Sex combs on midleg


Adler, P. N., Martin, E. C., Charlton, J. and Jones, K. (1991). Phenotypic consequences and genetic interaction of a null mutation in the Drosophila Posterior Sex Combs gene. Dev. Genet. 12: 349-361. PubMed Citation: 1806331

Alkema, M. J., M. et al. (1997). Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian Polycomb complex. Genes Dev. 11: 226-240. PubMed Citation: 9009205

Bello, B., Holbro, N. and Reichert, H. (2007). Polycomb group genes are required for neural stem cell survival in postembryonic neurogenesis of Drosophila. Development 134(6): 1091-9. Medline abstract: 17287254

Berger, J., et al. (1999). The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34. Gene 237(1): 185-91. Medline abstract: 10524249

Bornemann, D., Miller, E. and Simon, J. (1996). The Drosophila Polycomb group gene Sex comb on midleg (Scm) encodes a zinc finger protein with similarity to polyhomeotic protein. Development 122: 1621-1630. Medline abstract: 8625848

Bornemann, D., Miller, E. and Simon J. (1998). Expression and properties of wild-type and mutant forms of the Drosophila Sex Comb on Midleg (SCM) repressor protein. Genetics 150: 675-686. Medline abstract: 9755199

Breen, T. R. and Duncan, I. M. (1986). Maternal expression of genes that regulate the bithorax complex of Drosophila melanogaster. Dev. Biol. 118: 442-456. 87081011

Campbell, R. B., et al. (1995). Genetic interactions and dosage effects of Polycomb group genes of Drosophila. Mol. Gen. Genet. 246(3): 291-300. PubMed Citation: 7854314

Cheng, N. N., et a. (1994). Interactions of polyhomeotic with Polycomb group genes of Drosophila melanogaster. Genetics 138(4): 1151-62. PubMed Citation: 7896097

DeCamillis, M., Cheng, N. S., Pierre, D. and Brock, H. W. (1992). The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome-binding sites with Polycomb. Genes Dev. 6: 223-32. PubMed Citation: 1346609

DeLuca, S. Z., Ghildiyal, M., Pang, L. Y. and Spradling, A. C. (2020). Differentiating Drosophila female germ cells initiate Polycomb silencing by regulating PRC2-interacting proteins. Elife 9. PubMed ID: 32773039

Endoh, M., Endo, T. A., Endoh, T., Isono, K., Sharif, J., Ohara, O., Toyoda, T., Ito, T., Eskeland, R., Bickmore, W. A., Vidal, M., Bernstein, B. E. and Koseki, H. (2012). Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity. PLoS Genet 8: e1002774. PubMed ID: 22844243

Finley, J. K., Miller, A. C. and Herman, T. G. (2015). Polycomb group genes are required to maintain a binary fate choice in the Drosophila eye. Neural Dev 10: 2. PubMed ID: 25636358

Gilde, J. J., Lopez, R. and Shearn, A. (2000). A screen for new Trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2. Genetics 156: 645-663. PubMed Citation: 11014813

Grimm, C., et al. (2009). Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt. EMBO J. 28: 1965-1977. PubMed Citation: 19494831

Hasegawa, M., et al. (1998). Mammalian Polycomb group genes are categorized as a new type of early response gene induced by B-cell receptor cross-linking. Mol. Immunol. 35(9): 559-63. PubMed Citation: 9809583

Hashimoto, N., et al. (1998). RAE28, BMI1, and M33 are members of heterogeneous multimeric mammalian Polycomb group complexes. Biochem. Biophys. Res. Commun. 245(2): 356-65. PubMed Citation: 9571155

Isono, K., Endo, T. A., Ku, M., Yamada, D., Suzuki, R., Sharif, J., Ishikura, T., Toyoda, T., Bernstein, B. E. and Koseki, H. (2013). SAM Domain Polymerization Links Subnuclear Clustering of PRC1 to Gene Silencing. Dev Cell 26: 565-577. PubMed ID: 24091011

Jurgens, G. (1985) A group of genes controlling the spatial expression of the bithorax complex in Drosophila. Nature 316: 153-155.

Kang, H., McElroy, K. A., Jung, Y. L., Alekseyenko, A. A., Zee, B. M., Park, P. J. and Kuroda, M. I. (2015). Sex comb on midleg (Scm) is a functional link between PcG-repressive complexes in Drosophila. Genes Dev 29: 1136-1150. PubMed ID: 26063573

Kennison, J. A. and Tamkun, J. W. (1988). Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila. Proc. Natl. Acad. Sci. 85(21): 8136-40. PubMed Citation: 3141923

Kim, C. A., Gingery, M., Pilpa, R. M. and Bowie, J. U. (2002). The SAM domain of polyhomeotic forms a helical polymer. Nat Struct Biol 9: 453-457. PubMed ID: 11992127

Kim, C. A., et al. (2005). Structural organization of a Sex-comb-on-midleg/Polyhomeotic copolymer. J. Biol. Chem. 280: 27769-27775. 15905166

Klebes, A., et al. (2005). Regulation of cellular plasticity in Drosophila imaginal disc cells by the Polycomb group, trithorax group and lama genes. Development 132: 3753-3765. 16077094

Koga, H., et al. (1999). A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes. Oncogene 18(26): 3799-809. PubMed Citation: 10445843

Langlais, K. K., Brown, J. L. and Kassis, J. A. (2012). Polycomb group proteins bind an engrailed PRE in both the 'ON' and 'OFF' transcriptional states of engrailed. PLoS One 7: e48765. PubMed ID: 23139817

