The Interactive Fly

Evolutionarily conserved developmental pathways



Axon repulsion: The role of Semaphorins/collapsins and a downstream target

The Semaphorin/collapsin family of cell surface and secreted proteins is conserved in Drosophila and vertebrates. A presumptive mediator of axon guidance signals, UNC-33, was first characterized in C. elegans. A vertebrate homolog was later found to mediated Semaphorin signals.


Drosophila                     Homologs in other species ----------                     ----------------------------Semaphorin I                   Mammals: Semaphorin III, Sema A-E, Sema A(V), Sema IV                               Chickens: CollapsinSemaphorin II                  Mammals: Semaphorin III, Sema A-E, Sema A(V), Sema IV                               Chickens: Collapsin                                Unknown in the fly             C. elegans: Unc 33(Putatitive target of          Rat: TOAD-64Semaphore signals)




date revised: 13 Oct 96

Developmental Pathways conserved in Evolution

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