Cyclin B


Abrieu, A., Brassac, T., Galas, S., Fisher, D., Labbe, J. C., and Doree, M. (1998). The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs. J. Cell Sci. 111: 1751-1757. PubMed Citation: 9601104

Amon, A. (1997). Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast. EMBO J. 16(10): 2693-702. PubMed Citation: 9184216

Andersen, D. S., et al. (2010). Drosophila MCRS2 associates with RNA polymerase II complexes to regulate transcription. Mol. Cell. Biol. 30(19): 4744-55. PubMed Citation: 20679484

Asano, S., et al. (2005). Concerted mechanism of Swe1/Wee1 regulation by multiple kinases in budding yeast. EMBO J. 24: 2194-2204. 15920482

Asaoka-Taguchi1, M., et al. (1999). Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos. Nat. Cell Biol. 1: 431-437. PubMed Citation: 10559987

Audic, Y., et al. (2001). Zygotic regulation of maternal Cyclin A1 and B2 mRNAs. Mol. Cell. Bio. 21: 1662-1671. 11238903

Ayyar, S., Jiang, J., Collu, A., White-Cooper, H. and White, R. A. H. (2003). Drosophila TGIF is essential for developmentally regulated transcription in spermatogenesis. Development 130: 2841-2852. 12756169

Baker, C.C., Gim, B.S. and Fuller, M.T. (2015). Cell type-specific translational repression of Cyclin B during meiosis in males. Development 142: 3394-3402. PubMed ID: 26443637

Baldinger, T. and Gossen, M. (2009). Binding of Drosophila ORC proteins to anaphase chromosomes requires cessation of mitotic cyclin-dependent kinase activity. Mol. Cell. Biol. 29(1):140-9. PubMed Citation: 18955499

Ban, K. H., et al. (2007). The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis. Dev. Cell 13(1): 29-42. PubMed citation: 17609108

Barnes, E. A., et al. (2001). Patched1 interacts with cyclin B1 to regulate cell cycle progression EMBO J. 20: 2214-2223. 11331587

Barkoff, A. F., et al. (2000). Translational control of Cyclin B1 mRNA during meiotic maturation: Coordinated repression and cytoplasmic polyadenylation. Dev. Biol. 220: 97-109. PubMed Citation: 10720434

Basto, R., et al. (2007). Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans. J. Cell Sci. 120(Pt 7): 1278-87. Medline abstract: 17376965

Beall, E. L., Lewis, P. W., Bell, M., Rocha, M., Jones, D. L. and Botchan, M. R. (2007). Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B. Genes Dev 21: 904-919. PubMed ID: 17403774

Benoit, B., et al. (1999). The Drosophila poly(A)-binding protein II is ubiquitous throughout Drosophila development and has the same function in mRNA polyadenylation as its bovine homolog in vitro. Nucleic Acids Res. 27(19): 3771-8. Medline abstract: 10481015

Benoit, B., et al. (2005). An essential cytoplasmic function for the nuclear poly(A) binding protein, PABP2, in poly(A) tail length control and early development in Drosophila. Dev. Cell. 9(4): 511-22. Medline abstract: 16198293

Bentley, A. M., et al. (2002). Phenotypic characterization of Drosophila ida mutants: defining the role of APC5 in cell cycle progression. J. Cell Sci. 115: 949-961. 11870214

Brandeis, M., et al. (1998). Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero. Proc. Natl. Acad. Sci. 95(8): 4344-4349. PubMed Citation: 9539739

Brito, D. A. and Rieder, C. L. (2006). Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint. Curr. Biol. 16(12): 1194-200. 16782009

Bromberg, J. F., et al. (1999). Stat3 as an Oncogene. Cell 98: 295-303. PubMed Citation: 10458605

Blangy, A., et al. (1995). Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell 83: 1159-1169. PubMed Citation: 8548803

Brook, A., Xie, J.-E., Du, W., and Dyson, N. (1996). Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells. EMBO J. 15: 3676-83. PubMed Citation: 8670871

Cai, Y., et al. (2010). Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. J. Biol. Chem. 285: 4268-4272. PubMed Citation: 20018852

Caspari, T., Murray, J. M. and Carr, A. M. (2002). Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III. Genes Dev. 16: 1195-1208. 12023299