Lavigne, M., Francis, N. J., King, I. F. and Kingston, R. E. (2004). Propagation of silencing; recruitment and repression of naive chromatin in trans by polycomb repressed chromatin. Mol Cell 13: 415-425. PubMed ID: 14967148

Lecona, E., Rojas, L. A., Bonasio, R., Johnston, A., Fernandez-Capetillo, O. and Reinberg, D. (2013). Polycomb Protein SCML2 Regulates the Cell Cycle by Binding and Modulating CDK/CYCLIN/p21 Complexes. PLoS Biol 11: e1001737. PubMed ID: 24358021

Lee, N., Maurange, C., Ringrose, L. and Paro, R. (2005). Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs. Nature 438(7065): 234-7. 16281037

McKeon, J. and Brock, H. W. (1991). Interactions of the Polycomb group of genes with homeotic loci of Drosophila. Roux’s Arch. Devl. Biol. 199: 387- 396

Moazed, D. and O’Farrell, P. H. (1992). Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila. Development 116: 805-810. PubMed Citation: 1363229

Montini, E., et al. (1999). Identification of SCML2, a second human gene homologous to the Drosophila sex comb on midleg (Scm): A new gene cluster on Xp22. Genomics 58(1): 65-72. Medline abstract: 10331946

Mozzetta, C., Pontis, J., Fritsch, L., Robin, P., Portoso, M., Proux, C., Margueron, R. and Ait-Si-Ali, S. (2014). The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing. Mol Cell 53: 277-289. PubMed ID: 24389103

Nomura, M., et al. (1998). Sequence-specific DNA binding activity in the RAE28 protein, a mouse homologue of the Drosophila polyhomeotic protein. Biochem. Mol. Biol. Int. 46(5): 905-12

Peterson, A. J., et al. (1997). A domain shared by the Polycomb group proteins Scm and ph mediates heterotypic and homotypic interactions. Mol. Cell. Biol. 17: 6683-6692. Medline abstract: 9343432

Peterson, A. J., et al. (2004). Requirement for sex comb on midleg protein interactions in Drosophila polycomb group repression. Genetics 167(3): 1225-39. 15280237

Ponting, C. P. 1995. SAM: a novel motif in yeast sterile and Drosophila polyhomeotic proteins. Protein Sci. 4: 1928-1930

Roseman, R. R., et al. (2001). Long-range repression by multiple Polycomb Group (PcG) proteins targeted by fusion to a defined DNA-binding domain in Drosophila. Genetics. 158: 291-307. 11333237

Schwermann, J., Rathinam, C., Schubert, M., Schumacher, S., Noyan, F., Koseki, H., Kotlyarov, A., Klein, C. and Gaestel, M. (2009). MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells. EMBO J 28: 1392-1406. PubMed ID: 19369945

Shanower, G. A., Muller, M., Blanton, J. L., Honti, V., Gyurkovics, H. and Schedl, P. (2005). Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase. Genetics 169(1): 173-84. Medline abstract: 15371351

Shao, Z., et al. (1999). Stabilization of chromatin structure by PRC1, a polycomb complex. Cell 98: 37-46

Simon, J., Chiang, A. and Bender, W. (1992). Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products. Development 114: 493-505

Simon, J., et al. (1993). Elements of the Drosophila bithorax complex that mediate repression by Polycomb group products. Dev. Biol. 158(1): 131-44

Sustar, A. and Schubiger, G. (2005). A transient cell cycle shift in Drosophila imaginal disc cells precedes multipotency. Cell 120: 383-393. 15707896

Takada, Y., et al. (2007). Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes. Development 134(3): 579-90. Medline abstract: 17215307

Tomotsune, D., et al. (1999). A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with RAE28/mph1 in vitro. Differentiation 65(4): 229-39. Medline abstract: 10653359

Usui, H., Ichikawa, T., Kobayashi, K. and Kumanishi, T. (2000). Cloning of a novel murine gene Sfmbt, Scm-related gene containing four mbt domains, structurally belonging to the Polycomb group of genes. Gene 248(1-2): 127-35. Medline abstract: 10806358

van de Vosse, E., et al. (1998). Characterization of SCML1, a new gene in Xp22, with homology to developmental polycomb genes. Genomics 49(1): 96-102. Medline abstract: 9570953

Wang, L., et al. (2010). Comparative analysis of chromatin binding by Sex Comb on Midleg (SCM) and other polycomb group repressors at a Drosophila Hox gene. Mol. Cell Biol. 30(11): 2584-93. PubMed Citation: 20351181

Wismar, J., et al. (1995). The Drosophila melanogaster tumor suppressor gene lethal(3)malignant brain tumor encodes a proline-rich protein with a novel zinc finger. Mech. Dev. 53(1): 141-54

Wu, C.-t., Jones, R. S., Lasko, P. F. and Gelbart, W. M. (1989). Homeosis and the interaction of zeste and white in Drosophila. Mol. Gen. Genet. 218: 559-564

Yuan, W., Wu, T., Fu, H., Dai, C., Wu, H., Liu, N., Li, X., Xu, M., Zhang, Z., Niu, T., Han, Z., Chai, J., Zhou, X. J., Gao, S. and Zhu, B. (2012). Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. Science 337: 971-975. PubMed ID: 22923582

Sex combs on midleg: Biological Overview | Evolutionary Homologs | Regulation | Developmental Biology | Effects of Mutation

date revised: 25 July 2015

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