REFERENCES (part 1/2)

Akiyama, T. and Gibson, M. C. (2015). Decapentaplegic and growth control in the developing Drosophila wing. Nature 527(7578):375-8. PubMed ID: 26550824

Agrawal, N., Delanoue, R., Mauri, A., Basco, D., Pasco, M., Thorens, B. and Leopold, P. (2016). The Drosophila TNF Eiger is an adipokine that acts on insulin-producing cells to mediate nutrient response. Cell Metab 23: 675-684. PubMed ID: 27076079

Alberts, A. S., Geneste, O. and Treisman, R. (1998a). Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation. Cell 92: 475-487. PubMed Citation: 9491889

Alberts, A. S. and Treisman, R. (1998b). Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1. EMBO J. 17(14): 4075-4085. PubMed Citation: 9670022

Ali, Y. O., Ruan, K. and Zhai, R. G. (2012). NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy. Hum Mol Genet 21: 237-250. PubMed ID: 21965302

Almeida, E. A. C., et al. (2000). Matrix survival signaling: From fibronectin via Focal adhesion kinase to c-Jun NH2-terminal kinase. J. Cell Biol. 149: 741-754. PubMed Citation: 10791986

Amcheslavsky, A., Jiang, J. and Ip, Y. T. (2009). Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell 4: 49-61. PubMed Citation: 19128792

Aronheim, A., et al. (1998). Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton. Curr. Biol. 8(20): 1125-8. PubMed Citation: 9778532

Aronson, D., Dufresne, S. D. and Goodyear, L. J. (1997). Contractile activity stimulates the c-Jun NH2-terminal kinase pathway in rat skeletal muscle. J. Biol. Chem. 272(41): 25636-25640. PubMed Citation: 9325285

Arudchandran, R., et al. (2000). The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1. J. Exp. Med. 191: 47-60. 10620604

Atfi, A., et al. (1997a). Evidence for a role of Rho-like GTPases and Stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in Transforming growth factor ß-mediated signaling. J. Biol. Chem. 272: 1429-32. PubMed Citation: 8999807

Atfi, A., et al. (1997b). Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-beta through stress-activated protein Kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway. J. Biol. Chem. 272(40): 24731-24734. PubMed Citation: 9312063

Avery, M. A., Rooney, T. M., Pandya, J. D., Wishart, T. M., Gillingwater, T. H., Geddes, J. W., Sullivan, P. G. and Freeman, M. R. (2012). WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering. Curr Biol 22: 596-600. PubMed ID: 22425157

Ayaz, D., et al. (2008). Axonal injury and regeneration in the adult brain of Drosophila. J. Neurosci. 28(23): 6010-21. PubMed Citation: 18524906

Bagowski, C. P., et al. (2003). The JNK cascade as a biochemical switch in mammalian cells: Ultrasensitive and all-or-none responses. Curr. Biol. 13: 315-320. 12593797

Bagrodia, S., et al. (1995). Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J Biol Chem 270 (47): 27995-27998. PubMed Citation: 7499279

Bakal, C., et al. (2008). Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science 322(5900): 453-6. PubMed Citation: 18927396

Balakireva, M., et al. (2006). The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster. Mol Cell Biol. 26(23): 8953-63. PubMed citation: 17000765

Barila, D., et al. (2000). A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK. EMBO J. 19: 273-281. PubMed Citation: 10637231

Bates, K. L., Higley, M. and Letsou, A. (2008). Raw mediates antagonism of AP-1 activity in Drosophila. Genetics 178(4): 1989-2002. PubMed Citation: 18430930

Bielinski, V. A. and Mumby, M. C. (2007). Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase. Exp Cell Res 313: 3117-3126. PubMed ID: 17570358

Bikkavilli, R. K., Feigin, M. E. and Malbon, C. C. (2008). G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells. J Cell Sci. 121(Pt 2): 234-45. PubMed Citation: 18187455

Behrens, A., Sibilia, M. and Wagner, E. F. (1999). Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat. Genet. 21(3): 326-9. PubMed Citation: 10080190

Benitez S., et al. (2010). Both JNK and apoptosis pathways regulate growth and terminalia rotation during Drosophila genital disc development. Int. J. Dev. Biol. 54: 643-653. PubMed Citation: 20209437

Bergantiños, C., Corominas, M. and Serras, F. (2010). Cell death-induced regeneration in wing imaginal discs requires JNK signalling. Development 137(7): 1169-79. PubMed Citation: 20215351

Bergmann, A., Tugentman, M., Shilo, B.-Z. and Steller, H. (2002). Regulation of cell number by MAPK-dependent control of apoptosis: A mechanism for trophic survival signaling. Dev. Cell 2: 159-170. 11832242

Biteau, B., Hochmuth, C. E. and Jasper, H. (2008). JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. Cell Stem Cell 3: 442-455. PubMed Citation: 18940735

