Ecdysone receptor

REFERENCES (part 1/2)

Ables, E. T. and Drummond-Barbosa, D. (2010). The steroid hormone ecdysone functions with intrinsic chromatin remodeling factors to control female germline stem cells in Drosophila. Cell Stem Cell 7: 581-592. PubMed Citation: 21040900

Adachi-Yamada, T., et al. (1994). Structure and expression of the gene for the prothoracicotropic hormone of the silkmoth Bombyx mori. Eur. J. Biochem. 220: 633-43. PubMed citation: 8125124

Ahmed, S. M. H., Maldera, J. A., Krunic, D., Paiva-Silva, G. O., Penalva, C., Teleman, A. A. and Edgar, B. A. (2020). Fitness trade-offs incurred by ovary-to-gut steroid signalling in Drosophila. Nature. PubMed ID: 32641829

Allan, D., et al. (2001). RARgamma and Cdx1 interactions in vertebral patterning. Dev. Biol. 240(1): 46-60. 11784046

Andres, A. J. and Thummel, C. S. (1995). The Drosophila 63F early puff contains E63-1, an ecdysone-inducible gene that encodes a novel Ca(2+)-binding protein. Development 121: 2667-2679. PubMed Citation: 7671827

Antoniewski, C., et al. (1995). Characterization of an EcR/USP heterodimer target site that mediates ecdysone responsiveness of the Drosophila Lsp-2 gene. Mol. Gen. Genet. 249: 545-556. PubMed Citation: 8544820

Antoniewski, C., et al. (1996). Direct repeats bind the EcR/USP receptor and mediate ecdysteroid responses in Drosophila melanogaster. Mol. Cell. Biol. 16: 2977-86. PubMed Citation: 8649409

Appel, L.F., Prout, M., Abu-Shumays, R., Hammonds, A., Garbe, J.C., Fristrom, D., and Fristrom, J. (1993). The Drosophila Stubble-stubbloid gene encodes an apparent transmembrane serine protease required for epithelial morphogenesis. Proc. Natl. Acad. Sci. 90: 4937-4941. 6289325

Arbeitman, M. N. and Hogness, D. S. (2000). Molecular chaperones activate the Drosophila ecdysone receptor, an RXR heterodimer. Cell 101: 67-77. PubMed Citation: 10778857

Ashburner, M. (1990). Puffs, genes, and hormones revisited. Cell 61: 1-3. PubMed Citation: 2180581

Awad, T. A. and Truman, J. W. (1997). Postembryonic development of the midline glia in the CNS of Drosophila: proliferation, programmed cell death, and endocrine regulation. Dev. Biol. 187(2): 283-297. PubMed Citation: 9242424

Awasaki, T. and Ito, K. (2004). Engulfing action of glial cells is required for programmed axon pruning during Drosophila metamorphosis. Curr. Biol. 14: 668-677. 15084281

Awasaki, T., Huang, Y., O'Connor, M. B. and Lee, T. (2011). Glia instruct developmental neuronal remodeling through TGF-β signaling. Nat. Neurosci. 14(7):821-3. PubMed Citation: 21685919

Baehrecke, E. H. (1997). who encodes a KH RNA binding protein that functions in muscle development. Development 124: 1323-1332. PubMed Citation: 9118803

Badenhorst, P., Xiao, H., Cherbas, L., Kwon, S. Y., Voas, M., Rebay, I., Cherbasm P. and Wu, C. (2005). The Drosophila nucleosome remodeling factor NURF is required for Ecdysteroid signaling and metamorphosis. Genes Dev. 19(21): 2540-5. 16264191

Bai, J. Uehara, Y. and Montell, D. J. (2000). Regulation of invasive cell behavior by Taiman, a Drosophila protein related to AIB1, a steroid receptor coactivator amplified in breast cancer. Cell 103: 1047-1058. 11163181

Beckstead, R., et al. (2001). Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit FTZ-F1-dependent transcription. Molec. Cell 7: 753-765. 11336699

Beckstead, R. B., Lam, G. and Thummel, C. S. (2005). The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis. Genome Biology 6: R99. 16356271

Bender, M., et al. (1997). Drosophila Ecdysone receptor mutations reveal functional differences among receptor isoforms. Cell 91(6): 777-788. PubMed Citation: 9413987

Benes, H., et al. (1996). Overlapping Lsp-2 gene sequences target expression to both the larval and adult Drosophila fat body. Insect Mol. Biol. 5(1): 39-49. PubMed Citation: 8630534

Bernardo, T. J., Dubrovskaya, V. A., Xie, X. and Dubrovsky, E. B. (2014). A view through a chromatin loop: insights into the ecdysone activation of early genes in Drosophila. Nucleic Acids Res. PubMed ID: 25143532

