Amin, A., Li, Y. and Finkelstein, R. (1999). Hedgehog activates the EGF receptor pathway during Drosophila head development. Development 126(12): 2623-2630. PubMed Citation: 10331974

Anton, E. S., et al. (1997). Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex. Development 124: 3501-3510. PubMed Citation: 9342043

Austin, C. L., Manivannan, S. N. and Simcox, A. (2014). TGF-alpha ligands can substitute for the neuregulin Vein in Drosophila development. Development 141: 4110-4114. PubMed ID: 25336739

Bao, J., et al. (2004). Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos. Nat. Neurosci. 7(11): 1250-8. 15494726

Baonza, A. and Garcia-Bellido, A. (1999). Dual role of extramacrochaetae in cell proliferation and cell differentiation during wing morphogenesis in Drosophila. Mech. Dev. 80(2): 133-46. PubMed Citation: 10072780

Bersell, K., Arab, S., Haring, B. and Kühn, B. (2009). Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 138(2): 257-70. PubMed Citation: 19632177

Biehs, B., Sturtevant, M. A. and Bier, E. (1998). Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs. Development 125: 4245-4257. PubMed Citation: 9753679

Biteau, B. and Jasper, H. (2011). EGF signaling regulates the proliferation of intestinal stem cells in Drosophila. Development 138(6): 1045-55. PubMed Citation: 21307097

Brinkmann, B. G., et al. (2008). Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system. Neuron 59: 581-595. PubMed Citation: 18760695

Britsch, S., et al. (1998). The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev. 12(12): 1825-1836. PubMed Citation: 9637684

Britto, J. M. et al. (2004). Generation and characterization of neuregulin-2-deficient mice. Mol. Cell. Biol. 24(18): 8221-6. 15340081

Busfield, S. J., et al. (1997). Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus. Mol. Cell. Biol. 17(7): 4007-14. PubMed Citation: 9199335

Butchar, J. P, et al. (2012). New negative feedback regulators of Egfr signaling in Drosophila. Genetics 191(4): 1213-26. PubMed Citation: 22595244

Campbell, G. (2002). Distalization of the Drosophila leg by graded EGF-receptor activity. Nature 418: 781-785. 12181568

Carraway, K. L. and Cantley, L. C. (1994). A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling. Cell 78: 5-8. PubMed Citation: 8033211

Carraway, K. L., et al. (1995). Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3. J Biol Chem 270: 7111-7116. PubMed Citation: 7535767

Carraway, K. L. et al. (1997). Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature 387(6632): 512-6. PubMed Citation: 9168115

Chang, H., et al. (1997). Ligands for ErbB-family receptors encoded by a neuregulin-like gene. Nature 387(6632): 509-12. PubMed Citation: 9168114

Chausovsky, A., et al. (1998). Morphogenetic effects of neuregulin (Neu differentiation factor) in cultured epithelial cells. Mol. Biol. Cell 9(11): 3195-209. PubMed Citation: 9802906

Chen, M. S., et al. (1994). Expression of multiple neuregulin transcripts in postnatal rat brains. J. Comp. Neurol. 349: 389-400. PubMed Citation: 7852632

Corfas, G., et al. (1995). Differential expression of ARIA isoforms in the rat brain. Neuron 14(1): 103-15. PubMed Citation: 7530017

Crone, S. A., et al. (2003). Colonic epithelial expression of ErbB2 is required for postnatal maintenance of the enteric nervous system. Neuron 37: 29-40. 12526770

Crovello, C. S., et al. (1998). Differential signaling by the epidermal growth factor-like growth factors neuregulin-1 and neuregulin-2. J. Biol. Chem. 273(41): 26954-61. PubMed Citation: 9756944

Crozatier, M., Glise B. and Vincent, A. (2002). Connecting Hh, Dpp and EGF signalling in patterning of the Drosophila wing; the pivotal role of collier/knot in the AP organiser. Development 129: 4261-4269. 12183378

Cruz, J., Martin, D. and Franch-Marro, X. (2020). Egfr signaling is a major regulator of ecdysone biosynthesis in the Drosophila prothoracic gland. Curr Biol 30(8): 1547-1554. PubMed ID: 32220314