Blake, K. J., Myette, G. and Jack, J. (1998). The products of ribbon and raw are necessary for proper cell shape and cellular localization of nonmuscle myosin in Drosophila. Dev. Biol. 203: 177-188. PubMed Citation: 9806782

Blake, K. J., Myette, G. and Jack, J. (1999). ribbon, raw, and zipper have distinct functions in reshaping the Drosophila cytoskeleton. Dev. Genes Evol. 209: 555-559. PubMed Citation: 10502112

Blank, U., Brown, A., Adams, D. C., Karolak, M. J. and Oxburgh, L. (2009). BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism. Development 136(21): 3557-66. PubMed Citation: 19793891

Bloor, J. W. and Kiehart, D. P. (2002). Drosophila RhoA regulates the cytoskeleton and cell-cell adhesion in the developing epidermis. Development 129: 3173-3183. 12070092

Bodenmiller, B., et al. (2007). An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells. Mol. Biosyst. 3(4): 275-86. PubMed Citation: 17372656

Brock, A. R., Wang, Y., Berger, S., Renkawitz-Pohl, R., Han, V. C., Wu, Y. and Galko, M. J. (2012). Transcriptional regulation of Profilin during wound closure in Drosophila larvae. J Cell Sci 125: 5667-5676. PubMed ID: 22976306

Bryk, B., Hahn, K., Cohen, S. M. and Teleman, A. A. (2010). MAP4K3 regulates body size and metabolism in Drosophila. Dev. Biol. 344(1): 150-7. PubMed Citation: 20457147

Boutros, M., et al. (1998). Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94(1): 109-118. PubMed Citation: 9674432

Bowman, A. B., et al. (2000). Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein. Cell 103: 583-594. 11106729

Brenner, B., et al. (1997). Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of jun N-terminal Kinase/p38 kinases and GADD153. J. Biol. Chem. 272(35): 22173-22181. PubMed Citation: 9268362

Brumby, A. M. and Richardson, H. E. (2003). scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J. 22: 5769-5779. 14592975

Brumby, A. M., Goulding, K. R., Schlosser, T., Loi, S., Galea, R., Khoo, P., Bolden, J. E., Aigaki, T., Humbert, P. O. and Richardson, H. E. (2011). Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis. Genetics 188: 105-125. PubMed ID: 21368274

Buchon, N., Broderick, N. A., Poidevin, M., Pradervand, S. and Lemaitre, B. (2009a). Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. Cell Host Microbe 5: 200-211. PubMed Citation: 19218090

Buchon, N., Broderick, N. A., Chakrabarti, S. and Lemaitre, B. (2009b). Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev. 23(19): 2333-44. PubMed Citation: 19797770

Hull-Thompson, J., Muffat, J., Sanchez, D., Walker, D. W., Benzer, S., Ganfornina, M. D. and Jasper, H. (2009). Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz. PLoS Genet. 5(4): e1000460. PubMed Citation: 19390610

Byars, C. L., Bates, K. L. and Letsou, A. (1999). The dorsal-open group gene raw is required for restricted DJNK signaling during closure. Development 126(21): 4913-23. PubMed Citation: 10518507

Byrd, D. T., et al. (2001). UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans. Neuron 32: 787-800. 11738026

Caelles, C., et al. (1997). Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Genes Dev. 11(24): 3351-3364. PubMed Citation: 9407028

Campos, I., et al. (2010). Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair. Genetics 184(1): 129-40. PubMed Citation: 19884309

Cha, G. H., Cho, K. S., Lee, J. H., Kim, M., Kim, E., Park, J., Lee, S. B. and Chung. J. (2003). Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways. Mol. Cell. Biol. 23(22):7982-91. 14585960

Chabu, C. and Xu, T. (2014). Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth. Development 141(24):4729-39. PubMed ID: 25411211

Ciapponi, L., et al. (2001). Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites. Genes Dev. 15: 1540-1553. 11410534

Cardone, M. H., et al. (1997). The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 90(2): 315-323. PubMed Citation: 9244305

Chambon, J. P., Nakayama, A., Takamura, K., McDougall, A. and Satoh, N. (2007). ERK- and JNK-signalling regulate gene networks that stimulate metamorphosis and apoptosis in tail tissues of ascidian tadpoles. Development 134(6): 1203-19. Medline abstract: 17332536

Chan, E. D., et al. (1997). Preferential activation of the p46 isoform of JNK/SAPK in mouse macrophages by TNF alpha. Proc. Natl. Acad. Sci. 94(24): 13169-13174. PubMed Citation: 9371818

Chang, L., et al. (2003). JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Developmental Cell 4: 521-533. 12689591

Chen, C. L., Schroeder, M. C., Kango-Singh, M., Tao, C. and Halder, G. (2012). Tumor suppression by cell competition through regulation of the Hippo pathway. Proc. Natl. Acad. Sci. 109(2): 484-9. PubMed Citation: 22190496

Chen, Y. R., Meyer, C. F. and Tan, T. H. (1996). Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis. J. Biol. Chem. 271: 631-4. PubMed Citation: 8557665