Berry, D. L., Schwartzman, R. A. and Brown, D. D. (1998a). The expression pattern of thyroid hormone response genes in the tadpole tail identifies multiple resorption programs. Dev. Biol. 203(1): 12-23. PubMed Citation: 9806769

Berry, D. L., et al. (1998b). The expression pattern of thyroid hormone response genes in remodeling tadpole tissues defines distinct growth and resorption gene expression programs. Dev. Biol. 203(1): 24-35. PubMed Citation: 9806770

Billas, I. M., et al. (2003). Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor. Nature. 426(6962): 91-6. 14595375

Billon, N., et al. (2002). Normal timing of oligodendrocyte development depends on thyroid hormone receptor alpha 1 (TRa1). EMBO J. 21: 6452-6460. 12456652

Biyasheva, A., et al. (2001). Glue secretion in the Drosophila salivary gland: a model for steroid-regulated exocytosis. Dev. Bio. 231: 234-251. 11180965

Blanco, J. C. G., et al. (1998). The histone acetylase PCAF is a nuclear receptor coactivator. Genes Dev. 12: 1638-1651. PubMed Citation: 9620851

Bonneton, F., et al. (2003). Rapid divergence of the Ecdysone receptor in Diptera and Lepidoptera suggests coevolution between ECR and USP-RXR. Mol. Biol. Evol. 20(4):541-53. 12654933

Botling, J., et al. (1997). Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation. J. Biol. Chem. 272 (14): 9443-9449. PubMed Citation: 9083083

Boukarabila, H., et al. (2009). The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation. Genes Dev. 23(10): 1195-206. PubMed Citation: 19451220

Boulanger, A., Farge, M., Ramanoudjame, C., Wharton, K. and Dura, J. M. (2012). Drosophila motor neuron retraction during metamorphosis is mediated by inputs from TGF-beta/BMP signaling and orphan nuclear receptors. PLoS One 7: e40255. PubMed Citation: 22792255

Bourguet, W., et al. (2000). Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains. Molec. Cell 5: 289-298. PubMed Citation: 10882070

Bownes, M., Ronaldson, E. and Mauchline, D. (1996). 20-Hydroxyecdysone, but not juvenile hormone, regulation of yolk protein gene expression can be mapped to cis-acting DNA sequences. Dev Biol 173 (2): 475-489. PubMed Citation: 8606006

Boyd, L., O'Toole, E. and Thummel, C. S. (1991). Patterns of E74A RNA and protein expression at the onset of metamorphosis in Drosophila. Development 112: 981-95. PubMed Citation: 1718680

Boyle, M. J. and Berg, C. A. (2009). Control in time and space: Tramtrack69 cooperates with Notch and Ecdysone to repress ectopic fate and shape changes during Drosophila egg chamber maturation. Development 136(24): 4187-97. PubMed Citation: 19934014

Brennan, C. A., Ashburner, M. and Moses, K. (1998). Ecdysone pathway is required for furrow progression in the developing Drosophila eye. Development 125: 2653-2664. PubMed Citation: 9636080

Brooks, S. C., et al. (1997). An RXR-selective analog attenuates the RAR alpha-selective analog-induced differentiation and non-G1-restricted growth arrest of NB4 cells. Exp. Cell Res. 234(2): 259-269. PubMed Citation: 9260893

Brown, H. L. D. and Truman, J. W. (2009). Fine-tuning of secondary arbor development: the effects of the ecdysone receptor on the adult neuronal lineages of the Drosophila thoracic CNS. Development 136: 3247-3256. PubMed Citation: 19710167

Buszczak, M., et al. (1999). Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila. Development 126: 4581-4589. PubMed Citation: 10498692

Carney, G. E. and Bender, M. (2000). The Drosophila ecdysone receptor (EcR) gene is required maternally for normal oogenesis. Genetics 154: 1203-1211. PubMed Citation: 10757764

Chakravarti, D., et al. (1996). Role of CBP/P300 in nuclear receptor signalling. Nature 383 (6595): 99-103. PubMed Citation: 8779723

Champlin, D. T. and Truman, J. W. (1998a). Ecdysteroid control of cell proliferation during optic lobe neurogenesis in the moth Manduca sexta. Development 125(2): 269-277. PubMed Citation: 9486800

Champlin, D. T. and Truman, J. W. (1998b). Ecdysteroids govern two phases of eye development during metamorphosis of the moth, Manduca sexta. Development 125: 2009-2018. PubMed Citation: 9570766

Chang, K. H., et al. (1997). A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein. Proc. Natl. Acad. Sci. 94(17): 9040-9045. PubMed Citation: 9256431