Deneault, E., et al. (2009). A functional screen to identify novel effectors of hematopoietic stem cell activity. Cell 137: 369-379. PubMed Citation: 19379700

Donaldson, T., Wang, S. H., Jacobsen, T. L., Schnepp, B., Price, J. and Simcox, A. (2004). Regulation of the Drosophila epidermal growth factor-ligand vein is mediated by multiple domains. Genetics 167(2): 687-98. 1523852

Duchek, P. and RØrth, P. (2001). Guidance of cell migration by EGF receptor signaling during Drosophila oogenesis. Science 291: 131-133. 11141565

Eilam, R., et al. (1998). Activity-dependent regulation of neu differentiation factor/neuregulin expression in rat brain. Proc. Natl. Acad. Sci. 95(4): 1888-1893. PubMed Citation: 9465112

Eresh, S., et al. (1997). A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction. EMBO J. 16: 2014-22. PubMed Citation: 9155027

Erickson, S. L., et al. (1997). ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development 124(24): 4999-5011. PubMed Citation: 9362461

Ferguson, K. M., et al. (2000). Extracellular domains drive homo- but not hetero-dimerization of erbB receptors. EMBO J. 19: 4632-4643. PubMed Citation: 10970856

Fernandez, P.-A., Tang, D. G., Cheng, L., Prochiantz, A., Mudge, A. W. and Raff, M. C. (2000). Evidence that axon-derived Neuregulin promotes oligodendrocyte survival in the developing rat optic nerve. Neuron 28: 81-90. 11086985

Flames, N., et al. (2004). Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1. Neuron 44(2): 251-61. 15473965

Ford, B. D., Loeb, J. A. and Fischbach, G. D. (1999). Neuregulin stimulates DNA synthesis in embryonic chick heart cells. Dev. Biol. 214(1): 139-50

Fromm, L. and Burden, S. J. (1998). Synapse-specific and neuregulin-induced transcription require an ets site that binds GABPalpha/GABPbeta. Genes Dev. 12(19): 3074-83

García-Bellido, A., Cortéz, F. and Milán, M. (1994). Cell interactions in the control of size in Drosophila wings. Proc. Natl. Acad. Sci. 91: 10222-26

Gassmann, M., et al. (1995). Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378: 390-394

Gerecke, K. M., Wyss, J. M. and Carroll, S. L. (2004). Neuregulin-1beta induces neurite extension and arborization in cultured hippocampal neurons. Mol. Cell. Neurosci. 27(4): 379-93. 15555917

Ghashghaei, H. T., et al. (2006). The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone. Proc. Natl. Acad. Sci. [Epub ahead of print]. 16446434

Ghashghaei, H. T., et al. (2007). Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex. Genes Dev. 21(24): 3258-71. PubMed citation: 18079173

Golembo, M., et al. (1999). Vein expression is induced by the EGF receptor pathway to provide a positive feedback loop in patterning the Drosophila embryonic ventral ectoderm. Genes Dev. 13(2): 158-162

Hidalgo, H., et al. (2001). The Drosophila neuregulin Vein maintains glial survival during axon guidance in the CNS. Developmental Cell 1: 679-690. 11709188

Hill, R. J. and Sternberg, P. W. (1993). Cell fate patterning during C. elegans vulval development. Dev Suppl : 9-18

Hippenmeyer, S., Shneider, N. A., Birchmeier, C., Burden, S. J., Jessell, T. M. and Arber, S. (2002). A role for neuregulin1 signaling in muscle spindle differentiation. Neuron 36: 1035-1049. 12495620

Huang, Y. Z., et al. (2000). Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron 26: 443-455

Inbal, A., Volk, T. and Salzberg, A. (2004). Recruitment of ectodermal attachment cells via an EGFR-dependent mechanism during the organogenesis of Drosophila proprioceptors. Dev. Cell 7: 241-250. 15296720

Iwamoto, R., et al. (2010). HB-EGF function in cardiac valve development requires interaction with heparan sulfate proteoglycans. Development 137(13): 2205-14. PubMed Citation: 20530548

Jacobson, C., Duggan, D. and Fischbach, G. (2004). Neuregulin induces the expression of transcription factors and myosin heavy chains typical of muscle spindles in cultured human muscle. Proc. Natl. Acad. Sci. 101(33): 12218-23. 15302938

Jiang, L. I. and Sternberg, P. W. (1998). Interactions of EGF, Wnt and HOM-C genes specify the P12 neuroectoblast fate in C. elegans. Development 125(12): 2337-2347

Jo, S. A., et al. (1995). Neuregulins are concentrated at nerve-muscle synapses and activate ACh-receptor gene expression. Nature 373: 158-161

Katz, W. S., et al. (1995). Different levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates. Cell 82: 297-307

Kramer, R., et al. (1996). Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development. Proc. Natl. Acad. Sci. 93: 4833-4838.

