Adler P.N., Krasnow, R. E. and Liu, J. (1997). Tissue polarity points from cells that have higher Frizzled levels towards cells that have lower Frizzled levels. Curr. Biol. 7(12): 940-949. PubMed Citation: 9382848

Ahumada, A., Slusarski, D. C., Liu, X., Moon, R. T., Malbon, C. C. and Wang, H. Y. (2002). Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP. Science 298(5600): 2006-10. PubMed citation: 12471263

Ataman, B., et al. (2006). Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP. Proc. Natl. Acad. Sci. 103(20): 7841-6. 16682643

Axelrod, J. D. (2001). Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling. Genes Dev. 15: 1182-1187. PubMed citation: 11358862

Baeg, G. H., Selva, E. M., Goodman, R. M., Dasgupta, R. and Perrimon, N. (2004). The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors. Dev. Biol. 276(1): 89-100. 15531366

Beermann, A., et al. (2012). A context-dependent combination of Wnt receptors controls axis elongation and leg development in a short germ insect. Development 138: 2793-2805. PubMed Citation: 21652652

Bhanot, P., et al. (1996). A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 382: 225-230. PubMed Citation: 8717036

Bhanot, P., et al. (1999). Frizzled and DFrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development. Development 126: 4175-4186. PubMed Citation: 10457026

Bhat, K. M. (1998). frizzled and frizzled 2 play a partially redundant role in wingless signaling and have similar requirements to Wingless in neurogenesis. Cell 95: 1027-1036. PubMed Citation: 9875856

Bikkavilli, R. K., Feigin, M. E. and Malbon, C. C. (2008). G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells. J Cell Sci. 121(Pt 2): 234-45. PubMed Citation: 18187455

Boutros, M., Mihaly, J., Bouwmeester, T. and Mlodzik, M. (2000). Signaling specificity by Frizzled receptors in Drosophila. Science 288(5472): 1825-8. PubMed Citation: 10846164

Bradley, L., et al. (2000). Different activities of the Frizzled-related proteins frzb2 and sizzled2 during Xenopus anteroposterior patterning. Dev. Bio. 227: 118-132. PubMed Citation: 11076681

Brunner, E., et al. (1997). pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila. Nature 385: 829-833. PubMed Citation: 9039917

Cadigan, K. M., et al. (1998). Wingless repression of Drosophila frizzled 2 expression shapes the wingless morphogen gradient in the wing. Cell 93: 767-777. PubMed Citation: 9630221

Cavodeassi, F., et al. (2005). Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/ß-Catenin pathway. Neuron 47: 43-56. 15996547

Chan, S.D., et al. (1992). Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues. J. Bio. Chem. 267: 25202-25207

Chen, C.-m. and Struhl, G. (1999). Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila. Development 126: 5441-5452. PubMed Citation: 10556068

Chen, W., et al. (2003). Dishevelled 2 recruits ß-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science 301(5638): 1391-4. 12958364

Cong, F., Schweizer, L. and Varmus, H. (2004). Casein kinase Iε modulates the signaling specificities of Dishevelled. Mol. Cell. Biol. 24: 2000-2011. 14966280

Dani, N., Nahm, M., Lee, S. and Broadie, K. (2012). A targeted glycan-related gene screen reveals heparan sulfate proteoglycan sulfation regulates WNT and BMP trans-synaptic signaling. PLoS Genet 8: e1003031. PubMed ID: 23144627

Dann, C. E., et al. (2001). Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature 412: 86-90. 11452312

Das, G., et al. (2004). Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes. Development 131: 4467-4476. PubMed citation: 15306567

Devenport, D., Oristian, D., Heller, E. and Fuchs, E. (2011). Mitotic internalization of planar cell polarity proteins preserves tissue polarity. Nat. Cell Biol. 13: 893-902. PubMed Citation: 21743464

Deardorff, M. A., et al. (1998). Frizzled-8 is expressed in the spemann organizer and plays a role in early morphogenesis. Development 125(14): 2687-2700. PubMed Citation: 9636083

Deardorff, M. A., et al. (2001). A role for frizzled 3 in neural crest development. Development 128: 3655-3663. 11585792