Chauhan, C., Zraly, C. B., Parilla, M., Diaz, M. O. and Dingwall. A. K. (2012). Histone recognition and nuclear receptor co-activator functions of Drosophila Cara Mitad, a homolog of the N-terminal portion of mammalian MLL2 and MLL3. Development 139(11): 1997-2008. PubMed Citation: 22569554

Chawla, G. and Sokol, N. S. (2012). Hormonal activation of let-7-C microRNAs via EcR is required for adult Drosophila melanogaster morphology and function. Development 139: 1788-1797. Pubmed: 22510985

Chen, G-C., Gajowniczek, P. and Settleman, J. (2004). Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis. Current Biol. 14: 309-313. 14972681

Chen, J. D. and Evans, R. M. (1995). A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377 (6548): 454-457. PubMed Citation: 7566127

Chen, J. D., Umesono, K., and Evans, R. M. (1996). SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers. Proc. Natl. Acad. Sci. 93 (15): 7567-7571. PubMed Citation: 8755515

Chen, L., et al. (2002). Induction of the early-late Ddc gene during Drosophila metamorphosis by the ecdysone receptor. Mech. Dev. 114: 95-107. 12175493

Chen, W., Liu, Z., Li, T., Zhang, R., Xue, Y., Zhong, Y., Bai, W., Zhou, D. and Zhao, Z. (2014). Regulation of Drosophila circadian rhythms by miRNA let-7 is mediated by a regulatory cycle. Nat Commun 5: 5549. PubMed ID: 25417916

Cheng, X., et al. (1997). The transcriptional integrator CREB-binding protein mediates positive cross talk between nuclear hormone receptors and the hematopoietic bZip protein p45/NF-E2. Mol. Cell. Biol. 17(3): 1407-16. PubMed Citation: 9032267

Cherbas, L., et al. (2003). EcR isoforms in Drosophila: testing tissue-specific requirements by targeted blockade and rescue. Development 130: 271-284. 12466195

Chiang, M. Y., et al. (1998). An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression. Neuron 21(6): 1353-61. PubMed Citation: 9883728

Christensen, C. F., Koyama, T., Nagy, S., Danielsen, E. T., Texada, M. J., Halberg, K. A. and Rewitz, K. (2020). Ecdysone-dependent feedback regulation of prothoracicotropic hormone controls the timing of developmental maturation. Development 147(14). PubMed ID: 32631830

Collingwood, T. N., et al. (1997). Thyroid hormone-mediated enhancement of heterodimer formation between thyroid hormone receptor beta and retinoid X receptor J. Biol. Chem. 272 (20): 13060-13065. PubMed Citation: 9148917

Colombani, J., et al. (2005). Antagonistic actions of ecdysone and insulins determine final size in Drosophila. Science 310(5748): 667-70. 16179433

Crispi, S., et al. (1998). Cross-talking among Drosophila nuclear receptors at the promiscuous response element of the ng-1 and ng-2 intermolt genes. J. Mol. Biol. 275(4): 561-574. PubMed Citation: 9466931

Crispi, S., et al. (2001). Functional analysis of regulatory elements controlling the expression of the ecdysone-regulated Drosophila ng-1 gene. Mech. Dev. 100: 25-35. 11118881

Cruz, J., Mane-Padros, D., Belles, X. and Martin, D. (2006). Functions of the ecdysone receptor isoform-A in the hemimetabolous insect Blattella germanica revealed by systemic RNAi in vivo. Dev. Biol. 297(1): 158-71. Medline abstract: 16890931

Cui, J., et al. (2003). Retinoid receptors and vitamin A deficiency: differential patterns of transcription during early avian development and the rapid induction of RARs by retinoic acid. Dev. Bio. 260: 496-511. 12921748

Dalton, J. E., Lebo, M. S., Sanders, L. E., Sun, F. and Arbeitman, M. N. (2009). Ecdysone receptor acts in fruitless- expressing neurons to mediate drosophila courtship behaviors. Curr Biol 19: 1447-1452. PubMed ID: 19646872

Darimont, B. D., et al. (1998). Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev. 12(21): 3343-56. PubMed Citation: 9808622

D'Avino, P. P. and Thummel, C. S. (1998). crooked legs encodes a family of zinc finger proteins required for leg morphogenesis and ecdysone-regulated gene expression during Drosophila metamorphosis. Development 125: 1733-1745. PubMed Citation: 9521911

D'Avino, P. P. and Thummel, C. S. (2000). The ecdysone regulatory pathway controls wing morphogenesis and integrin expression during Drosophila metamorphosis. Dev. Biol. 220(2): 211-224. PubMed Citation: 10753511