Cheng, L. Y., Bailey, A. P., Leevers, S. J., Ragan, T. J., Driscoll, P. C. and Gould, A. P. (2011). Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila. Cell 146: 435-447. PubMed ID: 21816278

Chow, C. W., et al. (1997). Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. Science 278(5343): 1638-1641. PubMed Citation: 9374467

Christofferson, D. E. and Yuan, J. (2010). Necroptosis as an alternative form of programmed cell death. Curr. Opin. Cell Biol. 22: 263–268. PubMed Citation: 20045303

Chu, Y., et al. (1996). The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. J. Biol. Chem. 271: 6497-6501. PubMed Citation: 8626452

Codelia, V. A., Sun, G. and Irvine, K. D. (2014). Regulation of YAP by mechanical strain through Jnk and Hippo signaling. Curr Biol 24: 2012-2017. PubMed ID: 25127217

Coleman, M. P. and Freeman, M. R. (2010). Wallerian degeneration, wld(s), and nmnat. Annu Rev Neurosci 33: 245-267. PubMed ID: 20345246

Collins, C. A., Wairkar, Y. P., Johnson, S. L. and DiAntonio, A. (2006). Highwire restrains synaptic growth by attenuating a MAP kinase signal. Neuron 51(1): 57-69. 16815332

Cong, B., Ohsawa, S. and Igaki, T. (2018). JNK and Yorkie drive tumor progression by generating polyploid giant cells in Drosophila. Oncogene. PubMed ID: 29535423

Cordero, J. B., et al. (2010). Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter. Dev. Cell 18: 999–1011. PubMed Citation: 20627081

Coso, O. A., et al. (1995). The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81: 1137-1146. PubMed Citation: 7600581

Coso, O. A., et al. (1996). Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway. J. Biol. Chem. 271: 3963-3966. PubMed Citation: 8626724

Cygnar, K. D., Gao, X., Pan, D. and Neufeld, T. P. (2005). The phosphatase subunit tap42 functions independently of target of rapamycin to regulate cell division and survival in Drosophila. Genetics 170: 733-740. PubMed ID: 15802506

Dajas-Bailador, F., Jones, E. V. and Whitmarsh, A. J. (2008). The JIP1 scaffold protein regulates axonal development in cortical neurons. Curr. Biol. 18(3): 221-6. PubMed Citation: 18261906

De Gregorio, E., Spellman, P. T., Rubin, G. M., and Lemaitre, B. (2001). Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays. Proc. Natl. Acad. Sci. 98: 12590-12595. 11606746

Delaney, J. R., Stoven, S., Uvell, H., Anderson, K. V., Engstrom, Y. and Mlodzik, M. (2006). Cooperative control of Drosophila immune responses by the JNK and NF-kappaB signaling pathways. EMBO J. 25(13): 3068-77. 16763552

Diener, K., et al. (1997). Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Proc. Natl. Acad. Sci. 94(18): 9687-9692. PubMed Citation: 9275185

Doggett, K., Turkel, N., Willoughby, L. F., Ellul, J., Murray, M. J., Richardson, H. E. and Brumby, A. M. (2015). BTB-zinc finger oncogenes are required for Ras and Notch-driven tumorigenesis in Drosophila. PLoS One 10: e0132987. PubMed ID: 26207831

Dolfi, F., et al. (1998). The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway. Proc. Natl. Acad. Sci. 95(26): 15394-9. PubMed Citation: 9860979

Dong, C., et al. (1998). Defective T cell differentiation in the absence of Jnk1. Science 282(5396): 2092-5. PubMed Citation: 9851932

Dumstrei, K., et al. (1998). EGFR signaling is required for the differentiation and maintenance of neural progenitors along the dorsal midline of the Drosophila embryonic head. Development 125(17): 3417-3426. PubMed Citation: 9693145

Eaton, S., et al. (1995). CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium. J. Cell Biol. 131: 151-164. PubMed Citation: 7559772

Essers MA., et al. (2004). FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J. 23(24): 4802-12. 15538382

Etchegaray, J. I., et al. (2012). Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells. Development 139(21): 4029-39. PubMed Citation: 22992958

Fang, X., et al. (1997). Lysophosphatidylcholine stimulates activator protein 1 and the c-Jun N-terminal kinase activity. J. Biol. Chem. 272 (21): 13683-13689. PubMed Citation: 9153219

Fang, Y., Soares, L., Teng, X., Geary, M. and Bonini, N. M. (2012). A novel Drosophila model of nerve injury reveals an essential role of Nmnat in maintaining axonal integrity. Curr Biol 22: 590-595. PubMed ID: 22425156

Fanger, G. R., Johnson, N. L. and Johnson, G. L. (1997). MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. EMBO J. 16(16): 4961-4972. PubMed Citation: 9305638

Fernandez, R., Takahashi, F., Liu, Z., Steward, R., Stein, D. and Stanley, E. R. (2000). The Drosophila Shark tyrosine kinase is required for embryonic dorsal closure. Genes Dev. 14: 604-614. 10716948