Deshpande, R., Inoue, T., Priess, J. R. and Hill, R. J. (2005). lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development. Dev. Biol. 278(1): 118-29. 15649465

Dickinson, A. J. G and Sive, H. L. (2009). The Wnt antagonists Frzb-1 and Crescent locally regulate basement membrane dissolution in the developing primary mouth. Development 136: 1071-1081. PubMed Citation: 19224982

Dreier, L., Burbea, M. and Kaplan, J. M. (2005). LIN-23-mediated degradation of beta-catenin regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans, Neuron 46: 51-64. PubMed citation: 15820693

Eldar, A., et al. (2003). Self-enhanced ligand degradation underlies robustness of morphogen gradients. Dev. Cell 5: 635-646. 14536064

Feiguin, F., Hannus, M., Mlodzik, M. and Eaton, S. (2001). The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization. Dev. Cell 1: 93-101. PubMed citation: 11703927

Fire, A., Xu, S., Montgomery, M., Kostas, S.A., Driver, S.E., and Mello, C.C. (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806-811. PubMed Citation: 9486653

Finch, P. W., et al. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proc. Natl. Acad. Sci. 94(13): 6770-6775. PubMed Citation: 9192640

Ghimire, S. R. and Deans, M. R. (2019). Frizzled3 and Frizzled6 Cooperate with Vangl2 to Direct Cochlear Innervation by Type II Spiral Ganglion Neurons. J Neurosci 39(41): 8013-8023. PubMed ID: 31462532

Giraldez, A. J., Copley, R. R. Cohen, S. M. (2002). HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient. Dev. Cell 2(5): 667-76. 12015973

Gomperts, S. N. (1996). Clustering membrane proteins: It's all coming together with the PSD-95/SAP90 protein family. Cell 84: 659-662. PubMed Citation: 8625403

Green, J. L., Inoue, T. and Sternberg, P. W. (2008). Opposing Wnt pathways orient cell polarity during organogenesis. Cell 134(4): 646-56. PubMed Citation: 18724937

Grumolato, L., et al. (2010). Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev. 24(22): 2517-30. PubMed Citation: 21078818

Han, C., et al. (2005). Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc. Development 132: 667-679. 15647319

Harris, K. E. and Beckendorf, S. K. (2007). Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration. Development 134(11): 2017-25. Medline abstract: 17507403

Harris, K.P., Akbergenova, Y., Cho, R.W., Baas-Thomas, M.S. and Littleton, J.T. (2016). Shank modulates postsynaptic wnt signaling to regulate synaptic development. J Neurosci. 36: 5820-5832. PubMed ID: 27225771

Harterink, M., et al. (2011). Neuroblast migration along the anteroposterior axis of C. elegans is controlled by opposing gradients of Wnts and a secreted Frizzled-related protein. Development 138(14): 2915-24. PubMed Citation: 21653614

He, X., et al. (1997). A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science 275: 1652-1654. PubMed Citation: 9054360

Herman, M. A. (2001). C. elegans POP-1/TCF functions in a canonical Wnt pathway that controls cell migration and in a noncanonical Wnt pathway that controls cell polarity. Development 128: 581-590. 11171341

Hoang, B. H., et al. (1998). Expression pattern of two Frizzled-related genes, Frzb-1 and Sfrp-1, during mouse embryogenesis suggests a role for modulating action of Wnt family members. Dev. Dyn. 212(3): 364-372. PubMed Citation: 9671940

Houart, C., et al. (2002). Establishment of the telencephalon during gastrulation by local antagonism of wnt signaling. Neuron 35: 255-265. 12160744

Hsieh, J. C., et al. (1999). Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein. Proc. Natl. Acad. Sci. 96(7): 3546-51. PubMed Citation: 10097073

Inaki, M., Yoshikawa, S., Thomas, J. B., Aburatani, H. and Nose, A. (2007). Wnt4 is a local repulsive cue that determines synaptic target specificity. Curr. Biol. 17(18): 1574-9. PubMed citation: 17764943

Inoue, T., Oz, H. S., Wiland, D., Gharib, S., Deshpande, R., Hill, R. J., Katz, W. S. and Sternberg, P. W. (2004). C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17/Frizzled in Wnt signaling. Cell 118(6): 795-806. 15369677