Clarke, P. R., et al. (1995). Regulation of Cdc2/cyclin B activation by Ran, a Ras-related GTPase. J Cell Sci 108: 1217-1225. PubMed Citation: 7622606

Clute, P. and Pines, J. (1999). Temporal and spatial control of cyclin B1 destruction in metaphase. Nat. Cell Biol. 1: 82-87. PubMed Citation: 10559878

Colgan, D. F., et al. (1998). Inhibition of poly(A) polymerase requires p34cdc2/cyclin B phosphorylation of multiple consensus and non-consensus sites. EMBO J. 17: 1053-1062. PubMed Citation: 9463383

Cong, B., Ohsawa, S. and Igaki, T. (2018). JNK and Yorkie drive tumor progression by generating polyploid giant cells in Drosophila. Oncogene. PubMed ID: 29535423

Coué, M., Kearsey, S. E. and Mechali, M. (1996). Chromatin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell-cycle dependent and associated with the control of initiation of DNA replication. EMBO J. 15: 1085-1097. PubMed Citation: 8605878

Crest, J., Oxnard, N., Ji, J. Y. and Schubiger, G. (2007). Onset of the DNA replication checkpoint in the early Drosophila embryo. Genetics 175(2): 567-84. PubMed Citation: 17151243

Cross, F. R., et al. (1999). Specialization and targeting of B-type cyclins. Mol. Cell 4(1): 11-9. PubMed Citation: 10445023

Dalby, B. and Glover, D. M. (1993). Discrete sequence elements control posterior pole accumulation and translational repression of maternal cyclin B RNA in Drosophila. EMBO J 12: 1219-27

D'Angiolella, V., et al. (2001). Role for cyclin-dependent kinase 2 in mitosis exit. Curr. Bio. 11: 1221-1226. 11516956

Dattoli, A. A., Carty, B. L., Kochendoerfer, A. M., Morgan, C., Walshe, A. E. and Dunleavy, E. M. (2020). Asymmetric assembly of centromeres epigenetically regulates stem cell fate. J Cell Biol 219(4). PubMed ID: 32328637

de Moor, C. H. and Richter, J. D. (1999). Cytoplasmic polyadenylation elements mediate masking and unmasking of cyclin B1 mRNA. EMBO J. 18(8): 2294-2303

Detweiler, C. S. and Li, J. J. (1998). Ectopic induction of Clb2 in early G1 phase is sufficient to block prereplicative complex formation in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 95(5): 2384-9

Dawson, I. A., Roth, S. and Artavanis-Tsakonas, S. (1995). The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. J Cell Biol 129: 725-737

Dulic, V., et al. (1998). Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2/M-phase transition. Mol. Cell. Biol. 18(1): 546-557

Duncker, B. P., et al. (1999). Cyclin B-cdk1 kinase stimulates ORC- and Cdc6-independent steps of semiconservative plasmid replication in yeast nuclear extracts. Mol. Cell. Biol. 19(2): 1226-41

Edgar, B. A., et al. (1994). Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis. Genes Dev 8: 440-52

Fenger, D. D., et al. (2000). PAN GU: a protein kinase that inhibits S phase and promotes mitosis in early Drosophila development. Development 127(22): 4763-4774. 11044392

Foley, E., O'Farrell, P. H. and Sprenger, F. (1999). Rux is a cyclin-dependent kinase inhibitor (CKI) specific for mitotic cyclin-Cdk complexes. Curr. Biol. 9: 1392-1402. 10607563

Frouin, I., et al. (2002). Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins. EMBO J. Vol. 21: 2485-2495. 12006500

Gabrielli, B. G., et al. (1997). Hyperphosphorylation of the N-terminal domain of Cdc25 regulates activity toward cyclin B1/cdc2 but not cyclin A/cdk2. J. Biol. Chem. 272(45): 28607-28614

Gaffré, M., et al. (2011). A critical balance between Cyclin B synthesis and Myt1 activity controls meiosis entry in Xenopus oocytes. Development 138(17): 3735-44. PubMed Citation: 21795279

Gergely, F., Kidd, D., Jeffers, K., Wakefield, J. G. and Raff, J.W. (2000). D-TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo. EMBO J. 19: 241-252.