Fogarty, C. E., Diwanji, N., Lindblad, J. L., Tare, M., Amcheslavsky, A., Makhijani, K., Bruckner, K., Fan, Y. and Bergmann, A. (2016). Extracellular reactive oxygen species drive apoptosis-induced proliferation via Drosophila macrophages. Curr Biol 26(5):575-84. PubMed ID: 26898463

Foldi, I., Anthoney, N., Harrison, N., Gangloff, M., Verstak, B., Nallasivan, M. P., AlAhmed, S., Zhu, B., Phizacklea, M., Losada-Perez, M., Moreira, M., Gay, N. J. and Hidalgo, A. (2017). Three-tier regulation of cell number plasticity by neurotrophins and Tolls in Drosophila. J Cell Biol 216(5):1421-1438. PubMed ID: 28373203

Foulds, C. E., Nelson, M. L., Blaszczak, A. G. and Graves, B. J. (2004). Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment. Mol. Cell Biol. 24: 10954-10964. 15572696

Franciscovich, A. L., Mortimer, A. D., Freeman, A. A., Gu, J. and Sanyal, S. (2008). Overexpression screen in Drosophila identifies neuronal roles of GSK-3 beta/shaggy as a regulator of AP-1-dependent developmental plasticity. Genetics 180(4): 2057-71. PubMed Citation: 18832361

Fuchs, S. Y., et al. (1998). JNK targets p53 ubiquitination and degradation in nonstressed cells. Genes Dev. 12(17): 2658-2663. PubMed Citation: 9732264

Fullard, J. F. and Baker, N. E. (2014). A modifier screen in Drosophila melanogaster implicates cytoskeletal regulators, Jun N-terminal kinase, and Yorkie in Draper signaling. Genetics 199(1):117-34. PubMed ID: 25395664

Gabai, V. L., et al. (1997). Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance. J. Biol. Chem. 272(29): 18033-18037. PubMed Citation: 9218432

Garriock, R. J., et al. (2005). Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus. Dev. Biol. 279: 179-192. 15708567

Genova, J. L., Jong, S., Camp, J. T. and Fehon, R. G. (2000). Functional analysis of Cdc42 in actin filament assembly, epithelial morphogenesis, and cell signaling during Drosophila development. Dev. Biol. 221: 181-194. 10772800

Girardin, S. E. and Yaniv, M. (2001). A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation. EMBO J. 20: 3437-3446. 11432831

Glise, B. and Noselli, S. (1997). Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis. Genes Dev. 11: 1738-1747. PubMed Citation: 9224722

Griswold, A. J., et al. (2008). Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila. Proc. Natl. Acad. Sci. 105(25): 8673-8. PubMed Citation: 18562277

Gros, J., et al. (2010). WNT5A/JNK and FGF/MAPK pathways regulate the cellular events shaping the vertebrate limb bud. Curr. Biol. 20(22): 1993-2002. PubMed Citation: 21055947

Grzeschik, N. A., Parsons, L. M., Allott, M. L., Harvey, K. F. and Richardson, H. E. (2010). Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr. Biol. 20(7): 573-581. PubMed Citation: 20362447

Gupta, S., et al. (1996). Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 15: 2760-2770. PubMed Citation: 8654373

Hambleton, J., et al. (1996). Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc. Natl. Acad. Sci. 93: 2774-2778. PubMed Citation: 8610116

Harden, N., et al. (1995). A dominant inhibitory version of the small GTP-binding protein Rac disrupts cytoskeletal structures and inhibits developmental cell shape changes in Drosophila. Development 121: 903-914. PubMed Citation: 7720592

Harden, N., et al. (1996). A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures. Mol. Cell. Biol. 16: 1896-190. PubMed Citation:

Herrmann, J. L., et al. (1997). Regulation of lipid signaling pathways for cell survival and apoptosis by bcl-2 in prostate carcinoma cells. Exp. Cell Res. 234(2): 442-451. PubMed Citation: 9260915

Herr I, Wilhelm D, Böhler T, Angel P, Debatin KM (1997). Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J. 16(20): 6200-6208. PubMed Citation: 9321399

Hida, H., et al. (1999). Regulation of mitogen-activated protein kinases by sphingolipid products in oligodendrocytes. J. Neurosci. 19(17): 7458-7467. PubMed Citation: 10460252

Hirai, S.-i., et al. (2002). MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo. Development 129: 4483-4495. 12223406

Hirai, S., et al. (2005). Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo. Gene Expr. Patterns 5: 517-523. 15749080

Hirosumi, J., et al. (2002). A central role for JNK in obesity and insulin resistance. Nature 420: 333-336. 12447443

Hitomi, J., et al. (2008). Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 135: 1311–1323. PubMed Citation: 19109899

Hocevar, B. A., Brown, T. L. and Howe, P. H. (1999). TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J. 18(5): 1345-56