Ishikawa, T., et al. (2001). Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development 128: 25-33

Itoh, K., Jacob, J. Y. and Sokol, S. (1998). A role for Xenopus Frizzled 8 in dorsal development. Mech. Dev. 74(1-2): 145-157

Janson, K., Cohen, E. D. and Wilder, E. L. (2001). Expression of DWnt6, DWnt10, and DFz4 during Drosophila development. Mech. Dev. 103: 117-120. 11335117

Jenny, A., et al. (2005). Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding. Nat. Cell Biol. 7: 691-697. PubMed citation: 15937478

Junion, G., et al. (2005). Mapping Dmef2-binding regulatory modules by using a ChIP-enriched in silico targets approach. Proc. Natl. Acad. Sci. 102(51): 18479-84. 16339902

Kuroda, J., et al. (2012). Canonical Wnt signaling in the visceral muscle is required for left-right asymmetric development of the Drosophila midgut. Mech Dev. 128(11-12): 625-39. PubMed Citation: 22198363

Katanaev, V. L., et al. (2005). Trimeric G protein-dependent Frizzled signaling in Drosophila. Cell 120: 111-122. 15652486

Katanaev, V. L., Tomlinson, A. (2006). Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila. Proc. Natl. Acad. Sci. 103: 6524-6529. 16617104

Kennerdell, J. R. and Carthew, R. W. (1998). Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the Wingless pathway. Cell 95: 1017-1026

Kim, S.-H., et al. (1998). Characterization of two frizzled8 homologues expressed in the embryonic shield and prechordal plate of zebrafish embryos. Mech. Dev. 78(1-2): 193-198

Kim, S.-H., et al. (2002). Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish. Development 129: 4443-4455. 12223403

Kinoshita, N., et al. (2003). PKCdelta is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements. Genes Dev. 17: 1663-1676. 12842914

Kirkpatrick, C. A., et al. (2004). Spatial regulation of Wingless morphogen distribution and signaling by Dally-like protein. Dev. Cell 7: 513-523. 15469840

Klassen, M. P. and Shen, K. (2007). Wnt signaling positions neuromuscular connectivity by inhibiting synapse formation in C. elegans. Cell 130(4): 704-16. PubMed citation: 17719547

Klein, T. J., Jenny, A., Djiane, A. and Mlodzik, M. (2006). CKIε/discs overgrown promotes both Wnt-Fz/β-catenin and Fz/PCP signaling in Drosophila. Curr. Biol. 16(13): 1337-43. 16824922

Klingensmith, J., Nusse R., and Perrimon, N. (1994). The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes Dev 8: 118-30

Krasnow, R. E., Wong, L.L. and Adler, P. N. (1995). dishevelled is a component of the frizzled signaling pathway in Drosophila. Development 121:4095-4102

Lecourtois, M., et al. (2001). Wingless capture by Frizzled and Frizzled2 in Drosophila embryos. Dev. Bio. 235: 467-475. 11437451

Leyns, L., et al. (1997). Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell 88 (6): 747-756

Li, C., et al. (2008). Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. BMC Mol. Biol. 9: 11. PubMed citation: 18215320

Li, Y. and Dudle, A. T. (2009). Noncanonical frizzled signaling regulates cell polarity of growth plate chondrocytes. Development 136: 1083-1092. PubMed Citation: 19224985

Lin, K., et al. (1997). The cysteine-rich frizzled domain of frzb-1 is required and sufficient for modulation of wnt signaling. Proc. Natl. Acad. Sci. 94(21): 11196-11200

Liu, C. and Nathans, J. (2008). An essential role for frizzled 5 in mammalian ocular development. Development 135: 3567-3576. PubMed Citation: 18832390

Liu, T., DeCostanzo, A. J., Liu, X., Wang, H., Hallagan, S., Moon, R. T. and Malbon, C. C. (2001). G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway. Science 292: 1718-1722. 11387477

Liu, X., et al. (1999). Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat. Proc. Natl. Acad. Sci. 96: 14383-8.