Krane, I. M. and Leder, P. (1996). NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice. Oncogene 12: 1781-1788

Laederich, M. B., et al. (2004). The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases. J. Biol. Chem. 279(45): 47050-6. 15345710

Lee, K. F., et al. (1995). Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378: 394-398

Leimeroth, R., Lobsiger, C., Lussi, A., Taylor, V., Suter, U. and Sommer, L. (2002). Membrane-bound neuregulin1 type III actively promotes Schwann cell differentiation of multipotent progenitor cells. Dev. Biol. 246(2): 245-58. 12051814

Leu, M., et al. (2003). Erbb2 regulates neuromuscular synapse formation and is essential for muscle spindle development. Development 130: 2291-2301. 12702645

Li, B., et al. (2007). The Neuregulin-1 receptor ErbB4 controls glutamatergic synapse maturation and plasticity. Neuron 54: 583-597. Medline abstract: 17521571

Li, W., et al. (1996). Heregulin is rapidly translocated to the nucleus and its transport is correlated with c-myc induction in breast cancer cells. Oncogene 12: 2473-2477

Liu, Z. C., Geisbrecht, E. R. (2011). Moleskin is essential for the formation of the myotendinous junction in Drosophila. Dev. Biol. 359(2): 176-89. PubMed Citation: 21925492

Loeb, J. A. and Fischbach, G. D. (1995). ARIA can be released from extracellular matrix through cleavage of a heparin-binding domain. J. Cell Biol. 130(1): 127-35

Loeb, J. A. and Fischbach, G. D. (1997). Neurotrophic factors increase neuregulin expression in embryonic ventral spinal cord neurons. J. Neurosci. 17(4): 1416-24

Loeb, J. A., Susanto, E. T. and Fischbach, G. D. (1998). The Neuregulin precursor proARIA Is processed to ARIA after expression on the cell surface by a Protein kinase C-enhanced mechanism. Mol. Cell. Neurosci. 11(1/2): 77-91

Loeb, J. A., et al. (1999). Expression patterns of transmembrane and released forms of neuregulin during spinal cord and neuromuscular synapse development. Development 126(4): 781-791

Lopez-Bendito, G., et al. (2006). Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation. Cell 125(1): 127-42. 16615895

Martin-Bermudo, M. D. (2000). Integrins modulate the Egfr signaling pathway to regulate tendon cell differentiation in the Drosophila embryo. Development 127: 2607-2615

Martin-Blanco, E., et al. (1999). A temporal switch in DER signaling controls the specification and differentiation of veins and interveins in the Drosophila wing. Development 126: 5739-5747

Mathur, D., Bost A., Driver I. and Ohlstein B. (2010). A transient niche regulates the specification of Drosophila intestinal stem cells. Science 327: 210-213. PubMed Citation: 20056890

Mayer, U. and Nusslein-Volhard, C. (1988). A group of genes required for pattern formation in the ventral ectoderm of the Drosophila embryo. Genes Dev. 2: 1496-1511. 3209069

Meyer, D. and Birchmeier, C. (1994). Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development. Proc Natl Acad Sci 91: 1064-8.

Meyer, D. and Birchmeier, C. (1995). Multiple essential functions of neuregulin in development. Nature 378: 386-390.