Golan, A., Yudkovsky, Y. and Hershko, A. (2002). The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk. J. Biol. Chem. 277: 15552-15557. 11859075

Goldstrohm, A. C., Hook, B. A., Seay, D. J. and Wickens, M. (2006). PUF proteins bind Pop2p to regulate messenger RNAs. Nat. Struct. Mol. Biol. 13: 533-539. Medline abstract: 16715093

Gong, D., et al. (2007). Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1. Curr. Biol. 17(1): 85-91. Medline abstract: 17208191

Grieco, D., et al. (1996). Requirement for cAMP-PKA pathway activation by M phase-promoting factor in the transition from mitosis to interphase. Science 271: 1718-1723

Groisman, I., et al. (2000). CPEB, Maskin, and Cyclin B1 mRNA at the mitotic apparatus: Implications for local translational control of cell division. Cell 103: 435-447.

Groisman, I., Jung, M. Y., Sarkissian, M., Cao, Q. and Richter, J. D. (2002). Translational control of the embryonic cell cycle. Cell 109: 473-483. 12086604

Grosskortenhaus, R. and Sprenger, F. (2002). Rca1 inhibits APC-Cdh1Fzr and is required to prevent cyclin degradation in G2. Dev. Cell 2: 29-40. 11782312

Guadagno, T. M. and Newport, J. W. (1996). Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity. Cell 84: 73-82

Hardwick, K. G. and Murray, A. W. (1995). Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast. J. Cell Biol. 131: 709-720

Holt, J. E., Weaver, J. and Jones, K. T. (2010). Spatial regulation of APCCdh1-induced cyclin B1 degradation maintains G2 arrest in mouse oocytes. Development 137(8): 1297-304. PubMed Citation: 20223764

Homer, H. A., et al. (2005). Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes. Genes Dev. 19: 202-207. 15655110

Honda, H., et al. (1995). Mouse p87wee1 kinase is regulated by M-phase specific phosphorylation. Chromosome Res 3: 300-308

Huang, J.-y. and Raff, J. W. (1999). The disappearance of cyclin B at the end of mitosis is regulated spatially in Drosophila cells. EMBO J. 18(8): 2184-2195

Huang, J. Y. and Raff, J. W. (2002). The dynamic localisation of the Drosophila APC/C: evidence for the existence of multiple complexes that perform distinct functions and are differentially localised J. Cell Sci. 115(14): 2847-2856. 12082146

Hyun, J., Becam, I., Yanicostas, C. and Bohmann, D. (2006). Control of G2/M transition by Drosophila Fos. Mol. Cell. Biol. 26(22): 8293-302. Medline abstract: 16966382

Innocente, S. A., et al. (1999). p53 regulates a G2 checkpoint through cyclin B1. Proc. Natl. Acad. Sci. 96(5): 2147-2152

Iwabuchi, M., et al. (2002). Coordinated regulation of M Phase exit and S phase entry by the Cdc2 activity level in the early embryonic cell cycle. Dev. Biol. 243: 34-43. 11846475

Jackman, M., Lindon, C., Nigg, E. A. and Pines, J. (2003). Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat. Cell Biol. 5(2): 143-8. 12524548

Jacobs, H. W. et al. (1998). Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B. Genes Dev. 23: 3741-3751

Jacobs, H. W., et al. (2002). Completion of mitosis requires neither fzr/rap nor fzr2, a male germline-specific Drosophila Cdh1 homolog. Curr. Biol. 12: 1435-1441. 12194827

Jallepalli, P. V. and Kelly, T. J. (1996). Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe. Genes Dev. 10: 541-552

Ji, J. Y., Haghnia, M., Trusty, C., Goldstein, L. S. B. and Schubiger, G. (2002). A genetic screen for suppressors and enhancers of the Drosophila Cdk1-Cyclin B identifies maternal factors that regulate microtubule and microfilament stability. Genetics 162: 1179-1195. 12454065

Ji, J. Y., Squirrel, J. M. and Schubiger, G. (2004). Both Cyclin B levels and DNA-replication checkpoint control the early embryonic mitoses in Drosophila. Development 131: 401-411. 14681192