Ma, L. and Wang, H. Y. (2007). Mitogen-activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non-canonical pathway. J. Biol. Chem. 282(39): 28980-90. PubMed citation: 17684012

Martyn, U., and Schulte-Merker, S. (2003). The ventralized ogon mutant phenotype is caused by a mutation in the zebrafish homologue of Sizzled, a secreted Frizzled-related protein. Dev. Bio. 260: 58-67. 12885555

Mathew, D., Ataman, B., Chen, J., Zhang, Y., Cumberledge, S. and Budnik, V. (2005). Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2. Science 310(5752): 1344-7. 16311339

McBride, H. J., Fatke, B. and Fraser, S. E. (2002). Wnt signaling components in the chicken intestinal tract. Dev. Biol. 256(1): 18-33. 12654289

Medina, A., Reintsch, W. and Steinbeisser, H. (2000). Xenopus frizzled 7 can act in canonical and non-canonical Wnt signaling pathways: implications on early patterning and morphogenesis. Mech. Dev. 92: 227-237.

Melkonyan, H. S., et al. (1997). SARPs: A family of secreted apoptosis-related proteins. Proc. Natl. Acad. Sci. 94(25): 13636-13641

Minobe, S., et al. (2000). Identification and characterization of the epithelial polarity receptor "Frizzled" in Hydra vulgaris. Dev. Genes Evol. 210: 258-262

Minor, P. J., He, T. F., Sohn, C. H., Asthagiri, A. R. and Sternberg, P. W. (2013). FGF signaling regulates Wnt ligand expression to control vulval cell lineage polarity in C. elegans. Development. PubMed ID: 23946444

Mitchell, B., et al. (2009). The PCP pathway instructs the planar orientation of ciliated cells in the Xenopus larval skin. Curr. Biol. 19: 924-929. PubMed Citation: 19427216

Mizumoto, K. and Shen, K. (2013). Two Wnts instruct topographic synaptic innervation in C. elegans. Cell Rep 5: 389-396. PubMed ID: 24139806

Mizuno, T., Amano, M., Kaibuchi, K. and Nishida, Y. (1999). Identification and characterization of Drosophila homolog of Rho-kinase. Gene 238(2): 437-444. 10570971

Moffat, L. L., Robinson, R. E., Bakoulis, A. and Clark, S. G. (2014). The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans. Development 141: 617-628 PubMed ID: 24401370

Molenaar, M., et al. (1996). XTcf-3 transcription factor mediates ß-catenin-induced axis formation in Xenopus embryos. Cell 86: 391-399

Moline, M. M., Dierick, H. A., Southern, C. and Bejsovec, A. (2000). Non-equivalent roles of Drosophila Frizzled and Dfrizzled2 in embryonic Wingless signal transduction. Curr. Biol. 10: 1127-1130. 10996794

Momoia, A., et al. (2003). Analysis of Wnt8 for neural posteriorizing factor by identifying Frizzled 8c and Frizzled 9 as functional receptors for Wnt8. Mech. Dev. 120: 477-489. 12676325

Mosca, T. J. and Schwarz, T. L. (2010). The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development. Nat Neurosci 13: 935-943. PubMed ID: 20601947

Nasevicius, A., et al. (1998). Evidence for a frizzled-mediated wnt pathway required for zebrafish dorsal mesoderm formation. Development 125(21): 4283-429

Packard, M., et al. (2002). The Drosophila Wnt, Wingless, provides an essential signal for pre- and postsynaptic differentiation. Cell 111: 319-330. 12419243

Paricio, N., et al. (1999). The Drosophila STE20-like kinase Misshapen is required downstream of the Frizzled receptor in planar polarity signaling. EMBO J. 18: 4669-4678

Park, F. D. and Priess, J. R. (2003). Establishment of POP-1 asymmetry in early C. elegans embryos. Development 130: 3547-3556. 12810601

Penzo-Mendez, A., et al. (2003). Activation of Gßgamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation. Dev. Biol. 257: 302-314. 12729560

Person, A. D., et al. (2005). Frzb modulates Wnt-9a-mediated beta-catenin signaling during avian atrioventricular cardiac cushion development. Dev. Biol. 278(1): 35-48. 15649459

Piddini, E., et al. (2005). Arrow (LRP6) and Frizzled2 cooperate to degrade Wingless in Drosophila imaginal discs. Development 132: 5479-5489. 16291792