Meyer, D., et al. (1997). Isoform-specific expression and function of neuregulin. Development 124: 3575-3586

Milan, M., Baonza, A. and Garcia-Bellido, A. (1997). Wing surface interactions in venation patterning in Drosophila. Mech. Dev. 67(2): 203-213

Moscoso, L. M., et al. (1995). Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle. Dev. Biol. 172(1): 158-69

Nagaraj, R., et al. (1999). Role of EGF receptor pathway in the growth and patterning of the Drosophila wing through the regulation of vestigial. Development 126: 975-985. Medline abstract: 9927598

Newcomb, S., Voutev, R., Jory, A., Delker, R. K., Slattery, M. and Mann, R. S. (2018). cis-regulatory architecture of a short-range EGFR organizing center in the Drosophila melanogaster leg. PLoS Genet 14(8): e1007568. PubMed ID: 30142157

Nie, S. and Chang, C. (2007). PI3K and Erk MAPK mediate ErbB signaling in Xenopus gastrulation. Mech. Dev. 124(9-10): 657-67. PubMed citation: 17716876

Oishi, K., et al. (2006). Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations. Hum. Mol. Genet. 15(4): 543-53. 16399795

Olayioye, M. A., et al. (1998). ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner. Mol. Cell. Biol. 18(9): 5042-51

Pallavi, S. K., Kannan, R. and Shashidhara, L. S. (2006). Negative regulation of Egfr/Ras pathway by Ultrabithorax during haltere development in Drosophila. Dev. Biol. 296(2): 340-52. Medline abstract: 16815386

Pankonin, M. S., Gallagher, J. T. and Loeb, J. A. (2005). Specific structural features of heparan sulfate proteoglycans potentiate neuregulin-1 signaling. J. Biol. Chem. 280(1): 383-8. 15528194

Paul, L., Wang, S. H., Manivannan, S. N., Bonanno, L., Lewis, S., Austin, C. L. and Simcox, A. (2013). Dpp-induced Egfr signaling triggers postembryonic wing development in Drosophila. Proc Natl Acad Sci U S A 110: 5058-5063. PubMed ID: 23479629

Perlin, J. R., et al. (2011). Neuronal Neuregulin 1 type III directs Schwann cell migration. Development 138(21): 4639-48. PubMed Citation: 21965611

Pinkas-Kramarski, R., et al. (1996a). Neu differentiation factor/neuregulin isoforms activate distinct receptor combinations. J. Biol. Chem. 271: 19029-19032.

Pinkas-Kramarski, R., et al. (1996). Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J. 15: 2452-2467

Prokop, A., et al. (1998). The kakapo mutation affects terminal arborization and central dendritic sprouting of Drosophila motorneurons. J. Cell Biol. 143(5): 1283-94

Rafel, N. and Milán M. (2008). Notch signalling coordinates tissue growth and wing fate specification in Drosophila. Development 135(24): 3995-4001. PubMed Citation: 18987026

Riese, D. J., et al. (1995). The cellular response to neuregulins is governed by complex interactions of the erbB receptor family. Mol Cell Biol 15: 5770-5776

Rimer, M., et al. (2004). Neuregulin-2 is synthesized by motor neurons and terminal Schwann cells and activates acetylcholine receptor transcription in muscle cells expressing ErbB4. Mol. Cell. Neurosci. 26(2): 271-81. 15207852

Rio, C., et al. (1997). Neuregulin and erbB receptors play a critical role in neuronal migration. Neuron 19: 39-50

Sandrock, A. W. et al. (1995). ARIA is concentrated in nerve terminals at neuromuscular junctions and at other synapses. J. Neurosci. 15(9): 6124-36

Sandrock, A. W. et al. (1997). Maintenance of acetylcholine receptor number by neuregulins at the neuromuscular junction in vivo. Science 276(5312): 599-603

Schnepp, B., et al. (1996). Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. Genes Dev. 10: 2302-13

Schnepp, B. (1998). EGF domain swap converts a Drosophila EGF receptor activator into an inhibitor. Genes Dev. 12: 908-913

Scopelliti, A., Cordero, J. B., Diao, F., Strathdee, K., White, B. H., Sansom, O. J., Vidal, M. (2014) Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut. Curr Biol 24: 1199-1211. PubMed ID: 24814146

Sen, A., Kuruvilla, D., Pinto, L., Sarin, A. and Rodrigues, V. (2004). Programmed cell death and context dependent activation of the EGF pathway regulate gliogenesis in the Drosophila olfactory system. Mech. Dev. 121: 65-78. 14706701

Simcox, A. A., et al. (1996). Molecular, phenotypic, and expression analysis of vein, a gene required for growth of the Drosophila wing disc. Dev. Biol. 177: 475-489