Ji, J.-Y., Crest, J. and Schubiger, G. (2005). Genetic interactions between Cdk1-CyclinB and the Separase complex in Drosophila. Development 132: 1875-1884. 15772129

Jiang, J. and White-Cooper, H. (2003). Transcriptional activation in Drosophila spermatogenesis involves the mutually dependent function of aly and a novel meiotic arrest gene cookie monster. Development 130: 563-573. 12490562

Kadyrova, L. Y., Habara, Y., Lee, T. H. and Wharton, R. P. (2007). Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline. Development 134(8): 1519-27. Medline abstract: 17360772

Kaiser, P., et al. (1999). Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets. Genes Dev. 13(9): 1190-202

Kashevsky, H., et al. (2002). The anaphase promoting complex/cyclosome is required during development for modified cell cycles. Proc. Natl. Acad. Sci. 11217-11222. 12169670

Kaldis, P., Sutton, A. and Solomon, M. J. (1996). The Cdk-activating kinase (CAK) from budding yeast. Cell 86: 553-564

Kellogg, D. R., et al. (1995a). Members of the NAP/SET family of proteins interact specifically with B-type cyclins. J. Cell Biol. 130: 661-673.

Kellogg, D. R. and Murray, A. W. (1995b). NAP1 acts with Clb1 to perform mitotic functions and to suppress polar bud growth in budding yeast. J Cell Biol 130 (3): 675-685

Kellogg, D. R., et al. (1995c). CP60: a microtubule-associated protein that is localized to the centrosome in a cell cycle-specific manner. Mol. Biol. Cell 6: 1673-1684

Kimata, Y., et al. (2008). A mutual inhibition between APC/C and its substrate Mes1 required for meiotic progression in fission yeast. Dev. Cell 14: 446-454. PubMed Citation: 18331722

Knoblich, J. A. and Lehner, C. F. (1993). Synergistic action of Drosophila cyclins A and B during the G2-M transition. EMBO J 12: 65-74

Kondo, T., et al. (1997). Introduction of cyclin B induces activation of the maturation-promoting factor and breakdown of germinal vesicle in growing zebrafish oocytes unresponsive to the maturation-inducing hormone. Dev. Biol. 190(1): 142-152

Kondo, T., Kotani, T. and Yamashita, M. (2001). Dispersion of Cyclin B mRNA aggregation is coupled with translational activation of the mRNA during zebrafish oocyte maturation. Dev. Biol. 229(2): 421-431. 11150242

Kong, M., et al. (2000). Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction. EMBO J. 19: 1378-1388.

Kotani, S., et al. (1999). Regulation of APC activity by phosphorylation and regulatory factors. J. Cell Biol. 146: 791-800

Kotani, T., Yasuda, K., Ota, R. and Yamashita, M. (2013). Cyclin B1 mRNA translation is temporally controlled through formation and disassembly of RNA granules. J Cell Biol 202: 1041-1055. PubMed ID: 24062337

Kotov, A. A., Olenkina, O. M., Kibanov, M. V. and Olenina, L. V. (2016). RNA helicase Belle (DDX3) is essential for male germline stem cell maintenance and division in Drosophila. Biochim Biophys Acta 1863: 1093-1105. PubMed ID: 26876306

Krek, W., and Nigg, E. A. (1991). Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates. EMBO J. 10: 3331-41

Lahav-Baratz, S., et al. (1995). Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase. Proc Natl Acad Sci 92: 9303-9307

Larochelle, S., et al. (1998). Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity. Genes Dev. 12(3): 370-381

Levasseur, M. and McDougall, A. (2000). Sperm-induced calcium oscillations at fertilisation in ascidians are controlled by cyclin B1-dependent kinase activity. Development 127: 631-641

Lehner, C. F., et al. (1992). Cyclins and cdc2 kinases in Drosophila: genetic analyses in a higher eukaryote. Ciba Found Symp 170: 97-109

Ledan, E., et al. (2001). Meiotic maturation of the mouse oocyte requires an equilibrium between Cyclin B synthesis and degradation. Dev. Bio. 232: 400-413

Lee, L. A., et al. (2001). A genetic screen for suppressors and enhancers of the Drosophila PAN GU cell cycle kinase identifies Cyclin B as a target. Genetics 158: 1545-1556. 11514446