Delanoue, R., Slaidina, M. and Léopold, P. (2010). The steroid hormone ecdysone controls systemic growth by repressing dMyc function in Drosophila fat cells. Dev. Cell 18(6): 1012-21. PubMed Citation: 20627082

Demarest, S. J., et al. (2002). Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature 415(6871): 549-53. 11823864

Denton, D., Aung-Htut, M. T., Lorensuhewa, N., Nicolson, S., Zhu, W., Mills, K., Cakouros, D., Bergmann, A. and Kumar, S. (2013). UTX coordinates steroid hormone-mediated autophagy and cell death. Nat Commun 4: 2916. PubMed ID: 24336022

Denver, R. J., Pavgi, S. and Shi, Y. B. (1997). Thyroid hormone-dependent gene expression program for Xenopus neural development. J. Biol. Chem. 272 (13): 8179-8188. PubMed Citation: 9079635

Devarakonda. S., et al. (2003). Structure of the heterodimeric ecdysone receptor DNA-binding complex. EMBO J. 22(21): 5827-5840. 14592980

Deveci, D., Martin, F. A., Leopold, P. and Romero, N. M. (2019). AstA signaling functions as an evolutionary conserved mechanism timing juvenile to adult transition. Curr Biol 29(5): 813-822. PubMed ID: 30799245

Dhordain, P., et al. (1997). Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein. Proc. Natl. Acad. Sci. 94(20): 10762-10767

Dickman, E. D., Thaller, C. and Smith, S. M. (1997). Temporally-regulated retinoic acid depletion produces specific neural crest, ocular and nervous system defects. Development 124(16): 3111-3121

Diez del Corral, R. D., Olivera-Martinez, I., Goriely, A., Gale, E., Maden, M. and Storey, K. (2003). Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension. Neuron 40: 65-79. 14527434

Dilworth, F. J., et al. (2000). ATP-driven chromatin remodeling activity and histone acetyltransferases act sequentially during transactivation by RAR/RXR in vitro. Mol. Cell 6: 1049-1058.

Dressel, U., et al. (1999). Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. Mol. Cell. Biol. 19: 3383-3394. 10207062

Dupe, V., et al. (1999). Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods. Dev. Biol. 208(1): 30-43

Fisk, G. J. and Thummel, C. S. (1998). The DHR78 nuclear receptor is required for ecdysteroid signaling during the onset of Drosophila metamorphosis. Cell 93(4): 543-555

Flamant, F. and Samarut, J. (1998). Involvement of thyroid hormone and its alpha receptor in avian neurulation. Dev. Biol. 197(1): 1-11

Fletcher, J. C., D'Avino, P. P. and Thummel, C. S. (1997). A steroid-triggered switch in E74 transcription factor isoforms regulates the timing of secondary-response gene expression. Proc. Natl. Acad. Sci. 94 (9): 4582-4586

Folberg, A., et al. (1999). Hoxd4 and Rarg interact synergistically in the specification of the cervical vertebrae. Mech Dev. 89: 65-74.

Fondell, J. D., et al. (1999). Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID. Proc. Natl. Acad. Sci. 96(5): 1959-1964

Forman, B. M., et al. (1995). Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell 81 (4): 541-550

Francis, V. A., Zorzano, A. and Teleman, A. A. (2010). dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling. Curr. Biol. 20(20): 1799-808. PubMed Citation: 20888228

Franco, P. G., et al. (1999). Functional association of retinoic acid and hedgehog signaling in Xenopus primary neurogenesis. Development 126: 4257-4265

Freeman, M. R., Dobritsa, A., Gaines, P., Segraves, W. A. and Carlson, J. R. (1999). The dare gene: steroid hormone production, olfactory behavior, and pleural degeneration in Drosophila. Development 126: 4591-4602

Fujiwara, H., et al. (1995). Cloning of an ecdysone receptor homolog from Manduca sexta and the developmental profile of its mRNA in wings. Insect Biochem. Mol. Biol. 25(7): 845-56

Gangishetti, U., et al. (2012). The transcription factor Grainy head and the steroid hormone ecdysone cooperate during differentiation of the skin of Drosophila melanogaster. Insect Mol. Biol. 21(3):283-95. PubMed Citation: 22458773

Garbuzov, A. and Tatar, M. (2010). Hormonal regulation of Drosophila microRNA let-7 and miR-125 that target innate immunity. Fly (Austin) 4(4): 306-11. PubMed Citation: 20798594

Garcia-Villalba, P., et al. (1997). Histone acetylation influences thyroid hormone and retinoic acid-mediated gene expression. DNA Cell Biol 16 (4): 421-431

Gates, J., et al. (2004). rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development. Development 131: 25-36. 14645129