Hooper, C., et al. (2007). Glycogen synthase kinase-3 inhibition is integral to long-term potentiation. Eur. J. Neurosci. 25: 81-86. PubMed Citation: 17241269

Horiuchi, D., Collins, C. A., Bhat, P., Barkus, R. V., Diantonio, A. and Saxton, W. M. (2007). Control of a kinesin-cargo linkage mechanism by JNK pathway kinases. Curr. Biol. 17(15): 1313-7. Medline abstract: 17658258

Hozumi, S., et al. (2006). An unconventional myosin in Drosophila reverses the default handedness in visceral organs. Nature 440: 798-802. PubMed Citation: 16598258

Hsiao, F. C., et al. (2001). Eyes absent mediates cross-talk between retinal determination genes and the receptor tyrosine kinase signaling pathway. Dev. Cell 1: 51-61

Hsu, H., et al. (1996). TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84: 299-308

Hu, D. J. and Jasper, H. (2019). Control of intestinal cell fate by dynamic mitotic spindle repositioning influences epithelial homeostasis and longevity. Cell Rep 28(11): 2807-2823. PubMed ID: 31509744

Huang, C., et al. (1997). Direct evidence for an important role of Sphingomyelinase in ultraviolet-induced activation of c-Jun N-terminal kinase. J. Biol. Chem. 272: 27753-27757

Huang, C., et al. (2003). JNK phosphorylates paxillin and regulates cell migration. Nature 424: 219-223. 12853963

Huang, H., et al. (2011). Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus. Development 138(12): 2477-85. PubMed Citation: 21561986

Huang, H., Lu-Bo, Y. and Haddad, G. G. (2014). A Drosophila ABC transporter regulates lifespan. PLoS Genet 10: e1004844. PubMed ID: 25474322

Hultmark, D. (1993). Immune reactions in Drosophila and other insects: A model for innate immunity. Trends. Genet. 9: 178-183

Hwangbo, D. S., Gershman, B., Tu, M. P., Palmer, M. and Tatar, M. (2004). Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429(6991): 562-6. PubMed citation: 15175753

Igaki, T., et al. (2002). Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. EMBO J. 21: 3009-3018. 12065414

Igaki, T., et al. (2006). Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr. Biol. 16: 1139-1146. 16753569

Igaki, T., et al. (2009). Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Dev. Cell 16: 458-465. PubMed Citation: 19289090

Ip, Y. T., et al. (1993). Dif, a Dorsal-related gene that mediates an immune response in Drosophila. Cell 75: 753-763. PubMed ID: 8242747

Jaeschke, A., Czech, M. P. and Davis, R. J. (2004). An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes Dev. 18: 1976-1980. 15314024

Jemc, J. C., Milutinovich, A. B., Weyers, J. J., Takeda, Y. and Van Doren, M. (2012). raw Functions through JNK signaling and cadherin-based adhesion to regulate Drosophila gonad morphogenesis. Dev Biol 367: 114-125. PubMed ID: 22575490

Jezowska, B., Fernandez, B. G., Amandio, A. R., Duarte, P., Mendes, C., Bras-Pereira, C. and Janody, F. (2011). A dual function of Drosophila capping protein on DE-cadherin maintains epithelial integrity and prevents JNK-mediated apoptosis. Dev Biol 360: 143-159. Pubmed: 21963538

Jho, E. H., Davis, R. J. and Malbon, C. C. (1997). c-Jun amino-terminal kinase is regulated by Galpha12/Galpha13 and obligate for differentiation of P19 embryonal carcinoma cells by retinoic acid. J. Biol. Chem. 272(39): 24468-24474

Ji, T., Zhang, L., Deng, M., Huang, S., Wang, Y., Pham, T. T., Smith, A. A., Sridhar, V., Cabernard, C., Wang, J. and Yan, Y. (2019). Dynamic MAPK signaling activity underlies a transition from growth arrest to proliferation in Drosophila scribble mutant tumors. Dis Model Mech. 12(8). PubMed ID: 31371383

Jia, H., Liu, Y., Yan, W. and Jia, J. (2009). PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development 136: 307-316. PubMed ID: 19088085

Jiang, H., et al. (2009). Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell 137(7): 1343-55. PubMed Citation: 19563763

Johnson, N. L., et al. (1996). Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. J. Biol. Chem. 271: 3229-3237

Jordan, K. C., Schaeffer, V., Fischer, K. A. Gray, E. E. and Ruohola-Baker, H. (2006). Notch signaling through tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells. BMC Dev. Biol. 6:16. 16542414

Juhasz, G., Erdi, B., Sass, M. and Neufeld, T. P. (2007a). Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev. 21: 3061-3066. PubMed Citation: 18056421

Juhasz, G., et al. (2007b). Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Cell Death. Differ. 14: 1181-1190. PubMed Citation: 17363962

Kadrmas, J. L., et al. (2004). The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1. J. Cell Biol. 167(6): 1019-24. 15596544

Kallunki, T., et al. (1996). cJun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell 87: 929-939