Li, J., Meyer, A. N. and Donoghue, D. J. (1995). Requirement for phosphorylation of cyclin B1 for Xenopus oocyte maturation. Mol Biol Cell 6: 1111-1124

Li, J., Meyer, A. N. and Donoghue, D. J, (1997). Nuclear localization of cyclin B1 mediates its biological activity and is regulated by phosphorylation. Proc. Natl. Acad. Sci. 94: 502-507

Lim, H. H., Goh, P. Y. and Surana, U. (1998). Cdc20 is essential for the cyclosome-mediated proteolysis of both Pds1 and Clb2 during M phase in budding yeast. Curr. Biol. 8(4): 231-4

Little, S. C., Sinsimer, K. S., Lee, J. J., Wieschaus, E. F. and Gavis, E. R. (2015). Independent and coordinate trafficking of single Drosophila germ plasm mRNAs. Nat Cell Biol 17(5):558-68. PubMed ID: 25848747

Liu, W., Jiang, F., Bi, X. and Zhang, Y.Q. (2012). Drosophila FMRP participates in the DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis. Hum Mol Genet 21: 4655-4668. PubMed ID: 22843500

Long, J. J., et al. (1998). Repression of TFIIH transcriptional activity and TFIIH-associated cdk7 kinase activity at mitosis. Mol. Cell. Biol. 18(3): 1467-1476

Lopes, C. S., et al. (2005). The Drosophila Bub3 protein is required for the mitotic checkpoint and for normal accumulation of cyclins during G2 and early stages of mitosis. J. Cell Sci. 118: 187-198. 15615783

Lozano, J. C., et al. (1998). A presumptive developmental role for a sea urchin cyclin B splice variant. J. Cell Biol. 140(2): 283-293

Lukas, C., et al. (1999). Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex. Nature 401(6755): 815-8.

Maldonado-Codina, G. and Glover, G. M. (1992). Cyclins A and B associate with chromatin and the polar regions of spindles, respectively, and do not undergo complete degradation at anaphase in syncytial Drosophila embryos. J Cell Biol 116: 967-76

Malureanu, L. A., et al. (2009). BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase. Dev. Cell 16(1): 118-31. PubMed Citation: 19154723

Marangos, P. and Carroll, J. (2004). Fertilization and InsP3-induced Ca2+ release stimulate a persistent increase in the rate of degradation of cyclin B1 specifically in mature mouse oocytes. Dev. Biol. 272: 26-38. 15242788

Mathe, E., Kraft, C., Giet, R., Deak, P., Peters, J. M. and Glover, D. M. (2004). The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation. Curr. Biol. 14(19): 1723-33. 15458643

Mayer-Jaekel, R. E., et al. (1994). Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2. J Cell Sci 107: 2609-2616

McCleland, M. L. and O'Farrell, P. H. (2008). RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle. Curr. Biol. 18: 245-254. PubMed Citation: 18291653

Mendjan, S., et al. (2006). Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. Mol. Cell 21: 811-823. PubMed Citation: 16543150

Meyer, C. A., et al. (2002). Drosophila p27Dacapo expression during embryogenesis is controlled by a complex regulatory region independent of cell cycle progression. Development 129: 319-328. 11807025

Minakhina, S., Druzhinina, M., and Steward R. (2007). Zfrp8, the Drosophila ortholog of PDCD2, functions in lymph gland development and controls cell proliferation. Development 134: 2387-2396. PubMed Citation: 17522156

Mohd-Sarip, A., Lagarou, A., Doyen, C. M., van der Knaap, J. A., Aslan, U., Bezstarosti, K., Yassin, Y., Brock, H. W., Demmers, J. A. and Verrijzer, C. P. (2012). Transcription-independent function of Polycomb group protein PSC in cell cycle control. Science 336: 744-747. PubMed ID: 22491092

Moore, J. D., et al. (1999). Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1. J. Cell Biol. 144(2): 213-24. PubMed ID: 9922449

Murray, A. W. (1992). Creative blocks: cell-cycle checkpoints and feedback controls. Nature 359: 599-604. PubMed ID: 1406993