Gautam, N. K., Verma, P. and Tapadia, M. G. (2014). Ecdysone regulates morphogenesis and function of malpighian tubules in Drosophila melanogaster through EcR-B2 isoform. Dev Biol 398(2):163-76. PubMed ID: 25476260

Gauthier. K., et al. (1999). Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development. EMBO J. 18(3): 623-631

Gauthier, S. A., VanHaaften, E., Cherbas, L., Cherbas, P. and Hewes, R. S. (2012). Cryptocephal, the Drosophila melanogaster ATF4, is a specific coactivator for ecdysone receptor isoform B2. PLoS Genet. 8(8): e1002883. PubMed Citation: 22912598

Géminard, C., Rulifson, E. J. and Léopold, P. (2009). Remote control of insulin secretion by fat cells in Drosophila. Cell Metab. 10: 199-207. PubMed Citation: 19723496

Geneste, O., Copeland, J.W., and Treisman, R. (2002). LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics. J. Cell Biol. 157: 831-838. 12034774

Ghbeish, N., et al. (2001). The dual role of Ultraspiracle, the Drosophila retinoid X receptor, in the ecdysone response. Proc. Natl. Acad. Sci. 98: 3867-3872. 11274407

Gianni, M., et al. (2002). Phosphorylation by p38MAPK and recruitment of SUG-1 are required for RA-induced RARgamma degradation and transactivation. EMBO J. 21: 3760-3769. 12110588

Giannini, G., et al. (1997). Activation of three distinct RXR/RAR heterodimers induces growth arrest and differentiation of neuroblastoma cells. J. Biol. Chem. 272(42): 26693-26701

Goncalves, M. B., et al. (2005). Timing of the retinoid-signalling pathway determines the expression of neuronal markers in neural progenitor cells. Dev. Biol. 278(1): 60-70. 15649461

Gothe S., et al. (1999). Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation. Genes Dev. 13(10): 1329-41

Gu, S. H., Chow, Y. S. and Yin, C. M. (1998). Involvement of juvenile hormone in regulation of prothoracicotropic hormone transduction during the early last larval instar of Bombyx mori. Mol. Cell. Endocrinol. 127(1): 109-116. PubMed citation: 9099906

Guo, Y., Flegel, K., Kumar, J., McKay, D.J. and Buttitta, L.A. (2016). Ecdysone signaling induces two phases of cell cycle exit in Drosophila cells. Biol Open 5(11):1648-1661. PubMed ID: 27737823

Haas, A. L., et al. (1995). Coordinated induction of the ubiquitin conjugation pathway accompanies the developmentally programmed death of insect skeletal muscle. J. Biol. Chem. 270: 9407-12

Hah, N., Danko, C. G., Core, L., Waterfall, J. J., Siepel, A., Lis, J. T. and Kraus, W. L. (2011). A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cells. Cell 145: 622-634. PubMed ID: 21549415

Hah, N., Murakami, S., Nagari, A., Danko, C. G. and Kraus, W. L. (2013). Enhancer transcripts mark active estrogen receptor binding sites. Genome Res 23: 1210-1223. PubMed ID: 23636943

Hall, B. L. and Thummel, C. S. (1998). The RXR homolog Ultraspiracle is an essential component of the Drosophila ecdysone receptor. Development 125: 4709-4717

Hara, Y., Hirai, K., Togane, Y., Akagawa, H., Iwabuchi, K. and Tsujimura, H. (2013). Ecdysone-dependent and ecdysone-independent programmed cell death in the developing optic lobe of Drosophila. Dev Biol 374: 127-141. PubMed ID: 23149076

Heery, D. M., et al. (1997). A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387(6634): 733-736

Hegstrom, C. D. and Truman, J. W. (1996a). Synapse loss and axon retraction in response to local muscle degeneration. J. Neurobiol. 31 (2): 175-188

Hegstrom, C. D. and Truman, J. W. (1996b). Steroid control of muscle remodeling during metamorphosis in Manduca sexta. J. Neurobiol. 29 (4): 535-550

Hegstrom, C. D., Riddiford, L. M. and Truman, J. W. (1998). Steroid and neuronal regulation of ecdysone receptor expression during metamorphosis of muscle in the moth, Manduca sexta. J. Neurosci. 18(5): 1786-1794

Henrich, V. C., et al. (2003). Juvenile hormone potentiates ecdysone receptor-dependent transcription in a mammalian cell culture system. Insect Biochem. Mol. Biol. 33(12): 1239-47. 14599496

Heller, L. C., et al. (1999). Transcriptional regulation of the Bmp2 gene. Retinoic acid induction in F9 embryonal carcinoma cells and Saccharomyces cerevisiae. J. Biol. Chem. 274(3): 1394-400