Kaneko, T., et al. (2004). Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway. Immunity 20(5): 637-49. 1514253

Kanda, H., et al. (2011). Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death. Proc. Natl. Acad. Sci. 108(47):18977-82. PubMed Citation: 22065747

Kapfhamer, D., King, I., Zou, M. E., Lim, J. P., Heberlein, U. and Wolf, F. W. (2012). JNK pathway activation is controlled by Tao/TAOK3 to modulate ethanol sensitivity. PLoS One 7: e50594. PubMed ID: 23227189

Karpac, J., Biteau, B. and Jasper, H. (2013). Misregulation of an adaptive metabolic response contributes to the age-related disruption of lipid homeostasis in Drosophila. Cell Rep 4: 1250-1261. PubMed ID: 24035390

Katsukawa, M., Ohsawa, S., Zhang, L., Yan, Y. and Igaki, T. (2018). Serpin facilitates tumor-suppressive cell competition by blocking Toll-mediated Yki activation in Drosophila. Curr Biol 28(11):1756-1767. PubMed ID: 29804808

Katz, B. Z., Zohar, M., Teramoto, H., Matsumoto, K., Gutkind, J. S., Lin, D. C., Lin, S. and Yamada, K. M. (2000). Tensin can induce JNK and p38 activation. Biochem. Biophys. Res. Commun. 272: 717-720. 10860821

Kawauchi, T., et al. (2003). The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration. EMBO J. 22: 4190-4201. 12912917

Kelkar, N., et al. (2000). Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. Mol. Cell. Biol. 20(3): 1030-43. 10629060

Kiefer, F., et al. (1996). HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J 15 (24): 7013-7025

Kieser, A., et al. (1997). Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade. EMBO J. 16(21): 6478-6485

Kim, J. W., et al. (2001). Negative Regulation of the SAPK/JNK Signaling Pathway by Presenilin. J. Cell Bio. 153: 457-464. 11331298

Kinoshita, N., et al. (2003). PKCdelta is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements. Genes Dev. 17: 1663-1676. 12842914

Kirchner, J., Gross, S., Bennett, D. and Alphey, L. (2007). The nonmuscle myosin phosphatase PP1β (flapwing) negatively regulates Jun N-terminal kinase in wing imaginal discs of Drosophila. Genetics 175(4): 1741-9. Medline abstract: 17277363

Knauf, U., et al. (1996). Repression of human heat shock factor 1 activity at control temperature by phosphorylation. Genes Dev. 10:2782-2793. PubMed Citation: 8946918

Kolahgar, G., et al. (2011). Apical deficiency triggers JNK-dependent apoptosis in the embryonic epidermis of Drosophila. Development 138(14): 3021-31. PubMed Citation: 21693518

Kolahgar, G., Suijkerbuijk, S. J., Kucinski, I., Poirier, E. Z., Mansour, S., Simons, B. D. and Piddini, E. (2015). Cell competition modifies adult stem cell and tissue population dynamics in a JAK-STAT-dependent manner. Dev Cell 34(3):297-309. PubMed ID: 26212135

Kong, M., Fox, C. J., Mu, J., Solt, L., Xu, A., Cinalli, R. M., Birnbaum, M. J., Lindsten, T. and Thompson, C. B. (2004). The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis. Science 306: 695-698. PubMed ID: 15499020

Krieser, R. J., (2007). The Drosophila homolog of the putative phosphatidylserine receptor functions to inhibit apoptosis. Development 134(13): 2407-14. Medline abstract: 17522160

Kuan, C. Y., et al. (1999). The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22(4): 667-76. PubMed Citation: 8946918

Kulshammer, E., Mundorf, J., Kilinc, M., Frommolt, P., Wagle, P. and Uhlirova, M. (2015). Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy. Dis Model Mech 8: 1279-1293. PubMed ID: 26398940

Kuranaga, E., Kanuka, H., Igaki, T., Sawamoto, K., Ichijo, H., Okano, H. and Miura, M. (2002). Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila. Nat Cell Biol. 4(9): 705-10. 12198495

Kuranaga, E., et al. (2011). Apoptosis controls the speed of looping morphogenesis in Drosophila male terminalia. Development 138(8): 1493-9. PubMed Citation: 21389055

Kuroki, D. W., et al. (1997). Regulation of a c-Jun Amino-terminal Kinase/Stress-activated Protein Kinase Cascade by a Sodium-dependent Signal Transduction Pathway. J. Biol. Chem. 272(38): 23905-23911

Lam, D., et al. (2010). Drosophila happyhour modulates JNK-dependent apoptosis. Cell Death Dis. 1(8): e66. PubMed Citation: 21364671

Lamarche, N., et al. (1996). Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK Map kinase cascade. Cell 87: 519-528

Lamb, J. A., et al. (2003). JunD mediates survival signaling by the JNK signal transduction pathway. Molec. Cell 11: 1479-1489. 12820962

Lawler S., et al. (1998). Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro. Curr. Biol. 8(25): 1387-90