Nakahata, S., et al. (2001). Biochemical identification of Xenopus Pumilio as a sequence-specific Cyclin B1 mRNA-binding protein that physically interacts with a Nanos homolog, Xcat-2, and a cytoplasmic polyadenylation element-binding protein. J. Biol. Chem. 276: 20945-20953. 11283000

Nakahata, S., et al. (2003). Involvement of Xenopus Pumilio in the translational regulation that is specific to cyclin B1 mRNA during oocyte maturation. Mech. Dev. 120: 865-880. 12963108

Nakato, H., Futch. T. A. and Selleck, S. B. (1995). The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila. Development 121(11): 3687-3702

Nam, H. J. and van Deursen, J. M. (2014). Cyclin B2 and p53 control proper timing of centrosome separation. Nat Cell Biol 16: 538-549. PubMed ID: 24776885

Nicklas, R. B., Ward, S. C. and Gorbsky, G. J. (1995). Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint. J. Cell Biol. 130: 929-939

Nishiyama, A., et al. (2000). A nonproteolytic function of the proteasome is required for the dissociation of Cdc2 and cyclin B at the end of M phase. Genes Dev. 14: 2344-2357

Nixon, V. L., et al. (2002). Ca2+ oscillations promote APC/C-dependent cyclin B1 degradation during metaphase arrest and completion of meiosis in fertilizing mouse eggs. Curr. Biol. 12: 746-750. 12007419

Okada, M., et al. (2002). Myb controls G2/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc. EMBO J. 21: 675-684. 11847115

Okano-Uchida, T., et al. (1998). In vivo regulation of Cyclin A/Cdc2 and Cyclin B/Cdc2 through meiotic and early cleavage cycles in starfish. Dev. Biol. 197(1): 39-53

Okumura, E., Morita, A., Wakai, M., Mochida, S., Hara, M. and Kishimoto, T. (2014). Cyclin B-Cdk1 inhibits protein phosphatase PP2A-B55 via a Greatwall kinase-independent mechanism. J Cell Biol 204: 881-889. PubMed ID: 24616226

Park, M and Krause, M. K. (1999). Regulation of postembryonic G1 cell cycle progression in Caenorhabditis elegans by a cyclin D/CDK-like complex. Development 126: 4849-4860

Parry, D. H. and O'Farrell, P. H (2001). The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis. Curr. Biol. Vol 11: 671-683. 11369230

Parry, D. H., Hickson, G. R. X. and O'Farrell, P. H. (2003). Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase. Curr. Biol. 13: 647-653. 12699620

Penton, A., Selleck, S. B., and Hoffmann, F. M. (1997). Regulation of cell cycle synchronization by decapentaplegic during Drosophila eye development. Science 275(5297): 203-206

Polanski Z., et al. (1998). Cyclin synthesis controls the progression of meiotic maturation in mouse oocytes. Development 125(24): 4989-97

Prestel, M., et al. (2010). The activation potential of MOF is constrained for dosage compensation. Mol. Cell 38: 815-826. PubMed Citation: 20620953

Pushpavalli, S. N., Sarkar, A., Bag, I., Hunt, C. R., Ramaiah, M. J., Pandita, T. K., Bhadra, U. and Pal-Bhadra, M. (2013). Argonaute-1 functions as a mitotic regulator by controlling Cyclin B during Drosophila early embryogenesis. FASEB J. PubMed ID: 24165481

Qian, Y. W., et al. (2001). The Polo-like kinase Plx1 is required for activation of the phosphatase Cdc25C and Cyclin B-Cdc2 in Xenopus oocytes. Mol. Biol. Cell 12: 1791-1799. 11408585

Raff, J. W., Jeffers, K. and Huang, J.-y. (2002). The roles of Fzy/Cdc20 and Fzr/Cdh1 in regulating the destruction of cyclin B in space and time. J. Cell Biol. 157: 1139-1149. 12082076

Rahal, R. and Amon, A. (2008). Mitotic CDKs control the metaphase-anaphase transition and trigger spindle elongation. Genes Dev. 22: 1534-1548. PubMed Citation: 18519644

Raja, S. J., et al. (2010). The nonspecific lethal complex is a transcriptional regulator in Drosophila. Mol. Cell 38: 827-841. PubMed Citation: 20620954