Henrich, V. C., et al. (2003). Juvenile hormone potentiates ecdysone receptor-dependent transcription in a mammalian cell culture system. Insect Biochem. Mol. Biol. 33(12): 1239-47. 14599496

Hiruma, K., et al. (1999). Juvenile hormone modulates 20-hydroxyecdysone-inducible ecdysone receptor and ultraspiracle gene expression in the tobacco hornworm, Manduca sexta. Dev. Genes Evol. 209(1): 18-30

Hodin, J. and Riddiford, L. M. (1998). The Ecdysone receptor and Ultraspiracle regulate the timing and progression of ovarian morphogenesis during Drosophila metamorphosis. Dev. Genes Evol. 208(6): 304-17

Hodin, J. and Riddiford, L. M. (2000). Parallel alterations in the timing of ovarian Ecdysone Receptor and Ultraspiracle expression characterize the independent evolution of larval reproduction in two species of gall midges (Diptera: Cecidomyiidae). Dev. Genes Evol. 210: 358-372

Horner, M. A., Chen, T. and Thummel, C. S. (1995). Ecdysteroid regulation and DNA binding properties of Drosophila nuclear hormone receptor superfamily members. Dev. Biol. 168: 490-502

Hu, X., Cherbas, L. and Cherbas, P. (2003). Transcription activation by the Ecdysone receptor (EcR/USP): Identification of activation functions. Mol. Endocrinol. 17(4):716-31. 12554759

Huang, N., et al. (1998). Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators. EMBO J. 17(12): 3398-3412

Hurtado, A., Holmes, K. A., Ross-Innes, C. S., Schmidt, D. and Carroll, J. S. (2011). FOXA1 is a key determinant of estrogen receptor function and endocrine response. Nat Genet 43: 27-33. PubMed ID: 21151129

Ishimoto, H., Sakai, T. and Kitamoto, T. (2009). Ecdysone signaling regulates the formation of long-term courtship memory in adult Drosophila melanogaster. Proc. Natl. Acad. Sci. 106: 6381-6386. PubMed Citation: 19342482

Ishimoto, H. and Kitamoto, T. (2010). The steroid molting hormone Ecdysone regulates sleep in adult Drosophila melanogaster. Genetics 185(1): 269-81. PubMed Citation: 20215472

Ito, M., et al. (2000). Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol. Cell 5(4): 683-93.

Iwamuro, S. and Tata, J. R. (1995). Contrasting patterns of expression of thyroid hormone and retinoid X receptor genes during hormonal manipulation of Xenopus tadpole tail regression in culture. Mol. Cell. Endocrinol. 113 (2): 235-243

Jang, A. C., Chang, Y. C., Bai, J. and Montell, D. (2009). Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt. Nat Cell Biol 11: 569-579. PubMed Citation: 19350016

Jepsen, K., et al. (2000). Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell 102: 753-763. PubMed Citation: 11030619

Jiang, C., Baehrecke, E. H. and Thummel, C. S. (1997). Steroid regulated programmed cell death during Drosophila metamorphosis. Development 124(22): 4673-4683. PubMed Citation: 9409683

Jin, H., Kim, V. N. and Hyun, S. (2012). Conserved microRNA miR-8 controls body size in response to steroid signaling in Drosophila. Genes Dev 26: 1427-1432. Pubmed: 22751499

Jindra, M., et al. (1996). Developmental profiles and ecdysteroid regulation of the mRNAs for two ecdysone receptor isoforms in the epidermis and wings of the tobacco hornworm, Manduca sexta. Dev Biol 180 (1): 258-272. PubMed Citation: 8948589

John, S., Sabo, P. J., Thurman, R. E., Sung, M. H., Biddie, S. C., Johnson, T. A., Hager, G. L. and Stamatoyannopoulos, J. A. (2011). Chromatin accessibility pre-determines glucocorticoid receptor binding patterns. Nat Genet 43: 264-268. PubMed ID: 21258342

Jones D., et al. (2010). Suppressed production of methyl farnesoid hormones yields developmental defects and lethality in Drosophila larvae. Gen. Comp. Endocrin. 165: 244-254. PubMed Citation: 19595690

Kamoshida, Y., et al. (2012). Ecdysone receptor (EcR) suppresses lipid accumulation in the Drosophila fat body via transcription control. Biochem. Biophys. Res. Commun. 421(2): 203-7. PubMed Citation: 22503687

Kamimura, M., Tomita, S., and Fujiwara, H. (1996). Molecular cloning of an ecdysone receptor (B1 isoform) homologue from the silkworm, Bombyx mori, and its mRNA expression during wing disc development. Comp Biochem Physiol. B Biochem. Mol. Biol. 113 (2): 341-347

Knapp, E. and Sun, J. (2017). Steroid signaling in mature follicles is important for Drosophila ovulation. Proc Natl Acad Sci U S A 114(4):699-704. PubMed ID: 28069934

Kao, H. Y., et al. (1998). A histone deacetylase corepressor complex regulates the notch signal transduction pathway. Genes Dev. 12(15): 2269-2277.