Lee, J. H., et al. (2005). JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in Drosophila. Cell Death and Differentiation 13(7): 1110-22. 16273080

Lee, N., Maurange, C., Ringrose, L. and Paro, R. (2005). Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs. Nature 438(7065): 234-7. 16281037

Lee, S. Y., et al. (1997). TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival. Immunity 7(5): 703-13

Lee, S. B., et al. (2003). blistery encodes Drosophila tensin protein and interacts with integrin and the JNK signaling pathway during wing development. Development 130: 4001-4010. 12874122

Lee, Y. H., et al. (2003). c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J. Biol. Chem. 278(5): 2896-2902. 12417588

Lenczowski, J. M., et al. (1997). Lack of a Role for Jun Kinase and AP-1 in Fas-Induced Apoptosis. Mol. Cell. Biol. 17: 170-181

Le-Niculescu, H., et al. (1999). Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol. Cell. Biol. 19(1): 751-63

Leulier, F., et al. (2003). The Drosophila immune system detects bacteria through specific peptidoglycan recognition. Nat. Immunol. 4(5): 478-84. 12692550

Leyssen, M. and Hassan, B. A. (2007). A fruitfly's guide to keeping the brain wired. EMBO Rep. 8: 46-50. PubMed Citation: 17203102

Li, B.-S., Zhang, L., Takahashi, S. ,Ma, W., Jaffe, H., Kulkarni, A. B. and Pant, H. C. (2002). Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3. EMBO J. 21: 324-333. 11823425

Li, J., Molkentin, J. D. and Colbert, M. C. (2001). Retinoic acid inhibits cardiac neural crest migration by blocking c-Jun N-terminal kinase activation. Dev. Bio. 232: 351-361

Li, P., Huang, P., Li, X., Yin, D., Ma, Z., Wang, H. and Song, H. (2018). Tankyrase mediates K63-linked ubiquitination of JNK to confer stress tolerance and influence lifespan in Drosophila. Cell Rep 25(2): 437-448. PubMed ID: 30304683

Li, W., et al. (1996b). Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4+ T cells. Science 271: 1272-1276

Li, X., et al., (1997). Protein kinase C and protein kinase A inhibit calcium-dependent but not stress-dependent c-Jun N-terminal kinase activation in rat liver epithelial cells. J. Biol. Chem. 272 (23): 14996-15002

Li, Y. Y., et al. (1996a). CD40 ligation results in protein kinase C-independent activation of ERK and JNK in resting murine splenic B cells. J. Immunol. 157: 1440-1447

Liang, G., et al. (1996). ATF3 gene. Genomic organization, promoter, and regulation. J. Biol. Chem. 271: 1695-1701

Lin, A., et al. (1995). Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268: 286-290

Liu, H., et al. (1999). A Drosophila TNF-receptor-associated factor (TRAF) binds the Ste20 kinase Misshapen and activates Jun kinase. Curr. Biol. 9(2): 101-4

Liu, L., Zhang, K., Sandoval, H., Yamamoto, S., Jaiswal, M., Sanz, E., Li, Z., Hui, J., Graham, B.H., Quintana, A. and Bellen, H.J. (2015). Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration. Cell 160: 177-190. PubMed ID: 25594180

Liu, Z., et al. (1996). Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 87: 565-576

Llense, F. and Martin-Blanco, E. (2008). JNK signaling controls border cell cluster integrity and collective cell migration. Curr. Biol. 18(7): 538-44. PubMed Citation: 18394890

Lu, X., Nemoto, S. and Lin, A. (1997). Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. J. Biol. Chem. 272(40): 24751-24754

Lu H. and Bilder, D. (2005). Endocytic control of epithelial polarity and proliferation in Drosophila. Nat. Cell Biol. 7: 1232-1239. PubMed Citation: 16258546

Ma, X., Chen, Y., Xu, W., Wu, N., Li, M., Cao, Y., Wu, S., Li, Q. and Xue, L. (2015). Impaired Hippo signaling promotes Rho1-JNK-dependent growth. Proc Natl Acad Sci USA. 112(4):1065-70. PubMed ID: 25583514

Maekawa, M., et al. (2005). Requirement of the MAP kinase signaling pathways for mouse preimplantation development. Development 132(8): 1773-83. 15772134

Maher, P. (2001). How protein kinase C activation protects nerve cells from oxidative stress-induced cell death. J. Neurosci. 21(9): 2929-2938. 11312276

Mantrova, E. Y. and Hsu, T. (1998). Down-regulation of transcription factor CF2 by Drosophila Ras/MAP kinase signaling in oogenesis: cytoplasmic retention and degradation. Genes Dev. 12(8): 1166-1175

Martin-Blanco, E., Gampel, A., Ring, J., Virdee, K., Kirov, N., Tolkovsky, A.M., and Martinez-Arias, A. (1998). puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila. Genes Dev. 12: 557-570. PubMed Citation: 9472024