Reber, A., Lehner, C. F. and Jacobs, H. W. (2006). Terminal mitoses require negative regulation of Fzr/Cdh1 by Cyclin A, preventing premature degradation of mitotic cyclins and String/Cdc25. Development 133(16): 3201-11. 16854973

Reed, B. H. and Orr-Weaver, T. L. (1997). The Drosophila gene morula inhibits mitotic functions in the endo cell cycle and the mitotic cell cycle. Development 124: 3543-3553

Richardson, H., et al. (1992). Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2. Genes Dev. 6(11): 2021-34

Rimmington, G., Dalby, B. and Glover, D. M. (1994). Expression of N-terminally truncated cyclin B in the Drosophila larval brain leads to mitotic delay at late anaphase. J Cell Sci 107: 2729-2738

Rosania, G. R., et al. (1999). A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts. Proc. Natl. Acad. Sci. 96(9): 4797-802

Ruden, D. M. and Jackle, H. (1995). Mitotic delay dependent survival identifies components of cell cycle control in the Drosophila blastoderm. Development 121: 63-73

Sakamoto, I., et al. (1998). Changes in cyclin B during oocyte maturation and early embryonic cell cycle in the newt, Cynops pyrrhogaster: requirement of germinal vesicle for MPF activation. Dev. Biol. 195(1): 60-69

Segal, M., Clarke, D. J. and Reed, S. I. (1998). Clb5-associated kinase activity is required early in the spindle pathway for correct preanaphase nuclear positioning in Saccharomyces cerevisiae. J. Cell Biol. 143(1): 135-45

Seino, H., Kishi, T., Nishitani, H. and Yamao, F. (2003). Two ubiquitin-conjugating enzymes, UbcP1/Ubc4 and UbcP4/Ubc11, have distinct functions for ubiquitination of mitotic cyclin. Mol Cell Biol. 23(10): 3497-505

Sigrist, S., et al. (1995). Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3. EMBO J 14: 4827-4838

Sigrist, S. J. and Lehner, C. F. (1997). Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell 90(4): 671-681

Smith, K. N., et al. (2001). B-type cyclins CLB5 and CLB6 control the initiation of recombination and synaptonemal complex formation in yeast meiosis. Curr. Biol. 11: 88-97. 11231124

Sonoda, J. and Wharton, R. P. (2001). Drosophila Brain tumor is a translational repressor. Genes Dev. 15(6): 762-73. 11274060

Stiffler, L. A., et al. (1999). Cyclin A and B functions in the early Drosophila embryo. Development 126: 5505-5513.

Swan, A. and Schupbach, T. (2007). The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila. Development 134(5): 891-9. Medline abstract: 17251266

Su, T. T., et al. (1998). Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation. Genes Dev. 12(10): 1495-1503

Takino, K., Ohsawa, S. and Igaki, T. (2014). Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila. Dev Biol 395(1): 19-28. PubMed ID: 25224221

Tay, J., Hodgman, R. and Richter, J. D. (2000). The control of Cyclin B1 mRNA translation during mouse oocyte maturation. Dev. Biol. 221: 1-9.

Temme, C., et al. (2004). A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila. EMBO J. 23. 2862-2871. Medline abstract: 15215893

Theurkauf, W. E., et al. (1993). A central role for microtubules in the differentiation of Drosophila oocytes. Development 118: 1169-80

Tio, M., et al. (2001). cdc2 links the Drosophila cell cycle and asymmetric division machineries. Nature 409: 1063-1067. 11234018

Tjandra, H., Compton, J. and Kellogg, D. (1998). Control of mitotic events by the Cdc42 GTPase, the Clb2 cyclin and a member of the PAK kinase family. Curr. Biol. 8(18): 991-1000

Tokumoto, T., et al. (1997). Initiation of cyclin B degradation by the 26S proteasome upon egg activation. J. Cell Biol. 138(6): 1313-1322

Townsley, F. M., et al. (1997). Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase. Proc. Natl. Acad. Sci. 94(6): 2362-7. 9122200

Toyoshima, F., et al. (1998). Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint. EMBO J. 17: 2728-2735