Simcox, A. (1997). Differential requirement for EGF-like ligands in Drosophila wing development. Mech Dev 62 (1): 41-50

Skeath, J. B. (1998). The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of the Drosophila embryo. Development 125(17): 3301-3312. PubMed ID: 9693134

Spencer, S. A., et al. (1998). Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina. Development 125: 4777-4790. PubMed ID: 9806926

Strand, M. and Micchelli, C. A. (2013). Regional control of Drosophila gut stem cell proliferation: EGF establishes GSSC proliferative set point & controls emergence from quiescence. PLoS One 8: e80608. PubMed ID: 24236188

Strumpf, D. and Volk, T. (1998). Kakapo, a novel cytoskeletal-associated protein is essential for the restricted localization of the neuregulin-like factor, vein, at the muscle-tendon junction site. J. Cell Biol. 143(5): 1259-70

Szuts, D., Eresh, S. and Bienz, M. (1998). Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction. Genes Dev. 12(13): 2022-2035

Tabernero, A. et al. (1998). The neuron-glia signal beta neuregulin induces sustained CREB phosphorylation on Ser-133 in cultured rat schwann cells. Mol. Cell. Neurosci. 10: 309-22

Taveggia, C., et al. (2005). Neuregulin-1 type III determines the ensheathment fate of axons. Neuron 47(5): 681-94. 16129398

Trachtenberg, J. T. and Thompson, W. J. (1996). Schwann cell apoptosis at developing neuromuscular junctions is regulated by glial growth factor. Nature 379: 174-177

Udolph G., et al. (1998). Differential effects of EGF receptor signalling on neuroblast lineages along the dorsoventral axis of the Drosophila CNS. Development 125(17): 3291-3299

Urban, S., Brown, G. and Freeman, M. (2004). EGF receptor signalling protects smooth-cuticle cells from apoptosis during Drosophila ventral epidermis development. Development 131: 1835-1845. 15084467

Van Buskirk C. and Sternberg P. W. (2007). Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans. Nat. Neurosci. 10: 1300-1307. PubMed Citation: 17891142

Verdi, J. M., et al. (1996). A reciprocal cell-cell interaction mediated by NT-3 and neuregulins controls the early survival and development of sympathetic neuroblasts. Neuron 16: 515-527

Wang, S.-H., Simcox, A. and Campbell, G. (2000). Dual role for Drosophila epidermal growth factor receptor signaling in early wing disc development. Genes Dev. 14: 2271-2276

Wasserman, J. D. and Freeman, M. (1998). An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg. Cell 95(3): 355-64

Wessells, R. J., et al. (1999). Tissue-specific regulation of vein/EGF receptor signaling in Drosophila. Dev. Biol. 216(1): 243-59

Wolpowitz, D., et al. (2000). Cysteine-rich domain isoforms of the Neuregulin-1 gene are required for maintenance of peripheral synapses Neuron 25: 79-91

Woo, R.-S., et al. (2007). Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54: 599-610. Medline abstract: 17521572

Xu, N., et al. (2011). EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells. Dev. Biol 354(1): 31-43. PubMed Citation: 21440535

Yan, S.-J., et al. (2004). Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development. Development 131: 285-298. 14701680

Yang, Y., et al. (1995). Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland. J Cell Biol 131: 215-226.

Yarnitzky, T., Min, L. and Volk, T. (1997). The Drosophila neuregulin homolog vein mediates inductive interactions between myotubes and their epidermal attachment cells. Genes Dev. 11(20):2691-2700

Yarnitzky, T., Min, L. and Volk, T. (1998). An interplay between two EGF-receptor ligands, Vein and Spitz, is required for the formation of a subset of muscle precursors in Drosophila Mech. Dev. 79(1-2): 73-82

Zecca, M. and Struhl, G. (2002). Control of growth and patterning of the Drosophila wing imaginal disc by EGFR-mediated signaling. Development 129: 1369-1376. 11880346

Zhang, D., et al. (1997). Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Proc. Natl. Acad. Sci. 94(18): 9562-7

vein: Biological Overview | Evolutionary Homologs | Regulation | Protein Interactions | Developmental Biology | Effects of Mutation

date revised: 17 August 2020

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