Matsuda, S., et al. (2001). c-Jun N-terminal kinase (JNK)-interacting protein-1b/Islet-Brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J. Neurosci. 21(17): 6597-6607. 11517249

Matsuguchi, T., et al. (2003). JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation. EMBO J. 22: 4455-4464. 12941697

Matzinger, P. (1994). Tolerance, danger, and the extended family. Annu. Rev. Immunol 12: 991-1045

Maundrell, K., et al. (1997). Bcl-2 undergoes phosphorylation by c-Jun N-terminal Kinase/Stress-activated protein kinases in the presence of the constitutively active GTP-binding protein rac1. J. Biol. Chem. 272(40): 25238-25242

May, G. H. W., et al. (1998). An oncogenic mutation uncouples the v-Jun oncoprotein from positive regulation by the SAPK/JNK pathway in vivo. Curr. Biol. 8(2): 117-120

Mayer, C., Bierhoff, H. and Grummt, I. (2005). The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. Genes Dev. 19: 933-941. 15805466

McDonough, P. M., et al. (1997). Collaborative Roles for c-Jun N-terminal Kinase, c-Jun, Serum Response Factor, and Sp1 in Calcium-regulated Myocardial Gene Expression. J. Biol. Chem. 272(38): 24046-24053.

McDonald, P. H., et al. (2000). ß-arrestin 2: A receptor-regulated MAPK scaffold for the activation of JNK3. Science 290(5496): 1574-7. 11090355

McEwen, D. G. and Peifer, M. (2005). Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis. Development 132(17): 3935-46. 16079158

McLaughlin, C. N., Nechipurenko, I. V., Liu, N. and Broihier, H. T. (2016). A Toll receptor-FoxO pathway represses Pavarotti/MKLP1 to promote microtubule dynamics in motoneurons. J Cell Biol 214(4): 459-474. PubMed ID: 27502486

Meier, R., et al. (1996). Cellular stresses and cytokines activate multiple mitogen-activated-protein kinase kinase homologues in PC12 and KB cells. Eur. J. Biochem. 236: 796-805

Melani, M., Simpson, K. J., Brugge, J. S. and Montell, D. (2008). Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1. Curr. Biol. 18(7): 532-7. PubMed Citation: 18394891

Milet, C., Rincheval-Arnold, A., Morieras, A., Clavier, A., Garrigue, A., Mignotte, B. and Guenal, I. (2014). Mutating RBF can enhance its pro-apoptotic activity and uncovers a new role in tissue homeostasis. PLoS One 9: e102902. PubMed ID: 25089524

Mihaly, J., et al. (2001). The role of the Drosophila TAK homologue dTAK during development. Mech. Dev. 102. 67-79. 11287182

Miller, B. R., et al. (2009). A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration. Nat. Neurosci. 12(4): 387-9. PubMed Citation: 19287387

Miller, B. S., et al. (1996). Activation of cJun NH2-terminal kinase/stress-activated protein kinase by insulin. Biochemistry 35: 8769-8775. PubMed Citation: 8679641

Minden, A., et al. (1995). Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81: 1147-1157. PubMed Citation: 7600582

Miotto, B., Sagnier, T., Berenger, H., Bohmann, D., Pradel, J. and Graba, Y. (2005). Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis. Genes Dev. 20(1): 101-12. 16391236

Miranti, C. K., et al. (1998). Identification of a novel integrin signaling pathway involving the kinase syk and the guanine nucleotide exchange factor vav1. Curr. Biol. 8(24): 1289-99

Miyashita, T., Kikuchi, E., Horiuchi, J. and Saitoe, M. (2018). Long-term memory engram cells are established by c-Fos/CREB transcriptional cycling. Cell Rep 25(10): 2716-2728. PubMed ID: 30517860

Moberg, K. H., et al. (2005). Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth. Dev. Cell 9: 699-710. PubMed Citation: 16256744

Moriguchi, T., et al. (1997). A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses. EMBO J. 16(23): 7045-7053

Morishita, K., Ozasa, F., Eguchi, K., Yoshioka, Y., Yoshida, H., Hiai, H. and Yamaguchi, M. (2014). Drosophila DOCK family protein Sponge regulates the JNK pathway during thorax development. Cell Struct Funct 39(2):113-24. PubMed ID: 25311449

Moreno, E., Yan, M. and Basler, K. (2002). Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Curr. Biol. 12: 1263-1268. 12176339

Mosser, D. D., et al. (1997). Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol. Cell. Biol. 17(9): 5317-5327

Mundorf, J., Donohoe, C. D., McClure, C. D., Southall, T. D. and Uhlirova, M. (2019). Ets21c governs tissue renewal, stress tolerance, and aging in the Drosophila intestine. Cell Rep 27(10): 3019-3033.e3015. PubMed ID: 31167145

Continued: Basket/JNK References part 2/2

basket/JNK: Biological Overview | Evolutionary Homologs | Regulation | Protein Interactions | Developmental Biology | Effects of Mutation

Home page: The Interactive Fly © 1995, 1996 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.