Kozlova, T. and Thummel, C. S. (2002). Spatial patterns of ecdysteroid receptor activation during the onset of Drosophila metamorphosis. Development 129: 1739-1750. 11923209

Koelle, M. R., et al. (1991). The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily. Cell 67: 59-77. PubMed Citation: 1913820

König, A., Yatsenko, A. S., Weiss, M. and Shcherbata, H. R. (2011). Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation. EMBO J. 30(8): 1549-62. PubMed Citation: 21423150

Koibuchi, N., et al. (1999). ROR alpha augments thyroid hormone receptor-mediated transcriptional activation. Endocrinology 140(3): 1356-1364. 10067863

Koide, T., et al. (2001). Active repression of RAR signaling is required for head formation. Genes Dev. 15: 2111-2121. 11511542

Kostetskii, I., et al. (1998). Initial retinoid requirement for early avian development coincides with retinoid receptor coexpression in the precardiac fields and induction of normal cardiovascular development. Dev. Dyn. 213(2): 188-98. PubMed Citation: 9786419

Koyama, E., et al. (1999). Retinoid signaling is required for chondrocyte maturation and endochondral bone formation during limb skeletogenesis. Dev. Biol. 208(2): 375-391. PubMed Citation: 10191052

Kraft, R., Levine, R. B. and Restifo, L. L. (1998). The steroid hormone 20-hydroxyecdysone enhances neurite growth of Drosophila mushroom body neurons isolated during metamorphosis. J. Neurosci. 18(21): 8886-99. PubMed Citation: 9786994

Kudoh, T., Wilson, S. W. and Dawid, I. B. (2002). Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm. Development 129: 4335-4346. 12183385

Kumar, M. B., et al. (2002). A single point mutation in ecdysone receptor leads to increased ligand specificity: implications for gene switch applications. Proc. Natl. Acad. Sci. 99(23):14710-5. 12411578

Kumar, S. and Duester, G. (2014a). Retinoic acid controls body axis extension by directly repressing Fgf8 transcription. Development 141: 2972-2977. PubMed ID: 25053430

Kumar, S., Chen, D., Jang, C., Nall, A., Zheng, X. and Sehgal, A. (2014b). An ecdysone-responsive nuclear receptor regulates circadian rhythms in Drosophila. Nat Commun 5: 5697. PubMed ID: 25511299

Kuo, C. T., Jan, L. Y. and Jan, Y. N. (2005). Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling. Proc. Natl. Acad. Sci. 102(42): 15230-5. 16210248

Kurokawa, R., et al. (1998). Differential use of CREB binding protein-coactivator complexes. Science 279(5351): 700-703

Lam, G. and Thummel, C. S. (2000). Inducible expression of double-stranded RNA directs specific genetic interference in Drosophila. Curr. Biol. 10: 957-963.

Lan, Q., Wu, Z. and Riddiford, L. M. (1997). Regulation of the ecdysone receptor, USP, E75 and MHR3 mRNAs by 20-hydroxyecdysone in the GV1 cell line of the tobacco hornworm, Manduca sexta. Insect Mol. Biol. 6 (1): 3-10

Lan, Q., et al. (1999). Activation of a delayed-early gene encoding MHR3 by the ecdysone receptor heterodimer EcR-B1-USP-1 but not by EcR-B1-USP-2. Mol. Cell. Biol. 19(7): 4897-4906. 10373539

Laudet, V. (1997). Evolution of the nuclear receptor superfamily: early diversification from an ancestral orphan receptor. J. Mol. Endocrinol. 19(3): 207-26. PubMed Citation: 9460643

Lavinsky, R. M., et al. (1998). Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes. Proc. Natl. Acad. Sci. 95(6): 2920-2925. PubMed Citation: 9501191

Lavorgna, G., et al. (1993). Potential role for FTZ-F1 steroid receptor superfamily member in the control of Drosophila metamorphosis. Proc. Natl. Acad. Sci. 90: 3004-8. PubMed Citation: 8096644

Lee, S., Lee, B., Lee, J. W. and Lee, S. K. (2009). Retinoid signaling and neurogenin2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBP. Neuron 62(5): 641-54. PubMed Citation: 19524524