Piddini, E. and Vincent, J. P. (2009). Interpretation of the wingless gradient requires signaling-induced self-inhibition. Cell 136: 296-307. PubMed ID: 19167331

Rehn, M. and Pihlajaniemi, T. (1995). Identification of three N terminal ends of type XVIII collagen chains and tissue-specific differences in the expression of the corresponding transcripts. The longest form contains a novel motif homologous to rat and Drosophila frizzled proteins. J.Biol. Chem. 270: 4705-11

Rocheleau, C. E., et al. (1997). Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. Cell 90(4): 707-716

Rives, A. F., Rochlin, K. M., Wehrli, M., Schwartz, S. L. and DiNardo, S. (2006). Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing. Dev. Biol. 293(1): 268-83. 16530179

Sahores, M., Gibb, A. and Salinas, P. C. (2010). Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis. Development 137(13): 2215-25. PubMed Citation: 20530549

Sato, M., et al. (2005). DWnt4 regulates the dorsoventral specificity of retinal projections in the Drosophila melanogaster visual system. Nat. Neurosci. 9: 67-75. 16369482

Sawa, H., Lobel, L., and Horvitz, H. R. (1996). The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein. Genes Dev 10 (17): 2189-2197

Schulze, S. R. et al. (2009).A comparative study of Drosophila and human A-type lamins. PLoS ONE 4: e7564. PubMed Citation: 19855837

Schwarz-Romond, T., et al. (2002). The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the β-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev. 16: 2073-2084. PubMed citation: 12183362

Schweizer, L. and Varmus, H. (2003). Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors. BMC Cell Biol. 4: 4. 12729465

Sheldahl, L. C., et al. (1999). Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. Curr. Biol. 9: 695-8

Shi, D. L., Goisset, C. and Boucaut, J. C. (1998). Expression of Xfz3, a Xenopus frizzled family member, is restricted to the early nervous system. Mech. Dev. 70: 35-47

Siegfried, E., Wilder, E. L. and Perrimon, N. (1994). Components of wingless signalling in Drosophila. Nature 367: 76-80

Simons, M. et al. (2005). Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat. Genet. 37: 537-543. PubMed citation: 15852005

Slusarski, D. C., Corces, V. G. and Moon, R. T. (1997). Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature 390(6658): 410-413

Solano, P. J., et al. (2003). Genome-wide identification of in vivo Drosophila Engrailed-binding DNA fragments and related target genes. Development 130: 1243-1254. 12588842

Speese, S. D., et al. (2012). Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling. Cell 149(4): 832-46. PubMed Citation: 22579286

Srahna, M., Leyssen, M., Choi, C. M., Fradkin, L. G., Noordermeer, J. N. and Hassan, B. A. (2006). A signaling network for patterning of neuronal connectivity in the Drosophila brain. PLoS Biol. 4(11): e348. Medline abstract: 17032066

Stark, M. R., et al. (2000). Frizzled-4 expression during chick kidney development. Mech. Dev. 98: 121-125.

Strapps, W. R. and Tomlinson, A. (2001). Transducing properties of Drosophila Frizzled proteins. Development 128: 4829-4835. 11731462

Strutt, D. I. (2001). Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing. Mol. cells 7: 367-375. PubMed citation: 11239465

Sumanas, S., et al. (2000). The putative Wnt receptor Xenopus frizzled-7 functions upstream of beta-catenin in vertebrate dorsoventral mesoderm patterning. Development 127: 1981-1990.

Tamai, K., et al. (2000). LDL-receptor-related proteins in Wnt signal transduction. Nature 407: 530-535.

