out by Dorsal groupproteins. The pathway for Dorsal activation is highly conserved, from thereceptor Toll to the I kappa B homolog Cactus. The activation of Dorsalis the major maternal pathway for Dorsal-ventral patterning and takes placeimmediately after fertilization. The Xenopus homolog of Dorsal (XrelA)is similarly involved in dorsal-ventral patterning in the frog. This conservedpathway is also involved in induction of the immune response in both fliesand vertebrates.

Drosophila                   Homologs in other species ----------                   ----------------------------Toll                         Mammalian: Interleukin-1 receptorPelle                        Mammalian: Interleukin-1 receptor associated kinaseTube                         Mammalian: ?Cactus                       Mammalian: I kappa B familyDorsal                       Xenopus: XrelA                             Mammalian: NF-kappaB

date revised: 14 Oct 96

Developmental Pathways conserved in Evolution

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