Lee, T., et al. (2000). Cell-autonomous requirement of the USP/EcR-B ecdysone receptor for mushroom body neuronal remodeling in Drosophila. Neuron 28: 807-818

Lehmann, M., Wattler, F. and Korge, G. (1997). Two new regulatory elements controlling the Drosophila Sgs-3 gene are potential ecdysone receptor and fork head binding sites. Mech. Dev. 62 (1): 15-27

Li, C., et al. (1997). Coexpression of nuclear receptor partners increases their solubility and biological activities. Proc. Natl. Acad. Sci. 94 (6): 2278-2283

Li, Q., et al. (1999). p300 stimulates transcription instigated by ligand-bound thyroid hormone receptor at a step subsequent to chromatin disruption. EMBO J. 18: 5634-5652

Li, T.-R. and Bender, M. (2000). A conditional rescue system reveals essential functions for the ecdysone receptor( EcR) gene during molting and metamorphosis in Drosophila. Development 127: 2897-2905. PubMed Citation: 10851134

Li, T.-R. and White, K. P. (2003). Tissue-specific gene expression and Ecdysone-regulated genomic networks in Drosophila. Dev. Cell 5: 59-72. 12852852

Li, Y., Ma, Q., Cherry, C. M., Matunis, E. L. (2014). Steroid signaling promotes stem cell maintenance in the Drosophila testis. Dev Biol [Epub ahead of print]. PubMed ID: 25093968

Liu, Z., et al. (2010). Distinct presynaptic and postsynaptic dismantling processes of Drosophila neuromuscular junctions during metamorphosis. J. Neurosci. 30(35): 11624-34. PubMed Citation: 20810883

Mangelsdorf, D. J., et al. (1995). The nuclear receptor superfamily: the second decade. Cell 83: 835-839

Mansilla, A., Martín, F.A., Martín, D. and Ferrús, A. (2015). Ligand-independent requirements of steroid receptors EcR and USP for cell survival. Cell Death Differ 23(3):405-16. PubMed ID: 26250909

Marchetti, G. and Tavosanis, G. (2019). Modulators of hormonal response regulate temporal fate specification in the Drosophila brain. PLoS Genet 15(12): e1008491. PubMed ID: 31809495

Mascrez B., et al. (1998). The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development. Development 125(23): 4691-4707.

Matt, N., et al. (2003). Retinoic acid-induced developmental defects are mediated by RARß/RXR heterodimers in the pharyngeal endoderm. Development 130: 2083-2093. 12668623

McInerney, E. M., et al. (1998). Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation. Genes Dev. 12(21): 3357-68

McNamara, P., et al. (2001). Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. Cell 105: 877-889. 11439184

McParland, A. L., Follansbee, T. L., Vesenka, G. D., Panaitiu, A. E. and Ganter, G. K. (2015). Steroid receptor isoform expression in Drosophila nociceptor neurons is required for normal dendritic arbor and sensitivity. PLoS One 10: e0140785. PubMed ID: 26495837

Melino G., et al. (1997). Retinoic acid receptors alpha and gamma mediate the induction of "tissue" transglutaminase activity and apoptosis in human neuroblastoma cells. Exp. Cell Res. 235(1): 55-61

Minakuchi, C., Nakagawa, Y., Kamimura, M. and Miyagawa, H. (2003). Binding affinity of nonsteroidal ecdysone agonists against the ecdysone receptor complex determines the strength of their molting hormonal activity. Eur. J. Biochem. 270(20): 4095-104. 14519121

Minucci, S., et al. (1997). A histone deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells. Proc. Natl. Acad. Sci. 94(21): 11295-11300

Mirth, C. (2005). Ecdysteroid control of metamorphosis in the differentiating adult leg structures of Drosophila melanogaster. Dev. Biol. 278(1): 163-74. 15649469

Moeller, M. E., Danielsen, E. T., Herder, R., O'Connor, M. B. and Rewitz, K. F. (2013). Dynamic feedback circuits function as a switch for shaping a maturation-inducing steroid pulse in Drosophila. Development 140: 4730-4739. PubMed ID: 24173800

Mohan, M., et al. (2011). The COMPASS family of H3K4 methylases in Drosophila. Mol. Cell. Biol. 31: 4310-4318. PubMed Citation: 21875999

Morris, L. X. and Spradling, A. C. (2012). Steroid signaling within Drosophila ovarian epithelial cells sex-specifically modulates early germ cell development and meiotic entry. PLoS One 7: e46109. PubMed ID: 23056242

Continued: Ecdysone receptor References part 2/2

Ecdysone receptor: Biological Overview | Evolutionary homologs | Regulation | Targets of Activity | Protein interactions | Developmental Biology | Effects of Mutation

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.