Tan, C., et al. (2001). Kermit, a frizzled interacting protein, regulates frizzled 3 signaling in neural crest development. Development 128: 3665-3674. 11585793

Tanaka, S., et al. (1998). A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. Proc. Natl. Acad. Sci. 95(17): 10164-9

Tolwinski, N. S., et al. (2003). Wg/Wnt signal can be transmitted through Arrow/LRP5,6 and Axin independently of Zw3/Gsk3ß activity. Developmental Cell 4: 407-418. 12636921

Toyofuku, T., et al. (2000). Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-ß-catenin complex. J. Cell Biol. 150(1): 225-41. 10893270

Umbhauer, M., et al. (2000). The C-terminal cytoplasmic Lys-Thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signaling. EMBO J. 19: 4944-4954.

van Gijn, M. E., et al. (2001). Overexpression of components of the Frizzled-Dishevelled cascade results in apoptotic cell death, mediated by ß-Catenin. Exp. Cell Res. 265: 46-53. 11281642

Van Raay, T. J., et al. (2005). Frizzled 5 signaling governs the neural potential of progenitors in the developing Xenopus retina. Neuron 46(1): 23-36. 15820691

Wada, H., et al. (2006). Frizzled3a and Celsr2 function in the neuroepithelium to regulate migration of facial motor neurons in the developing zebrafish hindbrain. Development 133: 4749-4759. Medline abstract: 17079269

Walston, T., et al. (2004). Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos. Dev. Cell 7: 831-841. 15572126

Wang, S., et al. (1997). Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Cell 88 (6): 757-766

Wang, M. and Sternberg, P. W. (2000). Patterning of the C. elegans 1o vulval lineage by RAS and Wnt pathways. Development 127: 5047-5058

Wang, Y., et al. (1996). A large family of putative receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J. Biol. Chem. 271: 4468-76

Wang, Y., Guo, N., Nathans, J. (2006). The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. J. Neurosci. 26(8): 2147-56. 16495441

Wesley, C. S. (1999). Notch and Wingless regulate expression of cuticle patterning genes. Mol. Cell. Biol. 19: 5743-5758

Wehrli, M., et al. (2000). arrow encodes an LDL-receptor-related protein essential for Wingless signaling. Nature 407: 527-530.

Weng, S. C. and Shiao, S. H. (2015). Frizzled 2 is a key component in the regulation of TOR signaling-mediated egg production in the mosquito Aedes aegypti. Insect Biochem Mol Biol. PubMed ID: 25890109

Winter, C. G., et al. (2001). Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell 105: 81-91. 11301004

Wong, H. C., et al. (2003). Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-Terminal region of Frizzled. Molec. Cell 12: 1251-1260. 14636582

Wu, J., Klein, T.J., and Mlodzik, M. (2004). Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity. PLoS Biol. 2: e158. PubMed Citation: 15252441

Wu, J., Jenny, A., Mirkovic, I. and Mlodzik,M. (2008). Frizzled-Dishevelled signaling specificity outcome can be modulated by Diego in Drosophila. Mech. Dev. 125: 30-42. PubMed citation: 18065209

Xu, Q., D'Amore, P. A. and Sokol, S.Y. (1998). Functional and biochemical interactions of Wnts with FrzA, a secreted Wnt antagonist. Development 125(23): 4767-4776

Xu, Q., et al. (2004). Vascular development in the retina and inner ear: Control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 116: 883-895. 15035989

Yabe, T., et al. (2003). Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling. Development 130: 2705-2716. 12736214

Yanagawa, F., et al. (1995). The dishevelled protein is modified by wingless signaling in Drosophila. Genes Dev. 9: 1087-1097

Yanagawa, S.-I., Lee, J.-S. and Ishimoto, A. (1998). Identification and characterization of a novel line of Drosophila Schneider S2 cells that respond to Wingless signaling. J. Biol. Chem. 273(48): 32353-32359

Yang-Snyder, J., et al. (1996). A frizzled homolog functions in a vertebrate Wnt signaling pathway. Curr. Biol. 6 (10): 1302-1306

Yoshino, K., et al. (2001). Secreted Frizzled-related proteins can regulate metanephric development. Mech. Dev. 102: 45-55. 11287180

Yu, A., et al. (2007). Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling. Dev. Cell 12(1): 129-41. Medline abstract: 17199046

Zhang, J. and Carthew, R. W. (1998). Interactions between Wingless and DFz2 during Drosophila wing development. Development 125(16): 3075-3085

Zhao, Z., Lee, C., Baldini, A. and Caskey, C.T. (1995). A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1. Genomics 27: 370-373

frizzled2: Biological Overview | Evolutionary Homologs | Regulation | Developmental Biology | Effects of Mutation

date revised: 30 June 2015

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.