Trcek, T., Grosch, M., York, A., Shroff, H., Lionnet, T. and Lehmann, R. (2015). Drosophila germ granules are structured and contain homotypic mRNA clusters. Nat Commun 6: 7962. PubMed ID: 26242323

Vardy, L. and Orr-Weaver, T. (2007). The Drosophila PNG kinase complex regulates the translation of Cyclin B. Dev. Cell 12: 157-166. Medline abstract: 17199048

Vied, C., Halachmi, N., Salzberg, A. and Horabin, J. I. (2003). Antizyme is a target of Sex-lethal in the Drosophila germline and appears to act downstream of Hedgehog to regulate Sex-lethal and Cyclin B. Dev. Bio. 253: 214-229. 12645926

Vorlaufer, E. and Peters, J. M. (1998). Regulation of the cyclin B degradation system by an inhibitor of mitotic proteolysis. Mol. Biol. Cell 9(7): 1817-1831

Voronina, E., Marzluff, W. F. and Wessel, G. M. (2003). Cyclin B synthesis is required for sea urchin oocyte maturation. Dev. Biol. 256: 258-275. 12679101

Wakefield, J. G., Huang, J.-y. and Raff, J. W. (2000). Centrosomes have a role in regulating the destruction of cyclin B in early Drosophila embryos Curr. Biol. 10: 1367-1370. 11084336

Wang, Z. and Mann, R. S. (2003). Requirement for two nearly identical TGIF-related homeobox genes in Drosophila spermatogenesis. Development 130: 2853-2865. 12756170

Wang, Z., Fan, M., Candas, D., Zhang, T. Q., Qin, L., Eldridge, A., Wachsmann-Hogiu, S., Ahmed, K. M., Chromy, B. A., Nantajit, D., Duru, N., He, F., Chen, M., Finkel, T., Weinstein, L. S. and Li, J. J. (2014). Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression. Dev Cell 29: 217-232. PubMed ID: 24746669

White-Cooper, H., Schafer, M. A., Alphey, L. S. and Fuller, M. T. (1998). Transcriptional and post-transcriptional control mechanisms coordinate the onset of spermatid differentiation with meiosis I in Drosophila. Development 125: 125-134. PubMed ID: 9389670

White-Cooper, H., et al. (1998). Transcriptional and post-transcriptional control mechanisms coordinate the onset of spermatid differentiation with meiosis I in Drosophila. Development 125(1): 125-134

Whitfield, W. G. F., et al. (1990). The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transition. EMBO J. 9: 2563-72

Wu, C., et al. (1998). Cell cycle- and Cln2p-Cdc28p-dependent phosphorylation of the yeast Ste20p protein kinase. J. Biol. Chem. 273(43): 28107-15

Wu, Q., et al. (2007). A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest. Curr. Biol. 17: 213-224. Medline abstract: 17276914

Wuarin, J., et al. (2002). Stable association of mitotic Cyclin B/Cdc2 to replication origins prevents endoreduplication. Cell 111: 419-431. 12419251

Yang, J., et al. (1998). Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1. Genes Dev. 12(14): 2131-2143

Yeong, F. M., et al. (2000). Exit from mitosis in budding yeast: Biphasic inactivation of the Cdc28-Clb2 mitotic kinase and the role of Cdc20. Molec. Cell 5: 501-511

Yuan, K., Farrell, J. A., O'Farrell, P. H. (2012). Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis. J. Cell Biol. 198(6): 973-80. PubMed Citation: 22965907

Zhang, X., et al. (2008). Polar body emission requires a RhoA contractile ring and Cdc42-mediated membrane protrusion. Dev. Cell 15: 386-400. PubMed Citation: 18804436

Zhu, W., Giangrande, P. H. and Nevins, J. R. (2004) E2Fs link the control of G1/S and G2/M transcription. EMBO J. 23(23): 4615-26. 15510213

Zur A. and Brandeis, M. (2002). Timing of APC/C substrate degradation is determined by fzy/fzr specificity of destruction boxes. EMBO J. 21: 4500-4510. 12198152

Cyclin B: Biological Overview | Evolutionary Homologs | Regulation | Developmental Biology | Effects of Mutation

date revised: 10 December 2020

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